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Structural basis for the inhibition of pre-replicative complex assembly by Geminin

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Structural basis for the inhibition of pre-replicative compl...

Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： Changwook Lee Yugene Kim Bumsoo Hong Jungmin Choi Shusuke tada YoungChang Kim Yunje Cho National Creative Research Center for Structural Biology and Department of Life Science Pohang University of Science and TechnologyHyo-ja dongSan31PohangKyungBookSouth Korea National Creative Research Center for Structural Biology and Department of Life Science Pohang University of Science and TechnologyHyo-ja dongSan31PohangKyungBookSouth Korea National Creative Research Center for Structural Biology and Department of Life Science Pohang University of Science and TechnologyHyo-ja dongSan31PohangKyungBookSouth Korea National Creative Research Center for Structural Biology and Department of Life Science Pohang University of Science and TechnologyHyo-ja dongSan31PohangKyungBookSouth Korea Graduate School of Phamarceutical Sciences Tohoku UniversityAoba-KuSenda Miyagi 980-8578Japan Bioscience Division Structural Biology CenterArgonne National Laboratory9700 South Cass AvenueArgonneIL 60439USA National Creative Research Center for Structural Biology and Department of Life Science Pohang University of Science and TechnologyHyo-ja dongSan31PohangKyungBookSouth Korea

＜正＞ To maintain the chromosomal stability in eukarytic cell, origins of DNA must be licensed for replication only once in each cell cycle. Inhibition of pre-replicative complex formation by Geminin, a highly conserved protein in eukaryotes, represents a central mechanism to regulate the replication licensing during the cell cycle progression. Regulation of the assembly of pre-RC complex may provide an

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World Journal of Gastroenterology 2012年第41期18卷 5879-5888页

作者： Akihito Tsubota Noritomo Shimada Hiroshi Abe Kai Yoshizawa Rie Agata Yoko Yumoto Makiko Ika Yoshihisa Namiki Keisuke Nagatsuma Hiroshi Matsudaira Kiyotaka Fujise Norio tada Yoshio Aizawa Institute of Clinical Medicine and Research The Jikei University School of Medicine163-1 Kashiwa-shitaKashiwaChiba 277-8567Japan Division of Gastroenterology and Hepatology Kashiwa HospitalThe Jikei University School of Medicine163-1 Kashiwa-shitaKashiwaChiba 277-8567Japan Department of Gastroenterology Shinmatsudo Central General Hospital1-380 ShinmatsudoMatsudoChiba 270-0034Japan Division of Gastroenterology and Hepatology Katsushika Medical CenterThe Jikei University School of Medicine6-41-2 AotoKatsushika-kuTokyo 125-8506Japan

AIM： To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon plus ribavirin for chronic hepatitis C. METHODS： Five hundred and sixty-one Japanese patients with hepatitis C virus genotype lb who had received combination treatment were enrolled and as- signed randomly to the derivation and confirmatory groups. Single nucleotide polymorphisms at or nearby ITPA were genotyped by real-time detection poly- merase chain reaction. Factors influencing significant anemia （hemoglobin concentration 〈 10.0 g/dL at week 4 of treatment） and significant hemoglobin decline （declining concentrations 〉 3.0 g/dL at week 4） were analyzed using multiple regression analyses. Prediction formulae were constructed by significantly independent factors. RESULTS： Multivariate analysis for the derivation group identified four independent factors associated with significant hemoglobin decline： hemoglobin decline at week 2 [P = 3.29× 10^4, odds ratio （OR） = 7.54 （g/dL）], estimated glomerular filtration rate [P = 2.16× 10^4, OR = 0.962 （ml/min/1.73 m2）], rs1127354 （P = 5.75 × 10^4, OR = 10.94） and baseline hemoglobin [P = 7.86 × 10^4, OR = 1.50 （g/alL）]. Using the model constructed by these factors, positive and negative predictive values and predictive accuracy were 79.8%, 88.8% and 86.2%, respectively. For the confirmatory group, they were 83.3%, 91.0% and 88.3%. These factors were closely correlated with significant anemia. However, the model could not be constructed, because no patients with rs1127354 minor genotype CA/AA had significant anemia. CONCLUSION： Reliable formulae for predicting the likelihood of ribavirin-induced anemia were constructed. Such modeling may be useful in developing individual tailoring and optimization of ribavirin dosage.

关键词： Chronic hepatitis C virus infection Ribavi-rin Pegylated interferon Prediction model Hemolyticanemia Single nucleotide polymorphism

Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4

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World Journal of Gastrointestinal Endoscopy 2022年第4期14卷 215-225页

作者： Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji tada Department of Gastroenterology Kumamoto City HospitalKumamoto City 862-8505Japan Department of Gastroenterology Tsuruta HospitalKumamoto City 862-0925Japan Department of Gastroenterology Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Gastroenterology Saiseikai Kumamoto HospitalKumamoto City 861-4193Japan Department of Gastroenterological Surgery Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Biostatics Kurume UniversityKurume City 8300011Japan

BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been ***,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor *** To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or *** This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic *** a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were ***-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS *** The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),*** the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate *** success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or ***,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics.

关键词： Endoscopic retrograde Cholangiopancreatography Complication Performance status Risk factor

Laser-Treated Surfaces for VADs:From Inert Titanium to Potential Biofunctional Materials

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Biomedical Engineering Frontiers 2022年第1期3卷 399-406页

作者： Eduardo Bock Wilhelm Pfleging Dayane tada Erenilda Macedo Nathalia Premazzi Rosa Sá Juliana Solheid Heino Besser Aron Andrade Laboratory of Bioengineering and Biomaterials Federal Institute of Technology in Sao Paulo(IFSP)Sao PauloBrazil Center of Engineering in Circulatory Assistance Institute Dante Pazzanese of Cardiology(IDPC)Sao PauloBrazil Institute for Applied Materials-Applied Materials Physics Karlsruhe Institute of Technology(KIT)KarlsruheGermany Federal University of Sao Paulo(UNIFESP) Sao Jose dos CamposBrazil National Institute for Space Research(INPE) Sao Jose dos CamposBrazil

***-treated surfaces for ventricular assist *** *** work has scientific impact since it proposes a biofunctional surface created with laser processing in bioinert *** diseases are the world’s leading cause of *** especially debilitating heart disease is congestive heart *** the possible therapies,heart transplantation and mechanical circulatory assistance are the main treatments for its severe form at a more advanced *** development of biomaterials for ventricular assist devices is still being carried *** polished titanium is currently employed in several devices,its performance could be improved by enhancing the bioactivity of its *** to improve the titanium without using coatings that can be detached,this work presents the formation of laser-induced periodic surface structures with a topology suitable for cell adhesion and neointimal tissue *** surface was modified by femtosecond laser ablation and cell adhesion was evaluated in vitro by using fibroblast *** results indicate the formation of the desired topology,since the cells showed the appropriate adhesion compared to the control *** electron microscopy showed several positive characteristics in the cells shape and their surface *** in vitro results obtained with different topologies point that the proposed LIPSS would provide enhanced cell adhesion and *** laser processes studied can create new interactions in biomaterials already known and improve the performance of biomaterials for use in ventricular assist devices.

关键词： titanium biomaterials Titanium

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用敞开水平热模生产铝带坯

有色金属加工 1995年第6期24卷 23-25页

作者： K.tada 赵洪友

欧诺(ohno)铝带铸造(简称 OSC)工艺,是由日本千叶工程技术学院欧诺(Ohno)教授发明的。欧诺(ohno)水平连续铸造(occ)原理已广泛用于单向结晶结构的铜棒、线材、管材和铝合金棒的铸造。在 OSC 工艺中,敞开水平热模代替了传纺的水冷模铸造,... 详细信息

欧诺(ohno)铝带铸造(简称 OSC)工艺,是由日本千叶工程技术学院欧诺(Ohno)教授发明的。欧诺(ohno)水平连续铸造(occ)原理已广泛用于单向结晶结构的铜棒、线材、管材和铝合金棒的铸造。在 OSC 工艺中,敞开水平热模代替了传纺的水冷模铸造,OSC 工艺的特点是保持铸模温度高于铸造金属的凝固温度,冷却水作用在铸模中的凝固铸带坯的上表面,利用这一铸造特点,能够以高的铸造速度生产表面十分平滑的铝带坯。

关键词：敞开水平热模铝带材连铸

High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots

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Molecular Plant 2015年第8期8卷 1253-1273页

作者： Mitsuhiro Matsuo Joy MichalJohnson Ayaka Hieno Mutsutomo Tokizawa Mika Nomoto yasuom. tada Rinesh Godfrey Junichi Obokata Irena Sherameti Yoshiharu Y. Yamamoto~l Frank-D. Boehmer Ralf Oelmuller Institute of Plant Physiology Friedrich-Schiller University Jena Dornburger StraSe 159 07743 Jena Germany Graduate School of Life and Environmental Sciences Kyoto Prefectural University 1-5 Hangi-cho Shimogamo Sakyo-ku Kyoto 606-8522 Japan Faculty of Applied Biological Sciences Gifu University Yanagido 1-1 Gifu City 501-1193 Japan Center for Gene Research Nagoya University Furo-cho Chikusa-ku Nagoya 464-8601 Japan Institute of Molecular Cell Biology Center for Molecular Biomedicine Jena University Hospital 00743 Jena Germany Molecular Cardiology Department of Cardiovascular Medicine University Hospital M0nster 48149 M0nster Germany These authors contributed equally to this article.

Redox Responsive Transcription Factor1 （RRTF1） in Arabidopsis is rapidly and transiently upregulated by H202, as well as biotic- and abiotic-induced redox signals. RRTF1 is highly conserved in angio- sperms, but its physiological role remains elusive. Here we show that inactivation of RRTF1 restricts and overexpression promotes reactive oxygen species （ROS） accumulation in response to stress. Transgenic lines overexpressing RRTF1 are impaired in root and shoot development, light sensitive, and susceptible to Alternaria brassicae infection. These symptoms are diminished by the beneficial root endophyte Piriformospora indica, which reduces ROS accumulation locally in roots and systemi- cally in shoots, and by antioxidants and ROS inhibitors that scavenge ROS. More than 800 genes were detected in mature leaves and seedlings of transgenic lines overexpressing RRTF1; ∽40% of them have stress-, redox-, ROS-regulated-, ROS-scavenging-, defense-, cell death- and related functions. Bioinformatic analyses and in vitro DNA binding assays demonstrate that RRTF1 binds to GCC-box-like sequences in the promoter of RRTFl-responsive genes. Upregulation of RRTF1 by stress stimuli and H202 requires WRKY18/40/60. RRTF1 is co-regulated with the phylogenet- ically related RAP2.6, which contains a GCC-box-like sequence in its promoter, but transgenic lines overexpressing RAP2.6 do not accumulate higher ROS levels. RRTF1 also stimulates systemic ROS accumulation in distal non-stressed leaves. We conclude that the elevated levels of the highly conserved RRTF1 induce ROS accumulation in response to ROS and ROS-producing abiotic and biotic stress signals.

关键词： abiotic and biotic stress reactive oxygen species H202 REDOX RESPONSIVE TRANSCRIPTIONFACTOR1 RAP2.6 RRTF1 promoter binding sites

DEVELOPMENT OF LIFE-CONTROLLABLE-SMART（ LCS） CONCRETE USING RECYCLED PET RESIN BLOCKS

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DEVELOPMENT OF LIFE-CONTROLLABLE-SMART（ LCS） CONCRETE USIN...

中国对拉美农产品出口的影响因素分析及前景展望

作者： Takayuki Kusaka Hironori Namiki Kei Urabe Hiromasa Takeno Yukio tada Masaki Hojo Keiko Watanabe Kensuke Okubo Department of Mechanical Engineering Ritsumeikan UniversityJapan Kyobashi Corporation Japan National Institute of Advanced Industrial Science and Technology Japan Department of Electrical and Electronics Engineering Kobe UniversityJapan Keikon Corporation Japan Department of Mechanical Engineering Kyoto UniversityJapan Department of Mechanical Engineering Ritsumeikan UniversityJapan Department of Mechanical Engineering Ritsumeikan UniversityJapan

＜正＞A functional concrete, named "Life-Controllable-Smart" concrete, has been developed on the basis of the composite technology. The material, which was a kind of composite materials consisting of concrete and recycled PET blocks, could be easily and safely broken on demand by irradiating 2. 45 GHz microwave. The breakability, heatability, flowability and strength of the LCS concrete were investigated to improve the total performance of the material. Numerical and experimental results showed that the LCS concrete could be broken by heating up to 50-90 K above the room temperature, when the volume fraction of PET blocks was controlled within a range of 2% -5 % , where the compressive strength was reduced by 10% -20 %. The casting flowability of the LCS concrete could be adequately controlled by mixing a cellulose ether type thickener. The microwave heatability of the PET blocks could be effectively improved by mixing carbon milled fibers. Moreover, the applicability of the LCS concrete to temporary constructions was studied.

关键词： Smart Materials Microwave Heating Composite Concrete, PET

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农业展望 2008年第8期4卷 26-29页

作者：张洁刘合光 Chien Hsiaoping Minoru tada 中国人民大学农业与农村发展学院北京100872 中国农业科学院农业经济与发展研究所北京100081 日本国际农林水产业研究中心

利用引力模型,应用1995～2004年的贸易数据,考察了中国对拉美主要国家农产品出口的影响因素。计算结果显示,中国农产品供给能力、进口国GDP以及距离因素是中国对拉美农产品出口的重要影响因素。进一步的分析表明,中国对拉美主要贸易伙... 详细信息

利用引力模型,应用1995～2004年的贸易数据,考察了中国对拉美主要国家农产品出口的影响因素。计算结果显示,中国农产品供给能力、进口国GDP以及距离因素是中国对拉美农产品出口的重要影响因素。进一步的分析表明,中国对拉美主要贸易伙伴的农产品出口属于"贸易活跃"状况,其中乌拉圭的农产品市场已经得到较深入的开拓,而委内瑞拉、阿根廷和厄瓜多尔等3个国家的出口潜力还需要进一步挖掘。

关键词：引力模型农产品出口拉美国家

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日本国际理解教育的框架体系与未来课题

外国教育研究 2019年第10期46卷 115-128页

作者：熊梅刘志豪多田孝志贵州师范大学教育学院贵州贵阳550001 日本金沢学院大学文学部日本金沢920-1392

面对全球一体化的发展趋势,日本在1991年成立了国际理解教育学会,在民间组织和日本政府的共同努力之下,日本国际理解教育得以快速发展。日本国际理解教育学会在理论的层面上,厘清了国际理解教育的内涵和外延;在实践的层面上,围绕目标、... 详细信息

面对全球一体化的发展趋势,日本在1991年成立了国际理解教育学会,在民间组织和日本政府的共同努力之下,日本国际理解教育得以快速发展。日本国际理解教育学会在理论的层面上,厘清了国际理解教育的内涵和外延;在实践的层面上,围绕目标、学习领域、途径和方式、评价四个方面确定国际理解教育的框架体系。日本文部科学省在政策的层面上,从教育理念、学习目标、学习方法、评价方式四个方面提出日本国际理解教育未来将要面临的课题。

关键词：日本国际理解教育框架体系未来课题