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The Effect of Scoparone on Relaxing Tracheal Smooth Muscle and Regulating Intracellular Calcium Concentration

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中国药理通讯 2005年第4期22卷 41-43页

作者： Zan Teng Zhi Li Hong - rui Liu Mei - mi Zhao Jin - sheng Zhao Xiu - hua Yu yasuo watanabe Department of Ethnopharmacology China Medical University Shenyang 110001 China Department of Pharmacology/Pharmacotherapy Nihon Pharmaceutical University 10281 Komuro Ina - machi Kita - Adachi - gun Saitama 362 -0806 Japan

Inhibitiory Effect of Scoparone on Inflammatory Mediator of Asthmatic Models of Guinea Pigs

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中国药理通讯 2005年第4期22卷 43-44页

作者： Mei - mi Zhao Zan Teng Zhi Li Hong - rui Liu Jin - sheng Zhao Xiu - hua Yu Ying Fan yasuo watanabe Department of Ethnopharmacology China Medical University Shenyang 110001 China Department of Pharmacology/Pharmacotherapy Nihon PharmaceuticalUniversity 10281 Komuro Ina - machi Kita - Adachi - gun Saitama 362 - 0806

藻酸双酯钠改善模型大鼠的胰岛素抵抗和血脂异常(英文)

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药学学报 2007年第5期42卷 488-491页

作者：赵美眯李智滕赞赵金生于秀华渡边泰雄肇丽梅中国医科大学药学院辽宁沈阳110001 日本药科大学医药药学科中国医科大学附属第二医院临床药理实验室辽宁沈阳110001

藻酸双酯钠具有抗凝、抗血栓以及调节血脂等作用,是一种新型的抗动脉粥样硬化药物。但它对糖尿病伴脂代谢异常血症的治疗作用还没有明确。本研究建立糖尿病伴脂代谢异常血症大鼠模型,初步探讨藻酸双酯钠对其血糖和血脂的调节作用。Wista... 详细信息

藻酸双酯钠具有抗凝、抗血栓以及调节血脂等作用,是一种新型的抗动脉粥样硬化药物。但它对糖尿病伴脂代谢异常血症的治疗作用还没有明确。本研究建立糖尿病伴脂代谢异常血症大鼠模型,初步探讨藻酸双酯钠对其血糖和血脂的调节作用。Wistar大鼠高脂饲料喂养1.5个月后尾静脉注射链脲佐菌素。建模成功后,灌胃给予藻酸双酯钠1个月,检测血中血糖、胰岛素和脂质浓度。结果显示,藻酸双酯钠治疗组与糖尿病对照组相比,血中甘油三酯、总胆固醇和低密度脂蛋白明显降低,高密度脂蛋白显著升高,藻酸双酯钠治疗后血糖和胰岛素浓度有所下降,而胰岛素敏感指数比糖尿病对照组明显提高。本研究提示,藻酸双酯钠可以改善糖尿病伴脂代谢异常血症大鼠血脂异常,并提高胰岛素敏感性。

关键词：藻酸双酯钠实验性糖尿病链脲佐菌素脂代谢异常血症

BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy

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World Journal of Gastroenterology 2012年第17期18卷 2092-2098页

作者： yasuo Kakugawa Yutaka Saito Shoichi Saito Kenji watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki Ishikawa Hisao Tajiri Division of Screening Technology and Development Research Center for Cancer Prevention and ScreeningNational Cancer CenterTokyo 104-0045Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Endoscopy Jikei University School of MedicineTokyo 105-8461Japan Department of Gastroenterology Osaka City University Graduate School of MedicineOsaka 545-8685Japan Department of Therapeutic Medicine Nagoya University Graduate School of MedicineNagoya 466-8560Japan Second Department of Internal Medicine Osaka Medical CollegeOsaka 569-8686Japan Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan Department of Molecular-Targeting Cancer Prevention Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-0841Japan

AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(group A) with the "conventional volume method"(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.

关键词：胶囊结肠内镜检查随机对照试验制备方法电池寿命编制方案

Colorectal neuroendocrine carcinoma: A case report and review of the literature

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World Journal of Clinical Cases 2019年第14期7卷 1865-1875页

作者： Tomoaki Yoshida Kenya Kamimura Kazunori Hosaka Koji Doumori Hiromitsu Oka Akito Sato yasuo Fukuhara Shoji watanabe Tomomi Sato Akira Yoshikawa Takashi Tomidokoro Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Division of Gastroenterology and Hepatology Nagaoka Chuo General HospitalNiigata 940-0861Japan

BACKGROUND Colorectal neuroendocrine carcinoma (NEC) is a rare tumor that demonstrates aggressive growth pattern with ingrowth into the tract, metastasis to the other organs, and invasion to the surrounding organs;these clinical characteristics result in poor prognosis. Surgical resection appears as an effective approach;however, because it is difficult to accurately diagnose NEC during the early stage and owing to its aggressive growth pattern, development of a reliable standard chemotherapy regimen and management strategies are essential. CASE SUMMARY Here, we report the case of patient with NEC showing an aggressive growth pattern that resulted in the rupture of the tumor to the outside the colon after stenting of the internal colonic stenosis. In addition, the tumor invaded into the duodenum, thereby causing duodenal stenosis that required an additional stent in the duodenum. This aggressive growth pattern is one of the main features of the NEC that is different from adenocarcinoma. To clarify the clinical characteristics, we reviewed 60 recently reported cases, including data on tumor location, size, treatment, and prognosis. CONCLUSION We consider that the information presented here is of great significance for the diagnosis, treatment, and management of symptoms of the patients with NEC.

关键词： Neuroendocrine carcinoma Colon Colorectal mixed adenoneuroendocrine carcinoma Growth Case report

Development of a Heavy Ion Bearn Probe for Measuring Electrostatic Potential Profile and Its Fluctuation in LHD

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Plasma Science and Technology 2009年第4期11卷 460-464页

作者： TakeshiI DO Akihiro SHIMIZU Masaki NISHIURA Haruhisa NAKANO Shinji KATO Shinsuke OHSHIMA yasuo YOSHIMURA Shin KUBO Takashi SHIMOZUMA HiroeI GAMI Hiromi TAKAHASHI Kazuo TOI Fumitake watanabe Kazumichi NARIHARA Ichihiro YAMADA National Institute for Fusion Science

A heavy ion beam probe （HIBP） using a 3-MV tandem accelerator has been installed on large helical device （LHD）. Electrostatic potential in core plasma can be measured under the toroidal magnetic field strength of up to 3 T. By using the HIBP, the transition of potential profiles from electron-root to ion^root is observed in core plasmas during ramp-up of the electron density. Potential fluctuations are also measured electron cyclotron current drive （ECCD）. Two kind of characteristic fluctuations are observed. One is a reversed-shear-induced Alfv^n eigenmode （RSAE）, whose frequency varies during the evolution of the rotational transform profile, and the other is with a constant geodeisc acoustic mode （GAM） frequency.

关键词： electrostatic potential measurement HIBP GAM RSAE

One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent

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World Journal of Gastroenterology 2006年第15期12卷 2423-2426页

作者： Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji Uchida yasuo Arima Manabu watanabe Eiichi Uchida Takashi Tajiri Department of Surgery 1 Nippon Medical School Japan Uchida Hospital Japan

瞄准：为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法，在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法：由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被... 详细信息

瞄准：为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法，在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法：由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被包括。在这些病人的恶意是很先进的癌或老年的结果。经皮的 transhepatic 胆管造影术在 ultrasonographic 指导下面被执行。在有一个内部金属性的指南的一根导管是先进的进十二指肠以后，一他们被放在胆总管，在一个点之间在到肝的核的 Vater 和入口的乳头状的小突起以外的 1 厘米。在用就一个单身者跨越距离是困难的情况中他们，另外的斯滕特氏印模膏被放。一根排水导管在地方被离开充当一把止血钳子。在胆汁郁积和斯滕特氏印模膏明显的分辨率被证实以后，导管被移开 2 或 3 d 过程以后。结果：EMS 的一步舞插入与 24.4 min 的一过程平均数时间在所有病人被完成。从要求了 2 他们的病人， 4 需要一过程时间超过 30 min。导管的移动的吝啬的时间过程以后是 2.3 d。所有病人与 7.8 瞬间的一吝啬的后续时间死于恶意。没有 stent 相关的复杂并发症或斯滕特氏印模膏阻塞被遇到。结论：他们的一步舞经皮的 transhepatic 插入是为决定胆汁的阻塞和罐头有效地改进病人生命的质量的一个简单过程。

关键词：阻塞性黄疸经皮治疗金属扩张临床

Malignant lymphoma in the ileum diagnosed by double-balloon enteroscopy

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World Journal of Gastroenterology 2007年第24期13卷 3388-3391页

作者： Kazuko Beppu Taro Osada Akihito Nagahara Naoto Sakamoto Tomoyoshi Shibuya Masato Kawabe Takeshi Terai Toshifumi Ohkusa Tatsuo Ogihara Nobuhiro Sato Toshiki Kamano yasuo Hayashida Sumio watanabe Department of Gastroenterology Juntendo University School of Medicine 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan Department of Coloproctological Surgery Juntendo University School of Medicine dicine 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan Department of General Medicine Juntendo University School of Medicine 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421 Japan

A 73-year old man presented with abdominal pain. A tumor with central ulceration was observed in the ileum using double-balloon enteroscopy. Histological findings of the biopsy specimens were consistent with malignant lymphoma. Double-balloon enteroscopy confirmed the diagnosis of a malignant lymphoma tumor which was surgically resected. The patient is still in complete remission now.

关键词：淋巴瘤诊断治疗方法症状

The clinical signifi cance of circulating tumor cells in gastrointestinal cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 130-137页

作者： Masaaki Iwatsuki Junji Kurashige Takatsugu Ishimoto Keisuke Kosumi Yoshifumi Baba yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Masayuki watanabe Hideo Baba Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto University1-1-1 HonjoChuo-kuKumamoto 860-8556Japan Department of Gastroenterological Surgery Esophageal Cancer DivisionCancer Institute Hospital of Japanese Foundation for Cancer Research3-8-31 AriakeKoto-kuTokyo 135-8550Japan

Circulating tumor cells(CTCs)are originated from the primary tumor lesion into the blood stream.CTCs could lead to recurrence of gastrointestinal(GI)cancers,even after a curative resection and colonizing in the distant organs to facilitate tumor distant metastasis;however,it has been challenging in clinic to detect CTCs for a long time,such as detection methodology or molecular markers for identifi cation of CTCs.This review discussed the recent technical advances and biomarkers in the detection of CTCs and the molecular mechanism of CTC in cancer progression and metastasis.Moreover,novel concepts,such as cancer stem cells and epithelial-mesenchymal transition,could lead to CTCs and tumor progression and metastasis.Nevertheless,the involvement of CTCs varies greatly among cancer types in the GI and much remains to be learned.Thus,further study will provide more insightful information from a clinical and translational viewpoint to use CTCs for cancer early diagnosis or prediction of tumor recurrence and investigation of tumor progression and metastasis as well.

关键词： Cancer stem cells circulating tumor cells epithelial-mesenchymal transition gastrointestinal cancer tumor progression and metastasis