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Breast recurrence following local excision alone for ductal carcinoma in situ

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Breast recurrence following local excision alone for ductal ...

Thermally activated delayed fluorescence carbazole-triazine dendrimer with bulky substituents

2000全国肿瘤学术大会

作者： Miho Yoshida Yuichi Iino Jun Horiguchi Hiroyuki Takei Yukio koibuchi Fumihiro Ikeda Jun Ninomiya Kotaro Iijima, Ryo Ochiai Kazuhiro Uchida Takao Yokoe yasuo morisita Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan Second Departoment of Surgery Department of Emergency and Critical Care MedicineMaebashiJapan

＜正＞Objective:To assess recurrence of breast cancer following local excision alone for ductal carcinoma in situ Methods:Eighteen patients who received complete resection for noninvasive ductal carcinoma between 1982 and 1997 were investigated in this *** mean age of the patients was 45（29-78）years *** initial presentation was a clin- ically palpable tumor in 4 patients,nipple discharge in 6,and microcalcification on mammograms in *** with pal-

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Aggregate 2024年第1期5卷 236-243页

作者： Hiroki Ikebe Kohei Nakao Eri Hisamura Minori Furukori yasuo Nakayama Takuya Hosokai Minlang Yang Guanting Liu Takuma Yasuda Ken Albrecht Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityFukuokaJapan Institute for Materials Chemistry and Engineering Kyushu UniversityKasugaJapan Department of Pure and Applied Chemistry Graduate School of Science and TechnologyTokyo University of ScienceNodaChibaJapan National Metrology Institute of Japan(NMIJ) National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbarakiJapan Institute for Advanced Study Kyushu UniversityNishi-kuFukuokaJapan

Carbazole-triazine dendrimers with a bulky terminal substituent were synthesized,and the thermally activated delayed fluorescence(TADF)property was *** to unsubstituted carbazole dendrimers,dendrimers with bulky terminal substituents showed comparable to better photoluminescence quantum yields(PLQY)in neat ***(PF)-substituted dendrimers showed the highest PLQY of 81%,a smallΔEst of 0.06 eV,and the fastest reverse intersystem crossing(RISC)rate of∼1×10^(5 )s^(−1) compared to other *** measurements of dendrimers and dendrons(fragments)indicate that the close proximity of the triplet energy of phenylfluorene-substituted carbazole dendrons(^(3)LE)to that of phenylfluorene-substituted dendrimers(^(1)CT,^(3)CT)contributes to RISC promotion and improves TADF *** modification fine-tunes the energy level and suppresses intermolecular interactions,and this study provides a guideline for designing efficient solution-processable and non-doped TADF materials.

关键词： dendrimer OLED TADF 1 INTRODUCTION Thermally activated delayed fluorescence(TADF)materials which are inexpensive and highly efficient alternatives to fluorescent

Equations of state of iron and nickel to the pressure at the center of the Earth

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Matter and Radiation at Extremes 2022年第3期7卷 54-61页

作者： Naohisa Hirao Yuichi Akahama yasuo Ohishi Japan Synchrotron Radiation Research Institute(JASRI) SayoSayo-gunHyogo 679-5198Japan Graduate School of Material Science University of HyogoKoutoKamigohriHyogo 678-1297Japan

Synchrotron radiation x-ray diffraction investigations of iron(Fe)and nickel(Ni)are conducted at pressures up to 354 and 368 GPa,respectively,and the equations of state(EOSs)at 298 K for the two elements are obtained for data extending to pressures as high as those at the center of the Earth,using the latest Pt-EOS pressure *** a least-squares fit to the Vinet equation using the observed pressure–volume data,the isothermal bulk modulus K0 and its pressure derivative K′0 are estimated to be 159.27(99)GPa and 5.86(4)for hcp-Fe,and 173.5(1.4)GPa and 5.55(5)for *** comparing the present EOSs and extrapolated EOSs reported in the literature for Fe and Ni,the volumes of Fe and Ni at 365 GPa are found to be 2.3%and 1.5%larger than those estimated from extrapolated EOSs in previous studies,*** is concluded that these discrepancies are due to the pressure *** present results suggest that the densities of Fe and Ni at a pressure of 365 GPa corresponding to the center of the Earth are 2.3%and 1.5%,respectively,lower than previously thought.

关键词： nickel center state

Characterizing human driver characteristics using an artificial neural network and a theoretical model

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Control Theory and Technology 2022年第2期20卷 263-278页

作者： Sangmyoeng Kim Takeshi Miyamoto Tatsuya Kuboyama yasuo Moriyoshi Graduate School of Engineering Chiba University.1-33 Yayoicho InagekuChiba 2638522Japan

Human drivers seem to have different characteristics,so different drivers often yield different results from the same driving mode tests with identical vehicles and same chassis ***,drivers with different experiences often yield similar results under the same driving *** the features of human drivers are known,the control inputs to each driver,including warnings,will be customized to optimize each man–machine vehicle ***,it is crucial to determine how to characterize human drivers *** study proposes a method to estimate the parameters of a theoretical model of human *** method uses an artificial neural network(ANN)model and a numerical procedure to interpret the identified ANN models *** approach involves the following ***,we specify each ANN driver model through chassis dynamometer tests performed by each human driver and ***,we obtain the parameters of a theoretical driver model using the ANN model for the corresponding ***,we simulate the driver’s behaviors using the identified ANN models with controlled ***,we estimate the theoretical driver model parameters using the numerical simulation results.A proportional-integral-differential(PID)control model is used as the theoretical *** results of the parameter estimation indicate that the PID driver model parameter combination can characterize human ***,the results suggest that vehicular factors influence the parameter combinations of human drivers.

关键词： Neural network Identification Driver model Chassis dynamometer Driver characteristics

Numerical investigation on arching effect surrounding deep cylindrical shaft during excavation process

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Underground Space 2022年第5期7卷 944-965页

作者： Tanawat Tangjarusritaratorn Yuusuke Miyazaki yasuo Sawamura Kiyoshi Kishida Makoto Kimura Dept.of Urban Management Kyoto Univ.Katsura CampusKyoto 615-8540Japan Dept.of Civil and Earth Resources Engineering Kyoto Univ.Katsura CampusKyoto 615-8540Japan

Predicting the inner displacements of deep vertical shafts during the excavation process has been a difficult task considering the geological,structural,and constructional *** fact,the two-dimensional(2D)analytical solution based on the retaining wall model remains insufficient for understanding the actual behavior during an *** is because the deformation of vertical shafts becomes complicated due to the unexpected arching effect brought about by the three-dimensional(3D)flexible displacements occurring in the excavation *** analytical solutions only considered the limit ***,the present study deals with a 3D soil-structure simulation by considering the displacements of a cylindrical shaft and the mechanical behavior of the surrounding soil as well as the geometry of the cylindrical ***,this mechanical behaviors of the surrounding soil and shaft are controlled by the shaft stiffness;hence,the relationships among the shaft stiffness,mechanical behavior of the surrounding soil(in terms of earth pressure coefficient),and shaft displacement were investigated.A cylindrical model,120 m in depth and 20 m in diameter,was positioned at the center of a sand domain,and each excavation step was performed at an interval depth of 20 m.A 3D finite difference method analysis was applied using the modified Cam-Clay(MCC)model to represent the soil *** a result,the present study provides a new normalized lateral earth pressure theory for excavated shafts by considering the 3D arching effect obtained from parametric studies using various levels of shaft *** a comparison with the analytical solutions of previous studies(Terzaghi,1943a;Prater,1977;Cheng&Hu,2005),it is found that the previous studies underestimated the earth pressure acting on the cylindrical shaft because they did not consider the accurate arching effect.

关键词： Deep cylindrical shaft Excavation analysis Soil mixing wall method Arching effect Finite different method Three-dimensional analysis

Sunitinib-induced hyperammonemic encephalopathy in metastatic gastrointestinal stromal tumors:A case report

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World Journal of Clinical Cases 2023年第31期11卷 7629-7634页

作者： Takaoki Hayakawa Shinsuke Funakoshi yasuo Hamamoto Kenro Hirata Takanori Kanai Department of Internal Medicine Division of Gastroenterology and HepatologyKeio University School of MedicineShinjuku-ku 160-8582TokyoJapan Division of Medical Oncology Department of Internal MedicineTokyo Saiseikai Central HospitalMinato-ku 108-0073TokyoJapan Keio Cancer Center Keio University School of MedicineShinjuku-ku 160-8582TokyoJapan Department of Internal Medicine Keio University School of MedicineShinjuku-ku 160-8582TokyoJapan

BACKGROUND Sunitinib,a multi-targeted tyrosine kinase inhibitor(TKI),has been approved for the salvage treatment of gastrointestinal stromal tumors(GIST).Hyperammonemic encephalopathy is a rare but severe complication of sunitinib ***,we present the case of a 66-year-old male with metastatic GIST without underlying liver cirrhosis who developed sunitinib-induced hyperammonemic *** SUMMARY A 66-year-old male with metastatic GIST was admitted because of reduced *** was administered as the first-line systemic *** experienced repeated episodes of peritonitis due to tumor perforation,and surgery was *** disease was confirmed based on increased liver metastasis,and sunitinib was initiated as a salvage ***,23 d after the third course of sunitinib,he presented to the emergency room with an episode of altered consciousness and behavioral *** on the patient clinical history and examination findings,sunitinib-induced encephalopathy was *** was discontinued,and the patient was treated for *** patient had a normal level of consciousness four days later,and the serum ammonia level gradually *** further neurological symptoms were reported in subsequent *** TKI-induced hyperammonemic encephalopathy is potentially *** receiving TKIs experiencing adverse reactions should undergo systemic evaluation and prompt treatment.

关键词： Tyrosine protein kinase inhibitors Sunitinib malate Hyperammonemic encephalopathy Gastrointestinal stromal tumors Case report

One-year outcomes and predictable factors for microhook ab interno trabeculotomy

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 598-603页

作者： Daiki Sakai Masashi Fujihara Satoshi Yokota Makoto Nakamura yasuo Kurimoto Department of Ophthalmology Kobe City Eye HospitalKobe 650-0047Japan Department of Ophthalmology Kobe City Medical Center General HospitalKobe 650-0047Japan Department of Surgery Division of OphthalmologyKobe University Graduate School of MedicineKobe 650-0017Japan

AIM: To investigate the one-year outcomes and factors that influence the results of microhook ab interno trabeculotomy(μLOT). METHODS: The medical records of consecutive patients with open angle glaucoma who underwent μLOT(including combination of μLOT and cataract surgery) between Februar y 2018 and July 2019 were retrospectively reviewed. Surgical success was defined as the following: an intraocular pressure(IOP)≤21 mm Hg or IOP≤preoperative IOP with a reduced number of glaucoma eye drops, without additional glaucoma surgery, and assessed using KaplanMeier survival analysis. A multivariate Cox proportionalhazards regression model was used to investigate the factors associated with surgical ***: The 59 eyes of 59 patients comprising 28 eyes with primary open angle glaucoma(POAG) and 31 with secondary open angle glaucoma(SOAG) were included. The mean IOP and number of glaucoma eye drops significantly decreased from 25.3±7.2 mm Hg and 3.9±1.1, preoperatively to 16.1±4.4 mm Hg(P25 mm Hg within 2 wk post-surgery;P<0.001, a HR: 5.382, 95%CI:2.113-13.707) as independent factors associated with surgical ***: The μLOT is a good treatment option for POAG eyes. However, the postoperative course should be carefully followed in cases with postoperative IOP spike.

关键词： microhook ab interno trabeculotomy trabeculotomy ab interno minimally invasive glaucoma surgery survival analysis

PREPARATION OF POLYMER DISPERSED LIQUID CRYSTALS USING PHOTOPOLYMERIZATION

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Chinese Journal of Polymer Science 2001年第3期19卷 311-315页

作者： yasuo Hatate Department of Applied Chemistry and Chemical Engineering Faculty of Engineering Kagoshima University Kagoshima 890-0065 Japan

2-Hydroxyethyl methacrylate (HEMA) and styrene copolymers are prepared by photopolymerization. The electrooptical behavior and microstructure of the polymer dispersed liquid crystal films are investigated by using He-Ne laser and scanning electron microscopy, respectively. With increasing E7 content in the copolymer, droplet size increased, threshold voltage decreased.

关键词： electro-optical properties phase separation polymer dispersed liquid crystal

Ultrasonic echo signal fetures of dissimilar material bonding joints

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中国有色金属学会会刊：英文版 2004年第6期14卷 1050-1054页

作者：刚铁 yasuo TAKAHASHI State Key Lab of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China JWRI Osaka University Japan

An ultrasonic evaluation method of echo feature of diffusion bond joint between two dissimilar materials is presented. The echo signal was acquired by an automatic ultrasonic C-scan test system. It is found that the intensity of echo and its phase can be used to evaluate the joint quality, and interface products of dissimilar materials bonding can be evaluated by ultrasonic method.

关键词：超声波测试异金属扩散结合非破坏性演化