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Displacement and timing of left-lateral faulting in the Kunlun Fault Zone,northern Tibet,inferred from geologic and geomorphic features

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Displacement and timing of left-lateral faulting in the Kunl...

Identification of cellular genes showing differential expression associated with hepatitis B virus infection

中国科学院地质与地球物理研究所2007学术年会

作者：付碧宏 yasuo Awata State Key Laboratory of Lithospheric Evolution.Institute of Geology and Geophysics Chinese Academy of Sciences Active Fault Research Center.AIST.Tsukuba 305-8567 Japan

The E-W to WNW-ESE striking Kunlun Fault Zone,extending about 1600 km,is one of the large strike-slip faults in the northern Tibet,*** a major strike-slip fault,it plays an important role on the extrusion of Tibet Plateau in accommodating northeastward shortening caused by the India-Asia ***,the time of initiation left-lateral faulting of the Kunlun Fault Zone is still largely debated,ranging from the Middle to Late Triassic(240-200 Ma) to early Quaternary(2 Ma).We document displaced basement rocks and geomorphic features along the Kunlun Fault Zone,based on tectono-geomorphic interpretation of satellite remote sensing images and field geologic and geomorphic *** results show that the largest cumulative offset of basement rocks is likely to be 100±20 ***,a series of pull-apart basins(Kusai,Xiugou and Tuosu lake basins) and pressure ridges(East Deshuiwai and Maji Snow Mountains),each 45-70 km long and～8-12 km wide,are developed along the Kunlun Fault Zone,which resulted from long-term tectono-geomorphic growth since the Late Miocene or Early *** evidence indicates that the Kunlun Fault Zone had a long-term slip rate of ca.10 mm/yr during the late *** slip rate is similar to that shown by present-day GPS measurements. Thus,we estimate that the Kunlun Fault Zone probably began left-lateral faulting at 10±2 Ma based on a total displacement of 100±20 km,and assuming a constant long-term slip rate of ca.10 mm/yr for several millions of *** this timing constraint on initiation of left-lateral faulting of the Kunlun Fault Zone is consistent with widespread tectonic deformation which occurred in the Tibetan Plateau.

关键词： Left-lateral faulting Displaced basement rocks Pull-apart basin Pressure ridge Kunlun Fault Zone Northern Tibet

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World Journal of Hepatology 2012年第4期4卷 139-148页

作者： yasuo Fukuhara Takeshi Suda Makoto Kobayashi Yasushi Tamura Masato Igarashi Nobuo Waguri Hirokazu Kawai Yutaka Aoyagi Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University 1-757 Asahimachi-dori Chuo-ku Niigata Niigata 951-8122 Japan

AIM: To investigate the impact of hepatitis B virus (HBV) infection on cellular gene expression, by conducting both in vitro and in vivo studies. METHODS: Knockdown of HBV was targeted by stable expression of short hairpin RNA (shRNA) in huH-1 cells. Cellular gene expression was compared using a human 30K cDNA microarray in the cells and quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) (qRT-PCR) in the cells, hepatocellular carcinoma (HCC) and surrounding non-cancerous liver tissues (SL). RESULTS: The expressions of HBsAg and HBx protein were markedly suppressed in the cells and in HBx transgenic mouse liver, respectively, after introduction of shRNA. Of the 30K genes studied, 135 and 103 genes were identified as being down- and up-regulated, respectively, by at least twofold in the knockdown cells. Functional annotation revealed that 85 and 62 genes were classified into four up-regulated and five down-regulated functional categories, respectively. When gene expression levels were compared between HCC and SL, eight candidate genes that were confirmed to be up- or down-regulated in the knockdown cells by both microarray and qRT-PCR analyses were not expressed as expected from HBV reduction in HCC, but had similar expression patterns in HBV- and hepatitis C virus-associated cases. In contrast, among the eight genes, only APM2 was constantly repressed in HBV non-associated tissues irrespective of HCC or SL. CONCLUSION: The signature of cellular gene expression should provide new information regarding the pathophysiological mechanisms of persistent hepatitis and hepatocarcinogenesis that are associated with HBV infection.

关键词： Hepatitis B virus Differential gene expression Hepatocellular carcinoma Gene expression signature Adipose most abundant 2

Impact of postoperative sexual function on health-related quality of life after robot-assisted radical prostatectomy

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Current Urology 2024年第2期18卷 148-154页

作者： Yuya Iwahashi Ryusuke Deguchi Satoshi Muraoka Takahito Wakamiya Shimpei Yamashita Kazuro Kikkawa yasuo Kohjimoto Isao Hara Department of Urology Wakayama Medical UniversityWakayamaJapan

Background:We investigated potential disparities in health-related quality of life,particularly concerning urinary function,between patients with preserved and those with impaired sexual function after robot-assisted radical prostatectomy(RARP).Materials and methods:BetweenDecember 2012 and April 2020,704men underwent RARP in our *** study included 155 patients with a preoperative 5-item International Index of Erectile Function(IIEF-5)of≥12 points and an assessable IIEF-5 at 12 months ***-related quality of life was assessed using the 8-item Short-Form Health Survey and Expanded Prostate Cancer Index Composite(EPIC)preoperatively and at 3,6,and 12months postoperatively.A logistic regression analysis andWilcoxon rank sum tests were ***:Patients were grouped according to the median IIEF-5 score 12 months after surgery:those with preserved sexual function(n=71)and those with impaired sexual function(n=84).The mental component summary of the 8-item Short-Form Health Survey was better in the group with preserved sexual function at 6 months postoperatively than in the group with impaired sexual function(p<0.01).In the EPIC,the group with preserved sexual function performed better not only in the sexual domain but also in the urinary domain at all time points comparedwith the groupwith impaired sexual function(p<0.01).In the comparison of the urinary subdomains of the EPIC,there were no significant differences in urinary function or incontinence,but there were significant differences in urinary distress and irritative/obstructive scores(p<0.01).Conclusions:Patients with preserved postoperative sexual function after RARP showed better urinary function than those with impaired sexual ***,preserved sexual function is closely associated with urinary function.

关键词： Prostatectomy Robot-assisted radical prostatectomy Health-related quality of life Sexual function Urinary function

Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

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International Journal of Oral Science 2024年第3期16卷 499-514页

作者： Tokuju Okano Hiroshi Ashida Noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie Iwasawa Yuto Takahashi yasuo Takeuchi Takanori Iwata Miwa Sasai Masahiro Yamamoto Hiroshi Takayanagi Toshihiko Suzuki Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

Appendicitis with psoas abscess successfully treated by laparoscopic surgery

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World Journal of Gastroenterology 2014年第25期20卷 8317-8319页

作者： Yasunori Otowa yasuo Sumi Shingo Kanaji Kiyonori Kanemitsu Kimihiro Yamashita Tatsuya Imanishi Tetsu Nakamura Satoshi Suzuki Kenichi Tanaka Yoshihiro Kakeji Division of Gastrointestinal Surgery Department of SurgeryKobe University Graduate School of Medicine 7-5-2 Kusunokichou Chuo-ku Kobe Hyogo Prefecture 650-0017 Japan Division of Gastrointestinal Surgery Department of SurgeryKobe University Graduate School of Medicine7-5-2 KusunokichouChuo-ku KobeHyogo Prefecture 650-0017Japan

Although acute appendicitis is a common disease, retroperitoneal abscesses are rarely observed. Here, we report a case consisting of a psoas abscess and cutaneous fistula caused by appendicitis. The patient was a 56-year-old male who was introduced to our institution due to an intractable right psoas abscess. Imaging tests had been performed over the previous 3 years; however, clinicians could not find the origin of the abscess and failed to resolve the problem. A successful operation was performed via a laparoscopic approach, and 17 mo have passed without recurrence. The advantage of laparoscopic surgery is well understood in cases of appendicitis with abscesses. However, the indication for laparoscopic approach is not clear for retroperitoneal abscesses. From our experience, we can conclude that appendicitis with retroperitonealabscesses can be managed and treated using a laparoscopic approach.

关键词： Appendicitis Laparoscopic surgery Psoas abscess Retroperitoneal abscess Right leg pain

Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes

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World Journal of Gastroenterology 2013年第11期19卷 1834-1840页

作者： Hideki Fujii Naoki Ohnishi Kazuho Shimura Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida yasuo Ohkawara Tatsuro Kobata Kanji Yamaguchi Yoshito Itoh Department of Internal Medicine Aiseikai Yamashina HospitalShichouno-choTakehanaYamashinakuKyoto 602-8086Japan Department of Gastroenterology and Hepatology Uji Tokushukai HospitalKyoto 611-0042Japan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan

Autoimmune hepatitis(AIH) is a necroinflammatory liver disease of unknown *** disease is characterized histologically by interface hepatitis,biochemically by increased aspartate aminotransferase and alanine aminotransferase levels,and serologically by increased autoantibodies and immunoglobulin G *** we discuss AIH in a previously healthy 37-year-old male with highly elevated serum levels of soluble interleukin-2 receptor and markedly enlarged hepatoduodenal ligament lymph nodes(HLLNs,diameter,50 mm).Based on these observations,the differential diagnoses were AIH,lymphoma,or Castleman's *** biopsy revealed the features of interface hepatitis without bridging fibrosis along with plasma cell infiltration which is the typical characteristics of acute *** node biopsy revealed lymphoid follicles with inflammatory lymphocytic infiltration;immunohistochemical examination excluded the presence of lymphoma ***,he was administered corticosteroid therapy:after 2 mo,the enlarged liver reached an almost normal size and the enlarged HLLNs reduced in *** could not find AIH cases with such enlarged lymph nodes(diameter,50 mm) in our literature ***,we speculate that markedly enlarged lymph nodes observed in our patient may be caused by a highly activated,humoral immune response in AIH.

关键词： Autoimmune hepatitis Humoral immune response Hepatoduodenal ligament lymph nodes Corticosteroid Hepatomegaly

Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis

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World Journal of Gastroenterology 2015年第19期21卷 5985-5994页

作者： Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada yasuo Suzuki Department of Internal Medicine Faculty of MedicineToho University Toho University Sakura Medical Center

AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic *** outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing *** symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal ***: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis.

关键词： Ulcerative colitis Probiotics Inflammatorybowel disease Cluster analysis

一组高效稳定纤维素分解菌复合系MC1的筛选及功能

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环境科学 2002年第3期23卷 36-39页

作者：崔宗均李美丹朴哲黄志勇 Masaharu Ishii yasuo Igarashi 中国农业大学作物学院北京100094 中国科学院微生物研究所北京100080 东京大学农学部应用生命工学

从 4种堆肥样品中分别筛选出纤维素分解能力较强的 4组混合菌 ,再以酸碱反应互补的原则重新优化组合并驯化成 1组纤维素分解能力非常强而稳定的纤维素分解菌复合系MC1 .1 0 0mL培养物在 5 0℃静止培养 72h ,分别可分解 0 48g滤纸、0 ... 详细信息

从 4种堆肥样品中分别筛选出纤维素分解能力较强的 4组混合菌 ,再以酸碱反应互补的原则重新优化组合并驯化成 1组纤维素分解能力非常强而稳定的纤维素分解菌复合系MC1 .1 0 0mL培养物在 5 0℃静止培养 72h ,分别可分解 0 48g滤纸、0 49g脱脂棉、0 1 9g麦秆和 0 0 8g锯末 .分解滤纸时 ,第 2 4hCMC糖化力最高 ,为1 2 2 3U·mL- 1.在初始pH4～ 1 0的不同培养基上接种 ,均能把 pH调到中性 ,最后稳定在 8 0～ 8 5之间 .在连续投放滤纸情况下纤维素分解能力稳定保持 2 0d以上 ,其发酵液的 pH在有滤纸时稳定在 6 0～ 6 5之间 ,没有滤纸时稳定在 8 0～ 8

关键词：纤维素分解菌复合系功能稳定

硫掺杂钛酸(盐)纳米管的表征与可见光光催化活性

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应用化学 2012年第3期29卷 285-290页

作者：彭淑鸽 IZUMI yasuo 刘晓飞张军河南科技大学化工与制药学院洛阳471003 日本千叶大学化学系

以二硫化钛为钛源和硫源,通过与NaOH水热反应成功制备了硫掺杂钛酸(盐)纳米管。采用X射线衍射、高分辨透射电子显微镜、扫描电子显微镜、扩展X射线吸收精细结构(EXAFS)和X光微区分析等手段对所制备的硫掺杂钛酸(盐)纳米管的结构、形貌... 详细信息

以二硫化钛为钛源和硫源,通过与NaOH水热反应成功制备了硫掺杂钛酸(盐)纳米管。采用X射线衍射、高分辨透射电子显微镜、扫描电子显微镜、扩展X射线吸收精细结构(EXAFS)和X光微区分析等手段对所制备的硫掺杂钛酸(盐)纳米管的结构、形貌、硫掺杂状态和掺杂量进行了表征,并以可见光光催化氧化乙醇反应为探针,采用原位气相色谱技术研究了硫掺杂钛酸纳米管的可见光光催化活性;结果表明,S原子以S2-形式取代了钛酸纳米管骨架中O原子的位置,有效实现了硫掺杂;硫掺杂钛酸(盐)纳米管壁厚平均尺寸为2.9 nm,管径平均尺寸为9.7 nm。可见光光催化氧化乙醇反应结果表明,掺硫钛酸纳米管在极低的掺硫量条件下,表现出比未掺杂的二氧化钛纳米管具有更高的可见光光催化活性。

关键词：硫掺杂钛酸盐纳米管扩展X射线吸收精细结构光催化氧化乙醇