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Therapeutic response assessment of RFA for HCC:Contrast-enhanced US,CT and MRI

World Journal of Gastroenterology 2014年第15期20卷 4160-4166页

作者： yasunori minami Naoshi Nishida Masatoshi Kudo Department of Gastroenterology and Hepatology Kinki University Faculty of MedicineOsaka 589-8511Japan

Radiofrequency ablation (RFA) is commonly applied for the treatment of hepatocellular carcinoma (HCC) because of the facile procedure, and the safety and effectiveness for the treatment of this type of tumor. On the other hand, it is believed that HCC cells should spread predominantly through the blood flow of the portal vein, which could lead to the formation of intrahepatic micrometastases. Therefore, monitoring tumor response after the treatment is quite important and accurate assessment of treatment response is critical to obtain the most favorable outcome after the RFA. Indeed, several reports suggested that even small HCCs of ≤ 3 cm in diameter might carry intrahepatic micrometastases and/or microvascular invasion. From this point of view, for preventing local recurrences, RFA should be performed ablating a main tumor as well as its surrounding non-tumorous liver tissue where micrometastases and microvascular invasion might exist. Recent advancement of imaging modalities such as contrast-enhanced ultrasonic, computed tomography, and magnetic resonance imaging are playing an important role on assessing the therapeutic effects of RFA. The local recurrence rate tends to be low in HCC patients who were proven to have adequate ablation margin after RFA; namely, not only disappearance of vascular enhancement of main tumor, but also an adequate ablation margin. Therefore, contrast enhancement gives important findings for the diagnosis of recurrent HCCs on each imaging. However, hyperemia of non-tumorous liver surrounding the ablated lesion, which could be attributed to an inflammation after RFA, may well obscure the findings of local recurrence of HCCs after RFA. Therefore, we need to carefully address to these imaging findings given the fact that diagnostic difficulties of local recurrence of HCC. Here, we give an overview of the current status of the imaging assessment of HCC response to RFA.

关键词： Hepatocellular carcinoma Micrometastasis Microvascular invasion Radiofrequency ablation Safety margin

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Contrast-enhanced ultrasonography with Sonazoid in hepatocellular carcinoma diagnosis

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Hepatoma Research 2020年第8期6卷 1-11页

作者： yasunori minami Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 589-8511Japan.

With the development of second-generation contrast agents and advancement in contrast harmonic imaging,contrast-enhanced ultrasonography(CEUS)now has the capacity to sensitively and accurately show tumor ***,marked improvements have been achieved in the diagnosis of focal liver lesions(FLLs),including hepatocellular carcinoma(HCC),by *** contrast to other agents,Kupffer cells in liver sinusoids take up *** contrast enhancement phases occur in CEUS with Sonazoid:a vascular phase and Kupffer *** obtained in the Kupffer phase have higher diagnostic sensitivity for hepatic malignancies because the majority of these malignancies do not contain Kupffer *** images obtained in the vascular phase markedly narrow the clinical differential diagnoses of *** sustainable detection of inconspicuous HCC,adequate guidance of ablation therapy,and accurate assessment of treatment responses in HCC are all facilitated by *** principles,clinical applications,and techniques of CEUS with Sonazoid in the diagnosis of HCC will be reviewed herein.

关键词： Contrast-enhanced ultrasonography focal liver lesion hepatocellular carcinoma sonazoid

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Adjuvant therapy after radical surgery for hepatocellular carcinoma: still an unmet need

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 414-416页

作者： yasunori minami Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Osaka-Sayama Osaka Japan

Introduction Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related *** HCC typically occurs in patients with advanced liver disease,therapeutic decisions depend on the degree of underlying liver dysfunction and tumor *** treatment options,which result in 5-year survival rates of 60–80%(surgical resection)and 40–70%(local ablative therapies),are restricted to patients with early-stage HCC(1,2).However,surgical resection and local ablative therapies are limited by high tumor recurrence rates of 50%at 3 years and 70%at 5 years(1-6).Thus,monitoring treatment response is imperative for the clinical management of HCC patients(7),highlighting the need for adjuvant therapies.

关键词： mortality surgery clinical

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Review of dynamic contrast-enhanced ultrasound guidance in ablation therapy for hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第45期17卷 4952-4959页

作者： yasunori minami Masatoshi Kudo Department of Gastroen-terology and Hepatology Kinki University School of Medicine

Local ablative techniques-percutaneous ethanol injection, microwave coagulation therapy and radiofrequency ablation (RFA)-have been developed to treat unresectable hepatocellular carcinoma (HCC). The success rate of percutaneous ablation therapy for HCC depends on correct targeting of the tumor via an imaging technique. However, probe insertion often is not completely accurate for small HCC nodules, which are poorly def ined on conventional B-mode ultrasound (US) alone. Thus, multiple sessions of ablation therapy are frequently required in diffi cult cases. By means of two breakthroughs in US technology, harmonic imaging and the development of second-generation contrast agents, dynamic contrast-enhanced harmonic US imaging with an intravenous contrast agent can depict tumor vascularity sensitively and accurately, and is able to evaluate small hypervascular HCCs even when B-mode US cannot adequately characterize the tumors. Therefore, dynamic contrast-enhanced US can facilitate RFA electrode placement in hypervascular HCC, which is poorly depicted by B-mode US. The use of dynamic contrast-enhanced US guidance in ablation therapy for liver cancer is an effi cient approach. Here, we present an overview of the current status of dynamic contrast-enhanced US-guided ablation therapy, and summarize the current indications and outcomes of reported clinical use in comparison with that of other modalities.

关键词： Dynamic contrast-enhanced ultrasound Hepatocellular carcinoma Percutaneous ethanol injection Radiofrequency ablation

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Verrucous antral gastritis in relation to Helicobacter pylori infection,nutrition,and gastric atrophy

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Gastroenterology Report 2020年第4期8卷 293-298,I0002页

作者： Naoko Tsuji Yasuko Umehara Mamoru Takenaka yasunori minami Tomohiro Watanabe Naoshi Nishida Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-SayamaJapan

Background:There have been few studies in the English literature regarding verrucous gastritis(VG).The present study investigated the clinical and endoscopic features of verrucous antral gastritis,especially focusing on Helicobacter pylori infection,nutrition,and gastric ***:We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative *** was subdivided into classical and numerous types based on the number and distribution of verrucous ***,clinical,and endoscopic data including body mass index(BMI),serum albumin and cholesterol,gastric atrophy,reflux oesophagitis,Barrett’s oesophagus,and *** status were *** and multivariable analyses were performed to identify factors associated with ***:We analysed the data of 621 patients undergoing routine endoscopy and found that VG(n=352)was significantly associated with increased BMI(1.12[1.05-1.18],P<0.01),reflux esophagitis(1.96[1.10-3.28],P<0.01),and *** negativity with or without a history of eradication(9.94[6.00-16.47]and 6.12[3.51-10.68],P<0.001,respectively).Numerous-type(n=163)VG was associated with both closed-and open-type gastric atrophy(9.9[4.04-21.37]and 8.10[3.41-19.24],P<0.001,respectively).There were no statistical differences between groups regarding age,sex,total cholesterol,albumin,and bile-colored gastric ***:Verrucous antral gastritis was related to increased BMI,reflux esophagitis,and *** ***-type verrucous lesions were associated with gastric *** indicate that VG may be a physiological phenomenon due to high gastric acidity,mechanical overload,and vulnerability of background mucosa.

关键词： verrucous gastritis chromoendoscopy BMI Helicobacter pylori eradication gastric atrophy

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Contrast-enhanced harmonic ultrasound imaging in ablation therapy for primary hepatocellular carcinoma

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World Journal of Radiology 2009年第1期1卷 86-91页

作者： yasunori minami Masatoshi Kudo Division of Gastroenterology and Hepatology Department of Internal MedicineKinki University School of Medicine377-2 Ohno-Higashi Osaka-Sayama589-8511Japan

The success rate of percutaneous radiofrequency(RF)ablation for hepatocellular carcinoma(HCC)depends on correct targeting via an imaging ***,RF electrode insertion is not completely accurate for residual HCC nodules because B-mode ultrasound(US),color Doppler,and power Doppler US findings cannot adequately differentiate between treated and viable residual tumor *** insertion is also difficult when we must identify the true HCC nodule among many large regenerated nodules in cirrhotic *** breakthroughs in the field of US technology,harmonic imaging and the development of second-generation contrast agents,have recently been described and have demonstrated the potential to dramatically broaden the scope of US diagnosis of hepatic ***-enhanced harmonic US imaging with an intravenous contrast agent can evaluate small hypervascular HCC even when B-mode US cannot adequately characterize ***,contrast-enhanced harmonic US can facilitate RF ablation electrode placement in hypervascular HCC,which is poorly depicted by B-mode *** use of contrast-enhanced harmonic US in ablation therapy for liver cancer is an efficient approach.

关键词： Contrast-enhanced harmonic ultrasound Hepatocellular carcinoma Radiofrequency ablation Second generation microbubbles

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Hepatic malignancies:Correlation between sonographic findings and pathological features

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World Journal of Radiology 2010年第7期2卷 249-256页

作者： yasunori minami Masatoshi Kudo Division of Gastroenterology and Hepatology Department of Internal MedicineKinki University School of Medicine

Ultrasonography(US) findings are inevitably based on pathological *** of the pathological features of hepatic malignancies such as hepatocellular carcinoma(HCC),liver metastasis and intrahepatic cholangiocarcinoma is essential for correct US diagnosis and appropriate *** type of hepatocarcinogenesis is step-wise development from a low-grade dysplastic nodule(DN),high-grade DN,high-grade DN with malignant foci,and well-differentiated HCC,to classical *** intranodular blood supply changes in accordance with this ***,the malignant potential tends to change as the macroscopic configuration ***,typical US findings of advanced HCC are a mosaic pattern,septum formation,peripheral sonolucency(halo),lateral shadow produced by fibrotic pseudocapsule,posterior echo enhancement,arterial hypervascularity with dilated intratumoral blood sinusoids,and perinodular daughter nodule ***'s eye appearance is a common presentation of metastases from gastrointestinal(GI) adenocarcinomas,and represents histological findings that show an area of central necrosis surrounded by a zonal area of viable *** zonal area reflects the layer of viable cells that are fed by minute tumor *** imaging features of liver metastases from the GI tract are as follows:Bull's eye appearance,multiple masses,irregular tumor border,arterial rim-like enhancement,and hypoenhancement in the late vascular *** intrahepatic cholangiocarcinomas are ductal *** bile ducts peripheral to the tumor are usually dilated because of obstruction by *** imaging features of mass-forming cholangiocarcinoma are as follows:peripheral bile duct dilatation,irregular tumor border,arterial enhancement due to minute intratumoral blood sinusoids,and hypoenhancement in the late vascular phase.

关键词： Hepatocellular carcinoma Liver metastasis Intrahepatic cholangiocarcinoma Sonography Pathology

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Radiofrequency ablation of hepatocellular carcinoma:Current status

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World Journal of Radiology 2010年第11期2卷 417-424页

作者： yasunori minami Masatoshi Kudo Division of Gastroenterology and Hepatology Department of Internal MedicineKinki University School of Medicine377-2 Ohno-Higashi OsakaSayama589-8511Japan

Ablation therapy is one of the best curative treatment options for malignant liver tumors,and can be an alternative to *** ablation(RFA) of primary and secondary liver cancers can be performed safely using percutaneous,laparoscopic,or open surgical techniques,and RFA has markedly changed the treatment strategy for small hepatocellular carcinoma(HCC).Percutaneous RFA can achieve the same overall and disease-free survival as surgical resection for patients with small *** use of a laparoscopic or open approach allows repeated placements of RFA electrodes at multiple sites to ablate larger *** combined with transcatheter arterial chemoembolization will make the treatment of larger tumors a clinically viable treatment ***,an accurate evaluation of treatment response is very important to secure successful RFA *** a sufficient safety margin(at least 0.5 cm) can prevent local tumor recurrences,an accurate evaluation of treatment response is very important to secure successful RFA *** minimize complications of RFA,clinicians should be familiar with the imaging features of each type of *** management of complications is essential for successful RFA treatment.

关键词： Hepatocellular carcinoma Radiofrequency ablation Transcatheter arterial chemoembolization

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Taxonomic study of Favolus and Neofavolus gen. nov. segregated from Polyporus (Basidiomycota, Polyporales)

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Fungal Diversity 2013年第1期58卷 245-266页

作者： Kozue Sotome yasunori Akagi Su See Lee Noemia K.Ishikawa Tsutomu Hattori Fungus/Mushroom Resource and Research Center Faculty of AgricultureTottori UniversityMinami 4-101KoyamaTottoriTottori 680-8553Japan Laboratory of plantpathology Faculty of AgricultureTottori UniversityMinami 4-101KoyamaTottoriTottori 680-8553Japan Mycology and Pathology Forestry DivisionForest Research Institute Malaysia(FRIM)Kepong 52109 SelangorMalaysia Coordenação de Biodiversidade Instituto Nacional de Pesquisas da Amazônia(INPA)Av.AndréAraújo2.936PetrópolisCEP 69060-001ManausAMBrazil Kansai Research Center Forestry and Forest Products Research InstituteNagai-KyutaroMomoyamaFushimiKyoto 612-0855Japan

We present a taxonomic study of‘group Favolus’and related species in *** analyses of nurLSU and ITS regions revealed that the infrageneric‘group Favolus’is divided into two main *** within the group share laterally stipitate basidiocarps,with non-crustose stipe surfaces,and are distinguishable by the morphology of the pileus *** clade is characterized by species with hyaline to brown cutis,composed of hyaline to brown agglutinated generative *** other clade accommodates species with radially striate pileus,and lacks any distinct cutis of agglutinated *** propose Neofavolus ***.,typified by ***,for the former clade,and revise the genus Favolus,typified by ***,for the latter *** includes *** and *** ***.,known only from temperate eastern Asia,in addition to *** includes members of the Polyporus grammocephalus complex,the *** complex,and *** reveal that the polypore known as‘***’in Asia includes *** and ***(0 ***),whereas‘***’includes three distinct species;*** from tropical America,and *** and *** from tropical *** descriptions and illustrations are provided for the accepted species in Favolus and Neofavolus.

关键词： Polypores Polyporaceae Type study Wooddecaying fungi

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