检索结果-南通市图书馆

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria Price Kent Søe yasunori omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Role of Jasmonates as Antibulbing Substances in the Bulb Formation of Onion

引用

Agricultural Biotechnology 2024年第1期13卷 1-4,8页

作者： Noboru Takada Atsushi Saito Yuuki Matsuzuka Tatsushi Mochiduki Eriko Wakita Meng WANG yasunori Koda Faculty of Agriculture and Life Science Hirosaki University3Bunkyo-choHirosaki 036-8561Japan The United Graduate School of Agricultural Science Iwate UniversityMoriokaIwate 020-8550Japan National Institute of Vegitable and Tea Science National Agriculture and Food Research Organization360 KusawaAnoTsu 514-2392Japan Research Faculty of Agriculture Hokkaido UniversityKita-9 Nishi-9Kita-kuSapporo 060-8589Japan

Onion plants form spherical bulbs under long-day *** regulating bulb formation remain *** the course of chemical studies on the bulb formation,α-linolenic acid was isolated from onion extracts as an antibulbing substance,the amount of which was synchronized with the bulb *** allene oxide synthase inhibitor canceled the antibulbing activity ofα-linolenic acid,it was disclosed that jasmonic acid concerns this ***-activity-relationship study revealed that its(3R,7S)stereochemistry is necessary for showing its antibulbing *** is concluded that(3R,7S)-jasmonate derived fromα-linolenic acid actually participates in the regulation of bulb formation.

关键词： Onion(Allim cepa L.cv.Higuma) Isolation Bulb formation Antibulbing substance α-Linolenic acid Methyl jasmonate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distortion-free PCA on sample space for highly variable gene detection from single-cell RNA-seq data

引用

Frontiers of Computer Science 2023年第1期17卷 133-142页

作者： Momo MATSUDA yasunori FUTAMURA Xiucai YE Tetsuya SAKURAI Department of Computer Science University of TsukubaTsukuba 305-8573Japan

Single-cell RNA-seq (scRNA-seq) allows the analysis of gene expression in each cell, which enables the detection of highly variable genes (HVG) that contribute to cell-to-cell variation within a homogeneous cell population. HVG detection is necessary for clustering analysis to improve the clustering result. scRNA-seq includes some genes that are expressed with a certain probability in all cells which make the cells indistinguishable. These genes are referred to as background noise. To remove the background noise and select the informative genes for clustering analysis, in this paper, we propose an effective HVG detection method based on principal component analysis (PCA). The proposed method utilizes PCA to evaluate the genes (features) on the sample space. The distortion-free principal components are selected to calculate the distance from the origin to gene as the weight of each gene. The genes that have the greatest distances to the origin are selected for clustering analysis. Experimental results on both synthetic and gene expression datasets show that the proposed method not only removes the background noise to select the informative genes for clustering analysis, but also outperforms the existing HVG detection methods.

关键词： single-cell RNA-sequencing feature selection principal component analysis highly variable gene detection background noise clustering analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Review of dynamic contrast-enhanced ultrasound guidance in ablation therapy for hepatocellular carcinoma

引用

World Journal of Gastroenterology 2011年第45期17卷 4952-4959页

作者： yasunori Minami Masatoshi Kudo Department of Gastroen-terology and Hepatology Kinki University School of Medicine

Local ablative techniques-percutaneous ethanol injection, microwave coagulation therapy and radiofrequency ablation (RFA)-have been developed to treat unresectable hepatocellular carcinoma (HCC). The success rate of percutaneous ablation therapy for HCC depends on correct targeting of the tumor via an imaging technique. However, probe insertion often is not completely accurate for small HCC nodules, which are poorly def ined on conventional B-mode ultrasound (US) alone. Thus, multiple sessions of ablation therapy are frequently required in diffi cult cases. By means of two breakthroughs in US technology, harmonic imaging and the development of second-generation contrast agents, dynamic contrast-enhanced harmonic US imaging with an intravenous contrast agent can depict tumor vascularity sensitively and accurately, and is able to evaluate small hypervascular HCCs even when B-mode US cannot adequately characterize the tumors. Therefore, dynamic contrast-enhanced US can facilitate RFA electrode placement in hypervascular HCC, which is poorly depicted by B-mode US. The use of dynamic contrast-enhanced US guidance in ablation therapy for liver cancer is an effi cient approach. Here, we present an overview of the current status of dynamic contrast-enhanced US-guided ablation therapy, and summarize the current indications and outcomes of reported clinical use in comparison with that of other modalities.

关键词： B型超声治疗肝癌引导成像技术射频消融静脉注射对比度增强

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Explanatory Study Approach,Using Machine Learning to Forecast Solar Energy Outcome

引用

Journal of Energy and Power Engineering 2022年第2期16卷 81-89页

作者： Agada Ihuoma Nkechi Nagata yasunori Department of Electrical and Electronics Engineering University of the RyukyusOkinawa 903-0213Japan

AI(artificial intelligence)techniques play a crucially important role in predicting the expected energy outcome and its performance,analysis,modeling and control of renewable *** energy usage has grown exponentially over the *** the face of global energy consumption and increased depletion of most fossil fuel,the world is faced with the challenges of meeting the ever-increasing energy demands,also utility companies who provide solar energy have a challenge of unstable input of solar energy to the grid due to its intermittent nature,unlike other sources,hence the difference between expected generation and actual generation,demand and supply can lead to an unbalanced ***,incorporating accurately machine learning technology to predict the expected outcome of solar energy from the intermittent solar radiation will be crucial to keep a balance grid operation between supply and demand,production planning and energy management especially during installations of a photovoltaic power ***,one of the major problems of forecasting is the algorithms used to control,model,and predict performances of the energy systems which are complicated and involve large computer power,differential equations,and time *** having unreliable data(poor quality)for solar radiation over a geographical location as well as insufficient long series can be a bottleneck to *** overcome these problems,we employ the Anaconda Navigator(Jupyter Notebook)for machine learning which can combine large amounts of data with fast,iterative processing and intelligent algorithms allowing the software to learn automatically from patterns or features to predict the performance and outcome of Solar Energy which in turn enables the balance between supply and demand on loads,efficient operation of the utility company as well as enhances power production planning and management.

关键词： AI backward elimination data mining machine learning linear regression solar energy.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Topographical and hydrological effects on meso-scale vegetation in desert steppe, Mongolia

引用

Journal of Arid Land 2017年第1期9卷 132-142页

作者： Batdelger GANTSETSEG Masahide ISHIZUKA yasunori KUROSAKI Masao MIKAMI Information and Research Institute of Meteorology Hydrology and Environment Ulaanbaatar 15160 Mongolia Faculty of Engineering Kagawa University Takamatsu 761-03 96 Japan Arid Land Research Center Tottori University Tottori 680-0001 Japan Japan Meteorological Business Support Center Tokyo 101-0054 Japan

This study investigated the seasonal variations of the normalized difference vegetation index（NDVI） and its relationships with climatic variables and topography in a small-scale（20 km×20 km） area（i.e., Tsogt-Ovoo village） within the desert steppe zone of Mongolia using in-situ observed climate data and satellite remote sensing data. We found that the topography is very important for vegetation growth in the desert steppe although the summer precipitation is the constraining factor. The unexpectedly high NDVI（up to 0.56）, as well as the high aboveground biomass, in the valley bottom was primarily resulted from the topography-modulated redistribution of overland flow after relatively heavy precipitation events during the growing season. This makes the valley bottoms in desert steppes not only reliable feeding resources for livestock but also heavens for wild lives. But, the detected large standard deviation of annual maximum NDVI（NDVI_（max）） from 2000 to 2013 in the valley bottom in response to rather variable precipitation implies that the valley bottoms under desert steppe climates are more vulnerable to climatic change.

关键词： topography climatic variable desert valley vegetation soil moisture Terra-MODIS NDVI

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Titanium membrane layered between fluvastatin-loaded poly(lactic-co-glycolic)acid for guided bone regeneration

引用

Regenerative Biomaterials 2022年第1期9卷 816-826页

作者： Akihiro Furuhashi Yunia Dwi Rakhmatia yasunori Ayukawa Kiyoshi Koyano Section of Implant and Rehabilitative Dentistry Division of Oral RehabilitationFaculty of Dental ScienceKyushu UniversityHigashiFukuoka-ku 812-8582Japan Division of Advanced Dental Devices and Therapeutics Faculty of Dental ScienceKyushu UniversityHigashiFukuoka-ku 812-8582Japan Department of Prosthodontic Faculty of DentistryPadjadjaran UniversityKota BandungJawa Barat 40132Indonesia

The aimof this study was to investigate titaniummembranes(TMs)layered between poly(lactic-co-glycolic acid)(PLGA)containing fluvastatin(FS)for use in guided bone *** consisting of PLGA,FS-containing PLGA(PLGA–FS),TM layered between PLGA(TM–PLGA)and TM layered between FS-containing PLGA(TM–PLGA–FS)were prepared,and their mechanical and chemical properties were *** TM groups showed statistically significant differences,in terms of tensile strength and elastic modulus,when compared to the PLGA *** release of FS was demonstrated to be higher in the TM–PLGA–FS group than the PLGA–FS group after Day *** effect of membrane implantation on the calvaria of Wistar rats was measured using micro-computed tomography(micro-CT)and morphometrical analyses,as well as histological *** 4weeks,the TM–PLGA–FS and TM–PLGA groups were found to have lower bone mineral density but higher bone formation,when compared to the control and PLGA *** 8weeks,the use of TM–PLGA–FS membranes significantly enhanced bone formation in the calvaria model,compared to the other *** results suggest that a TM layered between PLGA containing FS potentially enhances bone formation,thus showing good potential as a GBR membrane.

关键词： titanium mesh PLGA statin guided bone regeneration(GBR)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adjuvant therapy after radical surgery for hepatocellular carcinoma: still an unmet need

引用

Hepatobiliary Surgery and Nutrition 2019年第4期8卷 414-416页

作者： yasunori Minami Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Osaka-Sayama Osaka Japan

Introduction Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related *** HCC typically occurs in patients with advanced liver disease,therapeutic decisions depend on the degree of underlying liver dysfunction and tumor *** treatment options,which result in 5-year survival rates of 60–80%(surgical resection)and 40–70%(local ablative therapies),are restricted to patients with early-stage HCC(1,2).However,surgical resection and local ablative therapies are limited by high tumor recurrence rates of 50%at 3 years and 70%at 5 years(1-6).Thus,monitoring treatment response is imperative for the clinical management of HCC patients(7),highlighting the need for adjuvant therapies.

关键词： mortality surgery clinical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carcinoma ex pleomorphic adenoma of the sublingual gland:a case report

引用

International Journal of Oral Science 2012年第1期4卷 50-53页

作者： yasunori Ariyoshi Masashi Shimahara Toshiyuki Konda Motomu Tsuji Department of Dentistry and Oral Surgery Division of Medicine for Function and Morphology of Sensory OrgansOsaka Medical CollegeTakatsukiJapan Department of Surgical Pathology Osaka Medical College HospitalTakatsukiJapan

We report a case of carcinoma ex pleomorphic adenoma of a sublingual gland in a 70-year-old *** a clinical diagnosis of benign salivary gland tumor,excision of the mass with the sublingual salivary gland in an en bloc fashion via an intraoral approach was ***,there was a rupture of the fibrous capsule and diffuse cell-rich sheets composed of myoepithelial cells with round nuclei were also ***,the cells that composed of cell rich sheets were positive to smooth muscle *** diagnosis of myoepithelial carcinoma ex pleomorphic adenoma was made.

关键词： Pleomorphic adenoma malignant myoepithelial carcinoma sublingual gland magnetic resonance imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report

引用

World Journal of Clinical Cases 2022年第10期10卷 3297-3305页

作者： Hirotaka Yonezawa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro Saito yasunori Tome Hiroko Ikeda Takayuki Nojima Hiroyuki Tsuchiya Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641IshikawaJapan Department of Orthopedic Surgery Graduate School of MedicineUniversity of the RyukyusNishihara 903-0215OkinawaJapan Department of Diagnostic Pathology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely ***,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant *** SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old *** had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same *** years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past *** radiographs showed an expansive osteolytic lesion with calcifications and residual grafting *** to the suspicion of malignancy,we performed ray *** findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma *** dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic *** patient was diagnosed with DDCS arising from a preexisting *** had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second *** The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma.

关键词： Dedifferentiated chondrosarcoma Enchondroma Finger Phalanx Ray amputation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：