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Anti-Hyperglycemic Effect of Single Administered Gardeniae Fructus in Streptozotocin-Induced Diabetic Mice by Improving Insulin Resistance and Enhancing Glucose Uptake in Skeletal Muscle

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Chinese Medicine 2013年第4期4卷 157-165页

作者： Qing Yu Tatsuo Takahashi Masaaki nomura Shinjiro Kobayashi Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University 3-Ho Kanagawa-Machi Kanazawa Japan Department of Education Center of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University 3-Ho Kanagawa-Machi Kanazawa Japan

The mechanisms of Gardeniae Fructus (GF) for anti-hyperglycemic action were demonstrated in streptozotocin (STZ)-diabetic mice. Six hours after single intraperitoneal administration of GF (300 mg/kg) or H2O into 3 hour-fasted STZ-diabetic mice, glucose and insulin tolerances were assessed by intraperitoneal glucose (1.5 g/kg) tolerance test (IPGTT) and intraperitoneal insulin (0.65 U/kg) tolerance test (IPITT), respectively. Effects of GF on insulin signaling pathways in soleus muscle such as glucose uptake, expression of glucose transporter 4 (GLUT4) in the plasma membrane and phosphorylation of Akt (P-Akt) in cytosolic fraction were examined in STZ-diabetic mice. In IPGTT test, GF significantly accelerated clearance of exogenous glucose and its glucose-lowering action was greater than H2O-treated controlin STZ-diabetic mice. GF also promoted an exogenous glucose-increased insulin level in STZ-diabetic mice. In IPITT test, GF decreased glucose level to the greater extent than H2O-treated control in STZ-diabetic mice. Furthermore, GF significantly decreased high HOMA-IR in STZ-diabetic mice from 21.6 ± 2.4 to 12.4 ± 1.9 (mg/dl × μU/ml). These results implied that GF improved insulin resistance in STZ-diabetic mice. GF increased glucose uptake of soleus muscle 1.5 times greater than H2O-treated control in STZ-diabetic mice. GF enlarged insulin (10 nmol/ml)-increased glucose uptake to 1.8 time-greater. Correspondingly, GF increased expression of GLUT4 in the plasma membrane of soleus muscle to 1.4 time-greater, and P-Akt in the cytosolic fraction of soleus muscle to 1.9 time-greater than those in H2O-treated control. In conclusion, the improvement of GF on insulin resistance is associated with the repair of insulin signaling via P-Akt, GLUT4 and glucose uptake pathway in soleus muscle of STZ-diabetic mice.

关键词： Gardeniae Fructus (GF) Streptozotocin (STZ) Soleus Muscle Insulin Resistance Glucose Uptake Glucose Transporter 4 (GLUT4) Phosphorylation of Akt (P-Akt)

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Economic Valuation of River Conservation towards International Tourists’ Preferences and Willingness to Pay for Ecofriendly Services of Hotel Industry: A Case Study of Namxong River in Vangvieng District, Laos

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Journal of Water Resource and Protection 2015年第12期7卷 897-908页

作者： Phouthivong Khamsay Yoshifumi Takahashi Hisako nomura Mitsuyasu Yabe Laboratory of Environmental Economics Division of International Agricultural and Resource Economics and Business Administration Department of Agricultural and Resource Economics Faculty of Agriculture Kyushu University Fukuoka Japan

Using choice experiment, the objective of this study is to estimate international tourists’ preferences and willingness to pay for ecofriendly services which related to river and natural environment conservation of hotel industry in Vangvieng, a popular tourist town in Lao PDR. We used the mixed logit to take into account of preference heterogeneity by allowing coefficients to be normally distributed and assumed to vary among individuals. The result shows that all ecofriendly practices offered in this study are significantly preferred by tourists. Income, age, and education did not have significant effect on the probability of choosing ecologically friendly practices of hotel and attributes to support the ecotourism of the area;however, this study provides important information that female tourists are more receptive to a new alternative. These findings do not only support the provision of good and green services in Vangvieng Town, but will also be useful for policy maker to enhance the sustainability of ecotourism in Laos.

关键词： Choice Experiment Ecofriendly Service Ecotourism Hotel Industry International Tourist River

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Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C

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World Journal of Gastroenterology 2010年第35期16卷 4400-4409页

作者： Mosaburo Kainuma Norihiro Furusyo Eiji Kajiwara Kazuhiro Takahashi Hideyuki nomura Yuichi Tanabe Takeaki Satoh Toshihiro Maruyama Makoto Nakamuta Kazuhiro Kotoh Koichi Azuma Junya Shimono Shinji Shimoda Jun Hayashi Department of General Internal Medicine Kyushu University Hospital Department of Internal Medicine Nippon Steel Yawata Memorial Hospital Department of Medicine Hamanomachi Hospital The Center for Liver Disease Shin-Kokura Hospital Department of Medicine Fukuoka City HospitalYoshiduka-honmachi Center for Liver Disease National Hospital Organization Kokura Medical Center Department of Medicine Kitakyushu Municipal Medical Center Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University Department of Medicine and Clinical Science Graduate School of Medical SciencesKyushu University Saiseikai Yahata General Hospital Harunomachi Department of Medicine and Biosystemic Science Graduate School of Medical ScienceKyushu University

AIM:To analyze the efficacy and safety of a combination therapy of pegylated interferon(PEG-IFN) α-2b plus ribavirin(RBV) in older Japanese patients(65 years or older) infected with hepatitis C virus(HCV).METHODS:This multicenter study included 938 patients with HCV genotype 1 who received 1.5 μg/kg per week PEG-IFN α-2b plus RBV 600-1000 mg/d for 48 wk and 313 HCV genotype 2 patients who received this treatment for 24 ***:At 24 wk after the end of combination therapy,the overall sustained virological response(SVR) for genotypes 1 and 2 were 40.7% and 79.6%,*** SVR rate decreased signif icantly with age in each genotype,and was markedly reduced in genotype 1(P<0.001).Moreover,the SVR was significantly higher in patients with genotype 1 who were less than 65 years(47.3% of 685) than in those 65 years or older(22.9% of 253)(P<0.001) and was higher in patients with genotype 2 who were less than 65 years(82.9% of 252) than in those 65 years or older(65.6% of 61)(P=0.004).When patients received a dosage at least 80% or more of the target dosage of PEG-IFN α-2b and 60% or more of the target dosage of RBV,the SVR rate significantly increased to 66.5% in patients less than 65 years and to 45.2% in those 65 years or older(P<0.001).Adverse effects resulted in treatment discontinuation more often in patients with genotype 1(14.4%) than in patients with genotype 2(7.3%),especially by patients 65 years or older(24.1%).CONCLUSION:PEG-IFN α-2b plus RBV treatment was effective in chronic hepatitis C patients 65 years or older who completed treatment with at least the minimum acceptable treatment dosage.

关键词： Hepatitis C virus Gerontology Pegylated interferon Ribavirin

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Study of High Power ICRF Antenna Design in LHD

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Plasma Science and Technology 2010年第1期12卷 15-19页

作者： Hiroshi KASAHARA Tetsuo SEKI Kenji SAITO Ryuhei KUMAZAWA Takashi MUTOH Goro nomura Fujio SHIMPO Shin KUBO Takashi SHIMOZUMA Yasuo YOSHIMURA Hiroe IGAMI Hiromi TAKAHASHI 赵燕平 Takuya OOSAKO Yuichi TAKASE National Institute for Fusion Science Institute of Plasma Physics Chinese Academy of Sciences University of Tokyo

In large helical device （LHD）, antenna loadings are different for minority ion cyclotron heating （MICH with 38.47 MHz） and mode-converted ion Bernstein wave heating （MC-IBW with 28.4 MHz）, and it is necessary to improve antenna loading with low heating efficiency to avoid arching on transmission line. To design a new ion cyclotron range of frequencies （ICRF） antenna in LHD, calculation for a simple antenna model is conducted using three-dimensional electrical magnetic code （high frequency structure simulator, HFSS） for an water loading as an imaginary plasma with low heating efficiency. At resonant frequencies, antenna loading is sensitive to strap width, and resonant frequencies are strongly related to strap height. There is no differences of RF current profile on the strap surface between resonant frequency and non-resonant frequency. The strap should be perpendicularly placed against the magnetic field line, since Faraday-shield angle will lead to a decrease in the effective antenna height.

关键词： ICRF minority heating mode conversion heating antenna design LHD

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A Review on Housing Affordability and Housing Policy Application in Neglected Border Cities in Jordan

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Journal of Civil Engineering and Architecture 2021年第3期15卷 156-166页

作者： Thamer Mahmmoud Muhammad Al Jbarat Suguru Mori Rie nomura Graduate School of Engineering Hokkaido UniversityNorth 13West 8Kita-kuSapporo 060-8628Japan Faculty of Engineering Hokkaido UniversitySapporo 060-8628Japan

The main task of this paper is to examine housing affordability and housing policy application in neglected border cities in *** the Iraq war in 2003 and Syria civil war in 2011 many border cities accommodated a large number of refugees in its urban context over different periods of *** lack of affordable housing and increase of unemployment were the main challenges for its vulnerable *** cities are facing different development challenges but applying the same housing policy as *** paper studies economic attributes and social characteristics of Mafraq city to analyze housing *** concludes that houses are unaffordable in these border cities and housing policies need *** paper recommended that housing affordability in border cities must include community participation and sufficient financial aid to low income *** order to maintain houses affordable in border cities,the real estate market,community participation,urban planning and promotion for tourism are all essential.

关键词： Affordable housing Mafraq city housing plan housing development

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A Versatile Liquid Culture Method to Control the <i>in Vitro</i>Development of Shoot and Root Apical Meristems of Bamboo Plants

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American Journal of Plant Sciences 2020年第2期11卷 262-275页

作者： Most Tanziman Ara Taiji nomura Yasuo Kato Shinjiro Ogita Graduate School of Comprehensive Scientific Research Prefectural University of Hiroshima Nanatsukacho Shobara Hiroshima Japan Biotechnology Research Center and Department of Biotechnology Toyama Prefectural University Kurokawa Imizu Toyama Japan

We focus on controlling morphological and histochemical responses of the shoot apical meristem (SAM) and root apical meristem (RAM) of bamboo node by using a simple and versatile liquid culture system. First, nodes of 11 different bamboo species that belong to seven major bamboo genera (Bambusa, Dendrocalamus, Phyllostachys, Tetragonocalamus, Chimonobambusa, Pleioblastus, and Sasa) were cultured using 2 mL per well of a liquid medium in a 6-well microplate to form a small-scale liquid culture environment (SLCE). The dormant lateral buds of all bamboo nodes resumed expanding and elongating within 7 days in the SLCE. The dormant and active lateral buds were sectioned longitudinally and stained with Sytox green (SG) to monitor mitotic activity and counterstained with safranin (SF) to detect the inward region of the SAM region. Further, mitotic activity was calculated using a digital imaging analysis, which showed an increase of up to 1.2- to 3.8-fold in terms of the SG/SF ratio after 7 days in the culture. Moreover, we used in vitro node cultures of two typical bamboo species, the sympodial clump-forming type (Bambusa multiplex Raeush, Bm) and the monopodial single culm-forming type (Phyllostachys meyeri McClure, Pm), and noted the following: 1) since gradual white-to-green tinge shoots were observed, we investigated the relation between color variation in the outer regions of culm and node tissues and their suitability as explants. By checking the autofluorescence property of whole shoots under LED 365 nm illumination with an RGB (red, green, and blue) digital imaging analysis using ImageJ software, we specified the color variation of explants as the relative intensity of the blue value. 2) Since the obtained shoots of a 1-month-old culture box showed growth variation, we distinguished shoot types based on plant height, i.e., short (less than 5 cm), medium (ca. 5 - 10 cm), and tall (more than 10 cm). Tall shoots that have ca. 5 nodes on average were suitable for expla

关键词： Bamboo Digital Imaging Node Culture RAM SAM SLCE

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Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan

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World Journal of Gastroenterology 2017年第29期23卷 5364-5370页

作者： Tomiyasu Arisawa Masakatsu Nakamura Toshimi Otsuka Wu Jing Naoko Sakurai Hikaru Takano Tasuku Hayashi Masafumi Ota Tomoe nomura Ranji Hayashi Takeo Shimasaki Tomomitsu Tahara Tomoyuki Shibata Department of Gastroenterology Kanazawa Medical University Department of Gastroenterology Fujita Health University

To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODSThis case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). RESULTSThe genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. CONCLUSIONOur results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.

关键词： Maf protein K Genetic polymorphism Reactive oxygen species Ulcerative colitis Nuclear factor-erythroid 2-related factor 2

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Effect of Specific Verbal Instructions on the Identification of Pain Location during a Passive Straight Leg Raise Test

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Open Journal of Therapy and Rehabilitation 2023年第2期11卷 45-53页

作者： Masae Ikeya Takumi Jiroumaru Hitomi Bunki Noriyuki Kida Teruo nomura Department of Physical Therapy Biwako Professional University of Rehabilitation Higashiomi City Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto City Japan Department of Physical Therapy Bukkyo University Kyoto City Japan Kanazawa Orthopedic & Sports Medicine Clinic Ritto City Japan

Musculoskeletal pain is common. Because pain is subjective, objectively describing it is crucial. However, pain assessment may cause distress in patients;therefore, physical therapists (PTs) should conduct these tests quickly and accurately. Simple and clear instructions are recommended for pain assessment. However, few studies have provided evidence to support this hypothesis. Correspondingly, this study aimed to confirm the effectiveness of specific verbal instructions for pain location during five consecutive Passive Straight Leg Raise (PSLR) tests. The 28 asymptomatic participants (age 27.4 ± 9.6 years) who provided informed consent received five consecutive PSLR tests: three without and two with specific verbal instructions to ascertain pain intensity, quality, and location. The participants drew pain locations on a body chart and described the pain intensity and quality after each test. All participants were interviewed regarding the differences they noted in the presence and absence of specific verbal instructions. Each pain location was classified into one of ten areas for statistical analysis. The proportion of participants who changed the pain location was compared between the tests using McNemar’s test, and the kappa coefficient was confirmed for consistency of pain location. There was a significant difference in the proportion of participants who changed their pain location between the second and third tests and from the third to the fourth test (McNemar’s test: p = 0.003). Kappa coefficients had low consistency (κ = 0.28) just after receiving the specific verbal instructions in the fourth test compared to the third test. Consistency improved in the fifth test (κ = 0.57);93% of the participants answered that the pain location had become clearer. This study revealed the effects of specific verbal instructions in identifying pain locations. This detailed information may help PTs provide appropriate treatment and contribute to reducing pain in clinical sett

关键词： Specific Verbal Instructions Pain Location Pain Assessment Passive Straight Leg Raise Test

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Influence of percutaneous local therapy for hepatocellular carcinoma on gastric function

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World Journal of Gastroenterology 2013年第10期19卷 1618-1624页

作者： Mitsuyoshi Kobayashi Fumihiko Kinekawa Kazuya Matsuda Shintaro Fujihara Noriko Nishiyama Takako nomura Joji Tani Hisaaki Miyoshi Hideki Kobara Akihiro Deguchi Hirohito Yoneyama Hirohito Mori Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of MedicineKagawa UniversityMiki-choKita-gunKagawa 761-0793Japan Department of Internal Medicine Sanuki Municipal HospitalSanuki-cityKagawa 769-2393Japan Department of Internal Medicine Matsuda ClinicTakamatsu-cityKagawa 760-0071Japan

AIM:To investigate the influence of percutaneous local therapy on gastric myoelectrical activity in patients with hepatocellular ***:Forty-four patients with hepatocellular carcinoma(HCC) [27 males and 17 females,ranging in age from 49 to 81 years old(69.7 ± 8.01 years)] who were admitted for percutaneous local therapy were enrolled in this *** examined clinical abdominal symptoms using the Gastrointestinal Symptom Rating Scale(GSRS) before and 3 d after percutaneous local *** also measured cutaneous fasting and postprandial electrogastrography(EGG) recordings before and 3 d after percutaneous local ***:We found that the percentage of normogastria in the fasting period was lower in the Child B group than in the Child A group(66.8% ± 8.6% vs 84.0% ± 3.8%).After percutaneous local therapy for HCC,the percentages of normogastria in the fasting period were significantly decreased(81.6% ± 3.5% vs 75.2% ± 4.5%).None of the postprandial EGG parameters changed significantly after percutaneous local therapy for *** local therapy for HCC reduced the power ratio(PR).In particular,the PR of tachygastria was significantly decreased after therapy(P < 0.01).However,no significant differences were found in the postprandial EGG ***,no significant differences were found in the calculated GSRS scores obtained from the questionnaire before and after ***:Gastric slow-wave dysrhythmias were induced by percutaneous local therapy in HCC patients,even though the GSRS scores obtained from the questionnaire did not change significantly.

关键词： Gastric myoelectrical activity Electrogastrography Hepatocellular carcinoma Percutaneous ethanol injection Radiofrequency ablation

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The Mutated Acetolactate Synthase Gene from Rice as a Non-Antibiotic Selection Marker for Transformation of Bamboo Cells

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American Journal of Plant Sciences 2012年第3期3卷 368-372页

作者： Shinjiro Ogita Nanaka Kikuchi Taiji nomura Yasuo Kato Laboratory of Plant and Cell Engineering Department of Biotechnology Toyama Prefectural University Toyama Japan

Previously, we developed a particle bombardment-mediated transformation protocol in Phyllostachys nigra bamboo by expressing hygromycin phosphotransferase gene (HPT) and neomycin phosphotransferase II gene (NPT II). Although these marker genes could introduce to several tissue cultured organs (e.g. leaves, buds, and calli) of Phyllostachs bamboo species, some organs showed a high susceptibility and/or a low selectivity to hygromycin and kanamycin. In this report, therefore, we describe advantages and technical details for generating stable transgenic bamboo cells using the particle bombardment method with the mutated-acetolactate synthase gene (mALS) from rice (W548L/S627IOsALS) as a non-antibiotic selection marker. A facile and efficient transformation was achieved with the mALS gene and enhanced fluorescent protein gene (mCherry). Approximately 490 and 1400 mCherry-expressing cells/dish/shot in average were observed in both P. bambusoides and P. nigra under fluorescent stereo-microscope. Stable transgenic bamboo cell lines were generated in a selection medium supplemented with 0.1 μM of bispyribac-sodium (BS) as ALS inhibitor. The integration of mALS gene was identified by in vivo ALS enzyme assay and a PCR-restriction fragment length polymerphism (RFLP) based detection procedures.

关键词： Bamboo Mutated Acetolactate Synthase Gene Particle Bombardment Suspension Culture

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