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World Journal of Gastroenterology 2016年第48期22卷 10523-10531页

作者： Masaki Miyazawa Mitsuru Matsuda Masaaki Yano yasumasa hara Fumitaka Arihara Yosuke Horita Koichiro Matsuda Akito Sakai Yatsugi Noda Department of Internal Medicine Toyama Prefectural Central Hospital

Gastric adenocarcinoma of the fundic gland(chief cellpredominant type, GA-FG-CCP) is a rare variant of welldifferentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis.

关键词： Narrow-band imaging Pepsinogen-I Fundic gland Gastric adenocarcinoma Chief cell

Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection

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World Journal of Gastroenterology 2015年第26期21卷 8208-8214页

Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was *** treated five cases of GA-FG with endoscopic submucosal *** tumors were small and located in the upper third of the *** tumors were macroscopically identified as 0-IIa and one was identified as 0-Ⅱ***-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the *** tumors arose from the deep layer of the lamina propria mucosae and showed submucosal *** invasion was seen only in one case,while no venous invasion was *** tumors were positive for pepsinogen-Ⅰ and MUC6 by *** showed p53 overexpression,and the labeling index of Ki-67 was low in all *** cases have been free from recurrence or ***,we discussed the clinicopathological features of GA-FG in comparison with past reports.

关键词： Gastric adenocarcinoma of fundic glandtype Pepsinogen-Ⅰ Chief cell Endoscopic diagnosis Narrow-band imaging with magnifying endoscopy Endoscopic submucosal dissection

Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

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Journal of Magnesium and Alloys 2024年第1期12卷 159-170页

作者： Dipak Patel Akiyoshi Matsumoto Hiroaki Kumakura Yuka hara Toru hara Minoru Maeda Hao Liang Yusuke Yamauchi Seyong Choi Jung Ho Kim Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia National Institute for Materials Science(NIMS) 1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Electrical Engineering and Kangwon High Magnetic Field Center Institute of Quantum Convergence TechnologyKangwon National UniversityGangwon 24341Republic of Korea Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityNagoyaAichi 464-8603Japan Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South Wales 2500Australia

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is *** achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment *** fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 *** evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting *** serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing *** findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

关键词： Mg B2 superconducting joint MgB_(2)conductor MRI applications Cryogen-free magnet Persistent-mode operation

Proposal of a Method to Easily Understand Rainfall Infiltration in Railway Embankments

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Journal of Civil Engineering and Architecture 2024年第6期18卷 261-268页

作者： Takashi Nakayama Tadashi hara Keigo Koizumi C.S.Inspector Co. Ltd.2-7-2 Nambanaka Naniwa-Ku Osaka-ShiOsaka-Fu 556-0011Japan Research and Education Faculty Kochi University2-5-1 Akebonocho Kochi-ShiKochi-Ken 780-8072Japan Earth Watch Institute Inc.8-10 Toyotsucho Suita-ShiOsaka-Fu 564-0051Japan

Slope failures due to heavy or prolonged rain have been occurring frequently in Japan in recent *** railway embankments,even small-scale surface collapse can result in track ***,train operation during rainy periods is regulated according to empirical rules based on rainfall and disaster ***,the validity of operation regulations is lacking because the rainfall infiltration circumstances inside the slope are *** have been attempting to understand rainfall infiltration in railway embankments by applying a method of predicting surface collapse from observations of volumetric water content in the *** used previous field monitoring and model experiments to propose a method for easily understanding the state of rainfall infiltration in the surface layer of an embankment using the relative history of volumetric water content at different *** this study,we applied this simple determination method to railway embankments with different topography and geological environments to demonstrate the versatility of the method.

关键词： Railway embankments field monitoring volumetric water content

Impact of postoperative sexual function on health-related quality of life after robot-assisted radical prostatectomy

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Current Urology 2024年第2期18卷 148-154页

作者： Yuya Iwahashi Ryusuke Deguchi Satoshi Muraoka Takahito Wakamiya Shimpei Yamashita Kazuro Kikkawa Yasuo Kohjimoto Isao hara Department of Urology Wakayama Medical UniversityWakayamaJapan

Background:We investigated potential disparities in health-related quality of life,particularly concerning urinary function,between patients with preserved and those with impaired sexual function after robot-assisted radical prostatectomy(RARP).Materials and methods:BetweenDecember 2012 and April 2020,704men underwent RARP in our *** study included 155 patients with a preoperative 5-item International Index of Erectile Function(IIEF-5)of≥12 points and an assessable IIEF-5 at 12 months ***-related quality of life was assessed using the 8-item Short-Form Health Survey and Expanded Prostate Cancer Index Composite(EPIC)preoperatively and at 3,6,and 12months postoperatively.A logistic regression analysis andWilcoxon rank sum tests were ***:Patients were grouped according to the median IIEF-5 score 12 months after surgery:those with preserved sexual function(n=71)and those with impaired sexual function(n=84).The mental component summary of the 8-item Short-Form Health Survey was better in the group with preserved sexual function at 6 months postoperatively than in the group with impaired sexual function(p<0.01).In the EPIC,the group with preserved sexual function performed better not only in the sexual domain but also in the urinary domain at all time points comparedwith the groupwith impaired sexual function(p<0.01).In the comparison of the urinary subdomains of the EPIC,there were no significant differences in urinary function or incontinence,but there were significant differences in urinary distress and irritative/obstructive scores(p<0.01).Conclusions:Patients with preserved postoperative sexual function after RARP showed better urinary function than those with impaired sexual ***,preserved sexual function is closely associated with urinary function.

关键词： Prostatectomy Robot-assisted radical prostatectomy Health-related quality of life Sexual function Urinary function

Use of color Doppler ultrasonography in the diagnosis of anomalous connection in pancreatobiliary disease

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World Journal of Gastroenterology 2005年第7期11卷 1018-1022页

作者： Hiroki Kawashima Yoshiki Hirooka Akihiro Itoh Senju Hashimoto Terutomo Itoh Kazuo hara Akira Kanamori Naoki Ohmiya yasumasa Niwa Hidemi Goto Department of Gastroenterology Department of Endoscopy

AIM: To estimate the detectability of anomalous connection in pancreatobiliary disease (ACPBD) cases, measuring gallbladder wall blood flow (GWBF).METHODS: In the retrospective study, we enrolled 42subjects with gallbladder wall thickening. GWBF velocity was determined as an average value of the peak velocity of color signals on the gallbladder wall, three times in each case. Based on the findings on endoscopic ultrasonography (EUS) or endoscopic retrograde cholangiopancreatography (ERCP), the 42 subjects were divided into 11 cases with ACPBD and 31 cases without ACPBD. In the prospective study, the subjects were 92 cases with gallbladder wall thickening. Using the cut-off level of the flow velocity obtained in the retrospective study, the usefulness of measuring GWBF velocity in diagnosing ACPBD was ***: In the retrospective study, imaging of GWBF was obtained in 40 of the 42 subjects. The mean GWBF velocity of the ACPBD cases was 29.4±3.9 cm/s(mean±SD), which was significantly different (P＜0.0001;95% CI 5.48-13.2) from that of the without ACPBD cases(20.1±5.9 cm/s). Based on this result, we prepared a receiver operating characteristic curve, and the cut-off level appropriate for diagnosing ACPBD was estimated to be 25 cm/s. In the prospective study, GWBF was detected in 86 of the 92 subjects. Based on the EUS or ERCP findings, the 92 subjects were divided into 15 cases with ACPBD and 77 cases without ACPBD. When a cut-off level of 25 cm/s was employed, ACPBD could be diagnosed with a sensitivity of 87.0% (13/15) and a specificity of87.3% (62/71).CONCLUSION: Measurement of GWBF velocity, which is less invasive and provides objective values, is very useful for diagnosing ACPBD prior to the development of malignant tumors in cases with gallbladder wall thickening.

关键词： Color Doppler ultrasonography Anomalous connection in pancreatobiliary disease Gallbladder cancer Gallbladder wall blood flow Endoscopic ultrasonography

Mineral sulphide-lime reactions and effect of CaO/C mole ratio during carbothermic reduction of complex mineral sulphides

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International Journal of Minerals,Metallurgy and Materials 2014年第1期21卷 1-11页

作者： Yotamu Stephen Rainford hara Institute for Materials Research(IMR) School of ProcessEnvironmental and Materials Engineering(SPEME)University of Leeds

Mineral sulphide （MS）-lime （CaO） ion exchange reactions （MS ＋ CaO = MO ＋ CaS） and the effect of CaO/C mole ratio during carbothermic reduction （MS ＋ CaO ＋ C = M ＋ CaS ＋ CO（g）） were investigated for complex froth flotation mineral sulphide concentrates. Phases in the partially and fully reacted samples were characterised by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. The primary phases during mineral sulphide-lime ion exchange reactions are Fe304, CaSO4 Cu2S, and CaS. A complex liquid phase of Ca2CuFeO3S forms during mineral sulphide-lime exchange reactions above 1173 K. The formation mechanisms of Ca2CuFeO3S liquid phase are determined by characterising the partially reacted samples. The reduction rate and extent of mineral sulphides in the presence of CaO and C increase with the increase in CaO/C ratio. The metallic phases are surrounded by the CaS rich phase at CaO/C 〉 1, but the metallic phases and CaS are found as separate phases at CaO/C 〈 1. Experimental results show that the stoichiometric ratio of carbon should be slightly higher than that of CaO. The reactions between CaO and gangue minerals （SiO2 and A1203） are only observed at CaO/C 〉 1 and the reacted samples are excessively sintered.

关键词： sulphide minerals ion exchange carbothermic reduction lime

Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation

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World Journal of Gastroenterology 2012年第20期18卷 2517-2525页

作者： Masahiro Tajika yasumasa Niwa Vikram Bhatia Hiroki Kawai Shinya Kondo Akira Sawaki Nobumasa Mizuno Kazuo hara Susumu Hijioka Kazuya Matsumoto Yuji Kobayashi Akira Saeki Asana Akabane Koji Komori Kenji Yamao Department of Endoscopy Aichi Cancer Center Hospital Nagoya 464-8681Japan Department of Medical Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol(PEG)-electrolyte *** 250 patients undergoing colonoscopy,124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group),and 126 received 2 L PEG plus placebo(placebo group).Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation *** efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's *** primary end point was optimal bowel preparation rates(scores of excellent/good/fair vs poor/inadequate). RESULTS:A total of 249 patients were included in the *** the mosapride group,optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group(78.2%vs 65.6%,P<0.05),but not in the right colon(76.5%vs 66.4%,P=0.08).After excluding patients with severe constipation,there was a significant difference in bowel preparation in both the left and right colon(82.4%vs 66.7%,80.8%vs 67.5%,P<0.05,P<0.01).The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience,a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group(34/72 patients vs 24/74 patients,P<0.05). CONCLUSION:Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation,especially in patients without severe constipation.

关键词： Mosapride citrate Bowel preparation Polyethylene glycol-electrolyte solution Colonoscopy Prokinetics

ATLAS commissioning and early physics of resonance and jet production

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Chinese Physics C 2010年第9期34卷 1530-1533页

作者： K.hara School of Pure and Applied Sciences University of Tsukuba

As early physics programs with the ATLAS detector,we present J/ψ and Υ production cross section and spin alignment measurements,and the strategy for the jet energy calibration.

关键词： ATLAS quarkonium spin alignment jet energy calibration

Unsteady Behavior of Leading-edge Vortex and Diffuser Stall in a Centrifugal Compressor with Vaned Diffuser

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Journal of Thermal Science 2016年第1期25卷 13-21页

作者： Nobumichi FUJISAWA Shotaro hara Yutaka OHTA Graduate Student Graduate School of Fundamental Science and EngineeringWaseda University 3-4-10kuboShinjukuTokyo 169-8555Japan Department of Applied Mechanics and Aerospace Engineering Waseda University 3-4-1 OkuboShinjukuTokyo 169-8555Japan

The characteristics of a rotating stall of an impeller and diffuser and the evolution of a vortex generated at the diffuser leading-edge(i.e., the leading-edge vortex(LEV)) in a centrifugal compressor were investigated by experiments and numerical analysis. The results of the experiments revealed that both the impeller and diffuser rotating stalls occurred at 55 and 25 Hz during off-design flow operation. For both, stall cells existed only on the shroud side of the flow passages, which is very close to the source location of the LEV. According to the CFD results, the LEV is made up of multiple vortices. The LEV is a combination of a separated vortex near the leading-edge and a longitudinal vortex generated by the extended tip-leakage flow from the impeller. Therefore, the LEV is generated by the accumulation of vorticity caused by the velocity gradient of the impeller discharge flow. In partial-flow operation, the spanwise extent and the position of the LEV origin are temporarily transmuted. The LEV develops with a drop in the velocity in the diffuser passage and forms a significant blockage within the diffuser passage. Therefore, the LEV may be regarded as being one of the causes of a diffuser stall in a centrifugal compressor.

关键词： Centrifugal Compressor Vaned Diffuser Rotating Stall Leading-edge Vortex CFD DES