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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 256-262页

作者： Yutaro Hyodo Takumi Jiroumaru Hikaru Kitagawa yasumasa oka Junko Ochi Nobuko Shichiri Takamitsu Fujikawa Department of Physical Therapy Bukkyo University Kyoto City Japan Kanazawa Orthopaedic and Sports Medicine Clinic Ritto Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto City Japan

Objective: This study aimed to evaluate the immediate psychological effects of coordination exercises on women in Japan. Methods: The subjects were 17 adult women (height, 160.1 ± 5.1 cm;weight, 54.3 ± 10.5 kg;age, 57.8 ± 8.3 years) living in the community and attending a fitness club. The subjects performed a coordination exercise called Life Kinetik®. The subjects responded to the Two-Dimensional Mood Scale–Short Term before and after performing 30 minutes of Life Kinetik®. The results were tabulated and four psychological states were calculated (i.e., vitality, stability, pleasure, and arousal). The pre- and post-implementation results were statistically analyzed using a corresponding t-test. Results: Significant differences were found in activation and arousal levels, but not in stability and comfort levels. Conclusion: The coordination exercise, Life Kinetik®, was found to be an exercise program with potential psychological benefits, as it could change women’s psychological condition to active and excited states.

关键词： Psychological State Life Kinetik® Mood Scale

Possibility of a Novel Warm-Up Strategy Using Capacitive and Resistive Electric Transfer: A Pilot Study

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Open Journal of Therapy and Rehabilitation 2022年第3期10卷 89-100页

作者： Michio Wachi Takumi Jiroumaru Ayako Satonaka Masae Ikeya Ryo Fujitani oka yasumasa Takamitsu Fujikawa Department of Physical Therapy Biwako Professional University of Rehabilitation Higashiomi City Japan Graduate School of Medicine Nagoya University Nagoya City Japan Department of Physical Therapy Bukkyo University Kyoto City Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto City Japan Department of Rehabilitation Kanazawa Orthopaedic & Sports Medicine Clinic Ritto City Japan

[Purpose] Capacitive and resistive electric transfer (CRET) is becoming prevalent in sports settings. CRET is effective for improving pain and healing injured tissue;however, its influence on muscle function and morphology is still unclear. This study confirmed the immediate effects of CRET on the duration of muscular stiffness and range of motion (ROM). [Method] This study describes the protocol for a single-arm trial with the non-blinding of participants and researchers. Twenty-four healthy men participated in the study. They received CRET therapy for their low back areas. The muscular stiffness of the multifidus muscle (superficial and deep) and the ROM using the active straight leg raise (ASLR) test were measured pre-intervention, post-intervention (immediately), and 15 and 30 min post-intervention. We compared these parameters using a one-way analysis of variance and Dunnett’s test (multiple comparison tests for subtests). [Results] The muscular stiffness of the superficial and deep multifidus muscles was significantly decreased, and the ASLR test showed a significant increase compared with the test performed pre-intervention. In addition, these effects persisted for 30 min. [Conclusion] Warm-up is vital for improving muscular stiffness and increasing the ROM. CRET is a useful device for achieving these aims, particularly as a passive warm-up method in sports settings.

关键词： Capacitive and Resistive Electric Transfer Muscular Stiffness Range of Motion Active Straight Leg Raise Multifidus Muscle

Relationship between Respiratory Muscle Strength and Static Balance in Older People Requiring Support and Care

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Open Journal of Therapy and Rehabilitation 2023年第3期11卷 90-97页

作者： Yutaro Hyodo Takumi Jiroumaru Kenji Mori Tomoka Hattori yasumasa oka Minoru Kuroda Takamitsu Fujikawa Kanazawa Orthopaedic and Sports Medicine Clinic 881 Ono Ritto Japan Department of Physical Therapy Bukkyo University Kyoto Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto Japan Department of Clinical Nursing Division of Psychiatric and Mental Health Nursing Shiga University Otsu Japan

Purpose: This study aimed to clarify the relationship between respiratory muscle strength and balance in older people requiring support or nursing care. Methods: Thirty-seven older subjects aged 65 years or older who were certified as requiring nursing care or support were included in the study. Maximal inspiratory pressure (PIMAX), maximal expiratory pressure (PEMAX), and one-leg standing time were measured. Additionally, the Functional Reach Test (FRT) was performed. Pearson correlation coefficient and multiple regression analyses were performed. Results: One-leg standing time was positively correlated with PEMAX, and was particularly correlated with PIMAX, while FRT score was not correlated with respiratory muscle strength. Multiple regression analysis with one-leg standing time as the dependent variable and PIMAX and PEMAX as independent variables showed that only PIMAX was significantly correlated with one-leg standing time. Conclusion: Focusing on expiratory and inspiratory muscle strength is important for improving one-leg standing ability and thus preventing falls in older people.

关键词： Respiratory Muscle Strength PIMAX PEMAX One-Leg Standing Older Person

Possibilities of Assessing Respiratory Muscle Strength and Trunk Muscle Mass in the Prevention of Sarcopenia in Older People Living in the Community

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Open Journal of Therapy and Rehabilitation 2023年第3期11卷 82-89页

Objective: The purpose of this study was to clarify the relationship between respiratory muscle strength and skeletal muscle mass (trunk, upper limbs, and lower limbs) in older people who were certified as requiring nursing or supportive care. Methods: Thirty-five older people (65 years or older) who were certified as requiring nursing care or support were included in the study. The subjects were divided into a non-sarcopenic group (n = 12) and a sarcopenic group (n = 23) according to the sarcopenia diagnostic criteria proposed by the Asian Working Group for Sarcopenia. Maximum inspiratory pressure, maximum expiratory pressure, skeletal muscle mass (trunk, upper and lower limbs), and hand grip strength were measured. Pearson’s correlation coefficient and multiple regression analysis were used for statistical processing. Results: In the non-sarcopenic group, both expiratory muscle strength and hand grip strength were correlated with skeletal muscle mass. In the sarcopenia group, expiratory muscle strength was not correlated with skeletal muscle mass, and only hand grip strength was correlated with upper limb muscle mass. Multiple regression analysis revealed that, in the non-sarcopenic group, trunk muscle mass was the primary factor in expiratory muscle strength and upper limb muscle mass was the primary factor in hand grip strength. In the sarcopenia group, upper limb muscle mass was found to be the main factor in hand grip strength. Conclusion: Our results highlight the importance of assessing expiratory muscle strength and trunk muscle mass before sarcopenia develops in older people who require support and nursing care.

关键词： Respiratory Strength PIMAX PEMAX Trunk Muscle Mass Skeletal Muscle Mass

Dynamic ultrasonography for optimizing treatment position in superior mesenteric artery syndrome:Two case reports and review of literature

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World Journal of Gastroenterology 2024年第5期30卷 499-508页

作者： Nobuaki Hasegawa Akihiko oka Muyiwa Awoniyi Yuri Yoshida Hiroshi Tobita Norihisa Ishimura Shunji Ishihara Department of Internal Medicine II Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteHepatology SectionCleveland ClinicClevelandOH 44195United States Clinical Laboratory Division Shimane University HospitalIzumo 693-8501ShimaneJapan Division of Hepatology Shimane University HospitalIzumo 693-8501Japan

BACKGROUND Superior mesenteric artery(SMA)syndrome is a rare cause of duodenal obstruction by extrinsic compression between the SMA and the aorta(SMA-Ao).Although the left lateral recumbent position is considered effective in the treatment of SMA syndrome,individual variations in the optimal patient position have been *** this report,we present two elderly cases of SMA syndrome that exhibited rapid recovery due to ultrasonographic dynamic evaluation of the optimal position for each *** SUMMARY Case 1:A 90-year-old man with nausea and *** diagnosis of SMA syndrome by computed tomography(CT),ultrasonography(US)revealed the SMA-Ao distance in the supine position(4 mm),which slightly improved in the lateral position(5.7–7.0 mm)without the passage of duodenal ***,in the sitting position,the SMA-Ao distance was increased to 15 mm accompanied by improved content ***,US indicated enhanced passage upon abdominal massage on the right *** day 2,the patient could eat comfortably with the optimal position and *** 2:An 87-year-old woman with *** the diagnosis of SMA syndrome and aspiration pneumonia by CT,dynamic US confirmed the optimal position(SMA-Ao distance was improved to 7 mm in forward-bent position,whereas it remained at 5 mm in the supine position).By day 7 when her pneumonia recovered,she could eat with the optimal *** The optimal position for SMA syndrome varies among *** US appears to be a valuable tool in improving patient outcomes.

关键词： Superior mesenteric artery syndrome Wilkie’s syndrome Cast syndrome Aorto-mesenteric compass syndrome Ultrasonography Case report

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混合磁悬浮系统零功率抗偏载控制方法研究

机械工程学报 2024年第8期60卷 360-369页

作者：赵川孙凤金俊杰徐方超张明 oka Koichi 沈阳工业大学机械工程学院沈阳110870 高知工科大学系统工学部高知7828502日本

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服... 详细信息

针对混合磁悬浮洁净传送装置无法兼顾零功率和抗偏载悬浮的问题,提出一种磁铁可动式混合磁悬浮系统,并设计了其零功率抗偏载控制策略。该系统中一个磁极固定,其他两个磁铁可绕悬浮圆盘中心轴线转动,通过调节气隙长度和磁铁转动角度克服偏载引起的扰动力和扰动力矩,从而实现零稳态电流和抗偏载悬浮。首先建立系统的线性变参数模型,分析该系统实现零功率水平悬浮需要满足的条件。零功率抗偏载控制策略在比例-微分控制器中引入电流和气隙偏差的积分反馈,并应用质心观测器反求磁体转动角度,求解方法分别采用雅可比逆变换解析求解和查表法内插取值两种方法。试验结果表明,该系统能够在偏载条件下保持零功率水平悬浮,应用雅可比的连续控制策略具有更好的纠偏特性,稳态时电流波动范围小。

关键词：混合磁悬浮零功率控制抗偏载特性离散控制

Population-based X-ray gastric cancer screening in Hiroshima prefecture, Japan

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World Journal of Clinical Oncology 2024年第2期15卷 271-281页

作者： Nhu Thi Hanh Vu Yuji Urabe Duc Trong Quach Shiro oka Toru Hiyama Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 700000Viet Nam Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan Department of Gastrointestinal Endoscopy and Medicine Hiroshima University HospitalHiroshima 734-8551Japan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551Japan Health Service Center Hiroshima UniversityHigashihiroshima 739-8514Japan

BACKGROUND X-ray gastric cancer(GC)screening has been shown to decrease ***-based X-ray GC screening has been performed in Hiroshima Prefe-cture,Japan,since 1983 but time trends and the efficacy of the method over 39 years have not been *** This was a population-based retrospective *** data were derived from aggregated data of the Hiroshima Regional Health Medical Promotion Organization,including the number and rate of participants and those requiring esophagogastroduodenoscopies(EGDs),the number and rate of participants diagnosed as having GC,and the positive predictive value of the abnormal findings detected by X-ray and confirmed by *** number and rate of esophageal cancers were also ***,the cost of detecting one GC was *** The number of participants has decreased during the last four decades,from 39925 in 1983 to 12923 in *** rate of those requiring EGDs decreased significantly in recent years(P<0.001).The number of participants diagnosed as having GC has also declined,from 76 to 10 ***,the rate of cases diagnosed as GC among the participants remained around 0.1%.The positive predictive value increased significantly in recent years except during *** number and rate of accidentally detected esophageal cancers have risen recently,from 0%in 2008 to 0.02%in 2021,one-fifth of the diagnosis rate of *** GC diagnosis costs approximately 4200000 Japanese Yen(30000 United States Dollars)for the X-ray screenings and *** X-ray GC screening in Hiroshima has been efficient,but one challenge is the *** cancers may also need to be considered because they have gradually increased in recent years.

关键词： Population Retrospective studies X-ray Gastric cancer Screening

High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

A Case of Warthin’s Tumor Together with IgG4-Related Sialadenitis

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Open Journal of Pathology 2024年第3期14卷 81-89页

作者： Ryogo Aoki Risa Ito Asuka Ohashi Riyoko Niwa Masashi Matsuyama Sachiko oka Naomi Kawaguchi Toshimasa Sakakima Daichi Kodama Naoki Watanabe Daisuke okamoto Takafumi Naiki Takuji Tanaka Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP) Gifu Municipal Hospital Gifu Japan Department of Central Clinical Laboratory Gifu Municipal Hospital Gifu Japan Department of Hematology Gifu Municipal Hospital Gifu Japan

Warthin’s tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland. The tumor contains the epithelial oncocyte cells with the presence of rich-mitochondria and their surrounding abundant lymphocytes. A relatively new disease entity of IgG4-related disease frequently occurs in the salivary gland. However, the coexistence of Warthin’s tumor and IgG4-related disease is scarcely observed. We have recently experienced a rare case of Warthin’s tumor with IgG4-related sialadenitis. A 51-year-old man presented to our hospital, complaining of a mass with right submandibular tenderness and spontaneous pain. A computed tomography scan of the cervical region revealed a suspicion of lymph node proliferative disease, including malignant lymphoma. Elevated serum levels of IL-2R: 1843 U/ml (reference value 122 - 496 U/ml), IgG: 3430 mg/dl (reference value 861 - 1747 mg/dl), and IgG4: 3140 mg/dl (reference value 11 - 121 mg/dl) were observed. Other laboratory data showed within normal ranges. The cervical tumor was diagnosed as Warthin’s tumor by the findings of fine-needle aspiration cytology and biopsy examination. Immunohistochemistry revealed numerous IgG4- and IgG-positive cells with fibrosis surrounding the epithelial component of Warthin’s tumor, suggesting IgG4-rerated sialadenitis. Finally, we diagnosed the cervical tumor as Warthin tumor with IgG4-related sialadenitis. This is the second report describing a case of Warthin’s tumor with possible involvement of IgG4-related sialadenitis.

关键词： Warthin’s Tumor Sialadenitis IgG4-Related Disease Immunohistochemistry

Current Developments in the Stable Production of Human Induced Pluripotent Stem Cells

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Engineering 2021年第2期7卷 144-152页

作者： Ikki Horiguchi Masahiro Kino-oka Department of Biotechnology Graduate School of EngineeringOsaka UniversityOsaka 565-0871Japan

Induced pluripotent stem cells(iPSCs)are considered to be ideal and promising cell sources for various applications such as regenerative medicine and drug ***,effective mass production systems for the stable supply of desired numbers of iPSCs are yet to be *** review introduces the various approaches that are currently available for stable iPSC *** start by discussing the limiting factors to be controlled during iPSC culture,such as nutrient supply,waste removal,and oxygen *** then introduce recent investigations on iPSC culture systems based on adhesion,suspension,and *** also discuss the downstream processes that follow the culture process,such as filling and freezing processes,which limit the production scale due to decreased cell viability during suspension in cryopreservation ***,we summarize the possibility of the stable mass production of iPSCs and highlight the limitations that remain to be *** suggest that multidisciplinary investigations are essential to understand the different factors that influence cell growth and quality in order to obtain an optimal and stable iPSC mass production system.

关键词： Induced pluripotent stem cell Cell manufacturing Expansion Filling Freezing