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Percutaneous endoscopic gastrostomy with Funada-style gastropexy greatly reduces the risk of peristomal infection

Gastroenterology Report 2015年第1期3卷 69-74页

作者： Naoki Okumura Naoko Tsuji Nobuto Ozaki Nozomu Matsumoto Takehisa Takaba Masanori Kawasaki Takafumi Tomita yasuko Umehara Satoko Taniike Masashi Kono Masatoshi Kudo Department of Gastroenterology Sakai HospitalKinki University Faculty of MedicineSakaiJapan Department of Gastroenterology and Hepatology Kinki University Faculty of MedicineOsaka-sayamaJapan

Background and aims:Peristomal wound infections are common complications of percutaneous endoscopic gastrostomy(PEG).The Funada-style gastropexy device has two parallel needles with a wire loop and suture thread,and was developed about 20 years ago in *** kit has allowed us to perform dual gastropexy very easily;PEG with gastropexy has become a very popular technique in *** present study aimed to compare the advantages and disadvantages of PEG with the gastropexy technique with the standard‘pull’***:We retrospectively reviewed 182 consecutive,non-randomized patients undergoing PEG in our hospital,and a comparative analysis was made between the gastropexy(87 patients)and non-gastropexy(95 patients)***:The rates of patients having erythema(11.6%vs.47.9%;P<0.001),exudates(2.3%vs.14.9%;P<0.01)and infection(0%vs.6.4%;P紏0.01)in the peristomal area were lower in the gastropexy than in the non-gastropexy *** rate of minor bleeding from the peristomal area was higher in the gastropexy than in the non-gastropexy group(12.8%vs.2.1%;P<0.01),but no patient required a blood *** procedure time was longer in the gastropexy group than in the non-gastropexy group(31 vs.24 min;P<0.001).The 30-day mortality rates were 4.7%and 5.3%respectively,and these deaths were not related to the gastrostomy ***:PEG with gastropexy markedly reduces peristomal *** minor bleeding and a longer procedure time were disadvantages,there were no severe *** findings suggested that PEG with Funada-style gastropexy was a safe and feasible method for reducing early complications of PEG.

关键词： percutaneous endoscopic gastrostomy gastropexy peristomal infection

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Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

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World Journal of Gastroenterology 2020年第9期26卷 918-932页

作者： Chieko Tashita Masato Hoshi Akihiro Hirata Kentaro Nakamoto Tatsuya Ando Takayuki Hattori yasuko Yamamoto Hiroyuki Tezuka Hiroyuki Tomita Akira Hara Kuniaki Saito Department of Disease Control and Prevention Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Department of Biochemical and Analytical Science Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Division of Animal Experiment Life Science Research CenterGifu UniversityGifu 501-1193Japan Department of Cellular Function Analysis Research Promotion and Support HeadquartersFujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Faculty of Medical Technology Gifu University of Medical ScienceGifu 501-3892Japan Department of Tumor Pathology Gifu University Graduate School of MedicineGifu 501-1193Japan

BACKGROUND Inflammatory bowel disease,such as Crohn’s disease and ulcerative colitis,is characterized by chronic intestinal inflammation leading to intestinal mucosal *** bowel disease causes dysregulation of mucosal T cell responses,especially the responses of CD4+T ***,we demonstrated that indoleamine-2,3-dioxygenase plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate(TNBS)-induced *** indoleamine-2,3-dioxygenase exerts immunosuppressive effects by altering the local concentration of tryptophan(Trp)and immunomodulatory Trp metabolites,the specific changes in immune regulation during colitis caused by Trp metabolites and its related enzymes remain *** To investigate role of kynurenine 3-monooxygenase(KMO)in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal *** Colitis was induced in eight-week-old male KMO+/+or KMO−/−mice of C57BL/6N background using *** days later,the colon was used for hematoxylin-eosin staining for histological grading,immunohistochemical or immunofluorescence staining for KMO,cytokines,and immune *** and anti-inflammatory cytokines were measured using quantitative RT-PCR,and kynurenine(Kyn)pathway metabolites were measured by high-performance liquid *** cell proportions of colonic lamina propria and mesenteric lymph nodes were analyzed by flow *** KMO expression levels in the colonic mononuclear phagocytes,including dendritic cells and macrophages increased upon TNBS ***,KMO deficiency reduced TNBS-induced colitis,resulting in an increased frequency of Foxp3+regulatory T cells and increased mRNA and protein levels of antiinflammatory cytokines,including transforming growth factor-βand *** Absence of KMO reduced TNBS-induced colitis via generation of Foxp3+regulatory T cells by producing ***,Kyn may play a therapeutic role in colon protection

关键词： Kynurenine 3-monooxygenase Kynurenine Regulatory T cell Inflammatory bowie diseases

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Association between white opaque substance under magnifying colonoscopy and lipid droplets in colorectal epithelial neoplasms

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World Journal of Gastroenterology 2017年第47期23卷 8367-8375页

作者： Keisuke Kawasaki Makoto Eizuka Shotaro Nakamura Masaki Endo Shunichi Yanai Risaburo Akasaka Yosuke Toya yasuko Fujita Noriyuki Uesugi Kazuyuki Ishida Tamotsu Sugai Takayuki Matsumoto Division of Gastroenterology Department of Internal MedicineIwate Medical University Department of Diagnostic Pathology Iwate Medical University Kaiunbashi Endoscopy Clinic

AIM To examine the association between white opaque substance(WOS) and histologically verified lipiddroplets in colorectal epithelial *** We reviewed colonoscopy records at our institution from 2014 to 2016 and identified cases of endoscopically or surgically resected colorectal epithelial neoplasms observed by magnifying narrow-band imaging(M-NBI) colonoscopy. Immunohistochemistry was used to stain tumors with a monoclonal antibody specific to adipophilin as a marker of lipids. The expression and distribution of adipophilin were compared between WOS-positive and WOS-negative lesions and among tumors classified by histologic type and depth of *** Under M-NBI colonoscopy, 81 lesions were positive for WOS and 48 lesions were negative for WOS. The rate of adipophilin expression was significantly higher in WOS-positive lesions(95.1%) than in WOS-negative lesions(68.7%)(P = 0.0001). The incidence of deep adipophilin expression was higher in WOS-positive lesions(24.7%) than in WOS-negative lesions(4.2%)(P = 0.001). The incidence of deep expression was predominant among cancers with massive submucosal invasion(62.5%) compared to adenoma(7.2%) and high-grade dysplasia or cancers with slight submucosal invasion(12.7%)(P = 0.0001).CONCLUSION The distribution of lipid droplets may be closely associated with the visibility of WOS under M-NBI colonoscopy, and with histologic grade and depth of tumor invasion.

关键词： White opaque substance Adipophilin Magnifying narrow-band imaging Colorectal neoplasm Magnifying endoscopy

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Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice

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World Journal of Gastroenterology 2008年第42期14卷 6473-6480页

作者： Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura Department of Gastroenterology and Hepatology Graduate School of Medicine Osaka University 2-2 Yamada-oka Suita Osaka 565-0871 Japan Department of Pathology Osaka Medical Center for Cancer and Cardiovascular Diseases Research Institute 1-3-2 Nakamichi Higashinari-ku Osaka 537-8511 Japan Department of Metabolic Medicine Graduate School of Medicine Osaka University 2-2 Yamada-oka Suita Osaka 565-0871 Japan Department of Biochemistry Osaka MedicaCenter for Cancer and Cardiovascular Diseases ResearchInstitute 1-3-2 Nakamichi Higashinari-ku Osaka 537-8511Japan Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular Diseases 1-3-3 Nakamichi Higashinari-ku Osaka 537-8511 Japan

AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and ***:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) ***:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO *** mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal *** addition,KO mice showed higher incidence and frequency of liver tumors after AOM *** percent of WT mice developed liver tumors,and these WT mice had only a single *** contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple ***:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in *** study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects.

关键词： Adiponectin Colorectal carcinogenesis Azoxymethane Cell proliferation Cyclooxygenase-2 Liver tumor formation

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Progress in researches about focal adhesion kinase in gastrointestinal tract

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World Journal of Gastroenterology 2009年第47期15卷 5916-5923页

作者： Hui Fang Hao Yoshio Naomoto Xiao-Hong Bao Nobuyuki Watanabe Kazufumi Sakurama Kazuhiro Noma yasuko Tomono Takuya Fukazawa Yasuhiro Shirakawa Tomoki Yamatsuji Junji matsuoka Munenori Takaoka Department of Gastroenterological Surgery Transplantation and Surgical Oncology Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama 700-8558 Japan Shigei Medical Research Institute Okayama 700-8558 Japan

Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein *** factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases,resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK *** plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal *** also plays an important role in the restitution,cell survival and apoptosis and carcinogenesis of the gastrointestinal *** is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer *** has been proposed as a potential target in cancer *** molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells,indicating a high potential for application in cancer therapy.

关键词： Focal adhesion kinase Restitution Survival and apoptosis Cancer Inhibitor

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Development of the Investigation Tool of a Study State and Practical Use of MyPage

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Computer Technology and Application 2012年第9期3卷 594-600页

作者： Yoshito Yamamoto yasuko Hayashibara Hiroshi Ichikawa Hiroo Hirose Faculty of Science Tokyo University of Science Tokyo 162-8601 Japan Faculty of Home Economics Otsuma Women's University Tokyo 102-8357 Japan Faculty of Management of Administration and Information Tokyo University of Science Suwa 391-0213 Japan

Internetwork environment at university has been improved to supply often the lecture materials to students through websites. Along with such a tendency, the number of students who use PC （Personal computer） has also increased during the lesson at university. Hereupon, the authors investigate whether the students will get high scores in tests when some limitations are imposed on the students＇ use of the PC during lecture and when they are not. The authors create the tool to check the students＇ learning situation and to grasp which student is performing the PC operations, which are not related to the ongoing lesson, during the lecture. Teaching assistant carrying the iPad is made to walk around the class during the lecture and collect data of the students. In addition, the authors develop ＂MyPage＂ that the students can be given access to their personal information including individual class absence/tardiness, lesson comprehension and question understanding level of them and after using MyPage, the authors examine its effectiveness as a tool and its relationship with their attendance rate.

关键词： Use ofwebsites student's lesson attitude limitations imposed on personal computer use.

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Effect of Indoor Concentrate Feeding vs. Outdoor Grazing on the Expression of Genes Involved in Muscle Growth and Nutrient Content in Japanese Black Steer Muscle

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Open Journal of Animal Sciences 2014年第5期4卷 297-304页

作者： Masahiro Shibata[*] Kazunori Matsumoto yasuko Hikino Naoyuki Yamamoto Livestock Production and Wildlife Management Research Division NARO Western Region Agricultural Research Center Shimane Japan

The objective of the present study was to investigate the effect of outdoor grazing on the expression of genes involved in muscle growth and the nutrient contents of skeletal muscle in steers. Ten Japanese Black steers were divided into two groups: grazing (GR) and concentrate (CT) groups. Crude protein, extractable lipid, moisture, fatty acid, cooking loss and Warner Bratzler shear force in muscle tissue were analyzed. The gene expression of myosin heavy chain (MyHC) isoform (2a, 2x and slow), myostatin, follistatin, peroxisome proliferator-activated receptor γ2 (PPARγ2), CCAAT/enhancer binding protein α (C/EBPα), heat shock protein (HSP) 27 and HSP40 in skeletal muscles was evaluated at the end of fattening. Decreases in MyHC-2a and MyHC-2x (fast-twitch fiber type) expression in the longissimus lumborum (LL) muscle were detected in the GR group compared with the CT group;in contrast, an increase in MyHC-slow (slow-twitch fiber type) expression was shown in the GR group. These results suggest that grazing initiated muscle fiber type conversion to slow-twitch from fast-twitch. A decrease in extractable lipid content was observed in the GR group in the LL and semitendinosus (ST) muscles. Crude protein content in the LL muscle in the GR group was higher than in the CT group. MyHC expression in LL muscle in the GR group was greater than in the CT group. A decrease in myostatin and PPARγ2 gene expression was detected in the GR group compared with the CT group in both muscles. Expression of C/EBPα in LL muscle in the GR group was lower than in the CT group. These results suggest that grazing steers at the end of fattening may lead to an increase in protein content and a decrease in fat accumulation in LL and/or ST muscles by regulation of myostatin, MyHC, PPARγ2 and C/EBPα gene expression.

关键词： Grazing Gene Expression Japanese Black Steer Muscle Growth Nutrient Content

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Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium

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World Journal of Gastroenterology 2011年第6期17卷 717-726页

作者： Takayuki Motoki Yoshio Naomoto Junji Hoshiba Yasuhiro Shirakawa Tomoki Yamatsuji Junji matsuoka Munenori Takaoka yasuko Tomono Yasuhiro Fujiwara Hiroshi Tsuchita Mehmet Gunduz Hitoshi Nagatsuka Noriaki Tanaka Toshiyoshi Fujiwara Department of Gastroenterological Surgery Transplantand Surgical OncologyGraduate School of MedicineDentistryand Pharmaceutical SciencesOkayama University Department of General Surgery Kawasaki Medical School Kawasaki Hospital Division of Molecular and Cell Biology Shigei Medical Research Institute Department of Animal Resources Advanced Science Research CenterOkayama University Food Technology Research Institute Meiji Dairies Corporation Department of Oral Pathology and Medicine Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama University

AIM:To investigate the possible biological outcome and effect of glutamine depletion in neonatal mice and rodent intestinal epithelial ***:We developed three kinds of artificial milk with different amounts of glutamine;Complete amino acid milk (CAM),which is based on maternal mouse milk,glutamine-depleted milk (GDM),and glutaminerich milk (GRM).GRM contains three-fold more glutamine than ***-seven newborn mice were divided into three groups and were fed with either of CAM,GDM,or GRM via a recently improved nipple-bottle system for seven *** the feeding period,the mice were subjected to macroscopic and microscopic observations by immunohistochemistry for 5-bromo-2'deoxyuridine (BrdU) and Ki-67 as markers of cell proliferation,and for cleaved-caspase-3 as a marker of ***,IEC6 rat intestinal epithelial cells were cultured in different concentrations of glutamine and were subject to a 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)2H-5-tetrazolio]-1,3-benzene disulfonate cell proliferation assay,flow cytometry,and western blotting to examine the biological effect of glutamine on cell growth and ***:During the feeding period,we found colonic hemorrhage in six of 28 GDM-fed mice (21.4%),but not in the GRM-fed mice,with no differences in body weight gain between each *** examination showed destruction of microvilli and the disappearance of glycocalyx of the intestinal wall in the colon epithelial tissues taken from GDM-fed *** of GDM reduced BrdU incorporation (the average percentage of BrdU-positive staining;GRM:13.8%,CAM:10.7%,GDM:1.14%,GRM vs GDM:P < 0.001,CAM vs GDM:P < 0.001) and Ki-67 labeling index (the average percentage of Ki67-positive staining;GRM:24.5%,CAM:22.4% GDM:19.4%,GRM vs GDM:P=0.001,CAM vs GDM:P =0.049),suggesting that glutamine depletion inhibited cell proliferation of intestinal epithelial *** deprivation further caused the deformation of the nuclear membrane and the plasma m

关键词： Glutamine Newborn mice Artificial milk Melena Intestinal epithelial cells Apoptosis

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Particle Simulation of Skin Basal Layer Formation

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Journal of Biosciences and Medicines 2016年第3期4卷 33-37页

作者： Katsuya Nagayama Takeshi Kurihara yasuko Amano Masanori Tanahashi Kyushu Institute of Technology Fukuoka Japan Kao Corporation Tokyo Japan

There has been increasing concern regarding the cosmetic aspects of skin in recent years. Computational simulation can be useful in understanding the mechanism underlying skin formation. The bottom of the epidermis is called the basal layer and is very undulation. In this study, we focus on the basal layer formation. We created a particle model, which forms an undulation basal layer and regenerates the basal layer formation by numerical simulation. At first, two-dimensional basal layer formation without epidermal turnover was simulated. The results showed film shape changes and the stability, as a layer in the process of long-time with an increase and decrease of basal cells. Next, the model was applied to three-dimensional basal layer formation with epidermal turnover. As the structure of the basal layer was deformed, the upper structure of the epidermis comprising the cells divided from the basal layer also became irregular. The simulation results accurately represented and reproduced the three-dimensional basal layer formation and epidermis turnover process.

关键词： Numerical Simulation Skin Formation Particle Model Basal Layer

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3D Numerical Simulation of Epidermal Skin Turnover Process Using a Particle Model

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Journal of Biosciences and Medicines 2015年第3期3卷 45-49页

作者： Katsuya Nagayama Takahiro Uehara yasuko Amano Masanori Tanahashi Kyushu Institute of Technology Fukuoka Japan Kao Corporation Tokyo Japan

Skin is the largest organ of the human body. In recent years, concern regarding the cosmetics area has increased, and research studies on anti-aging therapy or cosmetics have been rapidly conducted. Skin cells are not only changing its shape but also its physical properties during the epidermal skin turnover process. Computational simulation can be useful in further understanding the mechanisms of skin formation. We propose a particle model that can handle complex biological phenomena, including cell interactions and is a suitable method for simulating skin formation. The particle model was applied to simulate three-dimensional skin formation accompanied by proliferation and cornification of skin cells. The simulation results represented and reproduced the epidermal skin turnover phenomenon.

关键词： Numerical Simulation Skin Formation Particle Model

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