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The Principles of Starch Gelatinization and Retrogradation

Food and Nutrition Sciences 2014年第3期5卷 280-291页

作者： Masakuni Tako Yukihiro Tamaki Takeshi Teruya yasuhito takeda Department of Biochemical Science and Technology Kagoshima University Kagoshima Japan. Department of Subtropical Bioscience and Biotechnology University of the Ryukyus Nishihara Japan Department of Subtropical Bioscience and Biotechnology University of the Ryukyus Nishihara Japan Health and Longevity Research Laboratory Integrated Innovation Research Center University of the Ryukyus Nishihara Japan

The polysaccharides, such as κ-carrageenan, ι-carrageenan, agarose (agar), gellan gum, amylose, curdlan, alginate, and deacetylated rhamsan gum, in water changed into an ice-like structure with hydrogen bonding between polymer and water molecules, and between water-water molecules even at a concentration range of 0.1% - 1.0% (W/V) at room temperature, resulting in gelation. Such dramatic changes from liquid into gels have been understood at the molecular level in principles. In this review, we describe the structure-function relationship of starch on the view point of rheological aspects and discuss gelatinization and retrogradation mechanism including water molecules at molecular level. The starch molecules (amylose and amylopectin) play a dominant role in the center of the tetrahedral cavities occupied by water molecules, and the arrangement is partially similar to a tetrahedral structure in a gelatinization process. The arrangement should lead to a cooperative effect stabilizing extended regions of ice-like water with hydrogen bonding on the surface of the polymer molecules, where hemiacetal oxygen and hydroxyl groups might participate in hydrogen bonding with water molecules. Thus, a more extended ice-like hydrogen bonding within water molecules might be achieved in a retrogradation process. Though many investigations not only include starch gelatinization and retrogradaion, but also the gelling properties of the polysaccharides have been undertaken to elucidate the structure-function relationship, no other researchers have established mechanism at the molecular level. There is reasonable consistency in our investigations.

关键词： Principles Starch Amylose Amylopectin Hydrogen Bonding Gelatinization and Retrogradation Mechanism

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Combined laparoscopic and thoracoscopic repair of adult right-sided Bochdalek hernia with massive liver prolapse: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2420-2425页

作者： Shinya Mikami Sae Kimura Yoshitsugu Tsukamoto Masaki Hiwatari yasuhito Hisatsune Asako Fukuoka Tsunehisa Matsushita Takeharu Enomoto Takehito Otsubo Department of Gastrointestinal and General Surgery St.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND A Bochdalek hernia(BH)is a congenital diaphragmatic hernia that often develops in the neonatal *** typically occurs on the left side of the diaphragm.A right-sided BH in an adult is *** SUMMARY A 45-year-old man was referred to our hospital because of an abnormal shadow seen on chest radiography during a medical check-up.A chest radiograph showed elevation of the right *** tomography showed prolapse of multiple intraabdominal organs into the right thoracic cavity,corresponding to a right-sided *** herniated contents included the stomach,transverse colon,and left lobe of the *** left lobe of the liver was enlarged,particularly the medial *** surgery was ***,the left lobe of the liver was completely trapped in the thoracic ***,thoracoscopic manipulation had to be performed to return the liver to the abdominal *** hernia was repaired with interrupted nonabsorbable sutures and reinforced with *** Combined laparoscopic and thoracoscopic surgery was successfully performed for right-sided BH with massive liver prolapse and abnormal liver morphology.

关键词： Bochdalek hernia Right-sided Adult Laparoscopic and thoracoscopic repair Liver prolapse Abnormal liver morphology Case report

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Effectiveness of clip-and-snare method using pre-looping technique for gastric endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2016年第12期8卷 451-457页

作者： Naohiro Yoshida Hisashi Doyama Ryosuke Ota yasuhito takeda Hiroyoshi Nakanishi Kei Tominaga Shigetsugu Tsuji Kenichi Takemura Department of Gastroenterology Ishikawa Prefectural Central Hospital

AIM:To evaluate efficacy and safety of clip-and-snare method using pre-looping technique(CSM-PLT)for gastric endoscopic submucosal dissection(ESD).METHODS:In the CSM-PLT method,a clip attached to the lesion side was strangulated with a snare,followed by application of an appropriate tension to the lesion independent of an *** consecutive lesions were resected by ESD using CSM-PLT(CSM-PLT group)and compared with a control group,including20 lesions that were resected by conventional *** control group was matched based on the size and location of the lesion,presence of pathologic fibrosis,and experience of *** procedure time of ESD,proportion of en bloc resection,and complications were ***:The total procedure time for the CSM-PLT group was significantly shorter than that for the control group(38.5 min vs 59.5 min,P=0.023);all lesions were resected en bloc by *** was no significant difference in complications between the two ***,there was no complication in the CSM-PLT *** one large lesion(size:74 mm)that underwentextensive CSM-PLT during ESD,we used an additional CSM-PLT on another edge of the lesion after achieving submucosal resection to the maximum extent possible during initial *** two lesions,the snare came off the lesion together with the clip after a sudden pull;nevertheless,ESD was successful in all ***:CSM-PLT was an effective and safe method for gastric ESD.

关键词： Endoscopic submucosal dissection Clipand-snare method Pre-looping technique Endoscope Dissection

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Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu Mayumi Harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

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Numerical Investigation on Fracture Initiation Properties of Interface Crack in Dissimilar Steel Welded Joints

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Chinese Journal of Mechanical Engineering 2020年第3期33卷 142-149页

作者： Longfei Zhao Chendong Shao yasuhito Takashima Fumiyoshi Minami Fenggui Lu Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina Joining and Welding Research Institute Osaka UniversityOsakaJapan

Fracture toughness property is of significant importance when evaluating structural *** current research of fracture toughness mainly focused on crack in homogeneous material and experimental *** the crack is located in a welded joint with high-gradient microstructure and mechanical property distribution,it becomes difficult to evaluate the fracture toughness behavior since the stress distribution may be affected by various *** recent years,numerical method has become an ideal approach to reveal the essence and mechanism of fracture toughness *** study focuses on the crack initiation behavior and driving force at different interfaces in dissimilar steel welded *** stress and strain fields around the crack tip lying at the interfaces of ductile-ductile,ductile-brittle and brittle-brittle materials are analyzed by the numerical *** the interface of ductile-ductile materials,the strain concentration on the softer material side is responsible for ductile fracture *** the ductile-brittle interface,the shielding effect of the ductile material plays an important role in decreasing the fracture driving force on the brittle material *** the case of brittle-brittle interface,a careful matching is required,because the strength mismatch decreases the fracture driving force in one side,whereas the driving force in another side is *** results are deemed to offer support for the safety assessment of welded structures.

关键词： Dissimilar steel welded joint Fracture initiation Interface Strength mismatch Numerical simulation

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MicroRNA and liver cancer

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Cancer Drug Resistance 2020年第3期3卷 385-400页

作者： Masaya Onishi Takahiro Ochiya yasuhito Tanaka Department of Virology&Liver unit Nagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan. Department of Molecular and Cellular Medicine Institute of Medical ScienceTokyo Medical UniversityTokyo 160-8402Japan.

Hepatocellular carcinoma(HCC)is a major cause of cancer-related deaths *** is characterized by a poor prognosis and an ever increasing number of scientific studies aim to find new diagnostic,prognostic,and therapeutic ***(miRNAs),small non-coding RNAs that regulate the gene expression in many processes,have been shown to play a crucial role in regulating hepatocellular *** may act as oncogenic miRNAs and tumor suppressor miRNAs and regulate cancer cell proliferation,invasion,and metastasis by being differently upregulated or downregulated and targeting the genes related with *** secreted from cancer cells are found circulating in the blood,presenting an opportunity for their use as diseaserelated ***,extracellular vesicle-derived miRNAs are known to reflect the cell of origin and function and may provide effective biomarkers for predicting diagnosis and prognosis and new therapeutic target in *** this article,we describe the most recent findings regarding the molecular mechanisms and gene regulation of microRNA in HCC,as well as their application in diagnosis/prognosis and treatment.

关键词： MicroRNA hepatocellular carcinoma diagnosis extracellular vesicles

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Milestones in Molecular Dynamics Simulations of Single-Walled Carbon Nanotube Formation: A Brief Critical Review

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Nano Research 2009年第10期2卷 755-767页

作者： Stephan Irle yasuhito Ohta Yoshiko Okamoto Alister JPage Ying Wang Keiji Morokuma Fukui Institute for Fundamental Chemistry Kyoto UniversityKyoto 606-8103Japan Institute for Advanced Research and Department of Chemistry Nagoya UniversityNagoya 464-8602Japan Cherry L.Emerson Center for Scientic Computation and Department of Chemistry Emory UniversityAtlantaGA 30322USA Department of Chemistry Nara Women’s UniversityNara 630-8506Japan

We present a brief review of the most important efforts aimed at simulating single-walled carbon nanotube(SWNT)nucleation and growth processes using molecular dynamics(MD)techniques reported in the *** simulations allow the spatio-temporal movement of atoms during nonequilibrium growth to be ***,it is hoped that a successful MD simulation of the entire SWNT formation process will assist in the design of chirality-specic SWNT synthesis *** give special consideration to the role of the metal catalyst particles assumed in standard theories of SWNT formation,and describe the actual metal behavior observed in the reported MD simulations,including our own recent quantum chemical MD *** is concluded that the use of a quantum potential is essential for a qualitatively correct description of the catalytic behavior of the metal cluster,and that carbide formation does not seem to be a necessary requirement for nucleation and growth of SWNTs according to our most recent quantum chemical MD simulations.

关键词： Carbon nanotubes transition metal catalysis molecular dynamics reactive forceelds quantum chemistry

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Recent Advances in Therapeutics for B-Cell Lymphoma

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 10-19页

作者： yasuhito Terui Dept. of Hematology Oncology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo 135-8550 Japan

Objectives： The molecular targeting drugs for the treatment of B-cell lymphoma have been dramatically developed. Recently, novel drugs of monoclonal antibodies and small molecules are approved by US FDA （Food and Drug Administration）. Key Findings： This review summarizes characteristics, mechanisms, and results of the trials in the novel molecular targeting drugs for B-cell lymphoma such as obinutuzumab, polatuzumab vedotin, ibrutinib, idelalisib, and venetoclax. Summary： As a novel anti-CD20 antibody, obinutuzumab has been clinically developed on going. ADC （antibody drug conjugate） against CD79b molecules is also developed for B-cell lymphoma. BCR pathway is one of the most crucial pathways, and ibrutinib is a BTK （Bruton＇s tyrosine kinase） inhibitor that is under development for the treatment of B-cell malignancies, including CLL （chronic lymphocytic leukemia）, MCL （mantle cell lymphoma）, and DLBCL （diffuse large B-cell lymphoma）, as well as FL （follicular lymphoma）. BCL-2 family dysfunction and impairment of apoptosis are common in most B-cell lymphoid malignancies. Venetoclax, which is a highly selective BCL-2 inhibitor, a mimic for its BCL2 homolog 3-domain to induce apoptosis, is also reported to be active against B-cell malignancies. Conclusions： Mechanism-based combination regimens including these drugs may be required in the future.

关键词： obinutuzumab polatuzumab vedotin ibrutinib idelalisib venetoclax.

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Mutation of Oryza sativa CORONATINE INSENSITIVE 1b(OsCOI1b) delays leaf senescence

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Journal of Integrative Plant Biology 2015年第6期57卷 562-576页

作者： Sang-Hwa Lee yasuhito Sakuraba Taeyoung Lee Kyu-Won Kim Gynheung An Han Yong Lee Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National University Interdisciplinary Program in Bioinformatics Seoul National University Department of Plant Molecular Systems Biotechnology Crop Biotech InstituteKyung Hee University Department of Agricultural Biotechnology Seoul National University

Jasmonic acid （JA） functions in plant development, including senescence and immunity. Arabidopsis thaliana CORONATINE INSENSITIVE 1 encodes a JA receptor and functions in the JA‐responsive signaling pathway. The Arabidopsis genome harbors a single COI gene, but the rice （Oryza sativa） genome harbors three COI homologs, OsCOI1a, OsCOI1b, and OsCOI2. Thus, it remains unclear whether each OsCOI has distinct, additive, synergistic, or redundant func-tions in development. Here, we use the oscoi1b‐1 knockout mutants to show that OsCOI1b mainly affects leaf senescence under senescence‐promoting conditions. oscoi1b‐1 mutants stayed green during dark‐induced and natural senescence, with substantial retention of chlorophylls and photosyn-thetic capacity. Furthermore, several senescence‐associated genes were downregulated in oscoi1b‐1 mutants, including homologs of Arabidopsis thaliana ETHYLENE INSENSITIVE 3 and ORESARA 1, important regulators of leaf senescence. These results suggest that crosstalk between JA signaling and ethylene signaling affects leaf senescence. The Arabidopsis coi1‐1 plants containing 35S：OsCOI1a or 35S：OsCOI1b rescued the delayed leaf senescence during dark incubation, sug-gesting that both OsCOI1a and OsCOI1b are required for promoting leaf senescence in rice. oscoi1b‐1 mutants showed significant decreases in spikelet fertility and grain weight, leading to severe reduction of grain yield, indicating that OsCOI1‐mediated JA signaling affects spikelet fertility and grain filling.

关键词： Jasmonic acid leaf senescence OsCOI1b rice stay-green

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Arabidopsis STAY-GREEN2 Is a Negative Regulator of Chlorophyll Degradation during Leaf Senescence

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Molecular Plant 2014年第8期7卷 1288-1302页

作者： yasuhito Sakuraba So-Yon Park Ye-Sol Kim Seung-Hyun Wang Soo-Cheul Yoo Stefan Hortensteiner Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding Institute Research Institute of Agriculture and Life Sciences Seoul NationalUniversity Seoul 151-921 Korea Present address: Department of Plant Pathology Physiology and Weed Science Virginia Tech Blacksburg VA 24061 USA Present address: Advanced Radiation Technology Institute Korea Atomic Energy Research Institute Jeongeup 580-185 Korea Department of Plant & Environmental Science Hankyong National University Ansung 456-749 Korea Institute of Plant Biology University of Zurich CH-8008 Zurich Switzerland

Chlorophyll （Chl） degradation causes leaf yellowing during senescence or under stress conditions. For Chl breakdown, STAY-GREEN1 （SGR1） interacts with Chl catabolic enzymes （CCEs） and light-harvesting complex II （LHCII） at the thylakoid membrane, possibly to allow metabolic channeling of potentially phototoxic Chl breakdown intermediates. Among these Chl catabolic components, SGR1 acts as a key regulator of leaf yellowing. In addition to SGR1 （At4g22920）, the Arabidopsis thaliana genome contains an additional homolog, SGR2 （At4g11910）, whose biological function remains elusive. Under senescence-inducing conditions, SGR2 expression is highly up-regulated, similarly to SGR1 expression. Here we show that SGR2 function counteracts SGR1 activity in leaf Chl degradation; SGR2-overexpressing plants stayed green and the sgr2-1 knockout mutant exhibited early leaf yellowing under age-, dark-, and stress-induced senescence conditions. Like SGR1, SGR2 interacted with LHCII but, in contrast to SGR1, SGR2 interactions with CCEs were very limited. Furthermore, SGR1 and SGR2 formed homo- or heterodimers, strongly suggesting a role for SGR2 in negatively regulat- ing Chl degradation by possibly interfering with the proposed CCE-recruiting function of SGR1. Our data indicate an antagonistic evolution of the functions of SGR1 and SGR2 in Arabidopsis to balance Chl catabolism in chloroplasts with the dismantling and remobilizing of other cellular components in senescing leaf cells.

关键词： Arabidopsis thaliana stay-green SGR1 SGR2 chlorophyll degradation leaf senescence abiotic stress.

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