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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka yasuhito hagiwara Natsuko Yano Hiroko Akamatsu Mayumi Harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma

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World Journal of Gastroenterology 2014年第48期20卷 18480-18486页

作者： Takuma Nomiya Hiroko Akamatsu Mayumi Harada Ibuki Ota yasuhito hagiwara Mayumi Ichikawa Misako Miwa Shouhei Kawashiro Motohisa hagiwara Masahiro Chin Eiji Hashizume Kenji Nemoto Department of Radiation Oncology National Institute of Radiological Sciences Chiba 263-8555 Japan Department of Radiation Oncology Yamagata University Hospital Yamagata 990-8560 Japan Department of Surgery Nihonkai General Hospital Yamagata 990-8560 Japan

A clinical trial of radiotherapy with modified simultaneous integrated boost(SIB)technique against huge tumors was conducted.A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this *** total dose of 77 Gy(equivalent dose in 2Gy/fraction)and 64.5 Gy was delivered to the center of the tumor and the surrounding area respectively,andapproximately 20%dose escalation was achieved with the modified SIB *** tumor with an initial maximum size of 15 cm disappeared 120 d after the start of the *** status of the patient improved from 4 to *** with modified SIB may be effective for patients with a huge tumor in terms of tumor shrinkage/disappearance,improvement of QOL,and prolongation of survival.

关键词： Clinical trial Image-guided radiotherapy Rectal neoplasms Quality of life Neoplasm recurrence

Experience of a Videoconference System with Medical Information Desktop Sharing for Radiation Therapy and Evaluation of Its Usefulness

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第1期3卷 20-24页

作者： Shohei Kawashiro yasuhito hagiwara Ibuki Ota Mayumi Ichikawa Misako Miwa Yuuki Kuroda Kenji Nemoto Department of Radiation Oncology Yamagata Uni-versity Faculty of Medicine Yamagata Japan

Purpose: To present our videoconference system with medical information desktop sharing for radiation therapy and report initial experience using the system and its usefulness. Materials and Methods: A videoconference system for radiation therapy enables radiation oncologists sent to affiliated hospitals to consult a more experienced board-certified doctor at our institution while sharing the same display showing a patient’s information, radiology information system (RIS), and radiation therapy planning (RTP) system. We evaluated cases discussed in videoconferences to determine the influence of the system on treatment policies and radiation therapy plans. Results: From December 2012 to March 2013, treatment policies for 56 cases and radiation therapy plans for 50 cases were discussed in videoconferences. As for treatment policies, no change was made in treatment policy for 33 cases (59%), and minor and major changes were made for 16 (29%) cases and 7 (12%) cases, respectively. Radiation therapy plans for 50 cases were checked. No change was needed for 32 cases (64%), and minor and major changes were needed for 17 (34%) cases and 1 (2%) case, respectively. Conclusion: The videoconference system can be effective for improving the quality of radiation therapy.

关键词： Radiation Therapy Shortage of Radiation Oncologists Videoconference Desktop Sharing Telemedicine

New scoring system in assessment of Hoffa's fat pad synovitis: A comparative study with established scoring systems

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World Journal of Radiology 2018年第11期10卷 162-171页

作者： Shigeo hagiwara Albert Yang Shoichiro Takao yasuhito Kaneko Taiki Nozaki Hiroshi Yoshioka Department of Radiological Sciences University of California Irvine Medical Center

AIM To investigate the reliability of the established and new scoring methods for Hoffa's fat pad synovitis using magnetic resonance imaging(MRI).METHODS A total of 139 knees of 115 patients who underwent MRI of the knee with and without gadolinium contrast were enrolled in this study. Proton density(PD)-weighted, PD-weighted fat-suppressed(PD-FS), and postcontrast T1-weighted fat-suppressed(T1CE) images were used for evaluation. Using contrast and noncontrast images, our grading method for synovitis was performed to measure synovial thickness and signal intensity changes of the fat pad [Synovial membrane(SM) score], which was compared with the established methods,including MRI Osteoarthritis Knee Score(MOAKS), parapatellar synovitis score,Whole-Organ Magnetic Resonance Imaging Score(WORMS), and suprapatellar effusion diameter. Intraclass correlation coefficients(ICC) for intra and interobserver reproducibility and Spearman correlation coefficients(r) were calculated for the parapatellar synovitis score and each scoring *** All of the scores presented substantial to almost perfect intrareliability. Among three readers, effusion diameter had substantial to almost perfect interreliability(ICC = 0.68-0.81) and WORMS had substantial interreliability(ICC = 0.61-0.70).For two out of three readers, there was substantial interreliability for the thickness score in T1CE(ICC = 0.55-0.69), SM scores in T1CE(ICC = 0.56-0.78)and PD-FS(ICC = 0.51-0.79), and parapatellar synovitis score in T1CE(ICC =0.53-0.72). The parapatellar synovitis score was significantly correlated with the thickness score in T1CE(r = 0.70) and the SM score in T1CE(r = 0.81) and PD-FS(r = 0.65).CONCLUSION The newly proposed quantitative thickness score on T1CE and the semiquantitative SM score on T1CE and PD-FS can be useful for Hoffa's fat pad synovitis.

关键词： Magnetic resonance imaging Hoffa’s fat pad synovitis Semiquantitative score Quantitative score Scoring system