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Gastrojejunostomy followed by induction chemotherapy for incurable gastric cancer with outlet obstruction

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World Journal of Gastroenterology 2010年第34期16卷 4367-4370页

作者： yasuhiro Okumura Manabu Ohashi Souya Nunobe Tomohiro Iwanaga Tatsuo Kanda Yoshiaki Iwasaki Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Gastrointestinal Surgery Tokyo University Hospital Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences

A 72-year-old male gastric cancer patient with outlet obstruction underwent laparoscopic exploration. The examination disclosed intraperitoneal free cancer cells with no overt peritoneal, lymphatic, or hepatic metastasis. The patient underwent laparoscopy-assisted gastroje-junostomy (LAGJ) and started chemotherapy with S-1 plus cisplatin on postoperative day 13. Three course of the chemotherapy shrank the tumor markedly. Then, the patient underwent gastrectomy with a curative intent. Laparotomy revealed no intraperitoneal free cancer cells, and microscopically complete resection was achieved. The patient received S-1 chemotherapy as postoperative adjuvant treatment for 1 year, and is still alive with no evidence of peritoneal recurrence. LAGJ followed by S-1 plus cisplatin is one of the optional treatments that should be considered for patients with outlet obstruction as it may widen opportunities for potentially curative resection.

关键词： Gastric cancer Outlet obstruction CY1 Laparoscopy-assisted gastrojejunostomy S-1 plus cisplatin

Anthropometric and Physical Performance Profiles of High School Age American Football Players: 11th and 12th Grade Japanese Athletes

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Journal of Science in Sport and Exercise 2023年第1期5卷 25-33页

作者： Daichi Yamashita Shota Yamaguchi Fred Ariel Hernandez yasuhiro Yuasa Depart of Sports Science Japan Institute of Sports Sciences3-15-1NishigaokaKita-kuTokyo 115-0056Japan Institute of Physical Education Keio University4-1-1HiyoshiKanagawa 223-8521Japan Department of Anthropology University of California-Irvine3203 Social&Behavioral Sciences GatewayIrvineCalifornia 92697-5100USA Faculty of Sports and Health Science Department of Sports Science Daito Bunka University1-9-1 TakashimadairaItabashi-kuTokyo 175-8571Japan

Purpose To compare anthropometric and physical performance profiles of Japanese 11th and 12th grade American football players within each positional *** Fifty-two 11th and 12th grade American football players from two Japanese high schools participated in the study during the summer pre-season *** performed anthropometric(height and body mass)and physical(vertical jump,broad jump,40-yard dash,pro-agility shuttle 4-kg medicine ball chest throw,front throw,and back throw)*** jump momentum and 10-yard sprint momentum were also calculated by multiplying the velocity and body *** were divided into two groups by playing positions:skill players and *** Skill players in the 12th grade were better at medicine ball chest throw(d=0.73,P=0.04)and vertical jump momen-tum(d=0.75,P=0.03)than those in the 11th ***,there were no differences in any measurements(P>0.05)between linemen from the two *** The current study suggests that upper and lower body absolute power and momentum production can be improved for skill players even over 17 years *** the other hand,body size and speed,attributes that did not change between 11th and 12th grades,seem to be essential talent identification criteria in the current *** study is needed to monitor longitudinal performance improvements in implementing talent development programs by focusing on the quality of speed,agility and power development at the youth level.

关键词： Cross-sectional study Physical fitness profile Talent identification Talent development Long-term athletic development

Guest Editorial:Advanced Materials for HVDC Insulation

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High Voltage 2020年第4期5卷 351-352页

作者： Du, Boxue Wang, Qing Tu, Youping Tanaka, yasuhiro Li, Jin Institute of High Voltage School of Electrical and Information Engineering Tianjin University China Materials Science and Engineering Department of Materials Science and Engineering Pennsylvania State University United States Department of Electrical Engineering North China Electric Power University China Measurement and Electric Machine Control Laboratory Tokyo City University Japan School of Electrical and Information Engineering Tianjin University China

The rapid increase in both voltage level and capability of HVDC power transmission and transformation equipment poses great challenges to both integration and reliability of power *** insulation systems deployed along with these equipments have to withstand the severe electric field distortion,higher temperature rise and greater mechanical stress,*** insulation materials with unique comprehensive performance provide effective solutions to meet new ***,investigating the dielectric properties,determining the failure mechanisms,and exploring novel insulation materials become the core issues in developing more capable insulation systems.

关键词： insulation dielectric power

Time-dependent effects of castration on the bladder function and histological changes in the bladder and blood vessels

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Asian Journal of Andrology 2014年第3期16卷 457-460页

作者： Tomohiro Magari yasuhiro Shibata Seiji Arai Bunzo Kashiwagi Keiji Suzuki Kazuhiro Suzuki Department of Urology Gunma University Graduate School of Medicine Maebashi Department of Urology Kurosawa Hospital Takasaki Department of Pathology Gunma University Graduate School of Health Sciences Maebashi Japan

We examined the effect of androgens on bladder blood flow （BBF）, bladder function and histological changes in castrated male rats. Male Wistar rats were classified into unoperated group （control group）, groups castrated at the age of 8weeks （group 8wPC） and groups castrated at the age of 4weeks （group 4wPC）. Each rat was used at the age of 20weeks. BBF was measured using fluorescent microspheres. Bladder cystometry was performed without anesthesia or restraint; the bladder was first irrigated with saline and then with 0.25% acetic acid （AA） solution. Maximum voiding pressure and voiding interval were measured. The bladder and lilac artery were histologically examined for differences in smooth muscle and quantity of collagen fiber to analyze the effect of castration on the smooth muscle content. No differences were noted in BBF following castration. The voiding intervals for all groups were shortened （P 〈 0.001） following AA irrigation. No significant difference was noted in the maximum voiding pressure. Histological changes were observed in bladder and lilac artery. Smooth muscle/collagen ratio at the bladder was lower in groups 8wPC and 4wPC compared to the control group （P 〈 0.01）, while that at the lilac artery was decreased in group 4wPC compared to the control group （P〈 0.001）. In conclusion, our findings indicate that castration does not alter BBF, but leads to histological changes in the bladder as well as its associated blood vessels.

关键词： bladder blood flow bladder function castration fluorescent microsphere method histological changes smooth muscle/collagen ratio

Flat friction spot joining of aluminum alloy to carbon fiber reinforced polymer sheets:Experiment and simulation

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Journal of Materials Science & Technology 2022年第12期107卷 266-289页

作者： Peihao Geng Ninshu Ma Hong Ma Yunwu Ma Kazuki Murakami Huihong Liu yasuhiro Aoki Hidetoshi Fujii Joining and Welding Research Institute Osaka University11-1 MihogaokaOsaka 567-0047IbarakiJapan MOE Key Lab for Liquid-Solid Structure Evolution and Material Processing Institute of Materials JoiningShandong UniversityJinan 250061China

The Al alloy and carbon fiber reinforced polymer(CFRP)hybrid structures,incorporating the performance advantages of the two materials,have been attracting more attention in high-end manufacturing *** the current investigation,the flat friction spot joining(FSJ)was employed in joining the AA6061-T6 alloy and CFRP *** significance of temperature distribution in influencing joint quality was highlighted through analyzing interface microstructural features,weld defect formation as well as *** understand the role of thermal energy generation and conduction in the process comprehensively,a 3D thermal-mechanical coupling finite element model was *** interfacial temperature was characterized by an uneven distribution behavior due to the inhomogeneous heat *** peak temperatures on the top surface and Al alloy to CFRP interface at 1500 rpm rotational speed with 0.1 mm/s plunging speed were 498℃and 489°C,*** peak interface temperature was reduced to286℃at 250 rpm,which produced an extremely small melted *** with the plunging speed,rotational speed was found to be the predominant parameter for determining the joint property,which could be optimized to simultaneously realize the avoidance of thermal decomposition of CFRP,the sufficient melting duration time,and the wide enough melted *** thermal histories and melted area profiles were in agreement with experimental *** findings could be utilized to provide some feasible guidance for process optimization of dissimilar FSJ of metals and composites.

关键词： Friction spot joining Numerical simulation CFRP/Al alloy Interface microstructure Thermal conduction

Coordinated control between a grid forming inverter and grid following inverters suppling power in a standalone microgrid

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Global Energy Interconnection 2022年第3期5卷 259-265页

作者： Junichi Arai yasuhiro Taguchi Kogakuin University 1-24-2 Nishi-ShinjukuShinjukuTokyo 163-8677Japan Energy and Environment Technology Research Institute 1-22-2 Nishi-Waseda ShinjukuNishi-Waseda East Wing 106Tokyo 169-0051Japan

Battery energy storage systems,fuel cells,and photovoltaic generators are being adopted in distribution networks to achieve CO;emission *** power sources require inverters to connect to AC ***,sub-networks,such as a microgrids containing inverter power sources,may be disconnected from the utility network and operated in a standalone mode during extended *** study focuses on a standalone microgrid supplied by inverter power sources without a synchronous generator and proposes a new microgrid inverter *** this inverter control,a single grid forming inverter is operated as a master power source to determine frequency and voltage,and other inverters,called grid following inverters,are operated as subordinate power sources with active and reactive power *** necessary functions in the energy management system are examined,and the coordinated operation of all inverters in the microgrid is demonstrated via simulation.

关键词： Inverter control Microgrid Standalone operation Energy management system Grid forming inverter Grid following inverter

Relating brain structure images to personality characteristics using 3D convolution neural network

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CAAI Transactions on Intelligence Technology 2021年第3期6卷 338-346页

作者： Lixian Cao Yanchun Liang Wei Lv Kaechang Park yasuhiro Miura Yuki Shinomiya Shinichi Yoshida Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education Zhuhai College of Jilin UniversityZhuhaiChina Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and TechnologyJilin UniversityChangchunChina School of Information&Research Institute Kochi University of TechnologyKochiJapan

The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural *** results obtained are matched with the content of personality *** Big Five personality traits provide easy differentiation for dividing personalities into different *** now,the highest accuracy obtained from the results of personality prediction from the analysis of brain structure is about 70%.Although there is still no effective evidence to prove a clear relationship between brain structure and personality,the obtained results could prove helpful in understanding the basic relationship between brain structure and personality characteristics.

关键词： convolution structure dividing

Synthesis, structural characterization and magnetic property of nanocomposite materials: Intercalation compounds of FePS_3 with 1,10-phenanthroline or 2,2'-bipyridine

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Chinese Journal of Chemistry 2000年第4期18卷 510-515页

作者：陈兴国杨楚罗秦金贵 YAKUSHI Kyuya NAKAZAWA yasuhiro ICHIMURA Kenji Department of Chemistry Wuhan University Wuhan Hubei 430072 China Institute for Molecular Science Okazaki 444 Japan Department of Chemistry Kumamoto University Kumamoto 860 Japan

Two new intercalation compounds Fe0.90PS3(phen)0.41 (1) (phen stands for 1,10-phenanthroline including a part of 1, 10-phenanthroline H+) and Fe0.83PS3(bipy)0.34 (2) (bipy stands for 2,2'-bipyridine H+ ) were synthesized by the reaction of the layered FePS, with 1,10-phenanthroline or 2,2'-bipyridine in the presence of anilinium chloride. They were characterized by elemental analyses, powder X-ray diffraction (XRD), infrared spectroscopy. The lattice spacing of the intercalate was expanded by 0.90 nm for Fe0.90PS3(phen)0.41 and 0.57 nm for Fe0.83PS3(bipy)0.34 withrespect to the pristine FePS3, indicating that the ring plane of the guests is perpendicular to the layer of the host. The UV-vis absorption spectra of the filtrate in preparation of the intercalates indicate that 1, 10-phenanthroline or 2,2'-bipyridine also acts as a complexing agent to remove intralamellar Fe2+ ions into the solution during intercalation. The magnetic properties of 1 and 2 were studied.

关键词： Intercalation FePS3 1,10-phenanthroline 2,2'-bipyridine magnetic property

Involvement of Sphingosine 1-Phosphate (S1P) Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells toward S1P

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Cellular & Molecular Immunology 2006年第6期3卷 429-437页

作者： Hirofumi Matsuyuki yasuhiro Maeda Kazuhiro Yano Kunio Sugahara Kenji Chiba Takayuki Kohno Yasuyuki Igarashi Research Laboratory III (Immunology) Pharmaceuticals Research Division Mitsubishi Pharma Corporation Yokohama Japan Discovery Technology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation Yokohama Japan Department of Biomembrane and Biofunctional Chemistry Graduate School of Pharmaceutical Sciences Hokkaido University Sapporo Japan

Sphingosine 1-phosphate （S1P）, a pleiotropic lysophospholipid, regulates signal transduction pathway via Gprotein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes. Higher levels of S1P4 mRNA as well as S1P1 mRNA are expressed in lymphoid tissues such as the spleen, thymus, lymph nodes, and Payer＇s patches. In contrast to S1P1 that plays an essential role in lymphocyte egress, little is known about the role of S1P4 in immune system. In this study, we found that S1P at 10 to 100 nM significantly induced the cell migration and the significant levels of S1P1 and S1P4 mRNA were expressed in mouse CD4 T cells, D10.G4.1 mouse Th2 cells, and ***-2 mouse thymoma cells. In D10.G4.1 and ***-2 cells, S1P-induced migration was almost completely inhibited by pretreatment with pertussis toxin, Clostoridium difficile toxin B, and （S）-enantiomer of FTY720-phosphate, a potent agonist at S1P1 and S1P4. The members of the Rho family small GTPase, Cdc42 and Rac were activated by S1P stimulation in these cells. The transfection with dominant negative or constitutively active forms of Cdc42 and Rac revealed that the activation of both Cdc42 and Rac is essential for S1P-induced migration of these cells. The immunoprecipitation assays using CHO cells co-expressing both S1P4 and S1P1 receptors indicated that S1P4 and S1P1 are associated on the cell surface. These results suggest that the association of S1P4 and S1PI plays an important role in migratory response of mouse T cells toward S1P.

关键词： S1Pi S1P4 S1P FTY720 T cell migration