检索结果-南通市图书馆

Diagnosis and initial management of cholangiocarcinoma with obstructive jaundice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第19期14卷 3000-3005页

作者： Takashi Tajiri Hiroshi Yoshida yasuhiro Mamada NobuhikoTaniai Shigeki Yokomuro Yoshiaki Mizuguchi Departmentof Surgery Nippon Medical School1-1-5 SendagiBunkyo-ku

Cholangiocarcinoma is the second most common primary hepatic cancer. Despite advances in diagnostic techniques during the past decade, cholangiocarcinoma is usually encountered at an advanced stage. In this review, we... 详细信息

关键词： Cholangiocarcinoma Obstructive jaundice Diagnosis Treatment Initial management

Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第35期18卷 4811-4822页

作者： Tetsuo Arakawa Toshio Watanabe Tetsuya Tanigawa Kazunari Tominaga yasuhiro Fujiwara Kenichi Morimoto Department of Gastroenterology Osaka City University Graduate School of Medicine

In this paper, we review the concept of quality of ulcer healing （QOUH） in the gastrointestinal tract and its role in the ulcer recurrence. In the past, peptic ulcer disease （PUD） has been a chronic disease with a cycle of repeated healing/remission and recurrence. The main etiological factor of PUD is Helicobacter pylori （H. pylorl~, which is also the cause of ulcer recur- rence. However, H. pylori-negative ulcers are pres- ent in 12%-20% of patients; they also recur and are on occasion intractable. QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated. Within the scars of healed ulcers, regenerated tissue is immature and with distorted architecture, suggesting poor QOUH. The abnormalities in mucosal regeneration can be the basis for ulcer recurrence. Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence. Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macro- phages, which in turn produce increased amounts of cytokines and chemokines, which attract neutrophils to the regenerated area. Neutrophils release proteolytic enzymes that destroy the tissue, resulting in ulcer re- currence. Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a defi- ciency and/or an imbalance of endogenous growth fac- tors. Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar. In addition to PUD, the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn＇s disease and ulcer- ative colitis.

关键词： Quality of ulcer healing Peptic ulcer dis-ease Recurrence Prostaglandin Cytokines Growthfactors

Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第11期23卷 2068-2076页

作者： Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami yasuhiro Nagata Masashi Yoshida Keishiro Aoyagi yasuhiro Kodera Koji Nakada Division of Gastroenterological Surgery Yokohama Municipal Citizen’s Hospital Division of Gastric Surgery Shizuoka Cancer Center Center for Frontier Medical Engineering Chiba University Department of Surgery and Science Graduate school of medicine Kyushu University Department of Digestive Surgery Kagoshima University Graduate School of Medicine Department of Surgical Oncology Kanazawa Medical School Center for Comprehensive Community Care Education Graduate School of Biomedical Sciences Nagasaki University Department of Surgery International University of Health and Welfare Hospital Department of Surgery Kurume University School of Medicine Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine Department of Laboratory Medicine The Jikei University School of Medicine

AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working *** The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause.

关键词： Postgastrectomy syndrome Quality of life Gastric cancer Gastrectomy Patient-reported outcome

Molecular Phylogeny and Evolution of Two Rhacophorus Species Endemic to Mainland Japan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Herpetological Research 2019年第2期10卷 86-104页

作者： Masafumi MATSUI yasuhiro KAWAHARA Kanto NISHIKAWA Seiji IKEDA Koshiro ETO Yusuke MIZUNO Graduate School of Human and Environmental Studies Kyoto UniversityYoshida Nihonmatsu-choSakyo-kuKyoto 606-8501Japan Hagi City Museum Horiuchi 355HagiYamaguchi 758-0057Japan Hiroshima University Museum Kagamiyama 1-1-1Higashi Hiroshima CityHiroshima 739-8524Japan Kitakyushu Museum of Natural History and Human History Higashida 2-4-1Yahatahigashi-kuKitakyushuFukuoka 805-0071Japan Takahari 4-1002 Meito-kuNagoya 465-0061Japan

We conducted molecular phylogenetic analyses of Japanese Rhacophorus species, especially of R. schlegelii and R. arboreus from the mainland, based on samples encompassing their known distribution ranges, and discussed about evolutionary history of Rhacophorus species within Japan. The common ancestor of Japanese Rhacophorus, except for R. owstoni from southern Ryukyus, was estimated to have diverged from a lineage occurring mainly in China about 7 MYBP. Both R. schlegelii and R. arboreus are genetically largely divergent between regions of eastern and western Japan, and this seems to have been promoted mainly by retreat to refugia. Retreats of the two species to different refugia sometimes in the past seem to have led restricted distribution of R. schlegelii in eastern and R. arboreus in western Japan, and brought their intraspecific variation patterns in morphology and breeding habit.

关键词： glacial period mitochondrial DNA differentiation refugia Rhacophorus arboreus Rhacophorus schlegelii

Ge quantum dots light-emitting devices

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2012年第1期5卷 13-20页

作者： Jinsong XIA Takuya MARUIZUMI yasuhiro SHIRAKI Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Advance Research Laboratories Tokyo City UniversityTokyo 158-0082Japan

Si photonics becomes one of the research focuses in the field of photonics. Si-based light-emitting devices are one of the most important devices in this field. In this paper, we review the Si-based light-emitting devices fabricated by embedding Ge self-assembled quantum dots into optical microcavities. Ge self-assembled quantum dots emit light in the telecommunication wavelength range from 1.3 to 1.6 pro, for which Si is transparent. Ge self- assembled quantum dots were grown on silicon-on- insulator （SOI） by molecular beam epitaxy （MBE） in Stranski-Krastanov （S-K） mode. Then, electron beam lithography （EBL） was used to define the pattern of optical microcavities on the wafer. Finally, the pattern was transferred onto the Si/Ge slab by inductive coupled plasma （ICP） dry etching. Room-temperature photolumi- nescence （PL） was used to characterize the light-emitting properties of fabricated devices. The results showed that strong resonant light emission was observed in different optical microcavities. Significant enhancement of the intensity was obtained by the optical resonance. Based on the results of PL, we designed and fabricated current- injected light-emitting devices based on Ge self-assembled quantum dots in optical microcavities. Room-temperature resonant light emission was observed from Ge dots in a 3.8 μm microdisk resonator.

关键词： Si-based light-emitting devices Ge self-assembled quantum dots microcavities photonic crystal(PhC) microdisk

Update on the pathological roles of prostaglandin E_(2) in neurodegeneration in amyotrophic lateral sclerosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2023年第1期12卷 464-478页

作者： Hiroshi Nango Komugi Tsuruta Hiroko Miyagishi Yuri Aono Tadashi Saigusa yasuhiro Kosuge Laboratory of Pharmacology School of PharmacyNihon University7-7-1 NarashinodaiFunabashi-ShiChiba 274-8555Japan Department of Pharmacology School of Dentistry at MatsudoNihon University2-870-1 SakaechonishiMatsudo-ShiChiba 271-8587Japan

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor *** pathogenesis of ALS remains largely unknown;however,inflammation of the spinal cord is a focus of ALS research and an important pathogenic process in *** E_(2)(PGE_(2))is a major lipid mediator generated by the arachidonic-acid cascade and is abundant at inflammatory ***_(2)levels are increased in the postmortem spinal cords of ALS patients and in ALS model *** therapeutic effects have been obtained in ALS model mice using cyclooxygenase-2 inhibitors to inhibit the biosynthesis of PGE_(2),but the usefulness of this inhibitor has not yet been proven in clinical *** this review,we present current evidence on the involvement of PGE_(2)in the progression of ALS and discuss the potential of microsomal prostaglandin E syn-thase(mPGES)and the prostaglandin receptor E-prostanoid(EP)2 as therapeutic targets for *** pathways involving prostaglandin receptors mediate toxic effects in the central nervous *** some situations,however,the receptors mediate neuroprotective *** recent studies demonstrated that levels of mPGES-1,which catalyzes the final step of PGE_(2)biosynthesis,are increased at the early-symptomatic stage in the spinal cords of transgenic ALS model mice carrying the G93A variant of superoxide *** addition,in an experimental motor-neuron model used in studies of ALS,PGE_(2)induces the production of reactive oxygen species and subsequent caspase-3-de-pendent cytotoxicity through activation of the EP2 ***,this PGE_(2)-induced EP2 up-regulation in motor neurons plays a role in the death of motor neurons in ALS model *** understanding of the pathophysiologi-cal role of PGE_(2)in neurodegeneration may provide new insights to guide the development of novel therapies for ALS.

关键词： Prostaglandin E_(2) Amyotrophic lateral sclerosis Motor neuron death E-prostanoid receptor Microsomal prostaglandin E synthetase-1

A hydrochemical study of the Hammam Righa geothermal waters in north-central Algeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geochimica 2016年第3期35卷 271-287页

作者： Mohamed Belhai yasuhiro Fujimitsu Fatima Zohra Bouchareb-Haouchine Abdelhamid Haouchine Jun Nishijima Department of Earth Resources Engineering GraduateSchool of EngineeringKyushu UniversityFukuoka 819-0395Japan Department of Earth Resources Engineering Faculty ofEngineeringKyushu UniversityFukuoka 819-0395Japan Laboratoire de Geo-Environnement FSTGAT/USTHB BP 32El-Alia16000 AlgiersAlgeria

This study focuses on the hydrochemical characteristics of 47 water samples collected from thermal and cold springs that emerge from the Hammam Righa geothermal field, located in north-central Algeria. The aquifer that feeds these springs is mainly situated in the deeply fractured Jurassic limestone and dolomite of the Zaccar Mount. Measured discharge temperatures of the cold waters range from 16.0 to 26.5 ℃ and the hot waters from 32.1 to 68.2 ℃. All waters exhibited a near-neutral pH of 6.0-7.6. The thermal waters had a high total dis- solved solids （TDS） content of up to 2527 mg/l, while the TDS for cold waters was 659.0-852.0 mg/l. Chemical analyses suggest that two main types of water exist： hot waters in the upflow area of the Ca-Na-SO4 type （Ham- mam Righa） and cold waters in the recharge zone of the Ca-Na-HCO3 type （Zaccar Mount）. Reservoir tempera- tures were estimated using silica geothermometers and fluid/mineral equilibria at 78, 92, and 95℃ for HR4, HR2, and HRI, respectively. Stable isotopic analyses of the δ18O and δD composition of the waters suggest that the thermal waters of Hammam Righa are of meteoric origin. We conclude that meteoric recharge infiltrates through the fractured dolomitic limestones of the Zaccar Mount and is conductively heated at a depth of 2.1-2.2 km. The hotwaters then interact at depth with Triassic evaporites located in the hydrothermal conduit （fault）, giving rise to the Ca-Na-SO4 water type. As they ascend to the surface, the thermal waters mix with shallower Mg-rich ground- water, resulting in waters that plot in the immature water field in the Na-K-Mg diagram. The mixing trend between cold groundwaters from the recharge zone area （Zaccar Mount） and hot waters in the upflow area （Hammam Righa） is apparent via a chloride-enthalpy diagram that shows a mixing ratio of 22.6 〈 R 〈 29.2 %. We summa- rize these results with a geothermal conceptual model of the Hammam Righa geothermal field.

关键词： Thermal waters North-central Algeria Geochemistry Geothermometry Geothermal conceptualmodel Cold groundwaters

Integrated in-process chatter monitoring and automatic suppression with adaptive pitch control in parallel turning

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2018年第3期6卷 291-300页

作者： Shuntaro Yamato Yuki Yamada Kenichi Nakanishi Norikazu Suzuki Hayato Yoshioka yasuhiro Kakinuma Department of System Design Engineering Keio University3-14-1 Hiyoshi Kohoku-ku Yokohama 223-8522 Japan Nakamura-Tome Precision Industry Co. Ltd. 15 NetsunoHakusan Ishikawa 920-2195 Japan Department of Mechanical Science and Engineering Nagoya University Furo-cho Chikusa-ku Nagoya 464-8603 Japan Precision and Intelligent Laboratory Tokyo Institute of Technology 4259-G2-19 Nagatsuta Midori-kuYokohama 226-8503 Japan

Simultaneous processes such as parallel turningor milling offer great opportunities for more efficientmanufacturing because of their higher material removalrates. To maximize their advantages, chatter suppressiontechnologies for simultaneous processes must be devel-oped. In this study, we constructed an automatic chattersuppression system with optimal pitch control for shared-surface parallel turning with rigid tools and a flexibleworkpiece, integrating in-process chatter monitoring basedon the cutting force estimation. The pitch angle betweentwo tools is tuned adaptively in a position control system inaccordance with the chatter frequency at a certain spindlespeed, in a similar manner as the design methodology forvariable-pitch cutters. The cutting force is estimatedwithout using an additional external sensor by employing amulti-encoder-based disturbance observer. In addition, thechatter frequency is measured during the process by per-forming a low-computational-load spectrum analysis at acertain frequency range, which makes it possible to cal-culate the power spectrum density in the control system ofthe machine tool. Thus, the constructed system for automatic chatter suppression does not require any addi-tional equipment.

关键词： Chatter Multitasking machine tool Parall elturning Adaptive control Sensorless Disturbance observer

Manipulation of Charge-Transfer States by Molecular Design:Perspective from“Dynamic Exciton”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accounts of Materials Research 2021年第7期2卷 501-514页

作者： Hiroshi Imahori yasuhiro Kobori Hironori Kaji Department of Molecular Engineering Graduate School of EngineeringKyoto UniversityNishikyokuKyoto 615-8510Japan Institute for Integrated Cell-Material Sciences(WPI-iCeMS) Kyoto UniversitySakyo-kuKyoto 606-8501Japan Molecular Photoscience Research Center and Department of Chemistry Graduate School of ScienceKobe UniversityNada-kuKobe 657-8501Japan Institute for Chemical Research Kyoto UniversityUjiKyoto 611-0011Japan

CONSPECTUS:“Dynamic exciton”,an umbrella term concept in photochemistry,plays an important role in nature,science,and technology,especially in photoinduced and electrically induced electron transfer(ET)between a donor(D)and an acceptor(A).Typically,an exciton in molecular D−A systems is considered a locally excited(LE)state of a donor(D*)or an acceptor(A*)molecule,but let us extend the terminology of“exciton”to an integrated class of LE,charge-transfer(CT),and charge-separated(CS)*** degree of CT(0−100%),spin multiplicity,and D−A interaction(i.e.,electronic coupling)are pivotal factors in the“exciton”.Another important aspect of the“exciton”is strongly related to the“dynamic”aspect of the“exciton”by movement of atomic nuclei(i.e.,vibration,rotation,and fluctuation)and their collective motions controlling behaviors of electrons and spins by the passage of *** concept of“dynamic exciton”should cover a wide variety of the photochemical phenomena that are all essential for the energy conversion devices and processes including various kinds of living *** these,a huge amount of the nuclear motional modes may cooperatively be entangled to electronic ***,the idea behind“dynamic exciton”includes usage of the cooperation between nuclear motions and the spin−orbital,as electron−phonon coupling for innovative designs of the energy conversion materials and *** this,it is particularly important to examine how this wide variety of the motions plays roles on electronic couplings,intermediate geometries and mobilities,exciton energies,CT characters,and so *** draw researchers’attention to this aspect of the vibronic effect,like the entropy role by collective movement of side chains of the conjugated polymer to modulate the electronic coupling time-dependently at the charge delocalization and dissociation,which is reinforced three-dimensionally at the D/A domain interface of organic photovoltaics(OPVs).In addition,to realize the ultimate high

关键词： excited vibrational collective