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Surgery and chemotherapy for intrahepatic cholangiocarcinoma

World Journal of Hepatology 2010年第2期2卷 58-64页

作者： Zenichi Morise Atsushi Sugioka Takamasa Tokoro Yoshinao Tanahashi yasuhiro okabe Tadashi Kagawa Chinatsu Takeura Department of Surgery Fujita Health University School of Medicine 1-98 Dengakugakubo Kutsu- kake-cho Toyoake Aichi 470-1192 Japan

Cholangiocarcinoma, arising from bile duct epithelium, is categorized into intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC), including hilarcholangiocarcinoma. Recently, there has been a worldwide increase in the incidence and mortality from ICC. Complete surgical resection is the only approach to cure the patients with ICC. However, locoregional extension of these tumors is usually advanced with intrahepatic and lymph-node metastases at the time of diagnosis. Resectability rates are quite low and variable (18%-70%). The five-year survival rate after surgical resection was reported to be 20%-40%. Median survival time after ICC resection was 12-37.4 mo. Only a small number of ICC cases, accompanied with ECC, gall bladder carcinoma, and ampullary carcinoma, have been reported in the studies of chemotherapy due to the rarity of the disease. However, in some reports, significant anti-cancer effects were achieved with a response rate of up to 40% and a median survival ofone year. Although recurrence rate after hepatectomy is high for the patients with ICC, the residual liver and the lung are the main sites of recurrence after tentative curative surgical resection. Several patients in our study had a long-term survival with repeated surgery and chemotherapy. Repeated surgery, combined with new effective regimens of chemotherapy, could benef it the survival of ICC patients.

关键词： Intrahepatic cholangiocarcinoma Surgery Chemotherapy

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Pigmented hidroacanthoma simplex:A diagnostic pitfall

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World Journal of Dermatology 2012年第2期1卷 10-12页

作者： Mitsuaki Ishida Fumiyoshi Kojima Machiko Hotta yasuhiro Iwai Hidetoshi okabe Division of Diagnostic Pathology and Department of Clinical Laboratory Medicine Shiga University of Medical Science Division of Diagnostic Pathology Takatsuki Hospital

Hidroacanthoma simplex(HAS) is a rare skin appendage tumor and is recognized as an intraepidermal variant of poroma. Pigmented HAS is an extremely rare variant with dendritic melanocytes and/or melanin pigment in the tumor cells and a few cases of pigmented HAS have been reported in the English literature. We herein report a case of pigmented HAS and discuss the clinicopathological features of pigmented HAS and the pitfall in the diagnosis of black lesions.

关键词： Pigmented hidroacanthoma simplex Seborrheic keratosis Porocarcinoma Skin appendage tumor Clinicopathological features

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