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Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45

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World Journal of Gastroenterology 2017年第11期23卷 2068-2076页

作者： Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami yasuhiro nagata Masashi Yoshida Keishiro Aoyagi yasuhiro Kodera Koji Nakada Division of Gastroenterological Surgery Yokohama Municipal Citizen’s Hospital Division of Gastric Surgery Shizuoka Cancer Center Center for Frontier Medical Engineering Chiba University Department of Surgery and Science Graduate school of medicine Kyushu University Department of Digestive Surgery Kagoshima University Graduate School of Medicine Department of Surgical Oncology Kanazawa Medical School Center for Comprehensive Community Care Education Graduate School of Biomedical Sciences Nagasaki University Department of Surgery International University of Health and Welfare Hospital Department of Surgery Kurume University School of Medicine Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine Department of Laboratory Medicine The Jikei University School of Medicine

AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working Party.METHODS The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause.

关键词： Postgastrectomy syndrome Quality of life Gastric cancer Gastrectomy Patient-reported outcome

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Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer

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World Journal of Gastroenterology 2012年第13期18卷 1470-1478页

作者： Akira Yoneda Shinichiro Ito Seiya Susumu Mitsutoshi Matsuo Ken Taniguchi Yoshitsugu Tajima Susumu Eguchi Takashi Kanematsu yasuhiro nagata Department of Surgery Nagasaki University Graduate School of Biomedical SciencesNagasaki 852-8051Japan Department of Surgery Yamaguchi Prefectural Medical CenterYamaguchi 747-8511Japan Department of Surgery National Hospital Organization Nagasaki Medical CenterNagasaki 856-8562Japan

AIM:To investigate the immunological repertoire in the peritoneal cavity of gastric cancer patients.METHODS:The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur.However,the role of lymphocytes in the peritoneal cavity of gastric cancer patients is unclear.We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent laparoscopic cholecystectomy for gallstones and acted as controls.Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry.CD4+CD25high T cells isolated from the patient's peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes,and a cytokine assay was performed.RESULTS:At gastrectomy,CCR7 -CD45RA-CD8+ef-fector memory T cells were observed in the peritoneal cavity.The frequency of CD4+CD25 high T cells in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage[control vs stage Ⅳin the peripheral blood:6.89(3.39-10.4)vs 15.34(11.37-19.31),P<0.05,control vs stageⅣin the peritoneal cavity:8.65(5.28-12.0)vs 19.56(14.81-24.32),P<0.05].On the other hand,the suppression was restored with CD4+CD25high T cells from their own peripheral blood.This study is the first to analyze lymphocyte and cytokine production in the peritoneal cavity in patients with gastric cancer.Immune regulation at advanced stage is reversible at the point of gastrectomy.CONCLUSION:The immunological milieu in the peritoneal cavity of patients with advanced gastric cancer elicited a Th2 response even at gastrectomy,but this response was reversible.

关键词：免疫调节作用胃癌腹腔环境淋巴细胞探查剖腹细胞因子

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Liver biopsy in the post-hepatitis C virus era in Japan

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World Journal of Gastroenterology 2024年第14期30卷 1949-1957页

作者： Yoshihiro Ikura Takako Okubo yasuhiro Sakai Department of Pathology Takatsuki General HospitalTakatsuki 569-1192Osaka PrefectureJapan Department of Pathology Kansai Medical University Medical CenterMoriguchi 570-8507Japan

In Japan,liver biopsies were previously crucial in evaluating the severity of hepatitis caused by the hepatitis C virus(HCV)and diagnosing HCV-related hepatocellular carcinoma(HCC).However,due to the development of effective antiviral treatments and advanced imaging,the necessity for biopsies has significantly decreased.This change has resulted in fewer chances for diagnosing liver disease,causing many general pathologists to feel less confident in making liver biopsy diagnoses.This article provides a comprehensive overview of the challenges and potential solutions related to liver biopsies in Japan.First,it highlights the importance of considering steatotic liver diseases as independent conditions that can coexist with other liver diseases due to their increasing prevalence.Second,it emphasizes the need to avoid hasty assumptions of HCC in nodular lesions,because clinically diagnosable HCCs are not targets for biopsy.Third,the importance of diagnosing hepatic immune-related adverse events caused by immune checkpoint inhibitors is increasing due to the anticipated widespread use of these drugs.In conclusion,pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.

关键词： Liver biopsy Alteration Post-hepatitis C virus era Steatotic liver disease Hepatic tumors Immune checkpoint inhibitors

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How are multiple satellites seen from the ground? Relative apparent motion and formation stabilization

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Astrodynamics 2024年第1期8卷 121-134页

作者： Kenta Nakajima yasuhiro Yoshimura Hongru Chen Toshiya Hanada Department of Aeronautics and Astronautics Kyushu University744 Motooka Nishi-kuFukuoka819-0395Japan

This paper answers how multiple satellites are seen from the ground. This question is inspired by space-advertising, a public exhibition in the night sky using a dot matrix of satellites that are bright enough to be seen by the naked eye. Thus, it is important for space advertisement that the specific dot matrix is seen. Moreover, the stability of the dot matrix during a visible span is very valuable. To stabilize the dot matrix, this study formulates an apparent position of a dot from a representative dot seen from the ground. The formulation, linear functions of a set of relative orbital elements, reveals the appearance of the dot matrix. The proposed relative variable in the formulation drives the instability of the dot matrix, thereby revealing an initial stable configuration of deputies from a chief. The arbitrary dot matrix designed using the configuration is stable even at low elevations without orbital control during the visible span.

关键词： formation flying relative motion stabilization astrodynamics multi-apparent motions space advertisement

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SPERA Hydrogen System^(TM)by LOHC-MCH Method for Massive Hydrogen Storage and Transportation

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Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi Okada Kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi Nagai yasuhiro Inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is necessary.The organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business risk.Chiyoda has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization stage.Currently,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as possible.In this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene

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Microbiota in the stomach and application of probiotics to gastroduodenal diseases

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World Journal of Gastroenterology 2022年第47期28卷 6702-6715页

作者： yasuhiro Koga Japanese Society for Probiotic Science Isehara 259-1143Japan

The stomach is a hostile environment for most microbes because strong gastric acid kills indigenous microorganisms.Thus,the mass of indigenous microbes detected by traditional culturing method in a highly acidic stomach is reported to be very small.However,in a stomach with less acidity due to atrophic changes of the gastric mucosa,the number of live gastric microbiota dramatically increases and their composition changes.A probiotic is defined as a live microorganism that,when administered in adequate amounts,confers a health benefit on the host.The administration of probiotics to the stomach has thus far been considered impractical,mainly due to the strong acidity in the stomach.The identification of candidate probiotic strains with sufficient resistance to acidity and the ability to achieve close proximity to the gastric mucosa could enable the application of probiotics to the stomach.The utilization of probiotics alone for Helicobacter pylori(H.pylori)infection significantly improves gastric mucosal inflammation and decreases the density of H.pylori on the mucosa,although complete eradication of H.pylori has not yet been demonstrated.The use of probiotics in combination with antimicrobial agents significantly increases the H.pylori eradication rate,especially when the H.pylori strains are resistant to antimicrobial agents.While H.pylori has been considered the most important pathogenic bacterium for the development of gastric cancer,bacteria other than H.pylori are also suggested to be causative pathogens that promote the development of gastric cancer,even after the eradication of H.pylori.Increased non-H.pylori Gram-negative bacteria in the stomach with weak acidity accompanying atrophic gastritis may perpetuate gastric mucosal inflammation and accelerate carcinogenic progression,even after H.pylori eradication.Probiotics restore the acidity in this stomach environment and may therefore prevent the development of gastric cancer by termination of Gram-negative bacteria-induced inflammation.Functional dyspepsia

关键词： Stomach Microbiota Probiotics Helicobacter pylori Post-eradication gastric cancers Functional dyspepsia

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Coordinated control between a grid forming inverter and grid following inverters suppling power in a standalone microgrid

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Global Energy Interconnection 2022年第3期5卷 259-265页

作者： Junichi Arai yasuhiro Taguchi Kogakuin University 1-24-2 Nishi-ShinjukuShinjukuTokyo 163-8677Japan Energy and Environment Technology Research Institute 1-22-2 Nishi-Waseda ShinjukuNishi-Waseda East Wing 106Tokyo 169-0051Japan

Battery energy storage systems,fuel cells,and photovoltaic generators are being adopted in distribution networks to achieve CO;emission reduction.These power sources require inverters to connect to AC networks.However,sub-networks,such as a microgrids containing inverter power sources,may be disconnected from the utility network and operated in a standalone mode during extended blackouts.This study focuses on a standalone microgrid supplied by inverter power sources without a synchronous generator and proposes a new microgrid inverter control.In this inverter control,a single grid forming inverter is operated as a master power source to determine frequency and voltage,and other inverters,called grid following inverters,are operated as subordinate power sources with active and reactive power control.The necessary functions in the energy management system are examined,and the coordinated operation of all inverters in the microgrid is demonstrated via simulation.

关键词： Inverter control Microgrid Standalone operation Energy management system Grid forming inverter Grid following inverter

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Probing CO on a rutile TiO_(2)(110)surface using atomic force microscopy and Kelvin probe force microscopy

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Nano Research 2022年第3期15卷 1909-1915页

作者： Yuuki Adachi yasuhiro Sugawara Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Probing CO at a specific site on a metal oxide surface is essential for characterizing various applications such as CO oxidation,hydrogenation,and water–gas shift reaction.Herein,we use atomic force microscopy and Kelvin probe force microscopy to probe the CO on a rutile TiO_(2)(110)surface.Our results indicate that CO can be manipulated along the Ti row by the repulsive lateral force of“pushing”mode.Furthermore,the joint combination of precise manipulation and the distance dependence of local contact potential difference allow us to resolve the interatomic dipole moment and charge state of CO at atomic resolution.Therefore,we found that the negatively charged CO with the dipole moment of negative pole down on the rutile TiO_(2)(110)surface.Our results suppose that both the charge state as well as the on-surface dipole interaction are very effective for CO reaction on rutile TiO_(2)(110)surface.

关键词： CO rutile TiO_(2) dipole moment charge state atomic force microscopy Kelvin probe force microscopy

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Fabrication,nanostructures and electronic properties of nanodiamond-based solar cells

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Progress in Natural Science:Materials International 2010年第1期20卷 38-43页

作者： Akihiko nagata Takeo OKU Kenji KIKUCHI Atsushi SUZUKI yasuhiro YAMASAKI Eiji OSAWA Department of Materials Science The University of Shiga Prefecture Orient Chemical industries Co.Ltd. Department of New Business8-1 Sanra-Higashi-MachiNeyagawaOsaka572-8581Japan 3. NanoCarbon Research Institute Ltd.3-15-1 TokidaUedaNagano386-8567Japan

Nanodiamond-based solar cells were fabricated and the photovoltaic properties were investigated.Fullerene(C60)and fullerenol(C60(OH)10-12)were used as n-type semiconductors,and diamond nanoparticles and metal phthalocyanine derivative were used as p-type semiconductors.The nanostructures of the solar cells were investigated by transmission electron microscopy and X-ray diffracometry,and the electronic property was discussed.

关键词： solar cell nanodiamond C60 phthalocyanine

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Analysis of the land suitability for paddy fields in Tanzania using a GIS-based analytical hierarchy process

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Geo-Spatial Information Science 2022年第2期25卷 212-228页

作者： Ahmad Al-Hanbali Kenichi Shibuta Bayan Alsaaideh yasuhiro Tawara Solution Department Geosphere Environmental Technology Corp..TokyoJapan Agriculture&Rural Development Department Nippon Koei Co.Ltd..TokyoJapan Independent Scholar ChibaJapan

The importance of irrigation development is considered a key factor for food security and poverty reduction because it improves crop productivity,and ensures stable expansion of agricultural production.However,irrigation development requires understanding of the avail-able resources including the suitability of the land for agriculture.In this study,the land suitability for paddy fields was evaluated within the United Republic of Tanzania mainland by integrating the geographic information system(GIS)and analytical hierarchy process(AHP).In this study,11 criteria based on various sources(soil type,soil drainage,soil organic carbon,soil pH,soil depth,elevation,slope,land use,topographic wetness index,temperature,and precipitation)were used.These criteria were used within the GIS-based AHP to identify the most suitable land for sustainable paddy field cultivation considering the preservation of the natural environment of forests and protected areas by examining two scenarios:rainfed condition and irrigation priority.The former ten criteria were assumed to be constant in both scenarios and were assigned the same scores,while the latter criterion(precipitation)was assigned different scores for varying amounts to plan new irrigation projects.Unsuitable land represents 72.8%of the study area,reducing the potential agriculture land(PAL)appropriate for cultivation to 27.2%.In the rainfed condition scenario,the very high and high suitability classes represent 17.6%of the total land of the study area and 64.7%of the PAL.In the irrigation priority scenario,the same classes represent 21.4%of the total land of the study area and 78.6%of the PAL.Finally,the distribution of the land suitability for both scenarios was analyzed within eight administrative irrigation zones to determine the irrigation zone with the greatest potential for paddy field cultivation.

关键词： Paddy field agriculture land suitability Geographic Information System(GIS) Analytical Hierarchy Process(AHP) sustainable development Tanzania

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