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Liver biopsy in the post-hepatitis C virus era in Japan

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World Journal of Gastroenterology 2024年第14期30卷 1949-1957页

作者： Yoshihiro Ikura Takako Okubo yasuhiro Sakai Department of Pathology Takatsuki General HospitalTakatsuki 569-1192Osaka PrefectureJapan Department of Pathology Kansai Medical University Medical CenterMoriguchi 570-8507Japan

In Japan,liver biopsies were previously crucial in evaluating the severity of hepatitis caused by the hepatitis C virus(HCV)and diagnosing HCV-related hepatocellular carcinoma(HCC).However,due to the development of effective antiviral treatments and advanced imaging,the necessity for biopsies has significantly *** change has resulted in fewer chances for diagnosing liver disease,causing many general pathologists to feel less confident in making liver biopsy *** article provides a comprehensive overview of the challenges and potential solutions related to liver biopsies in ***,it highlights the importance of considering steatotic liver diseases as independent conditions that can coexist with other liver diseases due to their increasing ***,it emphasizes the need to avoid hasty assumptions of HCC in nodular lesions,because clinically diagnosable HCCs are not targets for ***,the importance of diagnosing hepatic immune-related adverse events caused by immune checkpoint inhibitors is increasing due to the anticipated widespread use of these *** conclusion,pathologists should be attuned to the changing landscape of liver diseases and approach liver biopsies with care and attention to detail.

关键词： Liver biopsy Alteration Post-hepatitis C virus era Steatotic liver disease Hepatic tumors Immune checkpoint inhibitors

Geomorphological evidence inconvenient for the antecedent rivers of the Arun and Tista across the Himalayan range

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Journal of Mountain Science 2024年第9期21卷 3001-3017页

作者： NAKATA Takashi KUMAHARA yasuhiro NAIK Sambit Prasanajit SAKAI Harutaka Graduate School of Humanities and Social Sciences Hiroshima UniversityHigashi-Hiroshima 739-8522Japan Active Fault and Earthquake Hazard Mitigation Research Center Pukyong National UniversityBusan 48513South Korea Department of Petroleum Engineering and Earth Sciences University of Petroleum and Energy StudiesDehradun 248007India Graduate School of Science Kyoto UniversityKyoto 606-8502Japan

The Arun and Tista Rivers,which flow across the Himalayas,are commonly known as antecedent valleys that overcame the rapid uplift of the Higher Himalayan *** clarify whether the idea of antecedent rivers is acceptable,we investigated the geomorphology of the Himalayas between eastern Nepal and Bhutan *** southern part of Tibetan Plateau,extending across the Himalayas as tectonically un-deformed glaciated terrain named as'Tibetan Corridor,'does not suggest the regional uplift of the Higher *** 8,000-m class mountains of Everest,Makalu,and Kanchenjunga are isolated residual peaks on the glaciated terrain composed of mountain peaks of 4,000–6,000 m *** Tibetan glaciers commonly beheaded by Himalayan glaciers along the great watershed of the Himalayas suggest the expansion of Himalayan river drainage by *** the narrow upstream regions of the Arun and Tista Rivers with less precipitation behind the range,it is hard to collect enough water for the power of down-cutting their channels against the uplifting *** fission track ages of the Higher Himalayan Crystalline Nappe suggest that the Himalayas attained their present altitude by 11–10 Ma,and the Arun and Tista Rivers formed deep gorges across the Himalayas by headward erosion.

关键词： Himalaya Antecedent river Geomorphology AW3D30 DSM Glacier piracy

Modelling the preventive treatment under media impact on tuberculosis:A comparison in four regions of China

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Infectious Disease Modelling 2024年第2期9卷 483-500页

作者： Jun Zhang yasuhiro Takeuchi Yueping Dong Zhihang Peng School of Mathematics and Statistics and Key Laboratory of Nonlinear Analysis&Applications(Ministry of Education)Central China Normal UniversityWuhan430079China College of Science and Engineering Aoyama Gakuin UniversityKanagawa252-5258Japan National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijing102206China

Preventive treatment for people with latent Tuberculosis infection(LTBI)has aroused our great *** this paper,we propose and analyze a novel mathematical model of TB considering preventive treatment with media *** basic reproduction number R_(0)is defined by the next generation matrix *** the case without media impact,we prove that the disease-free equilibrium is globally asymptotically stable(unstable)if R_(0)1).Furthermore,we obtain that a unique endemic equilibrium exists when R_(0)>1,which is globally asymptotically stable in the case of permanent immunity and no media *** fit the model to the newly reported TB cases data from 2009 to 2019 of four regions in China and estimate the *** we estimatedR_(0)=0.50131 in Henan,R_(0)=1.282>1 in Jiangxi andR_(0)=1.930>1 in Xinjiang imply that TB will continue to persist in these three regions without further prevention and control ***,sensitivity analysis is carried out to illustrate the role of model parameters for TB *** finding reveals that appropriately improving the rate of timely treatment for actively infected people and increasing the rate of individuals with LTBI seeking preventive treatment could achieve the goal of TB *** addition,another interesting finding shows that media impact can only reduce the number of active infections to a limited extent,but cannot change the prevalence of TB.

关键词： Latent tuberculosis infection Preventive treatment Media impact Mathematical model Tuberculosis elimination

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坡面细沟侵蚀发生的临界水力条件研究

土壤侵蚀与水土保持学报 1998年第1期4卷 41-46页

作者：张科利秋吉康宏清华大学水利系日本宫崎大学

通过径流冲刷实验，研究了坡面侵蚀方式由面状侵蚀向细沟侵蚀过渡、发展过程中径流的水动力学特征；根据侵蚀量的观测对比，提出了表明细沟开始产生的形态尺度大小，以及细沟侵蚀产生的临界条件。实验结果表明：基于对侵蚀量的贡献程度... 详细信息

通过径流冲刷实验，研究了坡面侵蚀方式由面状侵蚀向细沟侵蚀过渡、发展过程中径流的水动力学特征；根据侵蚀量的观测对比，提出了表明细沟开始产生的形态尺度大小，以及细沟侵蚀产生的临界条件。实验结果表明：基于对侵蚀量的贡献程度，当具有明显沟缘的侵蚀沟深度在０８～１０ｃｍ时，侵蚀方式已由面状侵蚀发展为细沟侵蚀，径流的弗罗德数可作为反映细沟侵蚀发生的水动力临界参数，弗罗德数大于１是细沟形成的水动力临界条件。除满足水动力临界条件外，细沟侵蚀发生还要求具有最小径流量。对于一定的土壤，临界径流量的大小主要由坡面倾斜度决定。在实验土条件下，细沟侵蚀发生临界径流量与坡度有关系式：ｑｃ＝０８５７４（ｓｉｎθ）－７／６。

关键词：细沟侵蚀水力条件坡面临界水力条件径流量坡度

Mechanocatalysis of CO to CO_(2)on TiO_(2)surface controlled at atomic scale

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Nano Research 2024年第7期17卷 5826-5834页

作者： Yuuki Adachi Robert Turanský Ján Brndiar Kamil Tokár Qiang Zhu Huan Fei Wen yasuhiro Sugawara IvanŠtich Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Institute of Physics Slovak Academy of SciencesBratislava 84511Slovakia Institute of Informatics Slovak Academy of SciencesBratislava 84507Slovakia Faculty of Natural Sciences University of Ss.Cyril and MethodiusTrnava 91701Slovakia Key Laboratory of Instrumentation Science and Dynamic Measurement School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China

The common ways to activate a chemical reaction are by heat,electric current,or ***,mechanochemistry,where the chemical reaction is activated by applied mechanical force,is less common and only poorly understood at the atomic *** we report a tip-induced activation of chemical reaction of carbon monoxide to dioxide on oxidized rutile TiO_(2)(110)*** activation is studied by atomic force microscopy,Kelvin probe force microscopy under ultrahigh-vacuum and liquid nitrogen temperature conditions,and density functional theory(DFT)*** reaction is inferred from hysteretic behavior of frequency shift signal further supported by vector force mapping of vertical and lateral forces needed to trigger the chemical reaction with torque motion of carbon monoxide towards an oxygen *** reaction is found to proceed stochastically at very small tip-sample ***,the local contact potential difference reveals the atomic-scale charge redistribution in the reactants required to unlock the *** results open up new insights into the mechanochemistry on metal oxide surfaces at the atomic scale.

关键词： atomic resolution mechanochemistry atomic force microscopy Kelvin probe force microscopy density functional theory(DFT)simulation CO oxidation catalysis rutile TiO_(2)surface

Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity

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Engineering 2024年第7期38卷 113-123页

作者： Xiangyang Liu Fei-Peng Zhao Tian Tian Wei-Chen Wang Zaizhou Liu Qiang Zhou Xian-Feng Hou Jing Wang Wenli Guo Shuangjun Lin yasuhiro Igarashi Gong-Li Tang State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Microbial Metabolism&Joint International Research Laboratory on Metabolic and Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Biotechnology Research Center Toyama Prefectural UniversityImizu 939-0398Japan

A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea *** TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which generated a trace of the target products but accumulated a large amount of shunt *** on rational analysis of the relevant secondary metabolism,directed engineering of the biosynthetic pathways resulted in the high production of HBM B,as well as new HBM derivates with improved antitumor *** results not only establish a biosynthetic system to effectively synthesize HBMs-a class of the largest and most complex Type-Ⅱpolyketides,with a unique pseudo-dimeric structure-but also set the stage for further engineering and deep investigation of this complex biosynthetic pathway toward potent anticancer drugs.

关键词： Hibarimicin Biosynthesis Heterologous expression Biosynthetic gene cluster Rational engineering Type-II polyketide

Treatment of gastric outlet obstruction that results fromunresectable gastric cancer:Current evidence

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 165-172页

作者： yasuhiro miyazaki Shuji Takiguchi Tsuyoshi Takahashi Yukinori Kurokawa Tomoki Makino Makoto Yamasaki,Kiyokazu Nakajima Masaki Mori Yuichiro Doki Department of Gastroenterological Surgery Osaka University Graduate School of MedicineSuita-shiOsaka 565-0871Japan

Malignant gastric outlet obstruction(GOO) is a common condition that results from locally advanced malignancies in the upper gastrointestinal tract, such as pancreatic, gastric, and other carcinomas. Two types of procedures for malignant GOO, namely, gastrojejunostomy(GJ) with laparotomy or a laparoscopic approach and endoscopic stenting(ES), are currently available. Although numerous previous reports have clarified the benefits and drawbacks of each procedure, whether GJ or ES should be used in patients with GOO that results from gastric cancer who may have a longer life expectancy than patients with other malignancies has not been determined. In this review, which focuses on gastric cancer-induced GOO, we analyzed the two systematic reviews and a meta-analysis that compared GJ and ES and outlined the current status of GOO treatment. We also provide an updated review that includes laparoscopic GJ. Various data from 13 studies in one review and 6 studies in another review were analyzed. Although the main results of the present review indicated that both GJ and ES were efficacious treatments in patients with GOO that resulted from gastric cancer, current evidence suggests that GJ may be the preferable procedure given its good performance status and improved prognosis in gastric cancer patients.

关键词： Gastric outlet obstruction Gastrojejunostomy Endoscopic stenting Gastric cancer Review

Clinical practice guidelines for acute pancreatitis in the United States and Japan:similarities and differences

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 869-872页

作者： Yasuo Otsuka Ikue Sekai yasuhiro Masuta Kosuke Minaga Tomohiro Watanabe Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsakaJapan

Acute pancreatitis(AP)is defined as sudden inflammation that occurs in the pancreas(1-4).Although most cases of AP are mild,approximately 20%of patients develop severe acute pancreatitis(SAP),which is potentially lethal(3,4).Because of the rapid expansion of knowledge regarding the pathogenesis,diagnosis,and treatment of AP,remaining apprised of the latest information regarding clinical practice can be *** practice guidelines are published statements proposed by a panel of experts and include recommendations regarding the optimal diagnosis and treatment of disease(5).Therefore,many clinicians rely on clinical practice guidelines for patient ***,the American College of Gastroenterology(ACG)published clinical practice guidelines for AP management(1).However,in Japan,clinicians often rely on the 2021 Japanese clinical practice guidelines when managing AP(2).The ACG and Japanese clinical practice guidelines for AP share various recommendations regarding diagnosis,severity assessment,and management of this condition;however,these guidelines also have significant ***,this editorial article discusses these similarities and differences.

关键词： Acute pancreatitis(AP) clinical practice guideline severe acute pancreatitis(SAP)

SPERA Hydrogen System^(TM)by LOHC-MCH Method for Massive Hydrogen Storage and Transportation

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Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi Okada Kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi Nagai yasuhiro Inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is *** organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business *** has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization ***,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as *** this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene