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Cryptogenic cirrhosis in the region where obesity is not prevalent

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World Journal of Gastroenterology 2006年第13期12卷 2080-2085页

作者： Hideyuki Kojima Shinya Sakurai Masahiko Matsumura Norie Umemoto Masahito Uemura Hiroyo Morimoto yasuhiro Tamagawa Hiroshi fukui Third Department of Internal Medicine Nara Medical University 840 Shijo-cho Kashihara-shiNara 634-8522Japan Department of General Medicine and Clinical Investigation Nara Medical University 840 Shijo-cho Kashihara-shiNara 634-8522Japan Department of Internal Medicine Kokuho Central Hospital 404-1 Miyako TawaramotochoNara 636-0302Japan

AIM： Recent studies have demonstrated that obesity is the common feature of cryptogenic cirrhosis （CC） and non-alcoholic steatohepatitis. However, there is little information on CC in the region where obesity is not prevalent, METHODS： The clinical features, and the liver-related morbidity and mortality of CC were analyzed in Japan where the prevalence of obesity is low. Among 652 cirrhotic patients, we identified 29 patients （4.4%） with CC. Of these, 24 CC patients who were followed up for more than 6 months were compared in a case-control study with age-, sex-, and Child-Pugh score-matched controls having cirrhosis of viral etiology. RESULTS： Obesity （BMI≥25 kg/m^2）, diabetes mellitus, and hypertriglyceridemia were more frequent, and the visceral fat area was larger in the CC patients than in the controls. The indices of insulin resistance were higher and the serum aminotransferase levels were lower in the CC patients than in the controls. Logistic regression analysis identified the elevated hemoglobin A1c, BMI ≥ 25 kg/m^2, and normal aminotransferase levels as independent predictors of CC. Kaplan-Meier analysis demonstrated lower occurrence of hepatocellular carcinoma and higher survival rate in the CC than in the controls in contrast to the similar cumulatlve probability of liverrelated morbidity between those ***： CC more frequently presents with the clinical features suggestive of non-alcoholic steatohepatitis compared with controls even in the region where obesity is not prevalent. The lower occurrence of hepatocellular carcinoma and higher survival rate may indicate an indolent clinical course in CC as compared with viral cirrhosis.

关键词： Ke Cryptogenic cirrhosis Viral cirrhosis Nonalcoholic steatohepatitis Hepatocellular carcinoma Case-control study

Pediatric ileoileal intussusception with a lipoma lead point:a case report

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Gastroenterology Report 2014年第1期2卷 70-72页

作者： Yoshihide Asaumi Tamon Miyanaga yasuhiro Ishiyama Masakazu Hattori Yasuo Hashizume Department of Surgery Fukui Prefectural HospitalFukuiJapan

Intussusception is a common cause of mechanical bowel obstruction among children,with older children being more likely to have a pathological lead *** neoplasms are rare and small intestinal lipomas are even less *** we describe a case of a 7-year-old boy with ileoileal intussusception,with an ileal lipoma as the pathological lead *** tomography was useful pre-operatively for revealing intussusception due to lipoma as the pathologic lead point.

关键词： Lipoma Intussusception Child

Effects of Image Presentation Using a Head-Mounted Display on Muscle and Brain Activity during Swallowing

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World Journal of Neuroscience 2022年第2期12卷 68-81页

作者： Kengo Hoyano yasuhiro Ogoshi Department of Speech and Hearing Sciences Faculty of Health and Medical Sciences Fukui Health Science University Fukui Japan Department of Human and Artificial Intelligent Systems Graduate School of Engineering University of Fukui Fukui Japan

Introduction: It is well known that humans have an increased sense of taste and consume more food when eating with others. This effect is called social facilitation of eating. We previously reported that self-images also have the effect of social facilitation of eating. In the present study, we investigated the effect of a head-mounted display (HMD) as a means of presenting self-images. Methods: Fourteen healthy adults (7 females and 7 males) were included in the study. The mean age of the participants was 20.4 years. The experimental conditions were as follows: the presentation conditions include the SG condition, in which an image was projected on the smart glasses, and the MT condition, in which an image was projected on the monitor. The stimulation conditions include the self-image condition (Self condition), in which the participant’s own image was projected, and the background image condition (Background condition), in which the background image was projected. Participants were asked to consume green tea jelly three times under the four conditions, which consisted of combinations of the presentation and stimulation conditions. Electromyography (EMG) and electroencephalography (EEG) were used to measure the muscle activity of the suprahyoid muscle group and brain activity, respectively. Results: The EMG of the “SG-Self” condition was significantly higher than that of “SG-Background” and “MT-Background” conditions. The EMG of the “MT-Self” condition was significantly higher than that of the “MT-Background” condition. In the EEG before the start of swallowing, “SG-Self” was significantly lower in the alpha band and higher in the beta band than “MT-Background”. The beta-alpha ratio was significantly higher for “SG-Self” than for “SG-Background” and “MT-Background” and higher for “MT-Self” than for “MT-Background”. Conclusion: These results suggest that self-images influence muscle and brain activities during swallowing, regardless of the presentation conditions, s

关键词： Social Facilitation Swallowing Electroencephalography (EEG) Electromyography (EMG) Diet Modification for Dysphagia

A Parameter Determination Method of Distribution Voltage Regulators Considering Tap Change and Voltage Profile

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Journal of Energy and Power Engineering 2012年第1期6卷 117-125页

作者： Yuji Hanai yasuhiro Hayashi Junya Matsuki Yoshiaki Fuwa Kenjiro Mori Department of Electrical and Electronics Engineering University of Fukui Fukui 910-8507 Japan Graduate School of Advanced Science and Engineering Waseda University Tokyo 169-8050 Japan Distribution Department Power Network Division Tokyo Electric Power Company Tokyo Japan

This paper proposes a parameter determination method of distribution voltage regulators load ratio control transformers （LRT） and step voltage regulators （SVR） considering the tap change and voltage profile. The method takes two procedures in order to simplify the optimization problem and to reduce calculation time. One is to simultaneously determine the control parameters of LRT and SVR minimizing voltage violations and voltage variations. The algorithm is based on particle swarm optimization （PSO）, which is one of non-linear optimization methods by using a concept of swarm intelligence. Another is to determine the dead-band width of LRT and SVR on the basis of bi-evaluation of tap change and voltage margin. The concept of a Pareto optimal solution is used for the decision of the best dead-band width. As the results of numerical simulations using distribution network model, the validity of the proposed method has been affirmed.

关键词： Distribution network voltage control LRT SVR control parameter deadband PSO.

Single-incision laparoscopic surgery for colorectal cancer

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World Journal of Gastrointestinal Surgery 2016年第1期8卷 95-100页

作者： yasumitsu hirano masakazu hattori kenji douden yasuhiro ishiyama yasuo hashizume department of surgery fukui prefectural hospitalFukui 910-8526Japan

AIM: To determine the effect of single-incision laparoscopic colectomy(SILC) for colorectal cancer on short-term clinical and oncological outcomes by comparison with multiport conventional laparoscopic colectomy(CLC).METHODS: A systematic review was performed using MEDLINE for the time period of 2008 to December 2014 to retrieve all relevant literature. The search terms were "laparoscopy", "single incision", "single port", "single site", "SILS", "LESS" and "colorectal cancer". Publications were included if they were randomized controlled trials, case-matched controlled studies, or comparative studies, in which patients underwent single-incision(SILS or LESS) laparoscopic colorectal surgery. Studies were excluded if they were non-comparative, or not including surgery involving the colon or rectum. A total of 15 studies with 589 patients who underwent SILC for colorectal cancer were ***: No significant differences between the groups were noted in terms of mortality or morbidity. The benefit of the SILC approach included reduction in conversion rate to laparotomy, but there were no significant differences in other short-term clinical outcomes between the groups. Satisfactory oncological surgical quality was also demonstrated for SILC for the treatment of colorectal cancer with a similar average lymph node harvest and proximal and distal resection margin length as multiport ***: SILC can be performed safely with similar short-term clinical and oncological outcomes as multiport CLC.

关键词： Single-incision laparoscopic surgery Singleincisionlaparoscopic colectomy Colorectal cancer

Sex- and Age-Specific Associations of Social Status and Health-Related Behaviors with Health Check Attendance: Findings from the Cross-Sectional Kanazawa Study

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Health 2017年第9期9卷 1285-1300页

作者： Hiromasa Tsujiguchi Daisuke Hori yasuhiro Kambayashi Toshio Hamagishi Hiroki Asakura Junko Mitoma Masami Kitaoka Anyenda Enoch Olando Nguyen Thi Thu Thao Yohei Yamada Koichiro Hayashi Tadashi Konoshita Takiko Sagara Aki Shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Third Department of Internal Medicine Fukui University School of Medicine Eiheiji Japan

Health checks are key features of primary and secondary disease prevention. The aim of this study was to examine the sex- and age-specific association of social status and health-related behaviors with health check attendance in eligible persons. Data were derived from the Kanazawa Study 2011 (n = 12,781), a cross-sectional study which investigated all the residents in model areas of Kanazawa City, Ishikawa Prefecture, Japan. We selected participants aged 23 years or older with National Health Insurance (n = 4920). Attendance at health checks was the outcome. We used social status and health-related behaviors as predictor variables. We analyzed them by sex and applied stratified analyses by age groups for each sex. The bivariate analyses were conducted by means of cross-tabs. We calculated health check attendance rates by each variable. We used Pearson’s χ2-test to examine statistically significant differences. We fitted logistic regression models to estimate adjusted odds ratios (ORs) of attendance in the past one year. We computed ORs in a logistic regression model containing all variables described above. Workingmen and women aged 23 to 39 years and aged 40 to 64 years had significantly increased ORs for health check attendance compared with non-working persons. Men, men aged 23 to 39 years and men aged 65 years or older with more physical activity had significantly increased ORs for health check attendance. Male ex-smokers, female ex- and non-smokers, male ex-smokers aged 65 years or older, and female non-smokers aged 40 to 64 years had significantly increased ORs. The findings suggest that population groups with lower social status or increased risks of adverse health effects are less likely to attend health checks than those with higher social status or decreased risks in particular sex and age groups. It indicates that diverse approaches are required to realize the full benefit of health checks.

关键词： Health Check Social Status Health-Related Behaviors Secondary Prevention Health Care

Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents

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Health 2016年第1期8卷 116-124页

作者： Junko Mitoma Masami Kitaoka Hiroki Asakura Enoch Olando Anyenda Daisuke Hori Nguyen Thi Thu Tao Toshio Hamagishi Koichiro Hayashi Fumihiko Suzuki Yukari Shimizu Hiromasa Tsujiguchi yasuhiro Kambayashi Yuri Hibino Tadashi Konoshita Takiko Sagara Aki Shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.

关键词： Quality of Life Chronic Pain Headache SF-36 Pain

The Association between Activity of Daily Living and the Combination of Alzheimer’s Disease and Cataract in Elderly Requiring Nursing Care

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Health 2016年第10期8卷 994-1003页

作者： Toshio Hamagishi Toshimitsu Inagawa yasuhiro Kambayashi Hiromasa Tsujiguchi Masami Kitaoka Junko Mitoma Hiroki Asakura Fumihiko Suzuki Daisuke Hori Enoch Olando Anyenda Nguyen Thi Thu Thao Yuri Hibino Koichi Hayashi Aki Shibata Takiko Sagara Jiro Okochi Kiyoshi Takamoku Kotaro Hatta Tadashi Konoshita Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Department of Food Sciences and Nutrition School of Human Environmental Sciences Mukogawa Women’s University Hyogo Japan Department of Lifestyle Studies Kobe Shoin Women’s University Hyogo Japan Department of Nutritional Sciences for Well-Being Kansai University of Welfare Sciences Osaka Japan Japan Association of Geriatric Health Service Facilities Tokyo Japan Department of Psychiatry Juntendo University Nerima Hospital Tokyo Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

Some clinical and epidemiological studies have suggested that Alzheimer’s Disease (AD) and cataract, may share common pathogenetic mechanisms, subsequently a positive association between the prevalence of AD and cataract, although other studies found no significant relationship between dementia and visual impairment including cataract in the elderly. Little is known about the association between Activity of Daily Living (ADL) and the combination of AD and cataract. To examine the association between ADL and the combination of AD and cataract, we performed a national survey in nursing care institutions in Japan, examining the decreased ADL in elderly with and without AD and cataract for 453 elderly aged 85.0 ± 8.13 years. The proportion, 43.5% of AD in subjects without cataract was significantly higher than that, 23.5% with cataract. Almost all ADL in AD with cataract was significantly lower than that without cataract, although all ADL in cataract patients receiving surgery in AD was significantly (all p < 0.002) higher than that in cataract patients without surgery in AD, as was confirmed by the multiple regression analysis incorporating into the relevant factors as independent variables. These results showed that ADL scores including cognitive functions decreased by cataract were increased by the surgery in the patients with AD. A significantly negative association between AD and cataract seen in our data, which was inconsistent with the previous result, might lead to the necessities of the clinical diagnosis for slight severity of cataract for patients with AD.

关键词： Alzheimer’s Disease Cataract Elderly Activity of Daily Living Cognitive Function