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Japanese Community Pharmacists’ Barriers to Conducting or Participating in Practice Research

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Pharmacology & Pharmacy 2015年第9期6卷 421-427页

作者： yasuhiro sawada Rieko Takehira Shigeo Yamamura Faculty of Pharmaceutical Sciences Josai International University Chiba Japan Welcia Yakkyoku Co. Ltd. Tokyo Japan

Objectives: This study identified barriers to Japanese community pharmacists’ active conduct or participation in practice research. Methods: Community pharmacists (n = 478) who gave presentations at three major pharmacy-related conferences in 2012 and 2013 were questioned about their difficulties of giving presentations, support for better presentations, and barriers to conducting pharmacy practice research in their practical setting. A questionnaire was mailed to and returned by the pharmacists directly. Results: We obtained 230 responses (47.9%). Presentation difficulties included pharmacists’ time constraints and lack of experience organizing the report’s results or discussion. Many thought statistical analysis support was necessary. The barriers were in sufficient time, community pharmacies’ lack of research supervisors, and other community pharmacists’ lack of understanding practice research’s importance. These were comparable to pharmacists’ barriers in other countries, except for money and funds. Conclusions: Japanese community pharmacists should clarify that practice research in their professional roles improves patients’ outcomes. Barriers were similar to pharmacists in other countries. Publication of pharmacists’ practice research results is important to expand their roles. Collaboration between faculties and pharmacists is a challenge for practice research development in the Japanese community setting.

关键词： Pharmacy Practice Research Barrier Community Pharmacist in Japan

Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases:A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1281-1294页

作者： Kazuhisa Takeda Yu sawada yasuhiro Yabushita Yuki Honma Takafumi Kumamoto Jun Watanabe Ryusei Matsuyama Chikara Kunisaki Toshihiro Misumi Itaru Endo Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Gastroenterological Surgery Yokohama City University Graduate School of MedicineYokohama 236-0004Jordan Department of Biostatistics Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The liver is the most common metastatic site of colorectal *** is the mainstay of treatment for patients with colorectal liver metastases(CRLMs).However,there are cases of early recurrence after upfront hepatectomy *** selected high-risk patients,neoadjuvant chemotherapy(NAC)may improve longterm *** To determine the efficacy of NAC for initially resectable *** Among 644 patients who underwent their first hepatectomy for CRLMs at our institution,297 resectable cases were stratified into an upfront hepatectomy group(238 patients)and a NAC group(59 patients).Poor prognostic factors for upfront hepatectomy were identified using multivariate logistic regression *** score matching was used to compare clinical outcomes between the upfront hepatectomy and NAC groups,according to the number of poor prognostic *** curves were estimated using the Kaplan-Meier method and compared using the log-rank *** Preoperative carcinoembryonic antigen levels(≥10 ng/mL)(P=0.003),primary histological type(other than well/moderately differentiated)(P=0.04),and primary lymph node metastases(≥1)(P=0.04)were identified as independent poor prognostic factors for overall survival(OS)in the upfront hepatectomy ***-risk status was defined as the presence of two or more risk *** propensity score matching,50 patients were matched in each *** high-risk patients,the 5-year OS rate was significantly higher in the NAC group(13 patients)than in the upfront hepatectomy group(18 patients)(100%vs 34%;P=0.02).CONCLUSION NAC may improve the prognosis of high-risk patients with resectable CRLMs who have two or more risk factors.

关键词： Colorectal neoplasms Neoadjuvant therapy Neoplasm metastasis Prognosis Risk factors Survival

Two-layer cold storage method for pancreas and islet cell transplantation

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World Journal of Gastroenterology 2010年第26期16卷 3235-3238页

作者： yasuhiro Fujino Department of Surgery Hyogo Cancer Center Akashi 673-8558 Japan

The two-layer cold storage method (TLM) was f irst reported in 1988, consisting of a perfluorochemical (PFC) and initially Euro-Collins' solution, which was later replaced by University of Wisconsin solution (UW). PFC is a biologically inert liquid and acts as an oxygen-supplying agent. A pancreas preserved using the TLM is oxygenated through the PFC and substrates are supplied by the UW solution. This allows the pancreas preserved using the TLM to generate adenosine triphosphate during storage, prolonging the preservation time. In a canine model, the TLM was shown to repair and resuscitate warm ischemically damaged pancreata during preservation, improve pancreas graft survival after transplantation, and also improve the islet yield after isolation. Clinical trials using the TLM in pancreas preservation before whole-pancreas transplantation and islet isolation have shown promising outcomes. We describe the role of the TLM in pancreas and islet transplantation.

关键词： Two-layer method Pancreas preservation Pancreas transplantation Islet transplantation Perfluorochemical

Microbiota in the stomach and application of probiotics to gastroduodenal diseases

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World Journal of Gastroenterology 2022年第47期28卷 6702-6715页

作者： yasuhiro Koga Japanese Society for Probiotic Science Isehara 259-1143Japan

The stomach is a hostile environment for most microbes because strong gastric acid kills indigenous ***,the mass of indigenous microbes detected by traditional culturing method in a highly acidic stomach is reported to be very ***,in a stomach with less acidity due to atrophic changes of the gastric mucosa,the number of live gastric microbiota dramatically increases and their composition changes.A probiotic is defined as a live microorganism that,when administered in adequate amounts,confers a health benefit on the *** administration of probiotics to the stomach has thus far been considered impractical,mainly due to the strong acidity in the *** identification of candidate probiotic strains with sufficient resistance to acidity and the ability to achieve close proximity to the gastric mucosa could enable the application of probiotics to the *** utilization of probiotics alone for Helicobacter pylori(***)infection significantly improves gastric mucosal inflammation and decreases the density of *** on the mucosa,although complete eradication of *** has not yet been *** use of probiotics in combination with antimicrobial agents significantly increases the *** eradication rate,especially when the *** strains are resistant to antimicrobial *** *** has been considered the most important pathogenic bacterium for the development of gastric cancer,bacteria other than *** are also suggested to be causative pathogens that promote the development of gastric cancer,even after the eradication of *** *** Gram-negative bacteria in the stomach with weak acidity accompanying atrophic gastritis may perpetuate gastric mucosal inflammation and accelerate carcinogenic progression,even after *** *** restore the acidity in this stomach environment and may therefore prevent the development of gastric cancer by termination of Gram-negative ba

关键词： Stomach Microbiota Probiotics Helicobacter pylori Post-eradication gastric cancers Functional dyspepsia

Centrifuge model test on earthquake-induced differential settlement of foundation on cohesive ground

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Science China(Technological Sciences) 2009年第7期52卷 2138-2146页

作者： SHAMOTO yasuhiro HOTTA Hiroyuki MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University Hangzhou 310058 China Insititute of Technology Shimizu Corporation Tokyo 135-8530 Japan

Dynamic centrifuge model test was conducted to study the earthquake-induced differential settlement of foundation on cohesive ground, and the influence of asymmetry of building was investigated. During the experiment, the overconsolidated kaolin clay ground with a three-dimensional asymmetrical structure model was shaken by a basically balanced input motion, and bender elements were used to measure shear wave velocities of model ground to reveal the soil fabric evolution during and after shaking. The test results show that, the total seismic settlement of foundation is composed of instantaneous and long-term post-earthquake settlements, and most of the differential settlement occurs immediately after the earthquake while the post-earthquake settlement is relatively uniform despite its large amplitude. The asymmetry of building affects the settlement behavior considerably. Compared with 1-or 2-dimensional structures, more evident differential settlement occurs under threedimensional asymmetrical building during shaking, which accounts for one-half of the total seismic settlements and results in complex spatial tilting effects of foundation.

关键词： soft clay centrifuge model test shaking table earthquake-induced differential settlement bender elements

Perioperative management of distal pancreatectomy

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World Journal of Gastroenterology 2015年第11期21卷 3166-3169页

作者： yasuhiro Fujino Department of Surgery Hyogo Cancer Center

Recent advances in surgical techniques and perioperative management have markedly reduced operative morbidity after distal pancreatectomy(DP).However,some questions remain regarding the protocol for the perioperative management of DP,in particular,with regard to the development of pancreatic fistula(PF).A review of DP was therefore conducted in order to standardize the management of patients for a favorable ***,operative technique and perioperative management emerged as two critical factors contributing to favorable outcome in DP *** for the operative method,surgical and closure techniques exhibited differences in *** DP generally yields more favorable perioperative outcomes compared to open DP,and is applicable for benign tumors and some ductal carcinomas of the *** DP is also available for safe pancreatic *** bloc celiac axis resection offers a high R0 resection rate and potentially allows for some local control in the case of advanced pancreatic *** resection,staple closure was not found to reduce the rate of PF when compared to hand-sewn *** addition,ultrasonic dissection devices,fibrin glue sealing,and staple closure with mesh reinforcement were shown to significantly reduce PF,although there was some bias in these *** perioperative management,both preoperative and postoperative treatment affected ***,preoperative endoscopic pancreatic stenting may be an effective prophylactic measure against fistula development following DP in selected ***,in postoperative management,a multifactorial approach including prophylactic antibiotics improved high surgical site infection rates following complex hepato-pancreatobiliary ***,although conflicting results have been reported,somatostatin analogues should be administered selectively to patients considered to have a high risk for ***,careful drain management also facilitates a favorable outcome in

关键词： Distal pancreatectomy Pancreatic fistula Periopera

Ghost Imaging with Deep Learning for Position Mapping of Weakly Scattered Light Source

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Nanomanufacturing and Metrology 2021年第1期4卷 37-45页

作者： yasuhiro Mizutani Shoma Kataoka Tsutomu Uenohara yasuhiro Takaya Department of Mechanical Engineering Osaka UniversityOsaka 565-0871Japan

We propose ghost imaging(GI)with deep learning to improve detection ***,which uses an illumination light with random patterns and a single-pixel detector,is correlation-based and thus suitable for detecting weak ***,its detection time is too long for practical *** overcome this problem,we applied a convolutional neural network that was constructed based on a classification of the causes of ghost image degradation.A feasibility experiment showed that when using a digital mirror device projector and a photodiode,the proposed method improved the quality of ghost images.

关键词： Inspection Metrology Defect mapping Ghost imaging Single-pixel imaging Deep learning Weak light imaging

Manifold Decomposition Processes of Silicone Vapor and Electrical Contact Failure

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Manifold Decomposition Processes of Silicone Vapor and Elect...

Probing CO on a rutile TiO_(2)(110)surface using atomic force microscopy and Kelvin probe force microscopy

The 26th International Conference on Electrical contacts and the 4th International Conference on Reliability of Electrical Products & Electrical Contacts

作者： Terutaka Tamai Shigeru sawada yasuhiro Hattori (ElConTech Consulting Ltd.) Shiroi city ChibaJapan (Mie University) Tsu city MieJapan (AutoNetworls Technilogy Ltd.) YokkaichiMieJapan

ISBN: (纸本)9781622763136

Adsorbed silicone vapor on contact surfaces decomposes typically to SiO by elevated temperature due to discharge or Joule ***,even if temperature is lower than decomposition temperature,weak decomposition is induced in very complex ***,silicone molecule has an equilibrium reaction from linear molecular structure to ring structure,or its reverse reaction in the room temperature. Furthermore,in the oxidation process,as the molecular changes various structures and causes imperfect decomposition,and various types of compounds *** the present paper, electrical condition of load and occurrence of the failure due to silicone vapor contamination were discussed with practical *** it was clarified that various high polymer silicone compounds including liquid are formed by their polymerization in the decomposing ***,a mechanism of formation of carbon from the silicon vapor under this process is also discussed.

关键词： silicone vapor silicone contamination silicone compound contact failure decomposition relay

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Nano Research 2022年第3期15卷 1909-1915页

作者： Yuuki Adachi yasuhiro Sugawara Yan Jun Li Department of Applied Physics Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Probing CO at a specific site on a metal oxide surface is essential for characterizing various applications such as CO oxidation,hydrogenation,and water–gas shift ***,we use atomic force microscopy and Kelvin probe force microscopy to probe the CO on a rutile TiO_(2)(110)*** results indicate that CO can be manipulated along the Ti row by the repulsive lateral force of“pushing”***,the joint combination of precise manipulation and the distance dependence of local contact potential difference allow us to resolve the interatomic dipole moment and charge state of CO at atomic ***,we found that the negatively charged CO with the dipole moment of negative pole down on the rutile TiO_(2)(110)*** results suppose that both the charge state as well as the on-surface dipole interaction are very effective for CO reaction on rutile TiO_(2)(110)surface.

关键词： CO rutile TiO_(2) dipole moment charge state atomic force microscopy Kelvin probe force microscopy