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Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension

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World Journal of Emergency Medicine 2016年第1期7卷 68-70页

作者： Tomoya okazaki Toru Hifumi Arisa Manabe Hikari Matsumura Satoshi Egawa Hideyuki Hamaya Nastuyo Shinohara Koshiro Takano Hajime Shishido Yuko Abe Kenya Kawakita Masanobu Hagiike yasuhiro Kuroda Emergency Medical Center Kagawa University Hospital Kita Kagawa 761-0793 Japan

BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal *** this report we describe an alarming case of group B streptococcus(GBS)infection after splenectomy in a patient with ***:A 72-year-old woman with a history of LC was admitted to our emergency department because of respiratory *** patient had received left lateral segmentectomy of the liver and splenectomy three months before *** examination revealed significant wheezing during inspiration and expiration,but no crackles and *** radiography and CT showed no infiltrates.A presumptive diagnosis of bronchial asthma caused by upper respiratory infection was *** days after admission,GBS infection was confirmed by blood culture and penicillin G was *** were given intravenously for a total of 12 ***:The patient was discharged on the 12th day after ***:Although efficacy of splenectomy in patients with LC has been reported,immune status should be evaluated for a longer *** who have undergone splenectomy are highly susceptible to bacteria;moreover,LC itself is an independent risk factor for mortality in patients with *** prophylaxis against GBS has not been established,immediate action should be *** physicians should be aware of invasive GBS infection in the context of the critical risk factors related to splenectomy and LC,particularly the expected increase of splenectomy performed in LC patients.

关键词： Group B streptococcal infection Splenectomy Liver cirrhosis

Synthesis, structural characterization and magnetic property of nanocomposite materials: Intercalation compounds of FePS_3 with 1,10-phenanthroline or 2,2'-bipyridine

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Chinese Journal of Chemistry 2000年第4期18卷 510-515页

作者：陈兴国杨楚罗秦金贵 YAKUSHI Kyuya NAKAZAWA yasuhiro ICHIMURA Kenji Department of Chemistry Wuhan University Wuhan Hubei 430072 China Institute for Molecular Science Okazaki 444 Japan Department of Chemistry Kumamoto University Kumamoto 860 Japan

Two new intercalation compounds Fe0.90PS3(phen)0.41 (1) (phen stands for 1,10-phenanthroline including a part of 1, 10-phenanthroline H+) and Fe0.83PS3(bipy)0.34 (2) (bipy stands for 2,2'-bipyridine H+ ) were synthesized by the reaction of the layered FePS, with 1,10-phenanthroline or 2,2'-bipyridine in the presence of anilinium chloride. They were characterized by elemental analyses, powder X-ray diffraction (XRD), infrared spectroscopy. The lattice spacing of the intercalate was expanded by 0.90 nm for Fe0.90PS3(phen)0.41 and 0.57 nm for Fe0.83PS3(bipy)0.34 withrespect to the pristine FePS3, indicating that the ring plane of the guests is perpendicular to the layer of the host. The UV-vis absorption spectra of the filtrate in preparation of the intercalates indicate that 1, 10-phenanthroline or 2,2'-bipyridine also acts as a complexing agent to remove intralamellar Fe2+ ions into the solution during intercalation. The magnetic properties of 1 and 2 were studied.

关键词： Intercalation FePS3 1,10-phenanthroline 2,2'-bipyridine magnetic property

Management of gastric fundal varices without gastro-renal shunt in 15 patients

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World Journal of Gastroenterology 2008年第3期14卷 448-453页

作者： Natsuhiko Kameda Kazuhide Higuchi Masatsugu Shiba Kaori Kadouchi Hirohisa Machida Hirotoshi okazaki Tetsuya Tanigawa Toshio Watanabe Kazunari Tominaga yasuhiro Fujiwara Kenji Nakamura Tetsuo Arakawa Department of Gastroenterology Graduate School of Medicine Osaka City University Osaka 569-8686 Japan Second Department of Internal Medicine Osaka Medical College Osaka 569-8686 Japan Department of Radiology Graduate School of Medicine Osaka City University Osaka 569-8686 Japan

AIM:To examine the portal hemodynamics of gastric fundal varices (GV) without gastro-renal shunt (GRS), and to retrospectively investigate the effects of various kinds of treatment on eradication. METHODS: Ninety-four liver cirrhosis patients at high- risk of GV were treated in our hospital and enrolled in this study. We retrospectively examined their characteristics, liver function, and portal hemodynamics of GV. We performed balloon-occluded retrograde transvenous obliteration (BRTO) at first. If it was not technically possible to perform BRTO, endoscopic injection sclerotherapy using α-cyanoacrylate glue (CA) or percutaneous transhepatic obliteration (PTO) was performed. RESULTS: Among the 94 patients, a GRS was present in 79 (84.0%), and absent in the remaining 15 (16.0%). The subphrenic vein was connected to the inferior vena cava as the drainage vein in 13 (86.7%) out of the 15 cases without GRS. We performed BRTO in 6 patients, CA in 4 patients and PTO in 5 patients. The eradication rate was 100% for each procedure, but the rate of early recurrence within 6 mo was 16.7% for BRTO, 50.0% for CA and 40.0% for PTO, respectively. CONCLUSION: We should examine the hemodynamics before treatment of GV irrespective of the existence of GRS. If this hemodynamic examination reveals that the drainage vein connects directly to the inferior vena cava in GV without GRS, BRTO may be an effective treatment for GV with GRS.

关键词：胃静脉曲张症状治疗措施疗效

A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine

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World Journal of Gastroenterology 2007年第9期13卷 1453-1457页

作者： Naoto Hirata Kazunari Tominaga Kensuke Ohta Kaori Kadouchi Hirotoshi okazaki Tetsuya Tanigawa Masatsugu Shiba Toshio Watanabe yasuhiro Fujiwara Shiro Nakamura Nobuhide Oshitani Kazuhide Higuchi Tetsuo Arakawa Department of Gastroenterology Osaka City University Graduate School of Medicine 1-4-3 Asahimachi Abeno-ku Osaka 545-8585 Japan Department of Hematology Osaka City University Graduate School of Medicine1-4-3 Asahimachi Abeno-kuOsaka 545-8585 Japan Department of Gastroenterology Rinku General Medical Center 2-3 Rinkuouraikita Izumisano Osaka 598-0048Japan

A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano’s classification, its staging was clinically diagnosed as stage Ⅱ. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone) regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year follow- up EGD and histological examinations detected no recurrence of the disease.

关键词：黏膜相关性淋巴组织淋巴瘤小肠息肉多淋巴样息肉病例报告

Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant:Report of a case

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World Journal of Gastroenterology 2006年第33期12卷 5408-5411页

作者： Hirotoshi okazaki Kazuhide Higuchi Masatsugu Shiba Shirou Nakamura Tomoko Wada Kazuki Yamamori Ai Machida Kaori Kadouchi Akihiro Tamori Kazunari Tominaga Toshio Watanabe yasuhiro Fujiwara Kenji Nakamura Tetsuo Arakawa Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan Department of Radiology Osaka City University Graduate School of Medicine Osaka Japan

We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by giant rectal varices, we thought that they were not suitable to receive endoscopic treatment. We chose the modified percutaneous transhepatic obliteration with sclerosant, which is one of the interventional radiology techniques but a new clinical procedure for rectal varices. After the patient received this therapy, her condition of rectal varices was markedly improved.

关键词：直肠血管曲张致组织硬化物质临床病理机制

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铁催化2-烯基氮杂芳烃的绿色合成

有机化学 2014年第7期34卷 1369-1375页

作者：刘森生姜坤皮单违周海峰 yasuhiro Uozumi 邹坤三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室宜昌443002 分子科学研究所冈崎市日本444-8787

以廉价、低毒的醋酸亚铁为催化剂,在三氟乙酸助催化下,2-甲基氮杂芳烃与芳香醛经过加成与脱水反应,直接选择性合成具有生物活性的反式2-烯基氮杂芳烃化合物,水是唯一副产物.该合成方法催化剂用量少,后处理方便,产率高,选择性高,底物适... 详细信息

以廉价、低毒的醋酸亚铁为催化剂,在三氟乙酸助催化下,2-甲基氮杂芳烃与芳香醛经过加成与脱水反应,直接选择性合成具有生物活性的反式2-烯基氮杂芳烃化合物,水是唯一副产物.该合成方法催化剂用量少,后处理方便,产率高,选择性高,底物适用范围广.治疗哮喘药顺尔丁中间体(E)-3-[2-(7-氯-2-喹啉基)乙烯基]苯甲醛(3v)的克级合成展现了该方法的应用前景.

关键词：烯基化含氮杂环 C—H活化绿色化学

Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 17-27页

作者： Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani yasuhiro Kodera Department of Surgery Yokkaichi Municipal Hospital Department of Gastroenterological Surgery Aichi Cancer Center Department of Gastroenterological Surgery (Surgery Ⅱ) Nagoya University Graduate School of Medicine Department of Surgery Komaki Municipal Hospital Department of Surgery Konan Kosei Hospital Department of Surgery Ichinomiya Municipal Hospital Department of Surgery Gifu Prefectural Tajimi Hospital Department of Surgery Okazaki City Hospital Department of Surgery Tosei General Hospital Biostatistics Center Graduate School of Medicine Kurume University

AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric *** From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant *** The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall ***-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who

关键词： Gastric cancer Carcinoembryonic antigen Carbohydrate antigen 19-9 Perioperative levels Prognosis

Recovery of In Situ-generated Pd Nanoparticles with Linear Polystyrene

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Green and Sustainable Chemistry 2011年第2期1卷 19-25页

作者： Atsushi Ohtaka Ryozo Kuroki Takuto Teratani Tsutomu Shinagawa Go Hamasaka yasuhiro Uozumi Osamu Shimomura Ryoki Nomura Department of Applied Chemistry Faculty of EngineeringOsaka Institute of TechnologyOsakaJapan Electronic Materials Research Division Osaka Municipal Technical Research InstituteOsakaJapan Institute for Molecular Science(IMS) OkazakiJapan Nanomaterials and Microdevices Research Center Osaka Institute of TechnologyOsakaJapan

Palladium nanoparticles generated in situ for Suzuki coupling reactions and aerobic alcohol oxidation in water were recovered completely using linear polystyrene. The resultant polystyrene-stabilized palladium nanopar... 详细信息

关键词： Polystyrene Pd Nanoparticles Water Suzuki Coupling Alcohol Oxidation