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Asian Journal of Urology 2023年第2期10卷 210-212页

作者： Yuki Kohada Hiroki Kusumoto Takashi Kukimoto Jotaro Mikami Jun Ito Katsutoshi Asano Toru Yaegashi Kanichi Nakagawara Jun Teishima yasuhiro Kaiho Nobuyuki Hinata yasuhiro nakamura Makoto Sato Division of Urology Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan Department of Urology Hiroshima University Graduate School of Biomedical SciencesHiroshimaJapan Nihon Gene Research Laboratories Inc SendaiJapan Division of Pathology Faculty of MedicineTohoku Medical and Pharmaceutical UniversitySendaiJapan

Dear Editor,Prostate cancer is the most common cancer among men[1].Androgen deprivation therapy(ADT)has remained the primary treatment of metastatic-hormone-sensitive prostate cancer(mHSPC),providing a temporary disease control in the majority of *** initial ADT response,castration-resistance prostate cancer(CRPC)still *** study have attempted to determine possible biomarkers for poor prognosis in patients with CRPC[2].

关键词： patients metastatic cancer

Simultaneous Determination of Catechins and Caffeine in Green Tea-Based Beverages and Foods for Specified Health Uses

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Food and Nutrition Sciences 2017年第3期8卷 316-325页

作者： Keiji Maruyama Fumiko Kihara-Negishi Naoki Ohkura yasuhiro nakamura Miwako Nasui Moemi Saito Research Center for Practical Training of Student Pharmacists School of Pharma-Sciences Teikyo University Tokyo Japan Department of Life and Health Sciences School of Pharma-Sciences Teikyo University Tokyo Japan Department of Medical and Pharmaceutical Sciences School of Pharma-Sciences Teikyo University Tokyo Japan

Catechins in green tea have various useful features including antioxidant activity and preventive effects on metabolic syndrome. Various beverages that are enriched with tea catechins are marketed as Foods for Specified Health Uses (FOSHU) in Japan. However, recent reports have indicated that excessive consumption of green tea extracts as a dietary supplement are associated with adverse health effects such as liver disorders. Various catechins and caffeine are constituents of FOSHU tea-based beverages. The amount of catechins in FOSHU products is displayed on labels as total catechin content, but the content of individual catechins are not provided. Although health hazards of FOSHU products have rarely been reported, precise information about the content and types of catechins in FOSHU products is needed to ensure safety. We used high-performance liquid chromatography with a photodiode array (HPLC/PDA) to simultaneously identify and quantify catechins and caffeine in green tea-based popular beverages and FOSHU beverages. This technique allowed simultaneous quantitation of five types of catechins and caffeine in green tea without complicated sample preparation. Epigallocatechin gallate (EGCG) and epigallocatechin EGC were the main catechins in various FOSHU beverages and the concentrations of almost all catechins were higher in FOSHU, than in popular green tea-based beverages. The concentrations of EGCG in green tea-based popular beverages and in FOSHU beverages were 5.4 - 7.3 and 10.2 - 41.9 mg/100mL, respectively, with the highest concentration being in a product named Healthya (approximately 147 mg/bottle). The simultaneous determination of compounds such as catechins and caffeine in FOSHU beverages can help to estimate beneficial and adverse effects to prevent deleterious effects on health and the excessive consumption of FOSHU beverages containing high concentrations of tea catechins should be avoided.

关键词： Simultaneous Quantitation High-Performance Liquid Chromatography-Photodiode Catechin Caffeine Health Food Dietary Supplement

Acquisition of hyponymy relations for agricultural terms from a Japanese statutory corpus

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Information Processing in Agriculture 2014年第2期1卷 95-104页

作者： Makoto nakamura Tomohiro Ohno yasuhiro Ogawa Katsuhiko Toyama Japan Legal Information Institute Graduate School of LawNagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Information Technology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Graduate School of Information Science Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

This paper,which aims to increment the vocabulary of an existing thesaurus using hyponymy relations,focuses on an agricultural thesaurus called *** main goal is to acquire AGROVOC-qualified candidates from the hyponymy relations of legal texts and *** propose a pattern-based approach to hyponymy relation *** experimental result showed that 222 and 868 candidates are extracted from statutory sentences with 67.1%precision and tables with 37.0%precision,respectively.

关键词： AGROVOC Japanese statutory corpus Legal text processing

Selection of Suitable Maximum-heart-rate Formulas for Use with Karvonen Formula to Calculate Exercise Intensity

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International Journal of Automation and computing 2015年第1期12卷 62-69页

作者： Jinhua She Hitoshi nakamura Koji Makino yasuhiro Ohyama Hiroshi Hashimoto Graduate School of Bionics Computer and Media Sciences Tokyo University of Technology 1404-1 KatakuraHachioji Tokyo 192-0982 Japan Interdisciplinary Graduate School of Medical and Engineering University of Yamanashi4-3-11 Takeda Kofu 400-8511 Japan Master Program of Innovation for Design and Engineering Advanced Institute of Industrial Technology 1-10-40 HigashiooiShinagawa-ku Tokyo 140-0011 Japan

The Karvonen formula, which is widely used to estimate exercise intensity, contains maximum heart rate, H Rmax, as a variable. This study employed pedaling experiments to assess which of the proposed formulas for calculating H Rmaxwas the most suitable for use with the Karvonen formula. First, two kinds of experiments involving an ergometer were performed: an all-in-one-day experiment that tested eight pedaling loads in one day, and a one-load-per-day experiment that tested one load per day for eight days.A comparison of the data on 7 subjects showed that the all-in-one-day type of experiment was better for assessing H Rmaxformulas,at least for the load levels tested in our experiments. A statistical analysis of the experimental data on 47 subjects showed two of the H Rmaxformulas to be suitable for use in the Karvonen formula to estimate exercise intensity for males in their 20 s. In addition, the physical characteristics of a person having the greatest impact on exercise intensity were determined.

关键词： Borg CR10 scale Karvonen formula exercise intensity maximum heart rate pedaling statistical analysis

Continual few-shot patch-based learning for anime-style colorization

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Computational Visual Media 2024年第4期10卷 705-723页

作者： Akinobu Maejima Seitaro Shinagawa Hiroyuki Kubo Takuya Funatomi Tatsuo Yotsukura Satoshi nakamura yasuhiro Mukaigawa The Research and Development Division OLM DigitalInc.Advanced Research GroupIMAGICA GROUPTokyo 1540023Japan Division of Information Science Graduate School of Science and TechnologyNara Institute of Science and TechnologyNara 6300192Japan Graduate School of Informatics Chiba UniversityChiba 2638522Japan

The automatic colorization of anime line drawings is a challenging problem in production *** advances in deep neural networks have addressed this problem;however,collectingmany images of colorization targets in novel anime work before the colorization process starts leads to chicken-and-egg problems and has become an obstacle to using them in production *** overcome this obstacle,we propose a new patch-based learning method for few-shot anime-style *** learning method adopts an efficient patch sampling technique with position embedding according to the characteristics of anime line *** also present a continuous learning strategy that continuously updates our colorization model using new samples colorized by human *** advantage of our method is that it can learn our colorization model from scratch or pre-trained weights using only a few pre-and post-colorized line drawings that are created by artists in their usual colorization ***,our method can be easily incorporated within existing production *** quantitatively demonstrate that our colorizationmethod outperforms state-of-the-art methods.

关键词： anime colorization few-shot learning continuous learning strategy

Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis

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World Journal of Gastroenterology 2015年第28期21卷 8723-8729页

作者： Taro Oshikiri Yoshinobu Yamamoto Ikuya Miki Masahiro Tsuda Tetsu nakamura yasuhiro Fujino Masahiro Tominaga Yoshihiro Kakeji Department of Gastroenterological Surgery Hyogo Cancer Center Department of Gastroenterological Oncology Hyogo Cancer Center Division of Gastrointestinal Surgery Department of Surgery Graduate School of MedicineKobe University

Esophagectomy with extended lymphadenectomy and gastric conduit reconstruction is a radical procedure for the treatment of esophageal cancer that is associated with a high morbidity *** conduit necrosis is a fatal complication that occurs in 2%of ***,two-stage salvage surgery consisting of removal of the necrotic gastric conduit followed by reconstruction has been performed;however,this procedure has a high morbidity *** describe a61-year-old man who underwent minimally invasive esophagectomy complicated by slowly progressive gastric conduit necrosis associated with complete neck drainage and a stable overall *** was a 2 cm gap in the *** there was no evidence of residual gastric conduit necrosis,a removable,covered self-expanding metal stent(SEMS)was inserted to bridge the *** stent was fixed to the patient's ear with silk thread through the lasso on its proximal end to prevent *** weeks after insertion,the stent was removed easily without any associated *** anastomotic defect was completely bridged with granulation tissue,showing progressive epithelialization without leakage or *** patient was discharged home in good general *** is the first report of the successful conservative management of esophago-gastric conduit anastomosis disruption with SEMS placement.

关键词： Esophagectomy Gastric conduit necrosis Disruption of anastomosis Self-expanding metal stent Hanarostent Conservative management

Endovascular pseudoaneurysm repair after distal pancreatectomy with celiac axis resection

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World Journal of Gastroenterology 2013年第45期19卷 8435-8439页

作者： Tatsuaki Sumiyoshi Yasuo Shima Yoshihiro Noda Shingo Hosoki yasuhiro Hata Takehiro Okabayashi Akihito Kozuki Toshio nakamura Department of Gastroenterological Surgery Kochi Health Sciences Center Kochi cityKochi 781-8555 Japan Department of Radiology Kochi Health Sciences Center Kochi Kochi 781-8555 Japan Department of Cardiovascular Internal Medicine Kochi Health Sciences Center Kochi Kochi 781-8555Japan

Erosive hemorrhage due to pseudoaneurysm is one of the most life-threatening complications after ***,we report an extremely rare case of rupture of a pseudoaneurysm of the common hepatic artery(CHA)stump that developed after distal pancreatectomy with en block celiac axis resection(DP-CAR),and was successfully treated through covered stent *** patient is a 66-year-old woman who underwent DP-CAR after adjuvant chemoradiotherapy for locally advanced pancreatic body *** developed an intra-abdominal abscess around the remnant pancreas head 31 d after the surgery,and computed tomography(CT)showed an occluded portal vein due to the spreading inflammation around the *** general condition improved after CT-guided drainage of the ***,19 d later,she presented with melena,and CT showed a pseudoaneurysm arising from the CHA *** the CHA had been resected during the DP-CAR,this artery could not be used as the access route for endovascular treatment,and instead,we placed a covered stent via the inferior pancreaticoduodenal artery originating from the superior mesenteric *** stent placement,cessation of bleeding and anterograde hepatic artery flow were confirmed,and the patient recovered well without any further *** angiography at the 6-mo follow-up indicated the patency of the covered stent with sustained hepatic artery *** our knowledge,this is the first reported case of endovascular repair of a pseudoaneurysm that developed after DP-CAR.

关键词： Distal pancreatectomy En block celiac axis resection Pseudoaneurysm Endovascular treatment Covered stent

Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant:Report of a case

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World Journal of Gastroenterology 2006年第33期12卷 5408-5411页

作者： Hirotoshi Okazaki Kazuhide Higuchi Masatsugu Shiba Shirou nakamura Tomoko Wada Kazuki Yamamori Ai Machida Kaori Kadouchi Akihiro Tamori Kazunari Tominaga Toshio Watanabe yasuhiro Fujiwara Kenji nakamura Tetsuo Arakawa Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan Department of Radiology Osaka City University Graduate School of Medicine Osaka Japan

We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by giant rectal varices, we thought that they were not suitable to receive endoscopic treatment. We chose the modified percutaneous transhepatic obliteration with sclerosant, which is one of the interventional radiology techniques but a new clinical procedure for rectal varices. After the patient received this therapy, her condition of rectal varices was markedly improved.

关键词： Rectal varices Modified percutaneoustranshepatic obliteration with sclerosant

Placement of percutaneous transhepatic biliary stent using a silicone drain with channels

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World Journal of Gastroenterology 2009年第33期15卷 4201-4203页

作者： Hiroshi Yoshida yasuhiro Mamada Nobuhiko Taniai Sho Mineta Yoshiaki Mizuguchi Yoichi Kawano Junpei Sasaki Yoshiharu nakamura Takayuki Aimoto Takashi Tajiri Department of Surgery Nippon Medical School

This report describes a method for percutaneous transhepatic biliary stenting with a BLAKE Silicone Drain, and discusses the usefulness of placement of the drain connected to a J-VAC Suction Reservoir for the treatment of stenotic hepaticojejunostomy. Percutaneous transhepatic biliary drainage was performed under ultrasonographic guidance in a patient with stenotic hepaticojejunostomy after hepatectomy for hepatic hilum malignancy. The technique used was as follows. After dilatation of the drainage root, an 11-FF tube with several side holes was passed through the stenosis of the hepaticojejunostomy. A 10-Fr BLAKE Silicone Drain is flexible, which precludes onestep insertion. One week after insertion of the 11-Fr tube, a 0.035-inch guidewire was inserted into the tube. After removal of the 11-Fr tube, the guidewire was put into the channel of a 10-Fr BLAKE Silicone Drain. The drain was inserted into the jejunal limb through the intrahepatic bile duct and was connected to a J-VAC Suction Reservoir. Low-pressure continued suction was applied. Patients can be discharged after insertion of the 10-Fr BLAKE Silicone Drain connected to the J-VAC Suction Reservoir. Placement of a percutaneous transhepaUc biliary stent using a 10-Fr BLAKE Silicone Drain connected to a J-VAC Suction Reservoir is useful for the treatment of stenotic hepaticojejunostomy.

关键词： Biliary tract Drainage Hepaticojejunostomy Stenosis Stents

New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide

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Bone Research 2014年第4期2卷 252-258页

作者： Sakae Tanaka Taiji Adachi Tatsuhiko Kuroda Toshitaka nakamura Masataka Shiraki Toshitsugu Sugimoto yasuhiro Takeuchi Mitsuru Saito John P Bilezikian Department of Orthopaedic Surgery Faculty of MedicineUniversity of TokyoTokyoJapan Department of Biomechanics Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan Medical Affairs Department Asahi Kasei Pharma CorporationTokyoJapan National Center for Global Health and Medicine TokyoJapan Research Institute and Practice for Involutional Diseases NaganoJapan Internal Medicine 1 Shimane University Faculty of MedicineIzumoJapan Toranomon Hospital Endocrine Center TokyoJapan Department of Orthopaedic Surgery Jikei University School of MedicineTokyoJapan Metabolic Bone Diseases Program Division of EndocrinologyDepartment of MedicineCollege of Physicians and SurgeonsColumbia UniversityNew YorkUSA

Daily 20-mg and once-weekly 56.5-mg teriparatide（parathyroid hormone 1–34） treatment regimens increase bone mineral density（BMD） and prevent fractures, but changes in bone turnover markers differ between the two regimens. The aim of the present study was to explain changes in bone turnover markers using once-weekly teriparatide with a simulation model. Temporary increases in bone formation markers and subsequent decreases were observed during once-weekly teriparatide treatment for 72 weeks. These observations support the hypothesis that repeated weekly teriparatide administration stimulates bone remodeling, replacing old bone with new bone and leading to a reduction in the active remodeling surface. A simulation model was developed based on the iterative remodeling cycle that occurs on residual old bone. An increase in bone formation and a subsequent decrease were observed in the preliminary simulation. For each fitted time point, the predicted value was compared to the absolute values of the bone formation and resorption markers and lumbar BMD. The simulation model strongly matched actual changes in bone turnover markers and BMD. This simulation model indicates increased bone formation marker levels in the early stage and a subsequent decrease. It is therefore concluded that remodeling-based bone formation persisted during the entire treatment period with once-weekly teriparatide.

关键词： bone New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide BMD