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Neuroscience Bulletin 2018年第5期34卷 849-853页

作者： yasuhide mitsumoto Atsushi Mori Laboratory of Alternative Medicine and Experimental Ther- apeutics Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University Ho-3 Kana- gawa-machi Kanazawa Ishikawa 920-1181 Japan Department of Perioperative Management System Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya Aichi 466-8550 Japan

As an environmental risk factor, psychological stress may trigger the onset or accelerate the progression of Parkinson＇s disease （PD）. Here, we evaluated the effects of acute restraint stress on striatal dopaminergic terminals and the brain metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahy- dropyridine （MPTP）, which has been widely used for creating a mouse model of PD. Exposure to 2 h of restraint stress immediately after injection of a low dose of MPTP caused a severe loss of striatal dopaminergic terminals as indicated by decreases in the dopamine transporter protein and dopamine levels compared with MPTP administration alone. Both striatal 1-methyl-4-phenylpyridinium ion （MPP＋） and MPTP concentrations were significantly increased by the application of restraint stress. Striatal monoamine oxidase-B, which catalyzes the oxidation of MPTP to MPP＋, was not changed by the restraint stress. Our results indicate that the enhanced striatal dopaminergic terminal loss in the stressed mice is associated with an increase in the transport of neurotoxin into the brain.

关键词： MPTP MPP+ Mouse model Restraint stress Dopaminergic neuron Degeneration Dopamine transporter Dopamine

Attenuation of nicotine-evoked Ca<sup>2+</sup>influx by antibody to the nicotinic acetylcholine receptor <i>α</i>3 subunits in human embryonic kidney cells

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Advances in Bioscience and Biotechnology 2013年第6期4卷 9-14页

作者： Shota Kobayashi Shigeru Yokoyama Takahiro Maruta Akiko Muroyama Hiroaki Yoshikawa yasuhide mitsumoto Department of Biophysical Genetics Kanazawa University Graduate School of Medicine Kanazawa Japan Department of Neurology and Neurobiology of Aging Kanazawa University Graduate School of Medical Science Kanazawa Japan Laboratory of Alternative Medicine and Experimental Therapeutics Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences Hokuriku University Kanazawa Japan Neurological Center Kanazawa Nishi Hospital Kanazawa Japan

Autoantibody against neuronal nicotinic acetylcholine receptor (nAChR) α3 subunit is implicated in severe autonomic dysfunction in the patients with autoimmune autonomic ganglionopathy (AAG). Although this autoantibody has been revealed to impair fast excitatory synaptic transmission in autonomic ganglia, its precise mechanism remains unknown. Here, we show that antibody-induced reduction of cell-surface α3 subunits result in impairment of nicotine-evoked Ca2+ influx in stably transfected human embryonic kidney cells. These effects of the antibody were remarkably inhibited by interfering with the endocytic machinery at low-temperature. We conclude that reduction of nAChR in autonomic ganglia can be mediated by the endocytosis of α3 subunits, and resulted in autonomic failure in AAG patients.

关键词： Nicotinic Acetylcholine Receptor α3 Subunit Antibody Endocytosis Ca2+ Influx Autoimmune Autonomic Ganglionopathy

Prostate-specific antigen-based population screening for prostatecancer： current status in Japan and future perspective in Asia

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Asian Journal of Andrology 2015年第3期17卷 475-480页

作者： yasuhide Kitagawa Mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan

In Western countries, clinical trials on prostate cancer screening demonstrated a limited benefit for patient survival. In the Asia-Pacific region, including Japan, the rate of prostate-specific antigen （PSA） testing remains very low compared with Western countries, and the benefits of population-based screening remain unclear. This review describes the current status of population screening and diagnosis for prostate cancer in Japan and discusses the efficacy of population screening for the Asian population. Since the 1990s, screening systems have been administered by each municipal government in Japan, and decreases in the prostate cancer mortality rate are expected in some regions where the exposure rate to PSA screening has increased markedly. A population-based screening cohort revealed that the proportion of metastatic disease in cancer detected by screening gradually decreased according to the increased exposure rate, and a decreasing trend in the proportion of cancer with high serum PSA levels after population screening was started. The prognosis of the prostate cancer detected by population screening was demonstrated to be more favorable than those diagnosed outside of the population screening. Recent results in screening cohorts demonstrated the efficacy of PSA. These recent evidences regarding population-based screening in Japan may contribute to establishing the optimal prostate cancer screeninK system in Asian individuals.

关键词： free prostate-specific antigen pro-prostate-specific antigen prostate cancer prostate cancer gene 3 prostate-specificantigen-based population screening serum prostate-specific antigen distribution

Evaluation of dielectric and piezoelectric behavior of unpoled and poled barium titanate polycrystals with oxygen vacancies using phase field method

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International Journal of Smart and Nano Materials 2016年第4期7卷 265-275页

作者： Fumio Narita Takuya Kobayashi yasuhide Shindo Department of Materials Processing Graduate School of EngineeringTohoku UniversityAoba-yama 6-6-02SendaiJapan

This article studies the dielectric and piezoelectric behavior of unpoled and poled barium titanate(BaTiO_(3))polycrystals with oxygen vacancies.A phase field model is employed for BaTiO_(3) polycrystals,coupled with the time-dependent Ginzburg–Landau theory and the oxygen vacancies diffusion,to demonstrate the interaction between oxygen vacancies and domain *** generate grain structures,the phase field model for grain growth is also *** hysteresis loop and butterfly curve are predicted at room and high *** permittivity,and longitudinal and transverse piezoelectric constants of the BaTiO_(3) polycrystals are then examined for various grain sizes and oxygen vacancy densities.

关键词： Mesomechanics phase field method ferroelectric ceramics piezoelectric property smart materials and structures

Effectiveness and adverse effects of hormonal therapy for prostate cancer： Japanese experience and perspective

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Asian Journal of Andrology 2012年第3期14卷 451-457,I0007,I0008页

作者： Mikio Namiki Satoru Ueno yasuhide Kitagawa Takashi Fukagai Hideyuki Akaza Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan Department of Urology Showa University School of Medicine Tokyo 142-8666 Japan Research Center for Advanced Science and Technology University of Tokyo Tokyo 153-8903 Japan

Recently, novel anti-androgens and inhibitors of androgen biosynthesis have been developed through the elucidation of mechanisms of castration resistance of prostate cancer. We believe that these new developments will improve hormonal therapy. On the other hand, there has been an increase in criticism of hormonal therapy, because hormonal therapy is supposed to induce adverse effects such as cardiovascular disease. In this review, we have introduced the Japanese experience of hormonal therapy, because we believe that there may be ethnic differences between Caucasians and Asian people in the efficacy and adverse effects of hormonal therapy. First, we showed that primary hormonal therapy can achieve long-term control of localized prostate cancer in some cases and that quality of life of patients receiving hormonal therapy is rather better than previously thought. Neoadjuvant and adjuvant hormonal therapy in cases undergoing radical prostatectomy or radiotherapy are very useful for high-risk or locally advanced prostate cancer. Further clinical trials are required to confirm the efficacy of neoadjuvant or adjuvant hormonal therapy. We showed that the death from cardiovascular dis- eases in Japanese patients receiving hormonal therapy was not higher than that in the general population. However; efforts should be made to decrease the adverse effects of hormonal therapy, because life-style change may increase the susceptibility to adverse effects by hormonal therapy even in Japan. Managements of endocrine and metabolic dysfunction, such as diabetes mellitus, are essential. New hormonal compounds such as selective androgen receptor modulators capable of specifically targeting prostate cancer are expected to be developed.

关键词： adverse effects androgen deprivation therapy hormonal therapy prostate cancer

Electromagneto-mechanical fields of giant magnetostrictive/piezoelectric laminates under concentrated load

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International Journal of Smart and Nano Materials 2012年第2期3卷 169-182页

作者： yasuhide Shindo Yuzo Kori Kotaro Mori Fumio Narita Department of Materials Processing Graduate School of EngineeringTohoku UniversityAoba-yama 6-6-02Sendai 980-8579Japan

This paper presents the nonlinear electromagneto-mechanical behavior of magnetostrictive/piezoelectric laminates under three-point bending both numerically and *** laminates are fabricated using thin Terfenol-D and PZT *** three-point bending test was conducted on the Terfenol-D/PZT laminates,and the displacement,induced magnetic field and induced voltage due to mechanical loads were ***-dimensional finite element analysis was also carried out,and the electromagneto-mechanical fields in the laminates were predicted by introducing a second-order magnetoelastic constant for *** was then made between simulation and experiment.

关键词： Magnetostrictive/piezoelectric mechanics finite element method material testing electronic laminates detection and response characteristics smart materials and structures

Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome

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World Journal of Gastroenterology 2012年第41期18卷 5986-5989页

作者： Keita Fukuyama yasuhide Ishikawa Tetsuro Ogino Hidenobu Inoue Ryoya Yamaoka Tetsuro Hirose Tomohiko Nishihira Department of Gastroenterological Surgery Takamatsu Red Cross HospitalTakamatsu 760-0017Japan Department of Pathology Takamatsu Red Cross HospitalTakamatsu 760-0017Japan

This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with *** tomography showed portomesenteric venous gas and pneumatosis *** underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial *** showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic *** microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine.

关键词： Myopathy, encephalopathy, lactic acidosis,and stroke-like episodes syndrome Acute mesentericischemia Immunohistochemistry Anti-mitochondrialantibody Pathology

Cerebral lipiodol embolism related to a vascular lake during chemoembolization in hepatocellular carcinoma:A case report and review of the literature

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World Journal of Gastroenterology 2018年第37期24卷 4291-4296页

作者： Hideki Ishimaru Minoru Morikawa Takayuki Sakugawa Ichiro Sakamoto yasuhide Motoyoshi Yohei Ikebe Masataka Uetani Department of Radiology Nagasaki University HospitalNagasaki 852-8501Japan Department of Radiology Nagasaki Harbor Medical CancerNagasaki 850-8555Japan Department of Gastroenterology Nagasaki Harbor Medical CancerNagasaki 850-8555Japan Department of Radiological Sciences Nagasaki University Graduate School of Biomedical SciencesNagasaki 852-8501Japan

A male patient underwent conventional transcatheter chemoembolization for advanced recurrent hepatocellular carcinoma(HCC). Even after the injection of 7 m L of lipiodol followed by gelatin sponge particles, the flow of feeding arteries did not slow down. A repeat angiography revealed a newly developed vascular lake draining into systemic veins; however, embolization was continued without taking noticing of the vascular lake. The patient's level of consciousness deteriorated immediately after the procedure, and non-contrast computed tomography revealed pulmonary and cerebral lipiodol embolisms. The patient's level of consciousness gradually improved after 8 wk in intensive care. In this case, a vascular lake emerged during chemoembolization and drained into systemic veins, offering a pathway carrying lipiodol to pulmonary vessels, the most likely cause of this serious complication. We should be aware that vascular lakes in HCC may drain into systemic veins and can cause intratumoral arteriovenous shunts.

关键词： Transcatheter arterial chemoembolization Arteriovenous shunt Hepatocellular carcinoma Vascular lake Cerebral embolism

Concurrent systemic AA amyloidosis can discriminate primary sclerosing cholangitis from IgG4-associated cholangitis

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World Journal of Gastroenterology 2012年第2期18卷 192-196页

作者： Takehiro Kato Atsumasa Komori Sung-Kwan Bae Kiyoshi Migita Masahiro Ito yasuhide Motoyoshi Seigo Abiru Hiromi Ishibashi Clinical Research Center National Hospital Organization Nagasaki Medical CenterKubara 2-1001-1OmuraNagasaki 856-8562Japan Department of Hepatology Nagasaki University Graduate School of Biomedical SciencesKubara 2-1001-1OmuraNagasaki 856-8562Japan

Chronic hepatobiliary inflammatory diseases are not widely acknowledged as underlying disorders of systemic AA amyloidosis,except epidemic *** them,primary sclerosing cholangitis (PSC) might initiate amyloid A protein deposition in diverse tissues,giving rise to systemic amyloidosis,due to a progressive and unresolved inflammatory process,and its possible association with inflammatory bowel ***,only one such case has been reported in the literature to *** report a 69-year-old Japanese woman with cirrhosis who was diagnosed with PSC complicated with systemic AA amyloidosis,without any evidence of other inflammatory *** a result of cholestasis in conjunction with biliary strictures and increased serum IgG4,the presence of IgG4 + plasma cells was examined systemically,resulting in unexpected documentation of Congo-red-positive amyloid deposits,but not IgG4 + plasma cells,in the liver,stomach and salivary *** serum IgG4 is the hallmark of IgG4-related disease,including IgG4-associated cholangitis,but it has also been demonstrated in certain patients with *** A deposits in multiple organs associated with an indolent clinical course that progresses over many years might have a diagnostic value in discriminating PSC from IgG4-associated cholangitis.

关键词： Primary sclerosing cholangitis IgG4-associ-ated cholangitis AA amyloidosis

The ultra-low-frequency magnetic disturbances associated with earthquakes

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Earthquake Science 2011年第6期24卷 523-534页

作者： Masashi Hayakawa yasuhide Hobara Kenji Ohta Katsumi Hattori Advanced Wireless Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofu Tokyo 182-8585Japan Research Station on Seismo Electromagnetics The University of Electro-Communications1-5-1 ChofugaokaChofu Tokyo 182-8585Japan Hayakawa Institute of Seismo Electromagnetics Co.Ltd.Incubation Center The University of Electro-Communications Chofu Tokyo182-8585Japan Information Systems Corp. Earthquake Analysis LaboratoryKita-Aoyama 2-14-42-305Minato-ku Tokyo 107-0061Japan Graduate School of Informatics and Engineering The University of Electro-CommunicationsChofu Tokyo 182-8585Japan Department of Electronic Information Chubu University1200 Matsumoto-choKasugai Aichi 487-8501Japan Faculty of Science Chiba University1-33 YayoiInage Chiba 263-8522Japan

The ultra-low-frequency （ULF） electromagnetic emission is recently recognized as one of the most promising candidates for short-term earthquake （EQ） prediction. This paper reviews previous convincing evidence on the presence of ULF emissions before three major EQs. Then, we present further statistical study on the ULF occurrence, our networks of ULF monitoring in different spatial scales in Japan and finally we present several signal processings to identify the seismogenic emissions by showing latest results for recent large EQs.

关键词： seismogenic ULF emission earthquake prediction magnetic sensor signal processing