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Investigating Neural Representation of Finger-Movement Directions Using Electroencephalography Independent Components

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Journal of Biomedical Science and Engineering 2021年第6期14卷 240-265页

作者： Mohamed Mounir Tellache Hiroyuki Kambara yasuharu koike Makoto Miyakoshi Natsue Yoshimura School of Engineering Tokyo Institute of Technology Yokohama Japan Institute of Innovative Research Tokyo Institute of Technology Yokohama Japan Swartz Center for Computational Neuroscience Institute for Neural Computation University of California San Diego CA USA ATR Brain Information Communication Research Laboratory Group Kyoto Japan Integrative Brain Imaging Center National Center of Neurology and Psychiatry Tokyo Japan PRESTO JST Saitama Japan

There are few EEG studies on finger movement directions because ocular artifacts also convey directional information, which makes it hard to separate the contribution of EEG from that of the ocular artifacts. To overcome this issue, we designed an experiment in which EEG’s temporal dynamics and spatial information are evaluated together to improve the performance of brain-computer interface (BCI) for classifying finger movement directions. Six volunteers participated in the study. We examined their EEG using decoding analyses. Independent components (ICs) that represented brain-source signals successfully classified the directions of the finger movements with higher rates than chance level. The weight analyses of the classifiers revealed that maximal performance of the classification was recorded at the latencies prior to the onset of finger movements. The weight analyses also revealed the relevant cortical areas including the right lingual, left posterior cingulate, left inferior temporal gyrus, and right precuneus, which indicated the involvement of the visuospatial processing. We concluded that combining spatial distribution and temporal dynamics of the scalp EEG may improve BCI performance.

关键词： Electroencephalography Independent Component Analysis Finger Movement Decoding Brain-Computer Interface Occipital Lobe

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Development of the nervous system in mouse liver

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World Journal of Hepatology 2022年第2期14卷 386-399页

作者： Naoto koike Tomomi Tadokoro yasuharu Ueno Satoshi Okamoto Tatsuya Kobayashi Soichiro Murata Hideki Taniguchi Department of Surgery Seirei Sakura Citizen HospitalSakura 285-8765ChibaJapan Department of Regenerative Medicine Yokohama City University Graduate School of MedicineYokohama 236-0004KanagawaJapan Division of Regenerative Medicine Center for Stem Cell Biology and Regenerative MedicineThe Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan

BACKGROUND The role of the hepatic nervous system in liver development remains *** previously created functional human micro-hepatic tissue in mice by co-culturing human hepatic endodermal cells with endothelial and mesenchymal ***,they lacked Glisson’s sheath[the portal tract(PT)].The PT consists of branches of the hepatic artery(HA),portal vein,and intrahepatic bile duct(IHBD),collectively called the portal triad,together with autonomic *** To evaluate the development of the mouse hepatic nervous network in the PT using *** Liver samples from C57BL/6J mice were harvested at different developmental time periods,from embryonic day(E)10.5 to postnatal day(P)*** sections of the surface cut through the hepatic hilus were examined using protein gene product 9.5(PGP9.5)and cytokeratin 19(CK19)antibodies,markers of nerve fibers(NFs),and biliary epithelial cells(BECs),*** numbers of NFs and IHBDs were separately counted in a PT around the hepatic hilus(center)and the peripheral area(periphery)of the liver,comparing the average values between the center and the periphery at each developmental ***-IHBD and NF-HA contacts in a PT were counted,and their relationship was *** high mobility group-box gene 9(SOX9),another BEC marker;hepatocyte nuclear factor 4α(HNF4α),a marker of hepatocytes;and Jagged-1,a Notch ligand,were also immunostained to observe the PT *** HNF4αwas expressed in the nucleus,and Jagged-1 was diffusely positive in the primitive liver at E10.5;however,the PGP9.5 and CK19 were negative in the fetal ***9-positive cells were scattered in the periportal area in the liver at *** Jagged-1 was mainly expressed in the periportal tissue,and the number of SOX9-positive cells increased at ***9-positive cells constructed the ductal plate and primitive IHBDs mainly at the center,and SOX-9-positive IHBDs partly acquired CK19 positivity at the same perio

关键词： Nervous system Liver Portal tract Hepatic artery Immunohistochemistry Tissue engineering

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Arterial-phase contrast-enhanced ultrasonography for evaluating anti-angiogenesis treatment: A pilot study

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World Journal of Gastroenterology 2011年第8期17卷 1045-1050页

作者： Keiko Yoshida Tomihiko Hirokawa Fuminori Moriyasu Masahiko Yamada yasuharu Imai Department of Gastroenterology and Hepatology Tokyo Medical University

AIM:To verify whether arterial-phase contrast-enhanced ultrasonography(CEUS) of tumor parenchymal tissue is useful for evaluation of anti-angiogenesis ***:Rabbits with liver tumor were subjected to CEUS,and images of the nodular maximal diameter in vascular phase were *** analysis was performed to plot the time intensity curve(TIC) at the tumor parenchyma,which set the diameter of the region of interest of intensity *** TIC was calculated to obtain the time to peak intensity(TPI) and the magnitude of *** were randomly assigned to a treatment group with sorafenib and a control *** weeks later,the same ultrasound examination was repeated followed by pathological testing to assess the effect of sorafenib on the liver ***:In four rabbits in the treatment group,the rate of change of tumor size was decreased comparedwith that of the control(the rate 2.3 vs 7.9,P = 0.02).The TPI of the treatment group elongated significantly(the rate 3.1 vs 1.1,P = 0.07 for SonoVue,2.0 vs 0.88,P = 0.09 for Sonazoid).The magnitude of PI showed no significant *** pathological examination,capillary diameters in the treatment group were significantly smaller than those in the control group(26.4 vs 42.8 μm,P = 0.013).CONCLUSION:Analysis of the TIC in the arterial phase of tumor tissue could evaluate the efficacy of antiangiogenesis drug treatment in liver tumor.

关键词： Liver tumor Ultrasound agent Contrast-enhanced ultrasonography Sorafenib Animal model

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Microscopic evidence for the intra-unit-cell electronic nematicity inside the pseudogap phase in YBa_(2)Cu_(4)O_(8)

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Science China(Physics,Mechanics & Astronomy) 2021年第3期64卷 99-104页

作者： Wen Wang Jun Luo ChunGuang Wang Jie Yang yasuharu Kodama Rui Zhou Guo-Qing Zheng Institute of Physics Chinese Academy of SciencesBeijing National Laboratory for Condensed Matter PhysicsBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China National Institute of Advanced Industrial Science and Technology(AlST) Tsukuba 305-8568Japan Songs han Lake Materials Laboratory Dongguan 523808China Department of Physics Okayama UniversityOkayama 700-8530Japan

Understanding the nature of the mysterious pseudogap phenomenon is one of the most important issues associated with cuprate high-T_(c) ***,we report 17O nuclear magnetic resonance(NMR) studies on two planar oxygen sites in stoichio?metric cuprate YBa_(2)Cu_(4)O_(8) to investigate the symmetry breaking inside the pseudogap *** observe that the Knight shifts of the two oxygen sites are identical at high temperatures but different below T_(nem) ~185 K,which is close to the pseudogap temperature T^(*).Our result provides a microscopic evidence for intra-unit-cell electronic *** difference in quadrupole resonance frequency between the two oxygen sites is unchanged below T_(nem),which suggests that the observed nematicity does not directly stem from the local charge density ***,a short-range charge density wave(CDW) order is observed below T=150 *** additional broadening in the 17O-NMR spectra because of this CDW order is determined to be inequivalent for the two oxygen sites,which is similar to that observed in case of *** results suggest a possible connection between nematicity,CDW order,and pseudogap.

关键词： high-temperature superconductors nuclear magnetic resonance nematic order pseudogap

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Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 337-342页

作者： Nobuhiko Kurata Yasuhiro Ogura Satoshi Ogiso yasuharu Onishi Hideya Kamei Yasuhiro Kodera Department of Transplantation and Endocrine Surgery(Surgery II) Nagoya University Graduate School of MedicineNagoyaJapan Department of Transplantation Surgery Nagoya University Hospital65 Tsurumai-choShowa-kuNagoya 466-8560Japan Department of Gastroenterological Surgery(Surgery II) Nagoya University Graduate School of MedicineNagoyaJapan

Background:Graft inflow modulation(GIM)during adult-to-adult living donor liver transplantation(LDLT)is a common strategy to avoid small-for-size syndrome,and some transplant surgeons attempt small size graft strategy with frequent GIM procedures,which are mostly performed by splenectomy,in ***,splenectomy can cause serious complications such as portal vein thrombosis and overwhelming postsplenectomy ***:Forty-eight adult-to-adult LDLT recipients were enrolled in this study and retrospectively *** applied the graft selection criteria,which routinely fulfill graft-to-recipient weight ratio≥0.8%,and consider GIM as a backup strategy for high portal venous pressure(PVP).Results:In our current strategy of LDLT,splenectomy was performed mostly due to hepatitis C and splenic arterial aneurysms,but splenectomy for GIM was intended to only one patient(2.1%).The final PVP values≤20 mmHg were achieved in all recipients,and no significant difference was observed in patient survival or postoperative clinical course based on whether splenectomy was performed or ***,6 of 18 patients with splenectomy(33.3%)developed postsplenectomy portal vein thrombosis(PVT),while none of the 30 patients without splenectomy developed PVT after *** was identified as a risk factor of PVT in this study(P<0.001).Our study revealed that a lower final PVP could be risk factor of postsplenectomy ***:Using sufficient size grafts was one of the direct solutions to control PVP,and allowed GIM to be reserved as a backup *** should be avoided as much as possible during LDLT because splenectomy was found to be a definite risk factor of *** splenectomy cases with a lower final PVP,a close follow-up is required for early detection and treatment of PVT.

关键词： Living donor liver transplantation Splenectomy Portal venous pressure Graft-to-recipient weight ratio Portal vein thrombosis

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Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines

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World Journal of Gastroenterology 2010年第19期16卷 2355-2361页

作者： Ayako Kobori Shigeki Bamba Hirotsugu Imaeda Hiromitsu Ban Tomoyuki Tsujikawa yasuharu Saito Yoshihide Fujiyama Akira Andoh Division of Gastroenterology Department of Internal Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan Division of Mucosal Immunology Graduate School of Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan

AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL- 32α was determined by Western blotting analyses. IL- 32α mRNA expression was analyzed by real-time poly-merase chain reaction. RESULTS: Acetate and propionate had no effects on IL-32α mRNA expression. Butyrate significantly enhanced IL-32α expression in all cell lines. Butyrate also up-regulated IL-1β-induced IL-32α mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL- 32α expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1β-induced IL- 32α mRNA ***: Butyrate stimulated IL-32α expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32α expression.

关键词： Cytokine Histone acetylation Inflammatory bowel disease

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Remission of primary low-grade gastric lymphomas of the mucosa-associated lymphoid tissue type in immunocompromised pediatric patients

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World Journal of Gastroenterology 2006年第16期12卷 2625-2628页

作者： yasuharu Ohno Taichirou Kosaka Izumi Muraoka Takashi Kanematsu Akira Tsuru Eiichi Kinoshita Hiroyuki Moriuchi Division of Pediatric Surgery Department of SurgeryNagasaki University Graduate School of Biomedical SciencesNagasakiJapan Department of Pediatrics Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan

We report the remission of primary gastric lymphoma of the mucosa-associated lymphoid tissue （MALT） type in two immunocompromised pediatric patients. Patient 1, a 14-year-old boy in an immunocompromised state of unknown cause, complained of repeated abdominal pain. Examinations revealed gastric MALT with local invasion and lymph node involvement. Serum anti-Helicobacter pylori （H pylon） antibody was positive. H pylori eradication was abandoned due to its adverse effects. The MALT lesion spontaneously regressed over the next 24 months without any treatment for lymphoma. Patient 2, a 6-year-old boy, underwent cord blood transplantation for the treatment of adrenoleukodystrophy. He was administered immunosuppressants for graft-versus-host disease after transplantation. Nausea and hematochezia appeared and further examinations revealed gastric MALT with H pylori gastritis. Treatment consisting of medication for the Hpylori infection alone eradicated the Hpylori and completely resolved the patient＇s MALT lesion, as well. Patients i and 2 were followed up over periods of 10 years and 3 years, respectively, without any signs of relapse. In conclusion, gastric lymphoma of the MALT type can be cured by conservative treatment even in immunocompromised pediatric patients.

关键词： Pediatric gastric lymphoma IVlucosa-associated lymphoid tissue Immunocompromised states

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Ureteral calculi secondary to a gradually migrated acupuncture needle

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Asian Journal of Urology 2021年第1期8卷 134-136页

作者： Masahiro Matsuki Atsushi Wanifuchi Ryuta Inoue Fumiyasu Takei yasuharu Kunishima Department of Urology Hokkaido Social Work Association Obihiro HospitalObihiroJapan Medical Incorporated Association Tenshunkai Tokachi Urological Clinic ObihiroJapan

We herein presented a case of calculi secondary to a migrated acupuncture needle.A 74-year-old woman with a history of acupuncture therapy for lumbago was referred to our hospital for treatment of ureteral and renal pelvic *** multi-detector computed tomography scans showed ipsilateral hydronephrosis and two calculi secondary to a migrated acupuncture ***,a percutaneous nephrolithotomy was performed to extract two calculi and fine needle fragments from the ***,residual needle fragments and calculi in the ureter were then removed by flexible transurethral lithotripsy using a holmium *** the present case,the formation of the calculi was caused by a migrated acupuncture *** and needle fragments were removed safely endoscopically because the whole calculi and needle fragments were located in the ureteral lumen.ª2021 Editorial Office of Asian Journal of *** and hosting by Elsevier *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Acupuncture needle Endoscopic approach Ureteral calculus Renal calculus Flexible transurethral lithotripsy

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Fracture mode identification of low alloy steels and cast irons by electron back-scattered diffraction misorientation analysis

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Journal of Materials Science & Technology 2017年第12期33卷 1582-1595页

作者： Shao-Shi Rui Yi-Bo Shang Wenhui Qiu Li-Sha Niu Hui-Ji Shi Shunsaku Matsumoto yasuharu Chuman Applied Mechanics Laboratory School of Aerospace EngineeringTsinghua UniversityBeijing 100084China Residential Air Conditioning Division MIDEAFoshan528311China Strength Research Department Research&Innovation CenterMitsubishi Heavy IndustriesLtd.Nagasaki 851-0392Japan

The fracture modes of low alloy steels and cast irons under tensile and fatigue conditions were identified by electron back-scattered diffraction（EBSD） misorientation analysis in this research. The curves of grain reference orientation deviation（GROD） distribution perpendicular to the fracture surface were obtained by EBSD observation, and the characteristics of each fracture mode were identified. The GROD value of the specimen fractured in tension decreases to a constant related to the elongation of corresponding specimen in the far field（farther than 5 mm away from the fracture surface）. The peak exhibits in GROD curves of two smooth specimens and a notched specimen near the fracture surface（within 5 mm away from the fracture surface）, and the formation mechanisms were discussed in detail based on the influences of specimen geometries（smooth or notched） and material toughness. The GROD value of fatigue fractured specimen is close to that at undeformed condition in the whole field, except the small area near the crack path. The loading conditions（constant stress amplitude loading or constant stress intensity factor range K loading） and the EBSD striation formation during fatigue crack propagation were also studied by EBSD observation parallel to the crack path.

关键词： Fracture mode identification Low alloy steels Cast irons Electron back-scattered diffraction (EBSD) Misorientation

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Usefulness of bispectral monitoring of conscious sedation during endoscopic mucosal dissection

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World Journal of Gastroenterology 2009年第5期15卷 595-598页

作者： Kazunori Hata Akira Andoh Kiyoyuki Hayafuji Atsuhiro Ogawa Tamio Nakahara Tomoyuki Tsujikawa Yoshihide Fujiyama yasuharu Saito Department of Medicine Shiga University of Medical Science Seta-Tukinowa Otsu 520-2192 Japan Division of Endoscopy Shiga University of Medical Science Seta-Tukinowa Otsu 520-2192 Japan

AIM: To assess the usefulness of bispectral index (BIS) monitoring in order to carry out endoscopic submucosal dissection (ESD) safely and with patients' satisfaction. METHODS: Three hundred sixty-six patients with an early-stage neoplasm of the digestive tract were enrolled. The BIS monitor (A-1050: Aspect medical systems/NIHON KOHDEN, Tokyo, Japan) was used. The appropriate sedative condition was set at 55 to 75 BIS levels (BIS value) during the endoscopic procedures. RESULTS: Among 366 cases, 13 were accompanied by adverse events during and/or after ESD. All episodes occurred in cases with BIS value between 56 and 65. Hypotension was observed in four cases, and bradycardia in six. Respiratory distress was observed in two cases with chronic pulmonary obstructive disease. All patients with adverse events were able to leave the hospital without extension of the hospitalization. CONCLUSION: BIS monitoring is useful to safely perform ESD. A BIS value of 70 to 75 is suitable for ESD.

关键词： Endoscopy Cancer Sedation Propofol CO2

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