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Comparative study on pharmacokinetics and toxicity of intravitreal and sub-Tenon injection of triamcinolone acetonide in ocular tissues

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1864-1871页

作者： Yuko Arie Hiroko Miyai Ayako Suzuki Takeshi Okabe Mitsuyo Takashima Mayumi Takata Takashi Kurasawa Masaki Ito Reijiro arakawa Yuichiro Ogura Akira Naito Sagami Research Laboratories Wakamoto Pharmaceutical Corporation Ltd.Kanagawa 2580018Japan Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoya 4678601Japan

AIM:To compare the differences in kinetics,distribution,and toxicity of triamcinolone acetonide(TA)between the injection methods,sub-Tenon and intravitreal injections in rabbit ocular ***:TA was injected into the vitreous or the sub-Tenon in *** pharmacokinetic study,rabbits were sacrificed periodically and then TA in blood and ocular tissues(retina/choroids,vitreous,and aqueous humor)were measured over 91 *** toxicological study,clinical signs,slit-lamp microscopic examination,ophthalmological test were *** eyeballs and surrounding tissues were collected and fixed with glutaraldehyde-formalin solution,and then paraffin embedded for histological ***:Higher levels of TA were distributed in the intraocular tissues when injected into the vitreous compared to the ***,TA level was remarkably lower in the rabbits which received intravitreal TA injections than those treated with sub-Tenon injection throughout the study period in *** discharge probably caused by systemic circulation of TA was observed by receiving sub-Tenon TA ***,technicassociated toxicological ocular symptoms and findings were more frequently observed in intravitreal injection than in sub-Tenon ***:There are significant differences in kinetics and distribution of TA in vitreous body,aqueous humor and plasma,between the two injection *** further study is needed to explain the species difference between human and rabbit,it is assumed that the difference in the frequency of intraocular pressure elevation and cataract formation by TA between the two injection methods are directly related to the TA concentrations in aqueous humor and vitreous body in each injection *** toxicity and technic-associated toxicity are also closely related to kinetics of TA in plasma and each injection method itself,respectively.

关键词： corticosteroid(s) pharmacokinetics injection ophthalmic drug delivery toxicity

Clinical significance of serum procalcitonin in patients with ulcerative colitis

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World Journal of Gastroenterology 2013年第45期19卷 8335-8341页

作者： Shigeo Koido Toshifumi Ohkusa Kazuki Takakura Shunichi Odahara Shintaro Tsukinaga Toyokazu Yukawa Jimi Mitobe Mikio Kajihara Kan Uchiyama Hiroshi arakawa Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of MedicineChiba 277-8567 Japan

AIM:To investigate the association of procalcitonin(PCT)with ulcerative colitis(UC)***:Serum PCT levels,C-reactive protein(CRP)levels,the erythrocyte sedimentation rate,and the white blood cell count were analyzed in 18 patients with UC and 11 healthy *** PCT levels were analyzed by an electrochemiluminescence *** assessments were based on Truelove and Witts’severity *** of serum PCT and CRP levels with UC activity was ***,we assessed serum PCT and CRP levels in patients with a Mayo endoscopic ***:Serum PCT levels in severe UC patients(n=7)(0.096±0.034 ng/mL)were significantly higher than in mild-to-moderate UC patients(n=11)(0.033±0.012 ng/mL)and healthy volunteers(n=11)(0.035±0.005 ng/mL)(P=0.0005 and P<0.0001,respectively).In addition,there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy ***,patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT(0.075±0.043 ng/mL)compared with patients with a subscore of 2 points(0.03±0.011 ng/mL)(P=0.0302).Moreover,CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 ***:Serum PCT levels were significantly correlated with UC activity.

关键词： C-reactive protein Disease activity Procalcitonin Severity Ulcerative colitis

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用CNC压机压制成形的事例

粉末冶金技术 2013年第1期31卷 69-74页

作者： Tomoaki arakawa Tadao Masuda 韩凤麟 Hitachi Powdered Metals Co .Ltd

近年来,利用液压伺服机构的粉末成形压机日益普及,现在用CNC压机可压制成形过去用粉末冶金工艺无法压制成形的最终形零件。介绍了利用CNC压机的压制成形方法,其中包括近期才大量生产的与仍在研究大量生产的特殊产品。

关键词： CNC压机多台面压制横向沟槽成形

日本中部弧后盆地中有机质成分、沉积环境和海平面变化之间的关系

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海洋地质 2008年第2期24卷 58-72页

作者： iko OMURA KOICHI HOYANAGI 刘平（译）不详中科院广州地球化学研究所研究生

沉积有机质是古沉积环境的一种潜在指示．本文研究了位于日本中部的niigata和akita弧后盆地中新世到更新世沉积岩中干酪根（有机不溶物）成分、沉积环境和海平面变化之间的关系。文中主要的分析工具是一张包含有以木-煤有机质、含孢粉... 详细信息

沉积有机质是古沉积环境的一种潜在指示．本文研究了位于日本中部的niigata和akita弧后盆地中新世到更新世沉积岩中干酪根（有机不溶物）成分、沉积环境和海平面变化之间的关系。文中主要的分析工具是一张包含有以木-煤有机质、含孢粉的草本有机质以及含蜡质的未定型有机质三个为顶点的三角图表，把不同地区、不同沉积环境中的干酪根组分投入到三角图表中，此中的沉积环境包括河流相、河口湾、前三角洲、大陆架、大陆斜坡、盆地的海底扇以及远物源的洋底沉积。结果表明，河流、河口湾沉积高含木-煤有机质和含孢粉的草本有机质，而蜡质未定型有机质较少，那是因为孢粉主要沉积在河口湾；因为三角洲分流提供了大量粗颗粒的陆源有机质，所以前三角洲沉积具有高的木-煤质有机质比例；陆架沉积的干酪根组成与大陆斜坡、海底扇沉积类似。在三角图中，干酪根具有高含木-煤有机质、含孢粉的草本有机质而较少量含蜡质的未定型有机质，那是因为孢粉主要沉积在河口湾。因为三角洲分流提供了大量的粗粒陆源有机质，所以前三角洲沉积具有高含木-煤有机质。陆架沉积的干酪根与大陆斜坡近岸扇的一样，在三角图中，干酪根具有高含木-煤有机质和含蜡质的未定型有机质，而含孢粉的草本有机质较少。这些表明陆源沉积物中存在过浊流作用，远物源的洋盆沉积中含有较高的未定型有机质（AOM）。三角图中的每一种类型反映了不同的水动力条件、离物源的距离以及陆源有机物的供应状况。三个顶点由WFA、NFA＋FA以及藻类体组成的亚三角图进一步表明了AOM的来源。陆架沉积中的NFA与远物源洋盆沉积中的WFA分别代表着陆源高等植物和海相有机质的来源。NFA中干酪根高δ^13C值（-24．6～ -27．3‰）表明了陆源植物来源，而WFA中δ^13C（-20．0～123．6‰）则表明了海相浮游生物来源。这些同位素值与次三角图中得到的结论是一致的，这可以从三角图成分的变化中得出，就像其它已经使用过的图标一样，三角图将为以后干酪根、沉积环境和海平面变化之间的关系的研究提供方便。

关键词：沉积有机质古沉积环境海平面变化弧后盆地成分日本三角洲沉积陆源有机质

Five-Layer Asymmetric Coupled Quantum Well with Giant Electrorefractive Effect

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Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance

国际纳光电子学研讨会

作者： Kunio Tada Taro arakawa Kanazawa Institute of Technology 1-3-4 AtagoMinatokuTokyo Japan Yokohama National University 79-5 TokiwadaiHodogayakuYokohamaJapan

＜正＞The electrorefractive effect in five-layer asymmetric coupled quantum wells（FACQWs）is discussed. The FACQW exhibits giant electrorefractive index change in transparent wavelength region and it is very promisin...

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World Journal of Gastroenterology 2012年第35期18卷 4811-4822页

作者： Tetsuo arakawa Toshio Watanabe Tetsuya Tanigawa Kazunari Tominaga yasuhiro Fujiwara Kenichi Morimoto Department of Gastroenterology Osaka City University Graduate School of Medicine

In this paper, we review the concept of quality of ulcer healing （QOUH） in the gastrointestinal tract and its role in the ulcer recurrence. In the past, peptic ulcer disease （PUD） has been a chronic disease with a cycle of repeated healing/remission and recurrence. The main etiological factor of PUD is Helicobacter pylori （H. pylorl~, which is also the cause of ulcer recur- rence. However, H. pylori-negative ulcers are pres- ent in 12%-20% of patients; they also recur and are on occasion intractable. QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated. Within the scars of healed ulcers, regenerated tissue is immature and with distorted architecture, suggesting poor QOUH. The abnormalities in mucosal regeneration can be the basis for ulcer recurrence. Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence. Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macro- phages, which in turn produce increased amounts of cytokines and chemokines, which attract neutrophils to the regenerated area. Neutrophils release proteolytic enzymes that destroy the tissue, resulting in ulcer re- currence. Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a defi- ciency and/or an imbalance of endogenous growth fac- tors. Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar. In addition to PUD, the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn＇s disease and ulcer- ative colitis.

关键词： Quality of ulcer healing Peptic ulcer dis-ease Recurrence Prostaglandin Cytokines Growthfactors

Shinayaka Administration System: Pull type scheduling

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Shinayaka Administration System: Pull type scheduling

Factors associated with incomplete colonoscopy at a Japanese academic hospital

The Fourth China-Japan-Korea Joint symposium on Optimization of Structural and Mechanical Systems

作者： Tomoki MITANI Masao arakawa Maruzen Industry Ayagawa KagawaJAPAN 761-2103 Dept.RISE Kagawa University TakamatsuKagawaJAPAN 761-039e

＜正＞There are some effective product administration systems that are effective especially to big companies, which can produce products for a certain amount. ERP or MRP is the successful system among them. However, these system needs a lot of background data, so that the system can treat most of every things that has gone on in the company. However, these data are not always obtained especially in the small products. Therefore, every data needs some sort of buffer for estimation error, and which cause the reduction of product ability in those companies. In the previous study, we estimated product ability by total amount of product and the number of setups, and propose product limit line by using Data Envelopment Analysis. Then, patterns of workers characteristics for products for weekday are revealed. We use this pattern to give some over time working, and propose a scheduling method by using product limit line and these characteristics base on first-in first-out method. In this study, we will propose pull type scheduling based on limit line, which is considered to be effective just like in JIT or TOC.

关键词： Administration System Product Limit Line Data Envelopment Analysis

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World Journal of Gastroenterology 2014年第22期20卷 6961-6967页

作者： Shigeo Koido Toshifumi Ohkusa Kosaburo Nakae Tetsuji Yokoyama Tomoyoshi Shibuya Naoto Sakamoto Kan Uchiyama Hiroshi arakawa Taro Osada Akihito Nagahara Sumio Watanabe Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineChiba 277-8567Japan Department of Gastroenterology Juntendo University School of MedicineTokyo 113-8421Japan Department of Technology Assessment and Biostatistics National Institute of Public HealthSaitama 351-0197Japan

AIM: To evaluate significant risk factors for incomplete colonoscopy at a Japanese academic hospital.

关键词： Colonoscopy Incomplete Intubation rates Japanese academic hospital Risk factors Inflammatory bowel disease

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中国房地产炙手可热

海外经济评论 2006年第13期 16-17页

作者： Kathleen Chu Mariko yasu

2005年，摩根士丹利在日本的房地产投资达到了80亿美元，然而，它表示今年在中国的投资将是在日本投资的三倍，逐渐将投资重点从日本转移到中国。

关键词：中国房地产房地产投资摩根士丹利投资重点