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Immunomodulatory and Antioxidativepotentials of adipose-derived Mesenchymalstem cells isolated from breast versusabdominal tissue: a comparative study

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Cell Regeneration 2020年第1期9卷 190-203页

作者： Nourhan Abu-Shahba Marwa Mahmoud Mazen Abdel-Rasheed yasmine Darwish Ahmad AbdelKhaliq Eman Mohammed Mahmoud ElHefnawi Osama Azmy Stem Cell Research Group Centre of Excellence for Medical ResearchNational Research CentreCairoEgypt Medical Molecular Genetics Department Human Genetics and Genome Research DivisionNational Research CentreCairo 12622Egypt Department of Reproductive Health Research Medical Research Division.National Research CentreCairoEgypt Plastic and Reconstructive Surgery Unit General Surgery DepartmentKasr Al Ainy School of MedicineCairo UniversityCairoEgypt Biomedical Informatics and Chemoinformatics Group Centre of Excellence for Medical ResearchInformatics and Systems DepartmentNational Research CentreCairoEgypt

Background: Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapydue to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlike the subcutaneousabdominal fat depot, breast ASCs features are still not well recognized, limiting their possible therapeutic use. ASCswere found to exert immunomodulatory and antioxidative activities for maintaining homeostasis and functionality ofdiseased/damaged tissues. This study aims to investigate the immunomodulatory and antioxidative potentials of breastversus abdominal isolated ASCs to find out which anatomical site provides ASCs with better immunoregulatory andoxidative stress resistance ***: ASCs were isolated from abdominal and breast tissues. Gene expression analysis was conducted for a panelof immunomodulatory and antioxidative genes, as well as adipokines and proliferation genes. Flow cytometric analysisof a group of immunomodulatory surface proteins was also performed. Finally, the significantly expressed genes haveundergone protein-protein interaction and functional enrichment in silico ***: Our results revealed similar morphological and phenotypic characteristics for both breast and abdominalASCs. However, a significant elevation in the expression of two potent immunosuppressive genes, IL-10 and IDO aswell as the expression of the multifaceted immunomodulatory adipokine, visfatin, was detected in breast versusabdominal ASCs. Moreover, a significant overexpression of the antioxidative genes, GPX1, SIRT5, and STAT3 and theproliferation marker, Ki67, was also observed in breast ASCs relative to abdominal ones. In silico analysis showed thatboth of the differentially upregulated immunomodulatory and antioxidative mediators integratively involved inmultiple biological processes and pathways indicating their functional ***: Breast ASCs possess superior immunomodulatory and antioxidative c

关键词： Adipose-derived stem cells(ASCs) Breast adipose tissue Abdominal adipose tissue Immunomodulatory potential Antioxidative potential

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Efficient Speech-Based Random Number Generators

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通讯和计算机（中英文版） 2011年第7期8卷 560-568页

作者： Hassan Mohamed Elkamchouchi Gehan Abouelseoud Saleh yasmine Abouelseoud Saleh Faculty of Engineering Alexandria University Alexandria 21544 Egypt

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Sleep during and following critical illness:A narrative review

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World Journal of Critical Care Medicine 2023年第3期12卷 92-115页

作者： Laurie Showler yasmine Ali Abdelhamid Jeremy Goldin Adam M Deane Intensive Care Medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia Sleep and Respiratory Medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia

Sleep is a complex process influenced by biological and environmental *** of sleep quantity and quality occur frequently in the critically ill and remain prevalent in survivors for at least 12 *** disturbances are associated with adverse outcomes across multiple organ systems but are most strongly linked to delirium and cognitive *** review will outline the predisposing and precipitating factors for sleep disturbance,categorised into patient,environmental and treatment-related *** objective and subjective methodologies used to quantify sleep during critical illness will be *** polysomnography remains the gold-standard,its use in the critical care setting still presents many *** methodologies are needed to better understand the pathophysiology,epidemiology and treatment of sleep disturbance in this *** outcome measures,including the Richards-Campbell Sleep Questionnaire,are still required for trials involving a greater number of patients and provide valuable insight into patients’experiences of disturbed ***,sleep optimisation strategies are reviewed,including intervention bundles,ambient noise and light reduction,quiet time,and the use of ear plugs and eye *** drugs to improve sleep are frequently prescribed to patients in the ICU,evidence supporting their effectiveness is lacking.

关键词： Critical illness Critical care Sleep Sleep deprivation Polysomnography Melatonin

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Investigation of the Fermentation Mode of Rice Husk for the Stabilization of Earth Plaster

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Journal of Minerals and Materials Characterization and Engineering 2024年第1期12卷 17-36页

作者： Nafissatou Savadogo yasmine Binta Traore Nathael Lankoande Philbert Nshimiyimana Adamah Messan Département de Génie Civil Ecole Supérieure d’Ingénierie de Fada (ESI-F) Université de Fada N’Gourma (UFDG) Fada N’Gourma Burkina Faso Laboratoire Eco-Matériaux et Habitats Durables (LEMHaD) Institut International d’Ingénierie de l’Eau et de l’Environnement (Institut 2iE) Ouagadougou Burkina Faso

Despite its low resistance to humidity, adobe remains the most widely used material for housing construction, particularly in developing countries. The present study aims to assess different modes of use of fermented RH and to evaluate their influence on the behavior of raw earth for application in plaster. The influences of two types of RH are evaluated: granular rice husk (RHg) and powdered RH (RHp). The clay mainly consists of clay (40%), silt (22%), and sand (38.4%), with a small proportion of gravel (0.24%). Its liquidity limit is 40% and the plasticity index is 26.5%. The mixtures were designed using earth and each of the two rice husks at the volumetric content of 10%, 15% and 20% of the total volume mixed with water 36.5%, 38.5% and 40.3% and fermented for three weeks. Each fermented mixture was added to the soil to form the paste, and 40 × 40 × 160 mm3 test speciments were made for characterization. The results generally show an improvement in the physico-mechanical properties and water resistance of the mortars containing fermented RH, with an optimal content between 10% and 15%. The powdered RH improved the performance of the mortar better than granular RH.

关键词： Earth Plaster Rice Husk Clay Fermentation Adobe

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天津市区中老年人高血压前期合并糖代谢异常的现状调查

天津市区中老年人高血压前期合并糖代谢异常的现状调查

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作者： Bouraima yasmine A.B.（娅思咪）天津医科大学

学位级别：硕士

背景：2003年,美国预防、检测、评估与治疗高血压全国联合委员会第7次报告(JNC-7)提出“高血压前期”的概念,它是指收缩压在120～139mmHg和(或)舒张压在80～89mmHg,即正常血压到确诊高血压的过渡阶段[1]。高血压前期是临床高血压和一系... 详细信息

背景：2003年,美国预防、检测、评估与治疗高血压全国联合委员会第7次报告(JNC-7)提出“高血压前期”的概念,它是指收缩压在120～139mmHg和(或)舒张压在80～89mmHg,即正常血压到确诊高血压的过渡阶段[1]。高血压前期是临床高血压和一系列与血压增高相关的心血管事件的前期,不仅人群患病率高,而且未来进展为临床高血压和发生心血管事件的危险性增大。高血压与糖尿病均为老年人常见疾病且两者常并存,糖尿病患者中有40%～50%伴有高血压,而近年研究也发现,高血压常与糖代谢异常并存。也有研究显示,高血压前期人群已经存在了糖代谢异常情况。欧洲心脏研究显示,仅检测FPG会漏诊约2/3的糖代谢异常患者。“中国心脏调查”显示,住院冠心病患者中糖代谢异常总患病率为76.9%,若不进行OGTT,仅依靠检测空腹血糖,将有87.4%的IGT患者和80.5%糖尿病患者被漏诊。目的：本研究是通过对天津市市内六区部分未确诊高血压的中老年人进行调查分析,了解高血压前期合并糖代谢异常的情况。方法：采用自然抽样方法,于2011年5月～2012年5月对天津市市内6区年龄在40～70岁之间未明确患高血压的人群进行抽样调查。分为高血压前期组和正常血压组,依据《2010中国高血压指南》规定的诊断标准：不服用降压药物下,收缩压<120mmHg和舒张压<80mmHg诊断为正常血压;收缩压120～139mmHg和(或)舒张压80～89mmHg诊断为高血压前期。分别检测受检者空腹血清血糖(FPG)及OGTT试验中2小时血清血糖(OGTT2hPG)水平。依据2006年WHO/IDF诊断标准进行诊断,糖尿病(DM)的诊断标准：空腹血糖(FPG)≥7.0mmol/L和(或)OGTT2h血糖(OGTT2hPG)≥11.1mmol/L,或既往已明确诊断糖尿病,此次血糖水平虽达不到诊断标准,但己行降糖治疗者;空腹血糖受损(IFG)为6.1≤FPG<7.0mmol/L,且OGTT2hPG<7.8mmol/L;糖耐量异常(IGT)为7.8≤OGTT2hPG<11.1mmol/L,且FPG<6.1mmol/L;IFG合并IGT:6.1≤FPG<7.0mmol/L,且7.8

关键词：高血压前期空腹血糖简易OGTT 糖代谢异常

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Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

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Translational Neurodegeneration 2022年第1期11卷 129-147页

作者： yasmine Y.Fathy Laura E.Jonkman John J.Bol Evelien Timmermans Allert J.Jonker Annemieke J.M.Rozemuller Wilma D.J.van de Berg Amsterdam UMC Department of Anatomy and NeurosciencesSection Clinical Neuroanatomy and BiobankingAmsterdam NeuroscienceVrije University AmsterdamO|2 Life Sciences buildingDe Boelelaan 11081081 HZ Amster-damNetherlands Amsterdam Neuroscience Program NeurodegenerationAmsterdamthe Netherlands Amsterdam UMC Department of Pathol-ogyAmsterdam NeuroscienceVrije University AmsterdamDe BoelelaanAmsterdamNetherlands Department of Neurology Erasmus Medical CenterPostbus 20403000 CA RotterdamNetherlands.

Background:Axons,crucial for impulse transmission and cellular trafficking,are thought to be primary targets of neurodegeneration in Parkinson’s disease(PD)and dementia with Lewy bodies(DLB).Axonal degeneration occurs early,preceeding and exceeding neuronal loss,and contributes to the spread of pathology,yet is poorly described outside the nigrostriatal *** insula,a cortical brain hub,was recently discovered to be highly vulnerable to pathology and plays a role in cognitive deficits in PD and *** aim of this study was to evaluate morphological features as well as burden of proteinopathy and axonal degeneration in the anterior insular sub-regions in PD,PD with dementia(PDD),and ***:α-Synuclein,phosphorylated(p-)tau,and amyloid-βpathology load were evaluated in the anterior insular(agranular and dysgranular)subregions of post-mortem human brains(n=27).Axonal loss was evaluated using modified Bielschowsky silver staining and quantified using *** damage was comprehensively studied using immunofluorescent multi-labelling and 3D confocal laser-scanning ***:Compared to PD and PDD,DLB showed significantly higherα-synuclein and p-tau pathology load,argyrophilic grains,and more severe axonal loss,particularly in the anterior agranular ***,the dysgranular insula showed a significantly higher load of amyloid-βpathology and its axonal density correlated with cognitive performance.p-Tau contributed most to axonal loss in the DLB group,was highest in the anterior agranular insula and significantly correlated with CDR global scores for *** and myelin showed degenerative changes including swellings,demyelination,and detachment of the axon-myelin ***:Our results highlight the selective vulnerability of the anterior insular sub-regions to various converging pathologies,leading to impaired axonal integrity in PD,PDD and DLB,disrupting their functional properties and potentially con

关键词： α-Synuclein Insular subregions Axonal length density Alzheimer’s disease pathology Neurofilament Myelin

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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i>Infection

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Journal of Biosciences and Medicines 2015年第7期3卷 31-53页

作者： Tarek El-Banna Ahmed Abd El-Aziz Nageh EL-Mahdy yasmine Samy Microbiology Department Faculty of Pharmacy Tanta University Tanta Egypt Pharmacology Department Faculty of Pharmacy Tanta University Tanta Egypt Pharmaceutical Sciences Faculty of Pharmacy Tanta University Tanta Egypt

There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies have reported that some antibiotics have efficacy in clearing resistant bacterial infections. On account of that it was interesting to evaluate the efficacy of erythromycin, chloramphenicol and/or tenoxicam in curing and/or relieving wound infection of highly resistant Escherichia coli and investigate the possible mechanisms beyond their antibacterial activity. This was achieved through evaluating highly resistant E. coli strains in vitro using agar dilution and in vivo rat models of E. coli infected wound and acute inflammation by carrageenin, where possible mechanisms were evaluated through measuring immunological mediators and histopathological examination. This study revealed that in vivo, erythromycin alone or in combination with tenoxicam significantly improved the healing of infected skin wounds with E. coli irresspective of resistancy in vitro. In addition to the improvement of immunological mediators involved in inflammatory reaction, oxidative stress and in cytokines expression as response to the bacterial infection in vivo. On the other hand chloramphenicol neither alone nor in combination with tenoxicam, achieved any significant effect. Tenoxicam didn’t show antimicrobial activity alone nor in combination with tested antibiotics in vitro, but it has shown synergestic activity in combination with tested antibiotics in vivo. Thus we concluded that immunomodulatory activity of erythromycin through anti-inflammatory and antioxidant effects was the possible mechanisms by which this antibiotic had healed infection with resistant E. coli in vivo, despite its resistancy to this antibiotic in vitro.

关键词： Efficacy Antibiotics Resistant E. coli Infection

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莱茵斯堡家族湖滨酒店

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建筑技术及设计 2005年第9期 100-103页

作者： yasmine Mahmoudieh

该项目位于德国柏林郊外一个美丽的湖畔，距市中心60公里，该酒店工程的创意理念就是设计出全世界第一间专门为残障人士服务的，具有渡假胜地气氛，而不是看起来象医院或安老院的酒店。

关键词：酒店工程湖滨家族市中心残障人柏林

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Sanitary Quality of the Meals Served in the Canteens and Vicinity of the Lagoon Mother and Child University Hospital Centre and National Hospital and University Centre Hubert Koutoukou Maga of Cotonou (Benin)

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Open Journal of Preventive Medicine 2023年第5期13卷 183-197页

作者： Moussiliou Paraïso Cyriaque Comlan Degbey yasmine Bakary Ozavino Colette Azandjeme Charles Sossa-Jerome Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin

Background: Food safety is an integral part of food security. It refers to the protection of the food supply against risks of microbial, chemical and physical origin at every stage of the food chain. The study aimed to investigate the sanitary quality of meals served in the canteens and vicinity of the Lagoon Mother and Child University Hospital Centre (CHU-MEL) and National Hospital and University Centre Hubert Koutoukou Maga (CNHU-HKM) of Cotonou. Methods: It was a cross-sectional with a data collection period from 16 March to 22 April 2021. There were 32 vendors surveyed and 40 meals sampled for microbiological examination. We collected data on the vendors’ socio-demographic characteristics, working environment, health status, knowledge and food hygiene practices. Results: About 83% of the meals contained pathogenic microorganisms. All meals had a temperature from 4°C to 60°C called the “danger zone”. The level of knowledge about food hygiene was low in 65.7% of the vendors. About 47% had poor personal and clothing hygiene, food storage and service practices. Conclusion: These results show that the meals sold in the CHU-MEL and CNHU-HKM could present a health risk for the consumer. There is a need for improvement of the sanitary quality of the meals delivered in the canteens and vicinity of these hospitals.

关键词： Sanitary Quality Meals Canteens CHU-MEL CNHU-HKM Benin

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走访法国独立珠宝设计师速记寻找巴黎的“秘密花园”

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沪港经济 2015年第4期 106-113页

作者： yasmine Hung JeryYu

你以为高级珠宝只有大品牌能够制作吗？那么你恐怕就小看了法国人天生反骨的个性了。当全球奢侈品迷都在追逐“it”单品时，大部分法国人却在追求“不同”。法国人想拥有的高级珠宝，贵也要贵得有个性，甚至要加入个人的想法，最好全球... 详细信息

你以为高级珠宝只有大品牌能够制作吗？那么你恐怕就小看了法国人天生反骨的个性了。当全球奢侈品迷都在追逐“it”单品时，大部分法国人却在追求“不同”。法国人想拥有的高级珠宝，贵也要贵得有个性，甚至要加入个人的想法，最好全球只有这么一件。所以巴黎有一群珠宝设计师为了这些“唯一”，在认真地制作高级珠宝，或者致力寻找古董珠宝。

关键词：巴黎花园秘密法国人 “it” 珠宝奢侈品设计师

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