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Role of Immunostaining in Detecting Extra-Pattern and Subtle Lymphomatous Infiltration in Bone Marrow Biopsies of NHL Patients

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Open Journal of Blood Diseases 2018年第2期8卷 27-36页

作者： Noha Bassiouny Hassan yasmin N. El Sakhawy Gehan M. Hamed Department of clinical Pathology Faculty of Medicine Ain Shams University Hospital Cairo Egypt

Introduction: Immunohistochemistry (IHC) enables the examination of a greater number of trephine biopsy levels and is helpful in determining additional scattered malignant cells. The aim of this study is to detect extra-pattern and subtle lymphomatous infiltration in bone marrow biopsies using CD20 and CD3 immunostaining. Patients and Methods: This study was conducted on 100 newly diagnosed Non Hodgkin Lymphoma (NHL) patients. Their bone marrow trephine biopsies were assessed on routine histology [Hematoxylin and Eosin (H & E)], and were further subjected to IHC using CD20 and CD3. Results: Pattern of involvement by H & E was highlighted by IHC. It showed additional interstitial pattern in 9 cases, parasinusoidal streaks in one case and highlighted a patchy pattern in another case with interstitial involvement on H & E. IHC also detected subtle infiltrations on additional 5.5% cases compared with histology alone. It helped in differentiating reactive (12 cases) and malignant lymphoid infiltration (33 cases). Conclusion: CD20 and CD3 immunostaining performed routinely on bone marrow trephine biopsies has the ability to reveal extra-pattern of infiltration and improve detection of subtle lymphoid involvement. A combined procedure identifying several distinctive features, in particular histotopography and IHC, provides a promising way of discriminating reactive from neoplastic lymphoid infiltrates in bone marrow trephine biopsies.

关键词： Immunohistochemistry (IHC) Hematoxylin and Eosin (H & E) Non-Hodgkin Lymphoma (NHL)

Identification of anticancer drugs to radiosensitise BRAF-wild-type and mutant colorectal cancer

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Cancer Biology & Medicine 2019年第2期16卷 234-246页

作者： Rebecca Carter Azadeh Cheraghchi-Bashi Adam Westhorpe Sheng Yu yasmin Shanneik Elena Seraia Djamila Ouaret Yasuhiro Inoue Catherine Koch Jenny Wilding Daniel Ebner Anderson J. Ryan Francesca M. Buffa Ricky A. Sharma NIHR University College London Hospitals Biomedical Research Centre/ UCL Cancer Institute University College London London WC1E 6DD UK NIHR Oxford Biomedical Research Centre Department of Oncology University of Oxford Oxford 0X1 2JD UK Computational Biology and Integrative Genomics University of Oxford Oxford 0X1 2JD UK NDM Research Building Nuffield Department of Medicine University of Oxford Oxford 0X1 2JD UK Weatherall Institute of Molecular Medicine John Radcliffe Hospital University of Oxford Oxford 0X1 2JD UK Mie University Graduate School of Medicine Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Edobashi 2-174 Tsu Japan Departme nt of Biology Massachusetts In stitute of Tech no logy Cambridge Massachusetts 02142 USA Target Discovery Institute National Phenotypic Screening Centre Nuffield Department of Medicine University of OxfordOxford 0X1 2JD UK CRUK & MRC Oxford Institute for Radiation Oncology University of Oxford Oxford 0X1 2JD UK

Objective: Patients with BRAF-mutant colorectal cancer(CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with known BRAF ***: We screened 298 oncological drugs with and without ionising radiation in colorectal cancer cells isogenic for BRAF. Hits from rank product analysis were validated in a 16-cell line panel of human CRC cell lines, using clonogenic survival assays and xenograft models in ***: Most consistently identified hits were drugs targeting cell growth/proliferation or DNA damage repair. The most effective class of drugs that radiosensitised wild-type and mutant cell lines was PARP inhibitors. In clonogenic survival assays, talazoparib produced a radiation enhancement ratio of 1.9 in DLD1(BRAF-wildtype) cells and 1.8 in RKO(BRAF V600 E) cells. In DLD1 xenografts, talazoparib significantly increased the inhibitory effect of radiation on tumour growth(P ≤ 0.01).Conclusions: Our method for screening large drug libraries for radiosensitisation has identified PARP inhibitors as promising radiosensitisers of colorectal cancer cells with wild-type and mutant BRAF backgrounds.

关键词： Radiosensitizer colorectal cancer PARP inhibitor radiotherapy

Inter-Observer Variability in the Interpretation of ⁶⁸Ga-PSMA PET-CT Scan according to PROMISE Criteria

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Advances in Molecular Imaging 2022年第1期12卷 1-13页

作者： Amina Nasir Muhammad Numair Younis Sadia Adnan Tahira yasmin Ismat Fatima Abubaker Shahid Pakistan Institute of Engineering and Applied Sciences (PIEAS) Islamabad Pakistan Department of Nuclear Medicine and PET Imaging Institute of Nuclear Medicine and Oncology Lahore (INMOL) Lahore Pakistan Department of Clinical Oncology Institute of Nuclear Medicine and Oncology Lahore (INMOL) Lahore Pakistan

Aims & Objectives: Aim of the study was to evaluate inter-observer variability in interpretation of Gallium-68 labeled Prostate Specific Membrane Antigen sub-type 11 (68Ga-PSMA-11) Positron Emission Tomography-Computed Tomography PET_CT scan according to Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) criteria. Method and Materials: Forty-four consecutive patients of prostate cancer were prospectively studied between the duration of January 2021 to June 2021 at Institute of Nuclear Medicine and Oncology (INMOL), Lahore. All PET-CT scans were assessed by a researcher and 3 nuclear physicians and divided into two groups, interpreted in two phases. In the first phase, each group independently evaluated the scans while in the second phase, a consensus meeting was held and all the cases with discordance were discussed. Cohen’s Kappa test was used to measure interobserver variability with the cut-off of K’s alpha Results: The study showed 41 out of 44 scans with positive PSMA findings while 03 scans were negative for any PSMA avid disease. In the first phase of image analysis, the level of agreement was slight in T stage (Kappa = 0.068, p = 0.65), moderate in the miN stage (Kappa = 0.46, p = 0.02) and substantial in miM stage (Kappa = 0.77, p ≤ 0.001) was seen. For PSMA score, overall agreement was substantial agreement (Kappa = 0.64, p Conclusion: Remarkable inter-observer agreement was seen in PROMISE criteria.

关键词： 68Ga-PSMA PET-CT PROMISE Criteria PSMA Score Inter-Observer Variability

ICU and Aerosol-Generating Procedures in COVID Patients

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Journal of Clinical and Nursing Research 2022年第4期6卷 12-16页

作者： Haitham Saeed Hadeer S Harb yasmin M Madney Mohamed EA Abdelrahim Clinical Pharmacy Department Faculty of PharmacyBeni-Suef UniversityBeni-SuefEgypt

Some of the COVID-19 patients required an intensive care unit admission,additionally an aerosol delivery is an important treatment method in this type of *** present mini-review describes the best aerosol delivery method in this type of ***,the different delivery methods of aerosol,and the best placement of the aerosol which allows the best delivery was discussed in this paper.

关键词： COVID-19 ICU Mutation Aerosol

Optimization of Quantitative Analysis of Naproxin Sodium Using UV Spectrophotometery in Different Solvent Mediums

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American Journal of Analytical Chemistry 2014年第3期5卷 211-214页

作者： Muhammad Hashim Zuberi Urooj Haroon yasmin BiBi Talat Mehmood Iffat Mehmood Department of Chemistry Federal Urdu University for Arts Science and Technology Karachi Pakistan Department of Chemistry University of Karachi Karachi Pakistan

A new rapid, simple and reproducible UV spectrophotometric method was developed and validated for the estimation of Naproxen Sodium (NpSd) in bulk and pharmaceutical formulation. The quantification of NpSd was done at 230 nm in methanol and in buffer of pH 6.8 and 9. Beer’s law was obeyed in the concentration range of 4 - 36 (r2 = 0.999) in methanol and 5 - 25 μgmL﹣1 in buffer of pH 6.8 and 9 (r2 = 0.988 and 0.997) respectively. The apparent molar absorptivity values were also calculated in all mediums. All parameters according to ICH guideline were tested and validated. The detection and quantitation limits were found to be 0.054, 0.083, 0.073 and 0.181, 0.251, 0.211 μgmL﹣1 respectively. These methods were applied directly to the analysis of the pharmaceutical tablet preparations (Anex? tablet 250 mg). The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation 3%), while being simple, cheap and less time consuming and hence can be suitably applied for the estimation of NpSd in dosage forms and dissolution studies.

关键词： Naproxen Sodium UV Spectrophotometry Pharmaceutical Analysis

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川味:辣的文化与艺术的结晶

孔子学院（中阿文对照版） 2022年第2期 20-25页

作者：赵雪 yasmin(翻译) 不详

百馐百味百盘馔,一菜一-格一品花。川菜作为中国八大菜系之一,以其种类之多样、味道之丰富而备受人们青睐。川菜具有鲜明的地方特色,口味以麻辣辛香为主,加以清鲜醇浓调和,烹饪手法别具一格,在中华美食中占据重要地位,也以其独特的“辣... 详细信息

百馐百味百盘馔,一菜一-格一品花。川菜作为中国八大菜系之一,以其种类之多样、味道之丰富而备受人们青睐。川菜具有鲜明的地方特色,口味以麻辣辛香为主,加以清鲜醇浓调和,烹饪手法别具一格,在中华美食中占据重要地位,也以其独特的“辣”而闻名中外。

关键词：川菜八大菜系文化与艺术烹饪麻辣川味口味

Effect of Garlic Paste on the Physicochemical Attributes of Cheese

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Food and Nutrition Sciences 2022年第1期13卷 6-16页

作者： Mouluda Sohany Md. Abdul Halim Most. Jesmin Akhter Sabina yasmin Fatehatun Noor Department of Food Engineering and Technology Faculty of Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Department of Food Science and Nutrition Faculty of Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Department of Food Processing and Preservation Faculty of Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh

Cheese has recently gained a lot of popularity around the world. This experiment was carried out to make cheese from skim milk with the addition of garlic paste. This study focused on the impact of garlic paste on the physicochemical properties of cheese. Cheese samples S1, S2, S3, and S4 were prepared with 0%, 1%, 3%, and 5% garlic paste, respectively, where S1 was the control sample. Compared to sample S1, the higher proportion of garlic paste incorporation resulted in higher viscosity and water holding capacity;nevertheless, lower values for syneresis were obtained. Although no significant change was observed in the pH values, samples S4 (5% garlic) and S1 (0% garlic) exhibited the highest and lowest pH, respectively. The results in this investigation revealed that garlic inclusion had a substantial impact on the physicochemical parameters of the skim milk cheese.

关键词： Skim Milk Cheese Garlic Paste Physicochemical Properties Syneresis Water Holding Capacity

The Primacy of Moringa(Moringa oleifera Lam.)in Boosting Nutrition Status and Immunity Defence Amidst the COVID-19 Catastrophe:A Perspective

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Phyton-International Journal of Experimental Botany 2022年第9期91卷 1831-1858页

作者： Hirdayesh Anuragi Rajesh Kumar Singhal Yashfa Tanveer Humaira yasmin Ambati Srijan Alka Bharati Lal Chand Sukumar Taria Kunasekaran Rajarajan Asha Ram Arun Kumar Handa Ayyanadar Arunachalam Khalid Rehman Hakeem DenizÖzbilici Ayman EL Sabagh ICAR-Central Agroforestry Research Institute Jhansi284003India ICAR-Indian Grassland and Fodder Research Institute Jhansi284003India Department of Biosciences COMSATS University Islamabad(CUI)Islamabad45550Pakistan Agricultural College Professor Jayashankar Telangana State Agricultural UniversityWarangal506006India ICAR-Central Institute for Arid Horticulture Bikaner334006India Department of Biological Sciences Faculty of ScienceKing Abdulaziz UniversityJeddah22233Saudi Arabia Princess Dr.NajlaBint Saud Al-Saud Center for Excellence Research in Biotechnology King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Public Health Daffodil International UniversityDhaka1341Bangladesh Department of General Surgery Faculty of MedicineSiirt UniversitySiirt56100Turkey Faculty of Agriculture Department of Field CropsSiirt UniversitySiirt56100Turkey Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafrelsheikh33156Egypt

A severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)led novel coronavirus disease(COVID-19)outbreak spread through China has become the biggest global public health challenge *** virus upon several mutations has led to the resurgence of more infectious and lethal variants infecting over 298 million people with more than 5.46 million deaths worldwide by the end of December,*** vaccines are available,various preventive measures particularly a high body immunity is still extremely important which determines the likelihood of disease severity and subsequent recovery in the current and future *** review acknowledges the potentiality of miraculous Moringa oleifera *** recently evolved novel coronavirus and accompanying health *** a well-proven super-food,densely packed with an abundant quantity of 92 minerals,several vitamins,46 antioxidants,and numerous bioactive compounds,thus own a massive therapeutic potential for healing all levels of nutritional deficiencies and poor immunities and cure above 300 *** acts as anti-asthmatic,anti-cancerous,anti-diabetic,anti-inflammatory,hypotensive,hepatic,renal and cardio-protective,and anti-viral in *** it may reduce the severity of COVID-19 infections and associated serious medical *** addition,self-isolation at home or the workplace has put people at increased risk of physical and mental sicknesses,which could be simply addressed by integrating this wonderful plant into everyday ***,the immune-modulatory properties and viral inhibiting nature of moringa contribute to reduced risk of COVID-19 infection and quicker recovery from its *** per the existing pieces of literature,it is a great time to harness the esteemed moringa for safeguarding people from the terrible ongoing COVID-19 situation and other future pandemics.

关键词： COVID-19 SARS-CoV-2 Moringa oleifera immune-modulatory properties pandemics

Factors Affecting Depression among Married Women Living in Urban Squatter Settlements of Karachi, Pakistan

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Open Journal of Epidemiology 2016年第1期6卷 80-87页

作者： Shireen Shehzad Bhamani Salima Farooq yasmin Parpio Rozina Karmaliani Nargis Asad Iqbal Azam Omrana Pasha School of Nursing and Midwifery Aga Khan University Karachi Pakistan Department of Psychiatry Aga Khan University Karachi Pakistan Department of Community Health Sciences Aga Khan University Karachi Pakistan

Background: Depression is one of the growing public health concerns among women worldwide. This is one of the most under-recognized and under-treated mental illnesses worldwide. Women of developing countries are inexplicably affecting with depression. Purpose: The purpose of study is to assess the prevalence and associative factors of depression among women of aged 20 to 40 years living in urban squatter settlements of Karachi, Pakistan. The identification of all the potential determinants will potentially help in formulating preventive strategies in order to decline the prevalence of depression among women and improve the wellbeing of women. Methods: An analytical cross-sectional survey was employed among women living in Reta Plot and Kala Board communities of Karachi, Pakistan. Beck Depression Inventory II (BDI-II) was used to measure depression. Systematic sampling was used to recruit 636 married women. Cox proportional hazard was run to compute prevalence ratios and their 95% confidence interval. Results: Our study estimated 33.3% of depression among study participants. The current study showed that age, possession of own vehicle, years of schooling and recent deaths in family were significantly associated with depression. Conclusion: This research was a bold step to address the issue of increasing rate of depression among Pakistani population. Our study results can convince policy makers to extend mental health support to women by improving accessibility of services. Recommendation: Our study recommends that the women of our society should be encouraged for attaining education. This study also recommends that at primary health care setting, every health professional should be trained to screen the depression. Moreover, the results of our study can also encourage policy makers to expand mental health support services for women.

关键词： Depression Prevalence Ratio Married Women