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Transcranial Doppler screening in sickle cell disease: The implications of using peak systolic criteria

World Journal of Radiology 2015年第2期7卷 52-56页

作者： Lena N Naffaa yasmeen k tandon Neville Irani Department of Radiology Akron Children’s Hospital Department of Radiology Case Western Reserve University-Metro Health Medical Center Radiology Kansas University Medical Center

AIM: To compare time average maximum mean velocity(TAMV) and peak systolic velocity(PSV) criteria of Trans Cranial Doppler(TCD) in their ability to predict abnormalities on magnetic resonance imaging(MRI)/magnetic resonance angiogram(MRA) in patients with sickle cell disease. METHODS: A retrospective evaluation was performed of the outcomes in all patients with a Transcranial Doppler examination at our institution since the implementation of the hospital picture archiving and communication system(PACS) system in January 2003 through December 2012. All ultrasound imaging exams were performed by the same technologist with a 3 MHz transducer. Inclusion criteria was based upon the Transcranial Doppler procedure code in our PACS which had an indication of sickle cell disease in the history. The patient's age and gender along with the vessel with the highest time averaged mean velocity as well as the highest peak systolic velocity was recorded for analysis. A subset of the study cohort also had subsequent MR imaging and Angiograms performed within 6 mo of the TCD examination. MRI results were categorized as having a disease related abnormality(vessel narrowing, collateral formation/moya-moya, or abnormal fluid attenuation inversion recovery signal in parenchyma indicative of prior stroke) or normal. The MRI results formed the comparison standards for TCD exams in evaluating intracranial injury. Sensitivity and specificity for the two TCD criteria(TAMV and PSV) were calculated to determine which could be a better predictor for intracranial vasculopathy /clinically occult ***: The study cohort for our institution was 110patients with a total of 291 TCD examinations. These patients had a mean age of 7.6 years with a range from 2-18 years of age. Sixty-two of the 110 patients(56%) had two or more TCD exams. Thirty-seven patients(34%) had at least one MRI following a TCD examination. Of the 291 TCD examinations, 46(16%) were conditional or abnormal by TAMV criteria

关键词： Sickle Ischemic Stroke Trans Cranial Doppler Average maximum mean velocity Peak systolic velocity Magnetic resonance imaging

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Bilateral squamosal suture synostosis: A rare form of isolated craniosynostosis in Crouzon syndrome

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World Journal of Radiology 2014年第7期6卷 507-510页

作者： yasmeen k tandon Michael Rubin Mohamed kahlifa Gaby Doumit Lena Naffaa Department of Radiology Case Western Reserve University-Metro Health Medical Center Department of Radiology Akron Children’s Hospital One Perkins Square Department of Medical Genetics Akron Children’s Hospital One Perkins Square Department of Plastic Surgery Cleveland Clinic

Craniosynostosis is a pathologic condition which is characterized by the premature fusion of cranial *** may occur alone or in association with other anomalies making up various *** syndrome is the most common craniosynostosis *** sutures fusion is most commonly involved in Crouzon *** have only been a handful of cases of squamosal suture synostosis described in the surgery literature with the few ones described in Crouzon syndrome associated with other types of *** the best of our knowledge,we are presenting the first case of isolated bilateral squamosal suture synostosis in a patient with Crouzon syndrome in a radiology journal with emphasis on its radiological appearance.

关键词： Squamosal Suture Craniosynostosis Crouzon Syndrome

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