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Advancements and Challenges in Biomarkers for Colorectal Cancer Detection:A Comprehensive Review

Proceedings of Anticancer Research 2024年第5期8卷 64-75页

作者： yasir Hameed Department of Biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

This study provides an overview of the current landscape of biomarkers for colorectal cancer(CRC)detection,focusing on genetic,proteomic,circulating microRNA(miRNA),and metabolomic *** remains a significant global health challenge,ranking among the most prevalent cancers worldwide and being a leading cause of cancer-related *** advancements in screening methods such as colonoscopy,sigmoidoscopy,and fecal occult blood tests(FOBT),the asymptomatic nature of early-stage CRC often results in late diagnoses,negatively impacting patient *** biomarkers like APC,KRAS,TP53,and microsatellite instability(MSI)play critical roles in CRC pathogenesis and *** biomarkers,detectable through polymerase chain reaction,next-generation sequencing,and other advanced techniques,guide early detection and personalized treatment *** biomarkers such as CEA,CA 19-9,and novel signatures offer insights into CRC’s physiological changes and disease status,aiding prognosis and treatment response assessments through enzyme-linked immunosorbent assay and mass *** miRNAs,including miR-21 and miR-92a,present promising non-invasive biomarkers that can be detected in blood and stool samples,reflecting CRC presence,progression,and therapeutic *** biomarkers,encompassing amino acids,lipids,and TCA cycle intermediates,provide further insights into CRC-associated metabolic alterations,which are crucial for early detection and treatment monitoring using mass spectrometry and nuclear magnetic *** these advancements,challenges such as biomarker validation,standardization,and clinical utility *** research directions include integrating multi-omics approaches and leveraging technologies like liquid biopsies and AI for enhanced biomarker discovery and clinical *** addressing these challenges and advancing research in biomarker development,CRC screening and management could pote

关键词： Colorectal cancer Biomarker Diagnosis Detection

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Mechanism of Thermally Radiative Prandtl Nanofluids and Double-Diffusive Convection in Tapered Channel on Peristaltic Flow with Viscous Dissipation and Induced Magnetic Field

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1501-1520页

作者： yasir Khan Safia Akram Maria Athar Khalid Saeed Alia Razia A.Alameer Department of Mathematics University of Hafr Al-BatinHafr Al-Batin31991Saudi Arabia MCS National University of Sciences and TechnologyIslamabadPakistan SEECS National University of Sciences and TechnologyIslamabadPakistan College of Aeronautical Engineering National University of Sciences and TechnologyIslamabadPakistan

The application of mathematical modeling to biological fluids is of utmost importance, as it has diverse applicationsin medicine. The peristaltic mechanism plays a crucial role in understanding numerous biological flows. In thispaper, we present a theoretical investigation of the double diffusion convection in the peristaltic transport of aPrandtl nanofluid through an asymmetric tapered channel under the combined action of thermal radiation andan induced magnetic field. The equations for the current flow scenario are developed, incorporating relevantassumptions, and considering the effect of viscous dissipation. The impact of thermal radiation and doublediffusion on public health is of particular interest. For instance, infrared radiation techniques have been used totreat various skin-related diseases and can also be employed as a measure of thermotherapy for some bones toenhance blood circulation, with radiation increasing blood flow by approximately 80%. To solve the governingequations, we employ a numerical method with the aid of symbolic software such as Mathematica and *** velocity, magnetic force function, pressure rise, temperature, solute (species) concentration, and nanoparticlevolume fraction profiles are analytically derived and graphically displayed. The results outcomes are compared withthe findings of limiting situations for verification.

关键词： Double diffusion convection thermal radiation induced magnetic field peristaltic flow tapered asymmetric channel viscous dissipation Prandtl nanofluid

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A Pan-Cancer Analysis of GAPDH as a Common Biomarker for Various Cancers

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Proceedings of Anticancer Research 2024年第5期8卷 105-120页

作者： yasir Hameed Department of Biotechnology Institute of BiochemistryBiotechnologyand BioinformaticsThe Islamia University of BahawalpurPakistan

Objective:To investigate the expression levels of glyceraldehyde-3-phosphate dehydrogenase(GAPDH)and explore its prognostic value across 24 different human *** investigation was conducted using comprehensive bioinformatics and in vitro approaches,incorporating multiple layers of ***:GAPDH expression and methylation levels were assessed using bioinformatics tools and validated in cell lines through RNA-seq and targeted bisulfite-seq *** potential prognostic significance of GAPDH was evaluated using the KM ***,cBioPortal was employed to investigate genetic alterations associated with this *** analysis was conducted using ***,a correlation analysis between GAPDH expression and CD8+T immune cells was performed using TIMER and ***,a gene-drug interaction network analysis was conducted using Cytoscape to examine the relationship between GAPDH and various ***:GAPDH was found to be commonly upregulated in 24 types of human cancers,with its upregulation significantly correlated with poor relapse-free survival(RFS)and overall survival(OS)in BLCA,CESC,HNSC,KIRP,LIHC,and *** suggests that GAPDH plays a significant role in the development of these *** upregulation was also associated with various clinicopathological features in patients with BLCA,CESC,HNSC,KIRP,LIHC,and *** analysis revealed GAPDH’s involvement in diverse ***,notable correlations were observed between GAPDH expression and its promoter methylation level,genetic alterations,and CD8+T immune cell ***,several regulatory drugs targeting GAPDH were identified,with the potential to modulate its expression and potentially prevent conditions such as BLCA,CESC,HNSC,KIRP,LIHC,and ***:Based on our findings,GAPDH emerges as a promising diagnostic and prognostic biomarker for BLCA,CESC,HNSC,KIRP,LIHC,and LUAD.

关键词： Cancer Expression GAPDH Biomarker

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Xinjiang Blossoming Under Rule of Law

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Beijing Review 2024年第37期67卷 20-21页

作者： yasir Habib Khan Pakistan's Institute of International Relations and Media Research

Contrary to the West's false and misleading information regarding repression of Uygur Muslims in Xinjiang Uygur Autonomous Region,Islam is blossoming with all its religious colors and traditional fashion under the *** is an eye-witness observation of a nine-member Pakistani media delegation that visited Urumqi and Yining cities from August 19 to *** delegation visited the Xinjiang Counter-Terrorism and Counter-Extremism Exhibition,Xinjiang Islamic Institute(XII),Xinjiang Art Theater Muqam Art Troupe,Xinjiang International Grand Bazaar,Shaanxi Mosque and other places.

关键词： Xinjiang delegation religious

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Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration membranes via electron beam irradiation

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani Daniel Breite Muhammad yasir Vladimir Sedlarik Andrea Prager Nadja Schönherr Bernd Abel Roger Gläser Agnes Schulze Leibniz Institute of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic Institute of Chemical Technology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyethersulphone(PES)membranes modified with urethane functional groups were prepared through an interfacial reaction using electron beam *** removal of eight endocrine disrupting chemicals(EDCs)was studied using both pristine and functionalized PES *** prepared membranes underwent characterization using several techniques,including attenuated total reflectance-Fourier transform infrared(ATR-FTIR)spectroscopy,scanning electron microscopy,contact angle analysis,and measurements of pure water ***,dynamic adsorption experiments were conducted to evaluate the adsorption mechanism of the prepared membrane toward the eight *** urethane functionalized membranes were hydrophilic(52°contact angle)and maintained a high permeate flux(26000 L/h m^(2) bar)throughout the filtration *** adsorption results demonstrated that the introduction of urethane functional groups on the membranes significantly enhanced the removal efficiency of 17β-estradiol,estriol,bisphenol A,estrone,ethinylestradiol,and *** adsorption loading of 17β-estradiol on the functionalized PES membrane was 6.7±0.7 mg/m^(2),exhibiting a 5-fold increase compared to the unmodified PES *** membranes were successfully regenerated and reused for three adsorption cycles without experiencing any loss of adsorption capacity.

关键词： Surface functionalization Electron beam irradiation Microfiltration Endocrine disrupting chemicals

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A New Discovery of Mineralization as Subseafloor Hydrothermal Replacement in the Duddar Super-Large SEDEX Lead-Zinc Deposit in Pakistan

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Journal of Earth Science 2024年第3期35卷 1075-1078页

作者： Huishan Zhang Yucai Song Jianing Sun Jun Hong yasir Shaheen Khalil Yanguang Li Haidi Zhang Zhihua Wang MNR Key Laboratory for the Study of Focused Magmatism and Giant Ore Deposits Xi’an Center of Geological SurveyChina Geological SurveyXi’an 710054China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Chengdu Center of Geological Survey China Geological SurveyChengdu 610081China China Huaye Group Co. LtdBeijing 100037China Geological Survey of Pakistan Islamabad 44000Pakistan

0 INTRODUCTION Sedimentary exhalative(SEDEX)lead-zinc deposit was traditionally considered as a result of submarine hydrothermal exhalation,including exhalative plume and brine pool models(Izanloo et al.,2022;Spinks et al.,2021;Maghfouri et al.,2020;Sangster,2020,2018;Huang et al.,2019;Rajabi et al.,2015;Goodfellow and Lydon,2007;Large et al.,2005,2001;Peng et al.,2000;Goodfellow et al.,1993;Figures 1a,1b).However,recognition of mineralization as subseafloor hydrothermal replacement in a few SEDEX deposits has challenged the traditional consideration(Magnall et al.,2023,2021,2020a,b;Hayward et al.,2021;Figure 1c).Researchers come to believe that subseafloor replacement rather than submarine exhalation is a dominant process for SEDEX mineralization,but this needs to be examined through more case studies.

关键词： submarine mineralization seafloor

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Trends in upper gastrointestinal bleeding management

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World Journal of Clinical Cases 2024年第27期12卷 6007-6010页

作者： yasir M Khayyat Department of Medicine Faculty of MedicineUmm AL-Qura UniversityMakkah 8156-24381Saudi Arabia

Upper gastrointestinal bleeding(UGIB)can be attributed to either non-variceal or variceal *** latter is more aggressive with hemodynamic instability secondary to decompensated cirrhosis and portal ***-variceal UGIB(NVUGIB)occurs due to impaired gastroprotective mechanisms attributed to several drugs such as anticoagulants and nonsteroidal anti-inflammatory *** pylori infection contributes to the development of peptic ulcer bleeding as *** presentation can be either hemodynamically stable or *** the initial assessment a scoring system including patient-related factors(current cardiac,renal,and liver diseases and hemodynamic and labo-ratory parameters)is used to determine the patient’s *** Glasgow Blatchford score has been shown to be the most useful and *** with high-risk NVUGIB require urgent assessment and upper endoscopy to achieve better short-term and long-term outcomes such as less hospitalization,blood transfusion,and surgery.

关键词： Gastric Peptic Non-steroidal anti-inflammatory drugs Anticoagulants Melena

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GINS1 as a Novel Biomarker of Survival in Colon Adenocarcinoma Patients-A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 60-67页

作者： Muhammad Umair Abid yasir Hameed Department of Plant Breeding and Genetics University of Agriculture FaisalabadFaisalabadPakistan Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study focused on elaborating the role of GINS1 expression and its regulatory mechanisms in colon adenocarcinoma (COAD). Using the UALCAN informational index, GINS1 expression assessment unveiled a critical up- regulation in malignant cells that stood out from normal controls, suggesting its contribution to COAD expansion. Further dismantling GINS1 expression across various boundaries revealed unsurprising up-regulation in different malignant development stages, racial groups, genders, and age classes in COAD patients, characteristics for its imperative role in cancer progression. Moreover, this study investigated the promoter methylation status of GINS1, uncovering a critical uniqueness between COAD samples and normal controls. Analyzing promoter methylation across various clinical boundaries uncovered powerful variations, with particular methylation patterns seen across cancer stages, race groups, genders, and age groups. Survival analysis using the Kaplan-Meier (KM) plotter tool showed a colossal connection between GINS1 expression levels and overall survival (OS) in COAD patients, with low GINS1 expression interfacing with higher OS. Additionally, mutational examination using the cBioPortal stage revealed that no critical change was found in COAD. Overall, these findings revealed the complex contribution of GINS1 in COAD pathogenesis, underlining its actual limit as a prognostic biomarker and supportive therapeutic agent in COAD management.

关键词： Colon adenocarcinoma Diagnosis Treatment

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Comprehensive Analysis of Estrogen Receptor 1 Dysregulation in Liver Hepatocellular Carcinoma: Implications for Prognosis and Therapeutic Targeting - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 51-59页

作者： Syed Hussain Raza yasir Hameed Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study investigates the expression pattern and regulatory mechanisms of estrogen receptor 1 (ESR1) in liver hepatocellular carcinoma (LIHC) through comprehensive bioinformatics analysis. Utilizing UALCAN and GEPIA2 databases, significant down-regulation of ESR1 expression is observed in LIHC samples compared to normal controls, indicating its potential role in tumor progression. Further analysis reveals consistent down-regulation across different clinical variables including patient age, gender, race, and various stages of LIHC, affirming the regulatory role of ESR1 in tumor development and progression. Additionally, promoter methylation analysis demonstrates hypermethylation of ESR1 in LIHC samples, negatively correlating with its expression. This association persists across different clinical parameters, emphasizing the inverse relationship between ESR1 methylation and expression levels. Survival analysis indicates that up- regulation of ESR1 is associated with better overall survival, suggesting its potential as a prognostic biomarker in LIHC. Furthermore, genetic mutation analysis using cBioPortal reveals a spectrum of alterations in ESR1, including amplification, missense mutation, deep deletion, splice mutation, and truncating mutation, highlighting the genetic complexity of ESR1 in LIHC. These findings collectively contribute to a deeper understanding of ESR1 dysregulation in LIHC and its clinical implications as a potential therapeutic target and prognostic marker.

关键词： Estrogen receptor 1 Liver hepatocellular carcinoma Biomarker Prognosis

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Thermal analysis and Joule-Thomson expansion of black hole exhibiting metric-affine gravity

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Chinese Physics C 2024年第1期48卷 173-183页

作者： Muhammad yasir 夏铁成 Faisal Javed G.Mustafa Department of Mathematics Shanghai UniversityShanghai 200444China Department of Physics Zhejiang Normal UniversityJinhua 321004China Zhejiang Institute of Photoelectronics and Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua 321004China New Uzbekistan University Mustaqillik Ave.54Tashkent 100007Uzbekistan

This study examines a recently hypothesized black hole,which is a perfect solution of metric-affine gravity with a positive cosmological constant,and its thermodynamic features as well as the Joule-Thomson *** develop some thermodynamical quantities,such as volume,Gibbs free energy,and heat capacity,using the entropy and Hawking *** also examine the first law of thermodynamics and thermal fluctuations,which might eliminate certain black hole *** this regard,a phase transition from unstable to stable is conceivable when the first law order corrections are *** addition,we study the efficiency of this system as a heat engine and the effect of metric-affine gravity for the physical parameters q_(e),q_(m),κ_(s),κ_(d),and κ_(sh).Further,we study the Joule-Thomson coefficient and inversion temperature,and observe the isenthalpic curves in the Ti−Pi *** metric-affine gravity,a comparison is made between a van der Waals fluid and a black hole to study their similarities and differences.

关键词： black hole in metric-affine gravity thermodynamics Joule-Thomson expansion

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