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Desi.n, Synthesi. and Characteri.ati.n of Novel Sulfonami.es Deri.ati.es as Anti.ancer Agent Targeti.g EGFR TK, and Development of New Methods of Synthesi. by Mi.rowave i.radi.ti.n

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i.ternati.nal Journal of Organi. Chemi.try 2021年第4期11卷 199-223页

作者： Souad Aki.i.Djami.a Ben Hadda yaser Bi.ar Ami. Balash Mustapha Fawaz Chehna Department Quali.y Control and Pharmaceuti.al Chemi.try Faculty of Pharmacy University of Aleppo Aleppo Syria Department Quali.y Control and Pharmaceuti.al Chemi.try Faculty of Pharmacy Ebla Private University Aleppo Syria Department of Pharmaceuti.al Chemi.try Institute of Pharmacy University of Marburg Marburg Germany

Some novel sulfonami.e-deri.ati.es were desi.ned to develop novel ki.ase i.hi.i.ors. The molecular docki.g study was performed for the desi.ned compounds agai.st epi.ermal growth factor ki.ase receptor T790M/L858R (TMLR) (PDB i.: 5EDQ) to i.enti.y new drug candi.ates for treati.g cancer. Bi.di.g free energy was calculated by Molegro vi.tual docker (MVD) to select the most promi.i.g hi.s. The correspondi.g docki.g score values i.to EGFR (TMLR) of 4b gave the best energy docki.g -147.213 Kcal/mol. And some of the desi.ned sulfonami.e deri.ati.es have been synthesi.ed by conventi.nal method i. addi.i.n to a mi.rowave-assi.ted method of synthesi.. The reacti.n of an ami.o group-contai.i.g drug;sulfamethoxazole and sulfani.ami.e wi.h carbonyl group i. benzoyl chlori.e and phthali. aci. i. basi. medi., generated a seri.s of sulfonami.e deri.ati.es. The structures of all the synthesi.ed compounds were well characteri.ed by Mass spectrometry (MS), i.frared spectroscopy (i.), 1H nuclear magnetic resonance (1H NMR), 13C nuclear magnetic resonance (13C NMR) and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, conventional and microwave-assisted method, it was shown that the microwave-assisted method gave higher yield with shorter time and higher temperature compared to conventional heating methods.

关键词： Sulfonami.e Anti.ancer EGFR TMLR 5EDQ Molegro Vi.tual Docker Sul-famethoxazole Sulfani.ami.e Mi.rowave

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mi.-362-5p在胃癌中的表达及对胃癌细胞增殖和迁移的影响

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安徽医科大学学报 2018年第12期53卷 1883-1888页

作者：魏小丽 Ahmed yaser 赵奇红王华顾康生安徽医科大学第一附属医院肿瘤内科合肥230022 安徽医科大学公共卫生学院食品与营养卫生学系合肥230032

目的探讨mi.-362-5p在胃癌组织、胃癌细胞系中的差异表达情况以及mi.-362-5p组织差异表达与临床病理参数的相关性,并分析其对胃癌细胞增殖及迁移的影响。方法TRi.ol法提取胃癌组织、癌旁组织及胃癌细胞SGC7901、AGS和胃黏膜上皮细胞GES-... 详细信息

目的探讨mi.-362-5p在胃癌组织、胃癌细胞系中的差异表达情况以及mi.-362-5p组织差异表达与临床病理参数的相关性,并分析其对胃癌细胞增殖及迁移的影响。方法TRi.ol法提取胃癌组织、癌旁组织及胃癌细胞SGC7901、AGS和胃黏膜上皮细胞GES-1的RNA后,采用茎环逆转录实时荧光定量PCR(RT-PCR)方法,分别检测mi.-362-5p在癌组织、癌旁组织及胃癌细胞和胃黏膜细胞的表达水平;通过重组慢病毒转染法构建稳定过表达、敲低mi.-362-5p的细胞系,采用MTT法、迁移实验分别检测细胞的增殖、迁移能力。结果 mi.-362-5p在胃癌组织的表达明显高于其相应的癌旁组织(P i.-362-5p在胃癌细胞系SGC7901、AGS的表达量均高于胃黏膜细胞GES-1 (P i.-362-5p在TNM分期较晚、分化程度较低、有淋巴结转移的肿瘤中的表达量要高于TNM分期较早、分化程度较高、无淋巴结转移的肿瘤。在胃癌细胞SGC7901、AGS2018-07-16接收中敲低mi.-362-5p表达后,细胞的增殖、迁移能力显著下降;在胃黏膜细胞GES-1中上调mi.-362-5p表达后,细胞的增殖、迁移能力明显增强。结论 mi.-362-5p可能在胃癌发生、发展中发挥着促癌作用。

关键词：胃癌 mi.-362-5p 慢病毒载体增殖迁移

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Agri.ultural Water Foot Pri.t and Vi.tual Water Budget i. i.an Related to the Consumpti.n of Crop Products by Conservi.g i.ri.ati.n Effi.i.ncy

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Journal of Water Resource and Protecti.n 2012年第5期4卷 318-324页

作者： Azam Arabi.Ami. Ali.adeh yaser Vahab Rajaee Kazem Jam Naser Ni.ni. Ferdowsi.Uni.ersi.y of Mashhad Mashhad Iran Regi.nal Water Authori.y Company of Razavi.Khorasan Mashhad Iran Water Engi.eeri.g Department Azad University of Ferdows Iran Water Engi.eeri.g Department Shiraz University Shiraz Iran

i. thi. study we esti.ate agri.ultural water footpri.t and i.s components from consumpti.n perspecti.e i. ari. and semi.ari. regi.n li.e i.an. Thi. study i. based on blue water consumpti.n i. i.ri.ated land. i.an has i.ported net vi.tual water about 11.64 bi.li.n cubi. meters (bcm) as i.ternati.nal crop trade i. 2005-2006. Therefore, i.an has depended on vi.tual water i.ports. By conservi.g about 60% i.ri.ati.n effi.i.ncy, the total water requi.ement to produce i.ported crops i. i.an i. nearly 20.78 bi.li.n cubi. meters. i. i. nearly 9 percent of renewable water resources and 12.65% agri.ultural appropri.ted water whi.h has added to i.ternal water resources. Agri.ultural vi.tual water budget i. about 112.78 Gm3/yr. Agri.ultural water footpri.t i. 110.2 Gm3/yr. About 12.83% of agri.ultural water footpri.t of i.an i. related to external water resources on the country boundari.s. i. means external water footpri.t. Water dependency, water self-suffi.i.ncy and water scarci.y i.dexes i. agri.ultural sector of i.an, are esti.ated 10.1%, 89.9% and 70.8%, respecti.ely.

关键词： Water Footpri.t Vi.tual Water Trade Blue Water Resource Water Budget

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Evaluati.n of Di.gnosti. Effi.acy of Di.i.al Subtracti.n Radi.graphy i. the Di.gnosi. of Si.ulated External Root Resorpti.n: An <i.gt;i. Vi.ro</i.gt;Study

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Health 2015年第4期7卷 439-448页

作者： Nasi. Mokhtari.Goorabjavari.Ahmadreza Talaei.our Fatemeh Ezoddi.i.Ardakani.yaser Safi.Nafi.eh Shamloo Department of Oral and Maxi.lofaci.l Radi.logy Faculty of Dentistry Hormozgan University of Medical Sciences Bandar Abbas Iran Department of Oral and Maxi.lofaci.l Radi.logy Faculty of Dentistry Azad University Tehran Iran Department of Oral and Maxi.lofaci.l Radi.logy Faculty of Dentistry Shahid Sadoughi University of Medical Sciences Yazd Iran Department of Oral and Maxi.lofaci.l Radi.logy Faculty of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran Department of Oral Pathology Faculty of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran

External root resorpti.n can i.duce the degenerati.n of dental cementum and denti.e and may extend towards the pulp reducti.e. Di.i.al subtracti.n radi.graphy can functi.n as a useful tool i. di.gnosi.g degenerati.e cari.us lesi.ns. Thi. study i.vesti.ated the di.gnosti. value of di.i.al subtracti.n radi.graphy i. detecti.g external root resorpti.n. Thi. was a descri.ti.e study conducted usi.g the lab tri.l method. Arti.i.i.lly-i.duced external root resorpti.n was created i. di.ferent si.es at the coronal and api.al aspects of 20 premolar teeth. Di.i.al radi.graphs were obtai.ed of each tooth under standard condi.i.ns and these radi.graphs were subtracted by i.agi.g devi.es. The subtracted i.ages and the di.i.al radi.graphs were observed by three radi.logi.ts. Chi.square, Kappa test, and Z-test were used to analyze the data. The mean of general sensi.i.i.y of di.i.al subtracti.n radi.graphy and di.ect di.i.al radi.graphy was low i. di.gnosi.g 0.05 mm lesi.ns (Sen = 35%), yet, the accuracy i.dex was good for all lesi.ns (Acc ≥ 65%). Other di.gnosti. parameters were also acceptable. Both types of radi.graphy worked better i. di.gnosi.g coronal than api.al lesi.ns (P > 0.05). The i.terpreters (observers) showed a better performance i. di.gnosi.g external root resorpti.n usi.g di.i.al subtracti.n radi.graphy compared to di.i.al radi.graphy. Both modali.i.s were exact and accurate i. detecti.g 0.05 mm lesi.ns as well as other lesi.ns. However, the results of di.i.al subtracti.n radi.graphy were not si.ni.i.antly di.ferent from those of di.ect di.i.al radi.graphy.

关键词： Subtracti.n Radi.graphy Radi.graphy Di.ect Di.i.al Radi.graphy External Root Resorpti.n

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Open Journal of Rheumatology and Autoi.mune Di.eases 2021年第1期11卷 19-27页

作者： Mohammad Al Mousa Fahad Al Muhanna Ahmad Al Shami.yaser M. Ali Department of Medi.i.e Mubarak Al Kabeer Hospital Kuwait City Kuwait

i.G4 related di.ease i. a relati.ely recently recogni.ed systemi. enti.y, that has been observed i. nearly every organ system, wi.h si.i.ar hi.topathologi.al features across all i.enti.i.d organs. i.G4 i. an anti.ody... 详细信息

i. style="text-ali.n:justi.y;"> IgG4 related disease is a relatively recently recognized systemic entity, that has been observed in nearly every organ system, with similar histopathological features across all identified organs. IgG4 is an antibody molecule accounting for less than 5% of the total IgG count in a healthy person. The molecule is implicated in numerous autoimmune diseases;however its role in IgG4 related disease, whether primary or secondary, remains unknown. The gold standard in the diagnosis of this condition is demonstration of organ involvement from biopsy specimens. In this case report, the patient had exhibited symptoms related mainly to the gastrointestinal tract for 12 years prior to his diagnosis of IgG4 related disease. After this patient’s diagnosis of IgG4 related disease, he was commenced on Rituximab, a monoclonal antibody, which was successful in subsiding his symptoms and he has remained symptom free for the past two years of follow up since commencing treatment and hadn’t developed any complications of the disease nor any complications related to treatment. IgG4 related disease is a systemic autoimmune disease that involves multiple organs 60% - 90% of the time, therefore clinicians should be aware that IgG4 related disease can mimic some autoimmune rheumatic diseases and place it as a differential diagnosis when multi-organ disease with systemic features is involved. i.>

关键词： i.G4 Related Di.ease Autoi.mune Di.ease Ri.uxi.ab

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A Prospecti.e Study of the Effect of Di.ferent Palli.ti.e Radi.therapy Fracti.nati.n Schedules on Tumor Response and Toxi.i.y i. Advanced Non-Small Cell Lung Cancer (NSCLC) Pati.nts

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Journal of Cancer Therapy 2016年第12期7卷 924-938页

作者： Mohamed Lotayef yaser Abd Elkader Amr Ami. Azza Taher Ehab El-Kest Momen Abdelall Radi.ti.n Oncology and Nuclear Medi.i.e Department National Cancer Institute Cairo University Giza Egypt Cli.i.al Oncology Department Faculty of Medicine Cairo University Giza Egypt

Background: The opti.al dose of palli.ti.e radi.therapy (RT) i. symptomati. advanced lung cancer i. unclear. Pati.nts and methods: Pati.nts wi.h advanced NSCLC who were i.di.ated for thoraci. palli.ti.e RT wi.h age up to 65 y and Performance Status (PS) 0 - 2 and no si.ni.i.ant cardi.c or lung co-morbi.i.i.s were randomi.ed i.to two fracti.nati.n arms: arm A: 30 Gy/10 over 2 weeks and arm B: 27 Gy/6 over 3 weeks (2 fracti.ns per week) usi.g 2 anteri.r posteri.r (AP-PA) fi.lds i. both arms. Pri.ary end poi.ts were symptomati. and radi.logi.al tumor response, respi.atory functi.ns assessment. Secondary end poi.t was toxi.i.y. Results: From December 2014 to October 2015, 40 pati.nts were randomi.ed, 20 pati.nts i. each arm. There was stati.ti.ally i.si.ni.i.ant hi.her symptomati. i.provement i. arm B. Four weeks after treatment, 12 out of 40 pati.nts (30%), 6 pati.nts i. each arm, had radi.logi.al Parti.l Response (PR) of the pri.ary thoraci. lesi.n wi.hout si.ni.i.ant di.ference between the two arms. There was a tendency for i.provement i. the post treatment mean Forced Vi.al Capaci.y (FVC) and Forced Expi.atory Volume i. one second (FEV1) i. each arm wi.hout stati.ti.al si.ni.i.ance. There were no reported ski. reacti.ns or esophagi.i. i. both arms up to 4 weeks after treatment. Eleven out of the 40 pati.nts (27.5%), 6 i. arm B and 5 i. arm A, had radi.logi.al si.ns of radi.ti.n pneumoni.i. wi.hout si.ni.i.ant di.ference between both arms. Conclusi.n: The two RT fracti.nati.n schedules showed equal effi.acy i. terms of symptoms reli.f, radi.logi.al response of the pri.ary thoraci. tumor, respi.atory functi.ns and toxi.i.y. Thus the 27 Gy/6 fracti.nati.n arm appears preferable compared to 30 Gy/10 arm to mi.i.i.e the pati.nts’ vi.i.s and load on the machi.es.

关键词： Non-Small Cell Lung Cancer Palli.ti.e Thoraci. Radi.ti.n Fracti.nati.n Schedules Symptoms Randomi.ed Tri.l

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不透X线标记物法在评价结肠传输功能中的作用

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胃肠病学 2011年第6期16卷 337-340页

作者： yaser ALDUAi. 孔浩谢小平杜凡刘诗侯晓华华中科技大学同济医学院附属协和医院消化内科 430022

背景:功能性便秘(FC)常以结肠运动功能障碍为主要表现,结肠传输时间(CTT)是反映结肠运动功能的重要指标。目的:探讨不透X线标记物法在评价结肠传输功能以及诊断FC中的作用。方法:采用不透X线标记物法测定32名健康对照者的全结肠传输时间... 详细信息

背景:功能性便秘(FC)常以结肠运动功能障碍为主要表现,结肠传输时间(CTT)是反映结肠运动功能的重要指标。目的:探讨不透X线标记物法在评价结肠传输功能以及诊断FC中的作用。方法:采用不透X线标记物法测定32名健康对照者的全结肠传输时间(TCCT)、右半结肠传输时间(RCTT)、左半结肠传输时间(LCTT)和直肠乙状结肠传输时间(RSCTT),同时检测26例FC患者和32名健康对照者不同时间点钡条排出率。结果:健康对照者TCTT、RCTT、LCTT和RSCTT分别为(20.31±11.00)h、(4.43±4.58)h、(8.44±4.01)h和(7.48±7.89)h,男女之间相比差异无统计学意义(P>0.05)。FC组不同时间点钡条排出率均显著低于健康对照组(P20%为标准,26例FC患者中有19例可判断为结肠传输减慢。结论:不透X线标记物法简单易行、易于广泛开展,可准确有效地评价结肠传输功能,并在FC病因诊断中起有重要作用。

关键词：功能性便秘不透X线标记物胃肠通过试验诊断

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Ti.e of surgery and surgeon level i. supracondylar humerus fractures i. pedi.tri. pati.nts:A retrospecti.e study

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World Journal of Orthopedi.s 2023年第11期14卷 791-799页

作者： i.rahi. A Albrahi. Ammar K AlOmran Dalal A Bubshai. yaser Tawfeeq Arwa Alumran Jaffar Alsayi.h Ammar Abusultan Abdulraheem Altali. Zai. A Alzai. Shayma S Alsubai. Mohammad M Alzahrani Department of Orthopedi. College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 34212Saudi Arabia Health i.formati.n Management and Technology College of Public HealthImam Abdulrahman Bin Faisal UniversityDammam 34212Saudi Arabia

BACKGROUND Supracondylar humerus fractures account for more than 60%of all elbow fractures and about 1/5 of all pedi.tri. ***,these fractures can be associ.ted wi.h ri.k of compli.ati.ns i.cludi.g neurovascular i.juri.s,maluni.ns and li.b *** exi.ts regardi.g the effect of ti.e of surgi.al i.terventi.n and/or level of surgeon performi.g the surgery on outcome of these *** To determi.e whether ti.e of surgi.al i.terventi.n and/or surgeon level i.fluence the outcomes of surgi.ally managed pedi.tri. supracondylar humerus *** We retrospecti.ely studi.d 155 pedi.tri. pati.nts presenti.g wi.h a supracondylar humerus fracture i. a level 1 trauma center from January 2006 to December *** data extracted i.cluded demographi. data,fracture characteri.ti.s,surgi.al data,and follow-up *** collected data was analyzed and P values ofi.ered stati.ti.ally *** Of the cohort,11%of pati.nts had documented post-operati.e compli.ati.ns,of whi.h the majori.y occurred i. surgeri.s performed after day ti.e worki.g hours and i. fractures requi.i.g open *** the lowest compli.ati.n rate was found i. surgeri.s performed by pedi.tri. orthopaedi. surgeons,thi. di. not reach stati.ti.al *** i. pedi.tri. pati.nts undergoi.g surgery for supracondylar fractures,we found a hi.her compli.ati.n rate when surgeri.s were not performed duri.g worki.g *** level and trai.i.g had no si.ni.i.ant effect on the ri.k of post-operati.e compli.ati.ns.

关键词： Supracondylar humerus Fracture Ti.e of surgery Level Compli.ati.ns

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Synthesi. and Determi.ati.n of Stabi.i.y Constants of a New Bi.-1,2,4-tri.zole Li.and for Complexati.n wi.h Zi.c(i.), Copper(i.) and Ni.kel(i.) i. Acetoni.ri.e

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Ameri.an Journal of Analyti.al Chemi.try 2012年第6期3卷 437-442页

作者： Reza Emamali.Sabzi.Abbas Ni.oo yaser Ni.zad Morteza Bahram Kari. Akbari.Naser Samadi Department of Chemi.try Faculty of Science Urmia University Urmia Iran

i. thi. work, the synthesi. and complexati.n properti.s of a new compound, 1,3-bi.[5-(2-hydroxyphenyl)-4-phenyl- 1,2,4-tri.zole-3-yl-thi.]propane (BTP), towards certai. transi.i.n metal i.ns, (M(i.) where M = Zn, Cu, Ni. i. acetoni.ri.e i. reported. A hard-modeli.g strategy was appli.d to UV-Vi.i.le spectroscopy data obtai.ed from moni.ori.g the reacti.n between BTP and the selected metal i.ns to determi.e the concentrati.n profi.es of each speci.s and the correspondi.g stabi.i.y constant(s) of the complex(es). The stabi.i.y constants of complexes are always defi.ed i. terms of thei. free metal, free li.and and complexed forms. These constants are i.fluenced by parameters such as the type of metal, li.and, counteri.n or solvent. i. thi. study, the formati.n constants of the complexes were determi.ed for the synthesi.ed li.and wi.h several metalli. cati.ns i. acetoni.ri.e solvent by UV-Vi. spectrophotometry.

关键词： Zn(i.) Cu(i.) and Ni.i.) Complexes Tri.zole Li.and Spectrophotometry

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Structure and Properti.s of Sn-9Zn Lead-Free Solder Alloy wi.h Heat Treatment

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Engi.eeri.g（科研） 2010年第3期2卷 172-178页

作者： Mahmoud Hammam Fardos Saad Allah El Sai. Gouda yaser El Gendy Heba Abdel Azi. 不详

The Sn-9Zn lead-free solder alloy was prepared by conventi.nal casti.g techni.ue then cold-rolled i.to long sheets of 1 mm thi.kness and 3 mm wi.th. i. was annealed at 80, 120 and 160°C for 60 mi. to i.vesti.ate the effect of i.ochronal heat treatment on structure and mechani.al properti.s of the cold rolled Sn-9Zn alloy. The results showed that, the crystalli.e si.e and latti.e strai. have opposi.e behavi.r wi.h i.creasi.g anneali.g temperature due to recovery and recrystali.ati.n processes associ.ted wi.h the heat treatment process. Vi.kers mi.ro-hardness number i.creases conti.uously from 155 to 180 MPa wi.h i.creasi.g anneali.g temperature. Ulti.ate tensi.e strength (UTS) was also calculated. i. was found that, i. i. equal to 61.4 MPa for the non annealed sample and sli.htly decreases to 60.5 and 58.2 MPa for samples annealed at 80 and 120°C, respecti.ely. Whi.e, i.creases to 65.4 MPa for the sample annealed at 160°C. Also, ducti.i.y i.creases wi.h i.creasi.g anneali.g temperature i. opposi.e manor wi.h the UTS. The new method for Mi.ro-creep behavi.r as well as the creep rate calculated by thi. method has been characteri.ed at room temperature.

关键词： Cold Rolli.g Anneali.g Lead-Free Solder Alloy Mi.ro-Creep Mi.ro-Hardness

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