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FGF-2 is required to prevent astrogliosis in the facial nucleus after facial nerve injury and mechanical stimulation of denervated vibrissal muscles

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The Journal of Biomedical Research 2016年第2期30卷 142-148页

作者： Arzu Hizay Mark Seitz Maria Grosheva Nektarios Sinis yasemin kaya Habib Bendella Levent Sarikcioglu Sarah A.Dunlop Doychin N.Angelov Department of Anatomy Akdeniz UniversityFaculty of Medicine Department of Anatomy I University of Cologne Department of Oto-Rhino-Laryngology University Hospital Cologne Depeartment of Plastic- Hand-and Reconstructive Microsurgery Department of Neurosurgery Hospital MerheimUniversity of Witten-Herdecke Experimental and Regenerative Neurosciences School of Animal BiologyUniversity of Western Australia(M092) 35 Stirling Highway

Recently,we have shown that manual stimulation of paralyzed vibrissal muscles after facial-facial anastomosis reduced the poly-innervation of neuromuscular junctions and restored vibrissal *** gene knock outs,we found a differential dependence of manual stimulation effects on growth ***,insulin-like growth factor-1 and brain-derived neurotrophic factor are required to underpin manual stimulation-mediated improvements,whereas FGF-2 is *** lack of dependence on FGF-2 in mediating these peripheral effects prompted us to look centrally,*** the facial nucleus where increased astrogliosis after facial-facial anastomosis follows ＂synaptic stripping＂.We measured the intensity of Cy3-fluorescence after immunostaining for glial fibrillary acidic protein（GFAP） as an indirect indicator of synaptic coverage of axotomized neurons in the facial nucleus of mice lacking FGF-2（FGF-2^（-/-） mice）.There was no difference in GFAP-Cy3-fluorescence（pixel number,gray value range17-103） between intact wildtype mice（2.12± 0.37×10~7） and their intact FGF-2^（-/-） counterparts（2.12±0.27×10~7） nor after facial-facial anastomosis ＋handling（wildtype：4.06±0.32×10~7;FGF-2^（-/-）：4.39±0.17×10~7）.However,after facial-facial anastomosis,GFAP-Cy3-fluorescence remained elevated in FGF-2^（-/-）-animals（4.54±0.12×10~7）,whereas manual otimulation reduced the intensity of GFAP-immunofluorescence in wild type mice to values that were not significantly different from intact mice（2.63±0.39×10）.We conclude that FGF-2 is not required to underpin the beneficial effects of manual stimulation at the neuro-muscular junction,but it is required to minimize astrogliosis in the brainstem and,by implication,restore synaptic coverage of recovering facial motoneurons.

关键词： FGF-2 facial nerve axotomy astrogliosis whisking function polyinnervation

On the Voltage and Frequency Distribution of Dielectric Properties and ac Electrical Conductivity in Al/SiO_(2)/p-Si (MOS) Capacitors

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Chinese Physics Letters 2013年第1期30卷 165-168页

作者： Ahmet kaya Şemsettin Altındal yaseminŞafak Asar Zekayi Sönmez Department of Physics Faculty of SciencesGazi University06500AnkaraTurkey

An Al/SiO_(2)/p-Si(MOS)capacitor with a thick(826Å)interfacial oxide layer(SiO_(2))which is formed by using the thermal oxidation method is fabricated to investigate both frequency and applied bias voltage dependences of real and imaginary parts of dielectric constant(ϵ'andϵ")and electric modulus(M'and M"),loss tangent(tanδ)and ac electrical conductivity(σ_(ac))in a wide frequency range from 1 kHz to 1 MHz at room *** dielectric properties of the MOS capacitor are obtained using the forward and reverse bias capacitance-voltage(C–V)and conductance-voltage(G/ω–V)measurements in the applied bias voltage range 1.4–5.6 *** values ofϵ',ϵ",tanδ,M',M"and σ_(ac) are found to be strong functions of frequency and applied bias voltage in the depletion region due to excess capacitance Cex and conductance G_(ex)/ω especially at low *** experimental results show that the interfacial polarization can occur at low frequencies more easily,consequently contributing to the dispersion inϵ',ϵ",tanδ,M',M"and σ_(ac) values of the MOS *** other reason for dispersion in the dielectric properties may be attributed to a particular density distribution of interface states(Nss)localized at the Si/SiO_(2) interface,as well as space charge carriers and inhomogeneity of interfacial oxide *** increase in conductivity with increasing frequency can be attributed to the hopping type conduction *** can be concluded that theϵ',ϵ",tanδ,M',M"and σ_(ac) values of the Al/SiO_(2)/p-Si(MOS)capacitor are strongly dependent on both the frequency and applied bias voltage especially in the depletion region.

关键词： polarization dielectric interfacial

Gaussian Kernel Based SVR Model for Short-Term Photovoltaic MPP Power Prediction

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Computer Systems Science & Engineering 2022年第4期41卷 141-156页

作者： yasemin Onal Department of Electrical and Electronics Engineering Bilecik Seyh Edebali UniversityBilecik11000Turkey

Predicting the power obtained at the output of the photovoltaic(PV)system is fundamental for the optimum use of the PV ***,it varies at different times of the day depending on intermittent and nonlinear environmen-tal conditions including solar irradiation,temperature and the wind speed,Short-term power prediction is vital in PV systems to reconcile generation and demand in terms of the cost and capacity of the *** this study,a Gaussian kernel based Support Vector Regression(SVR)prediction model using multiple input variables is proposed for estimating the maximum power obtained from using per-turb observation method in the different irradiation and the different temperatures for a short-term in the DC-DC boost converter at the PV *** performance of the kernel-based prediction model depends on the availability of a suitable ker-nel function that matches the learning objective,since an unsuitable kernel func-tion or hyper parameter tuning results in signiﬁcantly poor *** this study for theﬁrst time in the literature both maximum power is obtained at max-imum power point and short-term maximum power estimation is *** evaluating the performance of the suggested model,the PV power data simulated at variable irradiations and variable temperatures for one day in the PV system simulated in MATLAB were *** maximum power obtained from the simu-lated system at maximum irradiance was 852.6 *** accuracy and the perfor-mance evaluation of suggested forecasting model were identiﬁed utilizing the computing error statistics such as root mean square error(RMSE)and mean square error(MSE)*** and RMSE rates which obtained were 4.5566*10-04 and 0.0213 using ANN *** and RMSE rates which obtained were 13.0000*10-04 and 0.0362 using SWD-FFNN *** SVR model,1.1548*10-05 MSE and 0.0034 RMSE rates were *** the short-term maximum power prediction,SVR gave higher prediction performance according to ANN and SWD-FFNN.

关键词： Short term power prediction Gaussian kernel support vector regression photovoltaic system

Removal of heavy metals from aqueous solution by sawdust adsorption

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Journal of Environmental Sciences 2007年第2期19卷 160-166页

作者： BULUT yasemin TEZ Zeki Faculty of Arts and Sciences Department of Chemistry University of Dicle21280 DiyarbakirTurkey. Faculty of Techniqual Education Department of Textile Marmara UniversityGztepeIstanbulTurkey

The adsorption of lead, cadmium and nicel from aqueous solution by sawdust of walnut was investigated. The effect of contact time, initial metal ion concentration and temperature on metal ions removal has been studied. The equilibrium time was found to be of the order of 60 min. Kinetics fit pseudo first-order, second-order and intraparticle diffusion models, hence adsorption rate constants were calculated. The adsorption data of metal ions at temperatures of 25, 45 and 60~C have been described by the Freundlich and Langmuir isotherm models. The thermodynamic parameters such as energy, entropy and enthalpy changes for the adsorption of heavy metal ions have also been computed and discussed. Ion exchange is probably one of the major adsorption mechanisms for binding divalent metal ions to the walnut sawdust. The selectivity order of the adsorbent is Pb（I1）~Cd（II）〉Ni（I1）. From these results, it can be concluded that the sawdust of walnut could be a good adsorbent for the metal ions from aqueous solutions.

关键词： adsorption heavy metals sawdust kinetic thermodynamic parameters

Performance of Lung Cancer Prediction Methods Using Different Classification Algorithms

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Computers, Materials & Continua 2021年第5期67卷 2015-2028页

作者： yasemin Gültepe Department of Computer Engineering Engineering and Architecture FacultyKastamonu UniversityKastamonu37200Turkey

In 2018,1.76 million people worldwide died of lung *** of these deaths are due to late diagnosis,and early-stage diagnosis significantly increases the likelihood of a successful treatment for lung *** learning is a branch of artificial intelligence that allows computers to quickly identify patterns within complex and large datasets by learning from existing ***-learning techniques have been improving rapidly and are increasingly used by medical professionals for the successful classification and diagnosis of early-stage *** are widely used in cancer *** particular,machine learning has been used in the diagnosis of lung cancer due to the benefits it offers doctors and *** this context,we performed a study on machine-learning techniques to increase the classification accuracy of lung cancer with 32×56 sized numerical data from the Machine Learning Repository web site of the University of California,*** this study,the precision of the classification model was increased by the effective employment of pre-processing methods instead of direct use of classification *** datasets were derived with pre-processing methods and six machine-learning classification methods were used to achieve this *** study results suggest that the accuracy of the k-nearest neighbors algorithm is superior to random forest,naïve Bayes,logistic regression,decision tree,and support vector *** performance of pre-processing methods was assessed on the lung cancer *** most successful preprocessing methods were Z-score(83%accuracy)for normalization methods,principal component analysis(87%accuracy)for dimensionality reduction methods,and information gain(71%accuracy)for feature selection methods.

关键词： Lung cancer machine learning dimensionality reduction normalization feature selection

An adult case of medulloblastoma in the cerebellopontine angle extending to the supratentorial area

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Neural Regeneration Research 2010年第21期5卷 1678-1680页

作者： yasemin Benderli Cihan Department of Radiation Oncology Kayseri Training and Research Hospital

Medulloblastoma is an undifferentiated embryonic neuroepithelial tumor. It is a rare tumor in the central nervous system, with an even rarer occurrence during adulthood. It may develop at an atypical and uncommon site, such as the cerebellopontine angle （CPA）, and such tumors rarely present with supratentorial extension. The present study reports an adult case of medulloblastoma in the CPA extending to the supratentorial area. The patient presented with complaints of headache, vertigo, hearing difficulty in the left ear, nausea/vomiting, and unsteady gait. Disequilibrium began 4 weeks earlier. Examination revealed normal cranial nerves, and computed tomography showed a hyperdense lesion, with a heterogeneously enhancing mass, in the left CPA region. The patient underwent a nearly total excision of the lesion in the CPA region. Histopathological examination confirmed medulloblastoma, WHO grade IV. Postoperatively, the patient received radiotherapy and remained asymptomatic for 30 months. However, he received two more surgeries for relapse and progression of medulloblastoma and eventually died. A CPA medulloblastoma with supratentorial extension is relatively rare in the clinic.

关键词： medulloblastoma adult cerebellopontine angle supratentorial extension

Ab Initio Study on Hypothetical Silver Nitride

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Chinese Physics Letters 2008年第6期25卷 2154-2157页

作者： DELIGOZ Enginl COLAKOGLU Kemal CIFTCI yasemin Oztekin Department of Physics Aksaray University 68100 Aksaray Turkey Department of Physics Gazi University Teknikokullar 06500 Ankara Turkey

We perform the ab initio calculations based on norm-conserving pseudopotentials and density functional theory to investigate the structural, elastic, and thermodynamical properties for silver nitride （AgN） compound that is a member of the 4d transition metal group and has not been synthesized yet. The obtained results are compared with the other available theoretical data, and the agreement is, generally, quite good. We also present the pressure-dependent behaviour of some mechanical and thermodynamical properties for the same compounds.

关键词： ELASTIC PROPERTIES 1ST-PRINCIPLES CALCULATIONS CONSTANTS STABILITY MODEL

Some Constacyclic Codes over Z4[u]/〈u^2〉, New Gray Maps, and New Quaternary Codes

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Algebra Colloquium 2018年第3期25卷 369-376页

作者： yasemin Cengellenmis Abdullah Dertli Nuh Aydin Department of Mathematics Trakya University Edirne Turkey Department of Mathematics Ondokuz Mayls University Samsun Turkey Department of Mathematics and Statistic Kenyon College Gambler OH USA

In this paper, we study λ-constacyclic codes over the ring R = Z4 ＋ uZ4, where u^2 = 0, for λ= 1 ＋ 3u and 3 ＋ u. We introduce two new Gray maps from R to Z4^4 and show that the Gray images of λ-constacyclic codes over R are quasi-cyclic over Z4. Moreover, we present many examples of λ-constacyclic codes over R whose Z4-images have better parameters than the currently best-known linear codes over Z4.

关键词： constacyclic codes codes over rings quaternary codes Gray maps

Effectiveness of breathing exercises during the second stage of labor on labor pain and duration： a randomized controlled trial

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Journal of Integrative Medicine 2017年第6期15卷 456-461页

作者： hilal yuksel yasemin cayir zahide kosan kenan tastan department of family medicine ataturk university faculty of medicineErzurum 25070Turkey department of public health ataturk university faculty of medicineErzurum 25070Turkey

BACKGROUND： Some research exists on the effect of non-pharmacological approaches for labor pain relief However, there is limited information about effectiveness of breathing exercises in pregnant women to reduce maternal pain during labor. OBJECTIVE： To determine whether breathing exercises for pregnant women during the second stage of labor have beneficial effects on maternal pain, duration of labor, and the first-minute Appearance, Pulse, Grimace, Activity and Respiration （APGAR） scores. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This randomized clinical trial involved 250 pregnant women, who were randomly divided into two groups： intervention group （IG; n = 125） and control group （CG; n = 125）. IG received one session breathing exercise training and performed breathing exercises during the second stage of labor versus the CG that did not receive any breathing exercise training. MAIN OUTCOME MEASURES： The effects of breathing exercises on maternal pain were determined by Visual Analogue Scale （VAS）, duration of the second stage of labor, and the first-minute APGAR scores. RESULTS： The mean age of the participants was （23.2 _＋ 4.2）（range： 18 to 42） years. Both IG and CG had similar baseline characteristics in terms of age, education level, occupation, and smoking （P 〉 0.05）. The mean VAS scores of IG and CG were （88.2 ＋_ 6.3） and （90.5 ＋_ 7.0）, respectively （P 〈 0.001）. The duration of the second stage of labor was （369.6 ＋ 92.0） s for IG and （440.7 ＋ 142.5） s for CG （P 〈 0.001 ）. The mean first-minute APGAR scores were （8.84 ＋ 0.50） for IG and （8.73 ＋ 0.89） for CG （P 〉 0.05）. CONCLUSION： Based on this study, breathing exercises with deep inhalation and exhalation in pregnant women are effective in reducing the perception of labor pain and shortening the duration of the second stage of delivery. Therefore, we recommend breathing exercises as an effective modality for labor pain management and shortening the duration of labor. TRIAL REGISTRATION： This study i

关键词： breathing exercise labor pain labor time labor pain management visual analogue scale randomized controlled tria~