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Integration of in vitro and in silico approaches to assess three Astragalus species from Turkey flora:A novel spotlight from lab bench to functional applications

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Food Bioscience 2022年第5期49卷 1183-1194页

作者： Gokhan Zengin Abdullahi Ibrahim Uba Mustafa Ocal Majid Sharifi-Rad Giovanni Caprioli Simone Angeloni yasemin celik altunoglu Mehmet Cengiz Baloglu Evren Yıldıztugay Department of Biology Science FacultySelcuk University42130KonyaTurkey Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Genetics and Bioengineering Faculty of Engineering and ArchitectureKastamonu UniversityKastamonuTurkey Department of Range and Watershed Management Faculty of Water and SoilUniversity of ZabolIran School of Pharmacy University of CamerinoVia Sant’Agostino 1I-62032CamerinoMCItaly Department of Biotechnology Science FacultySelcuk University42130KonyaTurkey

Members of the genus Astragalus have a great interest as a source of natural bioactive compounds on a scientific *** provide multidirectional insights into three Astragalus species(***,***,and ***),the current work focused on the chemical characterization and biological properties of their extracts(aerial parts and roots).The chemical characterization of the extracts was detected by HPLC-MS/MS *** biological properties were evaluated by antioxidant,enzyme inhibitory,and cytotoxic *** for radical quenching,reducing capacity,and metal chelation were also used to evaluate antioxidant *** test the enzyme inhibitory effects of the extracts,cholinesterases,tyrosinase,α-amylase,andα-glucosidase were utilized as target *** cancer cell lines,(MCF-7(human breast cancer cell line)and HeLa(Human cervix cancer cell line),were selected to evaluate cytotoxic ***,5-caffeoylquinic acid(2.43-283.92μg/g extract),hyperoside(4.33-216.22μg/g extract)and rutin(1.09-184.98μg/g extract)were the main *** extracts from aerial parts and roots of *** showed stronger radical scavenging and reducing power abilities compared to *** and *** best AChE and BChE inhibitory effects were determined in the aerial parts of ***(2.18 mg GALAE/g)and roots of ***(4.76 mg GALAE/g),*** extracts of *** had the highest tyrosinase inhibitory *** extract from aerial parts of *** showed stronger cytotoxic effects compared to other ***’s correlation analysis revealed that the presence of some compounds(resveratrol,p-coumaric,5-caffeoylquinic,and ferulic acids,etc)was linked to the observed biological *** docking was also provided for the possible interaction of enzymes as well as protein targets of the tested cell *** findings provide a scientific basis for the Astragalus species,which may serve as a source

关键词： Astragalus Phenolics Cytotoxic effect Molecular docking Bioactive agents

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Assessing the efficacy of a novel sperm-washing medium enriched with serotonin,L-carnitine,and coenzyme Q10:an observational cohort study

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Asian Journal of Andrology 2024年第6期26卷 635-639页

作者： Sinem Dogan Turgut Aydin Nadiye Koroglu yasemin Yilmazer Nazli Albayrak Fadime Cetin Elnaz Moshfeghi Ozge celik Department of Molecular Biology and Genetics Istanbul Kultur UniversityIstanbul 34158Türkiye Department of Obstetrics and Gynecology School of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbul 34303Türkiye Department of Obstetrics and Gynecology School of MedicineIstanbul Beykent UniversityIstanbul 34500Türkiye Department of Molecular Biology and Genetics Istanbul Sabahattin Zaim UniversityIstanbul 34303Türkiye Department of Bioengineering Istanbul Yildiz Technical UniversityIstanbul 34349Türkiye Department of Molecular Biology and Genetics Istanbul Yildiz Technical UniversityIstanbul 34349Türkiye

This observational cohort study investigated the potential of a novel sperm-washing medium(SWM)enriched with serotonin(5-HT),L-carnitine(L-C),and coenzyme Q10(CoQ10)to enhance sperm motility and reduce DNA *** compared this innovative medium(5-HT/L-C/CoQ10 SWM)with two widely used commercial media(SWM 1 and SWM 2).Ninety-eight volunteers from an infertility clinic provided semen samples,which were divided into three aliquots for analysis in different SWMs:group 1,SWM was composed of hydroxyethyl piperazineethanesulfonic acid(HEPES),sodium bicarbonate,human serum albumin(HSA),taurine,and gentamicin sulfate(SWM 1);group 2,SWM was composed of HEPES,sodium bicarbonate,and HSA(SWM 2);and group 3,SWM was composed of HEPES-buffered human tubal fluid supplemented with 5-HT,L-C,and CoQ10(5-HT/L-C/CoQ10 SWM).Sperm motility was categorized as progressive,nonprogressive,or ***,reactive oxygen species(ROS)production,and DNA fragmentation were also *** were no significant differences in total or progressive sperm motility among the *** in group 3 exhibited reduced apoptosis,necrosis,and ROS levels and increased *** significant differences were observed in the DNA fragmentation index among *** 5-HT/L-C/CoQ10 SWM reduced sperm oxidative stress and apoptosis compared with those of the two commercially available SWMs,suggesting that 5-HT/L-C/CoQ10 SWM could be useful for enhancing in vitro fertilization success rates.

关键词： apoptosis coenzyme Q10 DNA fragmentation L-carnitine serotonin sperm-washing medium

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Numerical Simulation of the Flow around Two-dimensional Partially Cavitating Hydrofoils

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Journal of Marine Science and Application 2014年第3期13卷 245-254页

作者： Fahri celik yasemin Arikan Ozden Sakir Bal Department of Naval Architecture and Marine Engineering Yildiz Technical University Istanbul 34349 Turkey Department of Naval Architecture and Marine Engineering Istanbul Technical University Istanbul 34469 Turkey

In the present study, a new approach is applied to the cavity prediction for two-dimensional （2D） hydrofoils by the potential based boundary element method （BEM）. The boundary element method is treated with the source and doublet distributions on the panel surface and cavity surface by usethe of the Dirichlet type boundary conditions. An iterative solution approach is used to determine the cavity shape on partially cavitating hydrofoils. In the case of a specified cavitation number and cavity length, the iterative solution method proceeds by addition or subtraction of a displacement thickness on the cavity surface of the hydrofoil. The appropriate cavity shape is obtained by the dynamic boundary condition of the cavity surface and the kinematic boundary condition of the whole foil surface including the cavity. For a given cavitation number the cavity length of the 2D hydrofoil is determined according to the minimum error criterion among different cavity lengths, which satisfies the dynamic boundary condition on the cavity surface. The NACA 16006, NACA 16012 and NACA 16015 hydrofoil sections are investigated for two angles of attack. The results are compared with other potential based boundary element codes, the PCPAN and a commercial CFD code （FLUENT）. Consequently, it has been shown that the results obtained from the two dimensional approach are consistent with those obtained from the others.

关键词： boundary element method (BEM):sheet cavitation CFD hydrofoil cavity closure model 2D hydrofoils

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