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Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey

Asian Pacific Journal of Tropical Biomedicine 2013年第9期3卷 743-747页

作者： aysegül Copur Cicek Azer Ozad Düzgün aysegül Saral Tuba Kayman Zeynep Cizmeci Pervin Ozlem Balci Tuba Dal Mehmet Firat Ismail Tosun yasemin ay alitntop Ahmet Caliskan Yelda Yazici Cemal Sandalli Department of Medical Microbiology Faculty of MedicineRecep Tayyip Erdogan University Department of Genetics and Bioengineering Faculty of Engineering and Natural SciencesGümüshane University Department of Biology Faculty of Arts and SciencesArtvin Coruh University Clinical Microbiology Laboratory Research and Training Hospital Clinical Microbiology Laboratory Kecioren Research and Training Hospital Clinical Microbiology Laboratory General State Hospital Department of Medical Microbiology Faculty of MedicineDicle University Clinic of Infectious Diseases and Clinical Microbiology PrivateOSM Ortadogu Hospital Microbiology Laboratory Kirikkale Highly Specialized Hospital General State Hospital Microbiology Laboratory Necip Fazil City Hospital Clinical Microbiology Laboratory Ahi Evren Chest and Cardiovascular Surgery Research and Training Hospital Department of Biology Faculty of Arts and SciencesRecep Tayyip Erdogan University

Objective:To investigate the antibiotic resistance genes inserted into class I and class 2integrons in Acinetobacler baumannii[***)isolates obtained from nine different cities in ***:A collection of 281 *** clinical isolates were collected from nine diferenl state hospitals in Turkey and were confirmed as *** by conventional biochemical,API testing and bla_(-OXA-51)specific *** isolates were examined by PCR for existence of class I and2 integron gene ***:They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin(90.03%),ciprofloxacin(87.54%),cefepime and trimethoprim/sulfamethoxazole(81.13%).The lowest resistance rates was for cefotaxime(3.55%).class 1 integrons were detected in 6.4%(18/281)of *** strains and no class 2 integron was *** gene casselles of class 1 inlegrons AacCI-AAC(3)l-aadAI,AacCI-aadA1,AAC(3)-I,AAC(3)-I-AAC(3)-I-aadA1,***(3)-I-aadA1-AAC(3)-I-AAC(3)-I,AAC(3)-I-AAC(3)-I-AAC(3)-I-aadA1,AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I,AAC(3)-I-aadA1-AAC(3)-I-aadA1,AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen *** aac genes family were most frequently found integrated into the class 1 inlegrons and it was followed by aadA genes and TEM-1 ***:This is an extensive study on the distribulion of class 1 integron among *** in *** addition to these,two new alleles were *** percentage rates of similarity to other cassettes are 95%aadA1(TK A18)and 89%,aadA 1(ANKA3).

关键词： Acinetobacter baumannii Class 1 integron Gene cassette Resistance

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Surgical treatment of a rare brachial artery aneurysm postarteriovenous fistula closure after kidney transplant:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4755-4761页

作者： Nahit Arda Demirkan yasemin Keskin Hakan Sevinç Ömer ArdaÇetinkaya Department of General Surgery Ankara University School of MedicineAnkara 06100Türkiye Department of General Surgery Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalAnkara 06100Türkiye

BACKGROUND Brachial artery aneurysms are defined as dilations greater than 50%of the normal diameter,which are rare among all peripheral arterial *** they are often present as pseudoaneurysms,true brachial artery aneurysms are also detected *** this case report,the surgical repair method of true brachial artery aneurysms,which is a rare condition,is *** SUMMARY Herein,we present a 61-year-old male patient with complaints of swelling and pain in the right arm antecubital region that had been progressing over 6 *** the diagnosis of a true brachial artery aneurysm associated with arteriovenous fistula,the aneurysm was surgically repaired with an autologous saphenous vein *** patient was discharged without any neurovascular complications *** True brachial artery aneurysms are rare and there are not any recommendations for their management in the current *** though the treatment of true aneurysms in this artery is primarily based on a surgical treatment,endovascular repair also might be an option.

关键词： Brachial artery aneurysm Arteriovenous fistula Kidney transplantation Surgical repair Autologous vein interposition Case report

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人工智能是蛋白质科学的终结者吗?

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世界科学 2024年第8期 4-12页

作者：刘迪一亚瑟明·萨普拉克奥卢

2020年12月，由于疫情令面对面会议难以举办，数百位计算科学家在电子屏幕前线上集会，并见证了科学新时代的到来。他们参加的会议是一场友好竞赛，正式名称为“结构预测关键评估”（CASP），一般被叫作“国际蛋白质结构预测竞赛”，每...

2020年12月，由于疫情令面对面会议难以举办，数百位计算科学家在电子屏幕前线上集会，并见证了科学新时代的到来。他们参加的会议是一场友好竞赛，正式名称为“结构预测关键评估”（CASP），一般被叫作“国际蛋白质结构预测竞赛”，每两年举办一次。有的学者已经参加了近三十年。参会同行们都痴迷于同一个问题，那就是蛋白质折叠问题。他们较量的方式很简明：能否根据最简单的蛋白质一级结构信息，即多肽链中氨基酸残基的排列顺序，准确预测蛋白质分子的三维形状？蛋白质形状决定其行为，因此准确预测形状将为我们理解疾病、生产新药和洞见生命运作方式带来深远影响。

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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova aysun Yalci yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

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Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul

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Asian Pacific Journal of Tropical Medicine 2022年第12期15卷 551-557页

作者： Berkin Berk Akbeyaz ayŞe Karaaslan CerenÇetin Mehmet Tolga Köle Zeynep AltaŞ yasemin Akın Department of Pediatrics University of Health SciencesKartal Dr.Lütfi Kirdar City HospitalPediatric Hematology and Oncology IstanbulTurkey Department of Pediatric Infectious Diseases University of Health SciencesKartal Dr.Lütfi Kirdar City HospitalIstanbulTurkey Department of Pediatrics University of Health SciencesKartal Dr.Lütfi Kirdar City HospitalIstanbulTurkey Department of Public Health Marmara UniversityIstanbulTurkey

Objective:To examine the effect of the COVID-19 virus,especially the Omicron variant,on hematological parameters of hospitalized pediatric patients during the COVID-19 ***:Medical records of pediatric COVID-19 patients hospitalized at Kartal Dr.Lütfi K?rdar City Hospital in Istanbul,Turkey,between March 2020 and May 2022 were retrospectively reviewed to analyze data regarding demographics,SARS-Co V-2 infection polymerase chain reaction(PCR)test results,reversetranscriptase(RT)-PCR for other respiratory agents,duration of hospital stay,and hematological and biochemical laboratory ***:Out of 467 children with a confirmed diagnosis of SARSCo V-2 infection,94(20.1%)had Omicron infection and 373(79.9%)were infected with other variants;the Omicron group had younger patients than the remaining samples(P<0.001).The most frequent clinical symptoms in all children were cough(53.5%)and fever(32.3%),followed by vomiting(20.8%).Lung involvement in the Omicron group(10.6%)was significantly lower than in the remaining samples(29.8%)(P<0.001).Hemoglobin and lymphocyte levels were lower in the Omicron-infected group(both P<0.001),while prothrombin time,activated partial thromboplastin time,international normalized ratio,and D-dimer levels were significantly higher in this group(P<0.001,P<0.001,P<0.001,and P=0.023,respectively).In terms of lung involvement,those with lung involvement were significantly older(P<0.001).Conclusions:Although lung involvement was less common with Omicron infection,this group had greater hematological system involvement,such as anemia,lymphopenia,D-dimer elevation,and coagulation disorders.

关键词： COVID Children Omicron Hematologic findings

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Gaussian Kernel Based SVR Model for Short-Term Photovoltaic MPP Power Prediction

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Computer Systems Science & Engineering 2022年第4期41卷 141-156页

作者： yasemin Onal Department of Electrical and Electronics Engineering Bilecik Seyh Edebali UniversityBilecik11000Turkey

Predicting the power obtained at the output of the photovoltaic(PV)system is fundamental for the optimum use of the PV ***,it varies at different times of the day depending on intermittent and nonlinear environmen-tal conditions including solar irradiation,temperature and the wind speed,Short-term power prediction is vital in PV systems to reconcile generation and demand in terms of the cost and capacity of the *** this study,a Gaussian kernel based Support Vector Regression(SVR)prediction model using multiple input variables is proposed for estimating the maximum power obtained from using per-turb observation method in the different irradiation and the different temperatures for a short-term in the DC-DC boost converter at the PV *** performance of the kernel-based prediction model depends on the availability of a suitable ker-nel function that matches the learning objective,since an unsuitable kernel func-tion or hyper parameter tuning results in signiﬁcantly poor *** this study for theﬁrst time in the literature both maximum power is obtained at max-imum power point and short-term maximum power estimation is *** evaluating the performance of the suggested model,the PV power data simulated at variable irradiations and variable temperatures for one day in the PV system simulated in MATLAB were *** maximum power obtained from the simu-lated system at maximum irradiance was 852.6 *** accuracy and the perfor-mance evaluation of suggested forecasting model were identiﬁed utilizing the computing error statistics such as root mean square error(RMSE)and mean square error(MSE)*** and RMSE rates which obtained were 4.5566*10-04 and 0.0213 using ANN *** and RMSE rates which obtained were 13.0000*10-04 and 0.0362 using SWD-FFNN *** SVR model,1.1548*10-05 MSE and 0.0034 RMSE rates were *** the short-term maximum power prediction,SVR gave higher prediction performance according to ANN and SWD-FFNN.

关键词： Short term power prediction Gaussian kernel support vector regression photovoltaic system

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Human bocavirus infection in children hospitalized with lower respiratory tract infections:Does viral load affect disease course?

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Asian Pacific Journal of Tropical Medicine 2022年第8期15卷 354-360页

作者： ayşe Karaaslan CerenÇetin Serap Demir Tekol Ufuk Yükselmiş Mehmet Tolga Köle yasemin Akın Department of Pediatric Infectious Diseases University of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey Department of Microbiology University of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey Department of Pediatric Intensive Care Unit University of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey Department of Pediatrics University of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey

Objective:To examine the effects of human bocavirus type 1(HBoV1)on the course of lower respiratory tract infections in cases of monoinfection and coinfection,and the effects of HBoV1 viral load on the disease in children under six years old hospitalized with a diagnosis of HBoV1-associated lower respiratory tract ***:Children under six years of age,who were hospitalized with the diagnosis of lower respiratory tract infection due to HBoV1 between 1 January 2021 and 1 January 2022 were included in the *** confirmation of the respiratory pathogens was performed using polymerase chain reaction(PCR).Results:Fifty-four(16.4%)children with HBoV1 among 329 children whose PCR was positive with bacterial/viral agent in nasopharyngeal swab samples were included in the *** were 28(51.9%)males and 26(48.1%)females with a median age 23.4 months[interquartile range(IQR):13.2,30.0 months](min-max:1 month-68 months).HBoV1 was detected as a monoinfecton in 26(48.1%)children,and as a coinfection with other respiratory agents in 28 children(51.9%).In multiple regression analysis,coinfection(P=0.032)was associated with the length of hospitalization(Pay and need for intensive *** was found to affect the length of hospitalization.

关键词： Human bocavirus Lower respiratory tract infection Children Viral load

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Practical points that gastrointestinal fellows should know in management of COVID-19

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World Journal of Clinical Cases 2022年第16期10卷 5133-5145页

作者： Tevhide Sahin Cem Simsek Hatice yasemin Balaban Department of Gastroenterology Hacettepe UniversityFaculty of MedicineAnkara 06100Turkey

Pandemics obligate providers to transform their clinical *** extensive effort has been put to find out feasible approaches for gastrointestinal diseases and also to manage coronavirus disease 2019(COVID-19)related gastrointestinal ***,hepatitis,and pancreatitis can be seen in the COVID-19 *** procedures increase the risk of contamination for medical staff and patients despite precautions,therefore indications should be tailored to balance risks vs ***,whether the immunosupression in inflammatory bowel diseases,liver transplantation,and autoimmune liver diseases increases COVID-19 related risks and how to modify immunosupression are topics of ongoing *** review aims to provide most up to date practical approaches that a gastrointestinal fellow should be aware on the problems and management of gastrointestinal and hepatobiliary diseases during the COVID-19 pandemic.

关键词： COVID-19 Gastrointestinal diseases Practical points Endoscopy Gastrointestinal fellows

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