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The Predictive Role of New Markers in Early Diagnosis of Acute Kidney Injury in Patients with Acute Pancreatitis

Open Journal of Nephrology 2020年第3期10卷 254-263页

作者： Ferdi karagöz Dede Sit Aysegül Kirankaya yasemin aker karagöz Arif Savas Yildiz Ipek Bennur Esen Atay Ahmet Engin Atay Clinic of Internal Medicine Bagcilar Training and Research Hospital Istanbul Turkey Clinic of Nephrology Umraniye Training and Research Hospital Istanbul Turkey Clinic of Biochemistry Bagcilar Training and Research Hospital Istanbul Turkey Clinic of Family Medicine Bagcilar Training and Research Hospital Istanbul Turkey Clinic of Nephrology Bagcilar Training and Research Hospital Istanbul Turkey

Objective: Acute Kidney Injury (AKI) is a serious early complication that significantly increases the mortality rate in patients with acute pancreatitis (AP). AKI can improve with an early diagnosis and appropriate treatment protocols. We aimed to evaluate the role of IL-6, IL-18, NGAL, IL-1β, TNF-α, Cys-C and KIM-1 in serum and IL-18 in urine in the early detection of AKI in patients with AP. Materials and Methods: Fifty-six patients, who were diagnosed with AP and underwent standard treatment, between July 2011 and December 2013, were included in the study. Patients were sampled for markers at admission and discharge, or when the patients died. Patients were grouped by presence or absence of AKI. Results: The mean age of the cases was 56.41 ± 20.23 (17 - 91), of which 21 (37.5%) of the cases were male and 35 (62.5%) were female. AKI was detected in 13 (23.2%) patients. The Cys-C level was significantly higher in AKI patients (at hospitalization p zation were significantly higher than discharge levels (p Conclusion: In this study, Cys-C and KIM-1 proved to be statistically significant to predict AKI in patients with AP. However further studies are required to support these conclusions.

关键词： Acute Pancreatitis AKI Cystatin-C KIM-1

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The Predictive Role of New Markers in Early Diagnosis of Acute Kidney Injury in Patients with Acute Pancreatitis

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Open Journal of Nephrology（肾脏病） 2020年第3期

作者： Ferdi karagöz Dede Şit Ayşegül Kırankaya yasemin aker karagöz ArifSava Yıldızİpek Bennur Esen Atay Ahmet Engin Atay

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