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Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement:Food for thought

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World Journal of Gastrointestinal Surgery 2022年第1期14卷 64-77页

作者： yaroslav m susak Kristina Opalchuk Olexandr Tkachenko mariia Rudyk Larysa Skivka Department of Surgery with the Course of Emergency and Vascular Surgery O.O.Bogomolet’s National Medical UniversityKyiv 01601Ukraine Department of Surgery Anesthesiology and Intensive Care Postgraduate EducationO.O.Bogomolet’s National Medical UniversityKyiv 01601Ukraine Department of Surgery N2 Kyiv City Clinical Emergency HospitalKyiv City Clinical Emergency HospitalKyiv 02000Ukraine Department of microbiology and Immunology Educational and Scientific Center“Institute of Biology and Medicine”Taras Shevchenko National University of KyivKyiv 01033Ukraine

BACKGROUND Timing of invasive intervention such as operative pancreatic debridement(OPD)in patients with acute necrotizing pancreatitis(ANP)is linked to the degree of encapsulation in necrotic collections and controlled *** markers of these processes might assist decision-making on the timing of surgical *** our opinion,it is logical to search for such markers among routine laboratory parameters traditionally used in ANP patients,considering simplicity and cost-efficacy of routine laboratory *** To evaluate laboratory variables in ANP patients in the preoperative period for the purpose of their use in the timing of *** A retrospective analysis of routine laboratory parameters in 53 ANP patients undergoing OPD between 2017 and 2020 was *** changes of routine hematological and biochemical indices were examined in the preoperative *** were divided into survivors and *** were divided into subgroups with short and long post-surgery length of stay(LOS)in *** analysis was used to evaluate association of laboratory variables with *** regression was used to assess risk factors for patient *** Seven patients(15%)with severe acute pancreatitis(SAP)and 46 patients(85%)with moderately SAP(mSAP)were included in the *** age of participants was 43.2 years;33(62.3%)were *** etiology included biliary(15%),alcohol(80%),and idiopathic/other(5%).median time from diagnosis to OPD was≥4 *** postoperative LOS was at the average of 53 *** was 19%.Progressive increase of platelet count in preoperative period was associated with shortened *** aspartate aminotransferase and direct bilirubin(DB)levels the day before the OPD along with weak progressive decrease of DB in preoperative period were reliable predictors for ANP patient *** multifactorial analysis of dynamic changes of routine labo

关键词： Acute necrotizing pancreatitis Operative pancreatic debridement timing Dynamic changes of laboratory variables Preoperative period Necrotic tissue encapsulation Hospital length of stay

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Effectiveness of a new approach to minimally invasive surgery in palliative treatment of patients with distal malignant biliary obstruction

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 698-711页

作者： yaroslav m susak Leonid L markulan Serhii m Lobanov Roman Y Palitsya mariia P Rudyk Larysa m Skivka Department of Surgery with the Course of Emergency and Vascular Surgery O.O.Bogomolets National Medical UniversityKyiv 01601Ukraine Department of Abdominal Surgery National Military Medical Clinical Centre“Main Military Clinical Hospital”Kyiv 01133Ukraine Department of microbiology and Immunology Taras Shevchenko National University of KyivKyiv 01033Ukraine

BACKGROUND Palliative endoscopic biliary drainage is the primary treatment option for the management of patients with jaundice which results from distal malignant biliary obstruction(DmBO).In this group of patients,decompression of the bile duct(BD)allows for pain reduction,symptom relief,chemotherapy administration,improved quality of life,and increased survival *** reduce the unfavorable effects of BD decompression,minimally invasive surgical techniques require continuous *** To develop a technique for internal-external biliary-jejunal drainage(IEBJD)and assess its effectiveness in comparison to other minimally invasive procedures in the palliative treatment of patients with *** A retrospective analysis of prospectively collected data was performed,which included 134 patients with DmBO who underwent palliative BD ***-jejunal drainage was developed to divert bile from the BD directly into the initial loops of the small intestine to prevent duodeno-biliary *** was carried out using percutaneous transhepatic *** transhepatic biliary drainage(PTBD),endoscopic retrograde biliary stenting(ERBS),and internal-external transpapillary biliary drainage (IETBD) were used for the treatment of studypatients. Endpoints of the study were the clinical success of the procedure, the frequency andnature of complications, and the cumulative survival *** were no significant differences in the frequency of minor complications between the studygroups. Significant complications occurred in 5 (17.2%) patients in the IEBJD group, in 16 (64.0%)in the ERBS group, in 9 (47.4%) in the IETBD group, and in 12 (17.4%) in the PTBD *** was the most common severe complication. In the IEBJD group, the course ofcholangitis was characterized by a delayed onset and shorter duration as compared to other studygroups. The cumulative survival rate of patients who underwent IEBJD was 2.6 times higher incomparison t

关键词： Distal malignant biliary obstruction Obstructive jaundice Bile duct decompression Palliative endoscopic biliary drainage Internal-external biliary-jejunal drainage

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Introduction of antineoplastic drug NSC631570 in an inpatient and outpatient setting:Comparative evaluation of biological effects

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Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 308-317页

作者： mariia Rudyk Olexander Fedorchuk yaroslav susak yaroslav Nowicky Larysa Skivka microbiology and General Immunology Department ESC“Institute of Biology”Taras Shevchenko National University of KyivUkraine R.E.Kavetsky Institute of Experimental Pathology Oncology and RadiobiologyNational Academy of Sciences of UkraineUkraine O.O Bogomolets National medical University KyivUkraine Ukrainian Anticancer Institute ViennaAustria

The aim of this study is to evaluate the effect of moderate physical exercise and treatment time on the organism’s response to NSC631570. The sensitivity of circulating phagocytes to the drug at different times of day was estimated in in vitro experiments. NSC631570 was administered intravenously to healthy volunteers (eleven men, 23 ± 2 years) in a single therapeutic dose in an inpatient and an outpatient setting. Blood samples were obtained before the drug administration, 30 min after the drug injection and every fourth hour throughout the 24 hour period. Biochemical parameters were determined using the hematological analyzer. Flow cytometry was used to evaluate phagocyte metabolism. Treatment of circulating phagocytes with NSC631570 in vitro resulted in an increase in ROS production along with a decrease in their phagocytic activity, most expressed in the morning time. Drug injection to sedentary persons resulted in pro-inflammatory metabolic polarization of circulating phagocytes. Introduction of NSC631570 to active persons was accompanied by a significant increase in phagocyte endocytosis along with a decrease in the daily mean of ROS generation. Significant oscillation (but in the normal ranges) of urea, creatinine, alanine aminotransferase and aspartate aminotransferase after NSC631570 introduction in the outpatient setting was shown during the day. Physical activity interferes with immunomodulatory action of NSC631570 and abrogates pro-inflammatory shift of circulating phagocytes. Biochemical parameters of blood from patients treated with NSC631570 in the outpatient setting must be interpreted cautiously considering the effect of physical activity on some metabolic biomarkers.

关键词： NSC631570 Physical exercise Blood biochemical parameters Phagocytes functional polarization

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modeling gut neuro-epithelial connections in a novel microfluidic device

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microsystems & Nanoengineering 2023年第6期9卷 235-246页

作者： Jose m.de Hoyos-Vega Xi Yu Alan m.Gonzalez-Suarez Sisi Chen Arnaldo mercado-Perez Eugene Krueger Jeric Hernandez yaroslav Fedyshyn Brooke R.Druliner David R.Linden Arthur Beyder Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Enteric Neuroscience Program(ENSP) Mayo ClinicRochesterMNUSA Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMNUSA

The intestinal lumen is filled with diverse chemical and physical *** epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract ***,the neuro-epithelial connections remain poorly resolved,in part because the tools for orchestrating interactions between these cellular compartments are *** describe the development of a two-compartment microfluidic device for co-culturing enteric neurons with intestinal epithelial *** device contains epithelial and neuronal compartments connected by *** epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal *** demonstrated that organoids planarized effectively and retained epithelial phenotype for over a *** the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary afferent neurons(IPANs)from transgenic mice that expressed the fluorescent protein *** extended projections into microgrooves,surrounded and frequently made contacts with epithelial *** density and directionality of neuronal projections were enhanced by the presence of epithelial cells in the adjacent *** microfluidic device represents a platform that may,in the future,be used to dissect structure and function of neuro-epithelial connections in the gut and other organs(skin,lung,bladder,and others)in health and disease.

关键词： fluid bladder organs

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Engineering Geological map of the Sakha(Yakutia) Republic

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Research in Cold and Arid Regions 2014年第5期6卷 484-493页

作者： Vladimir B.Spektor yaroslav I.Torgovkin Alena A.Shestakova Valentin V.Spektor Lena D.Ivanova Boris m.Kozmin melnikov Permafrost Institute Siberian Branch of the Russian Academy of Sciences Diamond and Precious metal Geology Institute Siberian Branch of the Russian Academy of Sciences

The Engineering Geological map of the Sakha（Yakutia） Republic covers about 3 million kilometers which is one-fifth of the territory of *** map displays ground and geocryological conditions and active *** intensity,schemes of zoning by factors of engineering geological conditions,and the general scheme of engineering geological zoning of the Sakha（Yakutia） Republic or the SR（Y）,are shown on the inset *** map is required to provide information for planning,construction and exploitation of engineering structures in the SR（Y）.A distinguishing feature of the map is the indication of almost blanket distribution of the frozen ground *** of the frozen ground class are separated by lithology,while ground varieties are separated by *** and ultra-fresh suprapermafrost water is predominant within the *** compiled map indicates parts of the Arctic-Asian and Baikalo-Stanovoi planetary seismic belts that make engineering geological conditions more complicated.

关键词： engineering geological map ground types frozen ground exogenous processes Sakha (Yakutia) Republic

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Effect of Anterior Capsule Polishing on the Need for Laser Capsulotomy

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Open Journal of Ophthalmology 2017年第4期7卷 319-331页

作者： Hamad Elzarrug Kevin m. miller Yu Fei Shahriar Farzad yaroslav O. Grusha Department of Ophthalmology Faculty of Medicine Benghazi University Benghazi Libya Department of Ophthalmology Jules Stein Eye Institute David Geffen School of Medicine at UCLA Los Angeles CA USA

Purpose: To determine the effect of anterior capsule polishing (APC) on the rate of posterior capsule opacification (PCO) as assessed by the need for laser posterior capsulotomy. Setting: University-based clinical practice, Jules Stein Eye Institute, Los Angles, California, USA. methods: This study involved a retrospective review of eyes that underwent phacoemulsification and intraocular lens implantation between September 1991 and June 1999. Lens epithelial cells in the 763 study eyes were mechanically debrided or polished from the inside surface of the anterior capsules using a pair of Shepherd-Rentsch (morning STAAR Inc.) capsule polishers. The 484 control eyes that had surgery earlier in the series were not polished. The rate of laser capsulotomy in the ACP and the non-ACP groups was compared using a Kaplan-meier survival analysis. multivariate regression was performed to determine if variables other than ACP influenced the need for laser posterior capsulotomy. Results: We identified 763 eyes that had ACP and 484 that did not. At the 24-month follow-up interval, 26.6% of the eyes in the ACP group had received a capsulotomy versus 19.50% in the non-APC. Next, a separate study was done using only one eye per patient, taking the patient as the unit of analysis. Again the capsulotomy rate was higher in the ACP group compared to the non-ACP (1.02 per 100 person-months of follow-up vs. 0.74 per 100 person-months of follow-up). Finally, a third Kaplan-meier analysis was done on 52 patients that had one eye treated with the ACP procedure and the other eye with the non-ACP procedure. Although the log-rank test showed the statistical significant of this analysis to be borderline, the results again favored the non-ACP group with a lower capsulotomy rate. multivariate analysis showed very similar results to the above univariate studies. The mean time to capsulotomy was 46 months for the polished group and 70 months for the unpolished group. The severity of cataract (p = 0.4

关键词： Anterior Capsule Polishing Posterior Capsule Opacification Laser Posterior Capsulotomy

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振荡波导阵列中孤子的实验发现

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科学通报:英文版 2023年第18期68卷 2017-2024,M0003页

作者： Antonina A.Arkhipova Yiqi Zhang yaroslav V.Kartashov Sergei A.Zhuravitskii Nikolay N.Skryabin Ivan V.Dyakonov Alexander A.Kalinkin Sergei P.Kulik Victor O.Kompanets Sergey V.Chekalin Victor N.Zadkov Institute of Spectroscopy Russian Academy of SciencesTroitsk 108840Russia Faculty of Physics Higher School of EconomicsMoscow 105066Russia Key Laboratory for Physical Electronics and Devices(ministry of Education) School of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Quantum Technology Centre Faculty of PhysicsM.V.Lomonosov Moscow State UniversityMoscow 119991Russia

时间参数周期变化的弗洛凯系统有助于发现常参数静态系统中不存在并常常伴有新颖拓扑态出现的非传统拓扑相.耦合系数被周期调制的Su-Schrieffer-Heeger晶格正是这种弗洛凯系统之一.尽管这个晶格在一半演化周期内处在拓扑非平庸相,在另... 详细信息

时间参数周期变化的弗洛凯系统有助于发现常参数静态系统中不存在并常常伴有新颖拓扑态出现的非传统拓扑相.耦合系数被周期调制的Su-Schrieffer-Heeger晶格正是这种弗洛凯系统之一.尽管这个晶格在一半演化周期内处在拓扑非平庸相,在另一半周期内处于拓扑平庸相,它的边界上仍然支持源于拓扑的反常π模.本文通过在透明非线性光学材料中刻蚀出周期振荡的Su-Schrieffer-Heeger波导阵列,分别实验观测到了一维系统中位于边界和二维系统中位于角落的光学反常π模.同时,在弗洛凯频谱的禁带中,作者还证实了在高功率情况下一类分化自光学反常π模的新拓扑π孤子.本文报道的π孤子是强振荡的非线性弗洛凯态,它们的波形在每经过一个纵向周期后都可以精确地复现.不论是在一维还是在二维振荡波导阵列中,这类π孤子都是动态稳定的,它们的局域特性都由其功率决定.二维的结果还表明作者实现了弗洛凯光学高阶拓扑绝缘体.

关键词： Floquet topological insulators p states Edge solitons SSH model

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Observation of nonlinear disclination states

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Light(Science & Applications) 2023年第9期12卷 1818-1829页

作者： Boquan Ren Antonina A.Arkhipova Yiqi Zhang yaroslav V.Kartashov Hongguang Wang Sergei A.Zhuravitskii Nikolay N.Skryabin Ivan V.Dyakonov Alexander A.Kalinkin Sergei P.Kulik Victor O.Kompanets Sergey V.Chekalin Victor N.Zadkov Key Laboratory for Physical Electronics and Devices Ministry of EducationSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Faculty of Physics Higher School of EconomicsMoscow 105066Russia Quantum Technology Centre Faculty of PhysicsM.V.Lomonosov Moscow State UniversityMoscow 119991Russia

Introduction of controllable deformations into periodic materials that lead to disclinations in their structure opens novel routes for construction of higher-order topological insulators hosting topological states at *** of these topological states is consistent with the bulk-disclination correspondence principle,and is due to the filling anomaly that results in fractional charges to the boundary unit *** far,topological disclination states were observed only in the linear regime,while the interplay between nonlinearity and topology in the systems with disclinations has been never studied *** report here on the experimental observation of the nonlinear photonic disclination states in waveguide arrays with pentagonal or heptagonal disclination cores inscribed in transparent optical medium using the fs-laser writing *** transition between nontopological and topological phases in such structures is controlled by the Kekulédistortion coefficient r with topological phase hosting simultaneously disclination states at the inner disclination core and spatially separated from them corner-I,corner-II,and extended edge states at the outer edge of the *** show that the robust nonlinear disclination states bifurcate from their linear counterparts and that location of their propagation constants in the gap and,hence,their spatial localization can be controlled by their *** disclination states can be efficiently excited by Gaussian input beams,but only if they are focused into the waveguides belonging to the disclination core,where such topological states *** results open new prospects for investigation of nonlinear effects in topological systems with disclinations and are relevant for different areas of science,including Bose-Einstein and polariton condensates,where potentials with the disclinations can be created.

关键词： structure topological nonlinear

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A deep convolutional neural network for real-time full profile analysis of big powder diffraction data

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npj Computational materials 2021年第1期7卷 671-679页

作者： Hongyang Dong Keith T.Butler Dorota matras Stephen W.T.Price yaroslav Odarchenko Rahul Khatry Andrew Thompson Vesna middelkoop Simon D.m.Jacques Andrew m.Beale Antonis Vamvakeros Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUnited Kingdom ScimL Scientific Computer DivisionSTFCRutherford Appleton LaboratoryHarwell OX110QXUnited Kingdom Finden Limited Merchant House5 East St Helens StreetAbingdon OX145EGUnited Kingdom National Physical Laboratory Hampton RoadTeddington TW110LWUnited Kingdom Flemish Institute for Technological Research VITO NVBoeretang 200Mol 2400Belgium Research Complex at Harwell Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOX110FA OxfordshireUnited Kingdom Present address:Diamond Light Source Harwell Science and Innovation CampusDidcotOxfordshire OX110DEUnited Kingdom Present address:The Faraday Institution Quad OneHarwell Science and Innovation CampusOX110RA OxfordshireUnited Kingdom

We present Parameter Quantification Network(PQ-Net),a regression deep convolutional neural network providing quantitative analysis of powder X-ray diffraction patterns from multi-phase *** network is tested against simulated and experimental datasets of increasing complexity with the last one being an X-ray diffraction computed tomography dataset of a multi-phase Ni-Pd/CeO_(2)-ZrO_(2)/Al_(2)O_(3) catalytic material system consisting of ca.20,000 diffraction *** is shown that the network predicts accurate scale factor,lattice parameter and crystallite size maps for all phases,which are comparable to those obtained through full profile analysis using the Rietveld method,also providing a reliable uncertainty measure on the *** main advantage of PQNet is its ability to yield these results orders of magnitude faster showing its potential as a tool for real-time diffraction data analysis during in situ/operando experiments.

关键词： network powder analysis

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紧凑型电子自旋共振(ESR)仪(英文)

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波谱学杂志 2016年第1期33卷 27-36页

作者： Yury V.BOGACHEV mikhail N.KNYAZEV yaroslav Yu.mARCHENKO Department of Physics Saint-Petersburg State Electrotechnical University Resonance-m Ltd.Saint-Petersburg State Electrotechnical University

描述了一种原创的紧凑型电子自旋共振(ESR)仪.该仪器具备高性能、低成本、简单可靠、结构紧凑、开放构架、多功能模块等一系列特点.分析了ESR谱仪的多个微波单位,研发并通过实验验证了自差ESR谱仪的最优双腔结构,并设计了一种可提供高... 详细信息

描述了一种原创的紧凑型电子自旋共振(ESR)仪.该仪器具备高性能、低成本、简单可靠、结构紧凑、开放构架、多功能模块等一系列特点.分析了ESR谱仪的多个微波单位,研发并通过实验验证了自差ESR谱仪的最优双腔结构,并设计了一种可提供高均匀磁场的电、永磁混合磁体.最后介绍了这种新型紧凑型电子自旋共振仪的主要参数和应用.

关键词：电子自旋共振(ESR) 零差和自差ESR谱仪磁体系统电子自旋共振应用

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