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Two-Hour Creatinine Clearance and Glomerular Filtration Rate Estimated from Serum Cystatin C and Creatinine in the Elderly to Preoperative Period

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Open Journal of Nephrology 2013年第4期3卷 184-188页

作者： Leopoldo Muniz da Silva Pedro Thadeu Galvao Vianna Mariana Takaku Glenio Bittencourt Mizubuti yara Marcondes Machado Castiglia Department of Anaesthesiology Botucatu School of MedicineSao Paulo State University(UNESP)Sao PauloBrazil

Introduction: The utility of estimates of glomerular filtration rate based on creatinine and cystatin C serum levels to assess renal function in older surgical patients remains to be determined. Objective: To determine whether 2h-creatinine clearance (CrCl-2h) can be an adequate substitute for glomerular filtration rate estimates obtained by measuring serum cystatin C and creatinine in the elderly at preoperation. Methods: A total of 102 consecutive elder patients undergoing pre-anesthesia evaluation for routine surgeries were included. Study subjects were allocated into three groups: Group 1 (G1)—hypertensive diabetic patients, Group 2 (G2)—hypertensive patients, and Group 3 (G3)—non-hypertensive and non-diabetic patients. Two-hour urine collection was performed and CrCl-2h adjusted for ultrasonic residual bladder volume was estimated. GFR was estimated based on creatinine and cystatin C serum levels. Bland-Altman analysis was used to compare methods. Results: The mean difference between the evaluated methods and CrCl-2h was ·min-1·1.73 m-2 for Cys-GFR, and >20 mL·min-1·1.73 m-2 for Cr-GFR in all groups. CrCl-2h adjusted for ultrasonic residual bladder volume did not differ from non-adjusted CrCl-2h in none of the groups. Conclusion: Two-hour creatinine clearance was not an adequate substitute for GFR estimates based on creatinine and cystatin C serum levels in older patients at preoperation. The ultrasonic assessment of residual bladder volume had no significant influence on the calculation of two-hour creatinine clearance.

关键词： Renal Function Creatinine Clearance Cystatin C Elderly

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Knowledge and Awareness of Caregivers about Diabetic Ketoacidosis among Type-1 Diabetic Children and Their Action and Response in Riyadh City

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Open Journal of Endocrine and Metabolic Diseases 2021年第5期11卷 119-128页

作者： Abdulaziz Fahad Al Kaabba Bandar Saleh Alzuair yara Faisal AlHarbi Juhainah Abdullah Alshehri Lujain Habeeb Allowaihiq Maha Hamoud Alrashid Reema Awad Alkhatabi Department of Family Medicine College of Medicine Imam Mohammad Ibn Saud Islamic University Riyadh Saudi Arabia College of Medicine Imam Mohammad Ibn Saud Islamic University Riyadh Saudi Arabia

Objectives: Diabetic ketoacidosis (DKA) is a life-threatening metabolic disorder in which its complications can be avoidable. The purpose of this study is to identify and measure the level of knowledge and awareness of caregivers about the symptoms of DKA in children in Riyadh city. Setting and Participants: This cross-sectional study design was conducted in Riyadh city in Saudi Arabia. A sample size of at least 412 was required. The total number of respondents that were included in the analysis was 414. The method of collection of data done by data collectors. Results: Two hundred and sixty-eight (64.7%) of the participants reported that they know about DKA, yet it was still a concerning figure since 35.3% did not know about it, which necessitating diabetes self-management education at national levels in Saudi Arabia. Conclusion: This study showed that the majority of type-1 diabetic caregivers had knowledge and awareness regarding DKA in Riyadh, Saudi Arabia. Further studies would assess more factors to enhance the level of knowledge and awareness, and increase the effectiveness toward the right action and response regarding DKA.

关键词： Diabetes Mellitus DKA Children Caregivers Emergency

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The Phytochemical Profile and Photoprotective Potential of Bark and Leaves of Erythrina velutina Willd.—A Medicinal Species from the Caatinga Region of Brazil

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Journal of Biosciences and Medicines 2023年第12期11卷 325-342页

作者： Bruno de Almeida Andrade Allan Jonathan Chernichiarro Corrêa Ana Klarissa Soares Gomes Patrícia Maria da Silva Neri Cruz Aline Michaele de Saint-George Albuquerque Cheron Valerium Thijan Nobre de Almeidae Castro Décio Henrique Araújo Salvadôr de Mello Cláudia Sampaio de Andrade Lima Ricardo yara Elba Lúcia Cavalcanti de Amorim Department of Pharmaceutical Sciences Federal University of Pernambuco Recife Brazil Pharmacy Course Mauricio de Nassau University Center Recife Brazil Department of Biophysics Federal University of Pernambuco Recife Brazil Departament of Biomedical Engineering Federal University of Pernambuco Recife Brazil

The use of medicinal plants as therapeutic and economic resources has been on the rise in recent years. In Brazil, however, increasing doubt is being cast on the quality of these products, owing to the prevalence of adulteration and fraud. Solar radiation can cause serious damage to human skin, as a result, mostly, of ultraviolet light, which is a cause of skin cancer. Photoprotective substances are capable of absorbing, reflecting, or refracting ultraviolet radiation and thus protecting skin from exposure to sunlight. The present study aimed to characterize samples and examine the phytochemical profile and photoprotective potential of bark and leaves of Erythrina velutina Willd. The samples underwent five extraction methods using 80% ethanol. The phenolic content was measured using spectrophotometry. Antioxidant activity was examined using the DPPH and the photoprotective properties of the plant extracts were assessed using the method developed by Mansur. There was a quantitative difference in some groups of metabolites, with higher levels of tannin in the bark and of flavonoids in the leaves. The latter showed greater DPPH free radical scavenging capacity than the bark, although higher levels of SPF were obtained from the bark, with no statistically significant differences between methods. The results indicate that Erythrina velutina Willd. has potential as a photoprotector.

关键词： Phytochemical Caatinga Phytochemistry Sun Protection Factor (SPF)

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当前气候变化下的雅库特中部地区土壤温度状况预测(英文)

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黑龙江大学工程学报 2014年第3期5卷 8-12页

作者： Peter Permyakov Stepan Varlamov Pavel Skryabin yara Ckachkov 俄罗斯科学院西伯利亚分院北极自然技术研究所俄罗斯科学院西伯利亚分院麦尔尼科夫冻土研究所

预测土壤温度采用通用的年平均气象数据中的空气温度和积雪深度。为改善冻土的预测可靠性,将每月的气象数据考虑在计算方法中。

关键词：冻土数学模型数值计算结果现场实测对比

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Hyperhomocysteinemia dysregulates plasma levels of polyunsaturated fatty acids-derived eicosanoids

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Life Research 2022年第2期5卷 32-41页

作者： Mohamed Al-Shabrawey Ahmed Elmarakby yara Samra Mohamed Moustafa Stephen WLooney Krishna Rao Maddipati Amany Tawfik Department of Foundational Medical Studies and Eye Research Center Oakland University William Beaumont School of MedicineRochesterMichiganUSA Eye Research Institute Oakland UniversityRochesterMichiganUSA Department of Oral Biology and Diagnostic Sciences Dental College of GeorgiaAugusta UniversityAugustaGeorgiaUSA Departments of Pharmacology&Toxicology Faculty of PharmacyMansoura UniversityMansouraEgypt Department of Biochemistry Faculty of PharmacyMansoura UniversityEgypt Department of Population Health Sciences Medical College of GeorgiaAugusta UniversityAugustaGeorgiaUSA Bioactive Lipids Research Program Department of PathologyWayne State UniversityMichiganUSA

Hyperhomocysteinemia(HHcy)contributes to the incidence of many cardiovascular diseases(CVD).Our group have previously established crucial roles of eicosanoids and homocysteine in the incidence of vascular injury in diabetic retinopathy and renal *** cystathionine-β-synthase heterozygous mice(cβs^(+/-))as a model of HHcy,the current study was designed to determine the impact of homocysteine on circulating levels of lipid mediators derived from polyunsaturated fatty acids(PUFA).Plasma samples were isolated from wild-type(WT)and cβs^(+/-)mice for the assessment of eicosanoids levels using LC/*** 12/15-lipoxygenase(12/15-LOX)activity significantly decreased in cβs^(+/-)*** control ***-derived metabolites from both omega-3 and omega-6 PUFA were also reduced in cβs^(+/-)mice compared to WT control(P<0.05).Contrary to LOX metabolites,cytochrome P450(CYP)metabolites from omega-3 and omega-6 PUFA were significantly elevated in cβs^(+/-)mice compared to WT *** acids(EETs)are epoxides derived from arachidonic acid(AA)metabolism by CYP with anti-inflammatory properties and are known to limit vascular injury,however their physiological role is limited by their rapid degradation by soluble epoxide hydrolase(sEH)to their corresponding diols(DiHETrEs).In cβs^(+/-)mice,a significant decrease in the plasma EETs bioavailability was obvious as evident by the decrease in EETs/DiHETrEs ratio relative to WT control ***(COX)metabolites were also significantly decreased in cβs^(+/-)*** control *** data suggest that HHcy impacts eicosanoids metabolism through decreasing LOX and COX metabolic activities while increasing CYP metabolic *** increase in AA metabolism by CYP was also associated with increase in sEH activity and decrease in EETs *** of eicosanoids metabolism could be a contributing factor to the incidence and progression of HHcy-induced CVD.

关键词： homocysteine cystathionine β-synthase eicosanoids cycloxygenase lipoxygenase cytochrome-P450

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选育期望的木材

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林业与环境科学 1987年第2期 39-46页

作者： Bruce Zobel Edgard Campinhos Jr yara Ikemori 霍应强

工业上一个主要的要求就是木材要具有较大的均匀性。由于树种、地理来源、不同树木个体以及在一株树木之内所出现的木材差异,造成加工上较大的困难。通过营林管理和直接的遗传处理来控制树形和生长率,有可能获得比较均一的木材。在巴西... 详细信息

工业上一个主要的要求就是木材要具有较大的均匀性。由于树种、地理来源、不同树木个体以及在一株树木之内所出现的木材差异,造成加工上较大的困难。通过营林管理和直接的遗传处理来控制树形和生长率,有可能获得比较均一的木材。在巴西阿拉克鲁兹林业公司(Aracruz Forestal)土地上的桉树,通过利用无性繁殖,达到了木材产量增加并具有均匀性,可说明这个问题。

关键词：林业遗传学变异性密度环境

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Renal function after laparoscopic cholecystectomy and analgesia with tramadol and dipyrone or ketorolac

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Health 2013年第11期5卷 35-41页

作者： Tiago Pechutti Medeiros Pedro Thadeu Galvao Vianna Leopoldo Muniz da Silva Lidia Raquel de Carvalho Gilberto Elias Wady Leandro Gobbo Braz yara Marcondes Machado Castiglia Graduate Program in Anesthesiology Botucatu Medical SchoolUNESP-Universidade Estadual PaulistaBotucatuBrazil Department of Anesthesiology Botucatu Medical SchoolUNESP-Universidade Estadual PaulistaBotucatuBrazil Sao Luiz Hospital Sao PauloBrazil Department of Biostatics Institute of BiosciencesUNESP-Universidade Estadual PaulistaBotucatuBrazil Mercy Hospital Sao CarlosBrazil

Background: Laparoscopic cholecystectomy (LC) reduces surgical trauma and hospital stay, but requires effective and safe postoperative analgesia. This prospective and double-blind study investigated the effects of analgesia with tramadol combined with either dipyrone or ketorolac on the postoperative renal function of patients submitted to LC. Methods: Pre-and post-operatively (PO), estimated glomerular filtration rates (GFR), obtained by two formulas dependent on blood Cr and one on blood cystatin C values, and tubular enzymuria—alkaline phosphatase (AP), γ-glutamiltransferase (γ-GT)— were determined in well hydrated patients who underwent LC and analgesia with tramadol combined with either dipyrone (Dipyrone, n = 63) or ketorolac (Ketorolac, n = 63). Upon discharge from the post-anesthetic care unit (PACU), pain (through Verbal Numerical Scale—VNS) and need for rescue analgesia with morphine were evaluated. Results: There was hemodilution PO, which made GFR profile analysis more difficult—those dependent on Cr increased and statistically correlated, but those dependent on cystatin C did not change. There was a significant PO increase in AP in the Dipyrone and Ketorolac groups, and in the product of the both enzymes in the Ketorolac group. Upon PACU discharge, the Dipyrone group showed signifi cantly higher VNS scores than the Ketorolac group. All patients received morphine PO, and the total dose needed for pain control differed between groups, but without statistical significance. Conclusions: The association of tramadol with dipyrone or ketorolac in well hydrated patients submitted to LC had similar analgesic effectiveness in the PACU. Postoperatively, the effect on GFR may have been masked by hemodilution, and enzymuria was discreetly enhanced when ketorolac was used.

关键词： Kidney Function Tests Pneumoperitoneum Biological Markers Cystatin C Ketorolac Analgesia

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Oncologic Outcomes of Breast Cancer Patients Treated with Oncoplastic Surgery

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Journal of Cancer Therapy 2013年第1期4卷 331-337页

作者： Leda Marques Ribeiro Daniela Francescato Veiga Ivanildo Archangelo-Junior Fabiola Soares Moreira Campos Renata Bites Amorim Mirian Fatima Brasil Engelman yara Juliano Lydia Masako Ferreira Division of Mastology Department of GynecologyUniversidade do Vale do SapucaiPouso AlegreBrazil Division of Plastic Surgery Department of SurgeryUniversidade do Vale do SapucaiPouso AlegreBrazil Division of Plastic Surgery Department of SurgeryUniversidade Federal de Sao PauloSao PauloBrazil Department of Pathology Universidade do Vale do SapucaiPouso AlegreBrazil Department of Bioestatistics Universidade do Vale do SapucaiPouso AlegreBrazil.

Background: The impact of breast appearance after breast cancer surgical treatment on patients’ quality of life led to the development of the oncoplastic approach. However, studies reporting oncologic results associated with this treatment strategy are scarce. This cross-sectional study was designed to assess oncologic outcomes among patients who underwent oncoplastic surgery. Methods: A total of 190 breast cancer patients who underwent breast-conserving surgery were enrolled. Fifty of them underwent oncoplastic surgery and 140 had none breast reconstruction procedure (control group). All surgeries were performed by the same surgical team. Results: Groups were similar with regard to staging, histological type, grade of the tumor, presence of intraductal component, hormone receptors and nodal commitment. Patients in oncoplastic surgery group had larger tumors (ρ = 0.001) and more lymphovascular invasion (ρ = 0.047). Further, a higher proportion of them underwent chemotherapy (ρ = 0.030). Follow-up time of control group was longer (ρ = 0.05), and these patients also had a longer relapse-free survival time (ρ = 0.001). Local recurrence rate was 5.8% (11/190) and it was significantly greater in the oncoplastic surgery group (8/11, ρ = 0.001). Time to local recurrence after surgery was longer in oncoplastic surgery group (ρ = 0.002). Overall, patients in oncoplastic surgery group were younger (ρ = 0.001), but at the time of local recurrence, patients in oncoplastic surgery group were older than those in control group (ρ = 0.0002). Conclusions: Among the studied patients, local recurrence rate was greater in those who underwent oncoplastic surgery.

关键词： Breast Cancer Mastectomy Segmental Breast Reconstruction Local Neoplasm Recurrence

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加速育种对材性的影响

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桉树科技 1988年第1期 38-43页

作者： yara Kiemi Ikemori Francisco Carlos Gilli Martin Bruce J.Zobel 李琼初

本文探讨选优和采用插条法繁殖桉树优树,采用高产无性系作为纸浆生产是有可能的, 这一作品叙述优树选择标准和确定木材基本密度和纸浆得率的方法。同时,还讨论母树的材质与其生长在不同土壤类型上的无性系植株的材质之间的关系。强调“... 详细信息

本文探讨选优和采用插条法繁殖桉树优树,采用高产无性系作为纸浆生产是有可能的, 这一作品叙述优树选择标准和确定木材基本密度和纸浆得率的方法。同时,还讨论母树的材质与其生长在不同土壤类型上的无性系植株的材质之间的关系。强调“无性系×土壤”的互相作用,说明这种互相作用是怎样影响材质,以至影响木材消耗率的。简介阿拉克鲁兹林业项目始于1967年。在里约北部,巴西东海岸的伊斯怕里多与圣多州这两个区域营造桉树林。在阿拉克鲁兹境内的林区,面积为5.5万公顷,另一区域在圣马多斯和巴拉两县境内,面积为4.5万公顷。桉树总种植纯面积为7万公顷,其余包括天然林,河湖道路和建筑。其纸浆厂于1978年10月投产,生产能力为45.6万吨/年桉树漂白纸浆。 1967～79年,主要种植种子来自巴西、津巴布韦和南非的巨桉。三年生时我们观察到群体间和群体内存在较大的基因差异,就从这些人工林中我们选择了优树,用作插条繁殖。选优

关键词：纸浆得率基本密度选优克鲁兹木材密度无性系植株蒸煮器纸浆生产木片源株材性

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Spontaneous Mammary Carcinomas in Female Dogs:Association between the Immunohistochemical Degree of Aggressiveness of Tumors,Intensity of DNA Damage and Residues of Pyrethroids

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Open Journal of Pathology 2013年第3期3卷 133-137页

作者： yara de Oliveira Brandao Marcia Moleta Colodel Glenda Nicioli da Silva Stephane Cássia Vexenat Isabelle Ferreira Yame Fabres Robaina Sancler da Silva Camilo Bulla Noeme Sousa Rocha Department of Clinical Veterinary Medicine Laboratory of Investigative and Comparative PathologySchool of Veterinary Medicine and Animal ScienceSao Paulo State UniversityBotucatuBrazil Departament of Pathology School of MedicineSao Paulo State UniversityBotucatuBrazil Laboratory of Biomedical Vibrational Spectroscopy(LEVB) Institute of Research and DevelopmentUniversidade do Vale do ParaíbaUrbanovaBrazil Department of Reproduction Sao Paulo State UniversityBotucatuBrazil Department of Pathobiology and Population Medicine College of Veterinary MedicineMississippi State UniversityStarkvilleUSA

Diagnosis and biological behavior of breast cancer of female dog represent one of the biggest challenges facing the Veterinarian in recent years. Due to its exponential growth and the degree of aggressiveness, the exact cause of this tumor is probably multifactorial and it is believed that may suffer influence from environmental factors. Among the suspected environmental contaminants are the pyrethroids. Aiming to investigate the participation of pyrethroids in tumorigenesis in female dogs, a study was conducted using 50 female dogs, 22 were positive for simple breast carcinoma (Group I), 18 with a diagnosis of complex breast carcinoma (Group II) and 10 negative (Group III) for breast cancer. In order to detect DNA damage, the Comet assay was performed on mammary samples of these animals, which also had samples submitted to the technique of High Performance Liquid Chromatography (HPLC), which aimed to quantify the concentration of pyrethroids. The results of HPLC of each animal were compared with those obtained by the Comet assay analysis of variance and the means were compared by the test groups “Student T” at the significance level of p ￡ 0.05. Despite presenting correlation between the amount of DNA damage and tumor aggressiveness, no statistical differences were found in the DNA damage of different histologic types of breast carcinoma. As for pyrethroids, even these were detected in 22% of tumor tissues and peritumoral fat, there was no difference in DNA damage between cells exposed and not exposed to environmental contaminant.

关键词： Mammary Carcinomas DNA Damage Pyrethroids

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