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A novel two-dimensional nanoheterojunction via facilitating electron–hole pairs separation for synergistic tumor phototherapy and immunotherapy

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Nano Research 2023年第5期16卷 7148-7163页

作者： Xiaoge Zhang Xiaomei Chen Peng Zhang Meiting Li Miao Feng yaqian Zhang Lili Cheng Junjie Tang Langtao xu Yadong Liu Zhuoyin Liu Zhong Cao Jie Liu School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

Nanomaterial-mediated phototherapy in tumor treatment has been developed rapidly in the past few years due to its noninvasive ***,the low energy conversion efficiency and high recombination rate of the photo-triggered electron–hole pairs of single nano-agent limit the phototherapy ***,we constructed a novel two-dimensional nanoheterojunction MoS_(2)-Ti_(3)C_(2)(MT),which allowed a high photothermal conversion efficiency(59.1%)as well as an effective separation of photo-triggered electron–hole pairs for reactive oxygen species(ROS)generation under single 808 nm laser *** the modification of the mitochondrial targeted molecule(3-proxycarboxylic)triphenyl phosphine bromide(TPP)and 4T1 cell membrane,m@MoS_(2)-Ti_(3)C_(2)/TPP(m@MTT)could effectively target to the tumor cell and further locate to the mitochondria to amplify tumor-specific oxidative stress,which not merely effectively inhibits the local tumor growth but also induces tumor immunogenic cell death(ICD)for activating antitumor immune ***,cytosine guanine dinucleotide(CPG),as a Toll-like receptor 9(TLR9)agonist,was further introduced to the system to boost adaptive immune responses,resulting in improved level of cytotoxic T cells as well as a decrease in the number of regulatory T *** vivo antitumor mechanism studies demonstrated that not only the primary and distant tumors in 4T1 bearing-tumor mice model were significantly inhibited,but also the lung metastasis of tumor was effectively ***,this work revealed the ROS generation mechanism of MT nanoheterojunction and provided a novel strategy to fabricate a biomedically applicable MT nanoheterojunction for tumor treatment.

关键词： two-dimensional nanoheterojunction mitochondrial targeting photothermal therapy photodynamic therapy immunotherapy

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丝瓜种质资源耐低温弱光性鉴定评价及筛选

浙江农业科学 2024年第5期65卷 1019-1024页

作者：陈小央柴亚倩董文其许云飞邱文敬孙玉燕浙江省种子管理总站浙江杭州310020 浙江省农业科学院蔬菜研究所浙江杭州310021

随着设施农业的不断发展,亟需选育出符合设施栽培的耐低温弱光丝瓜新品种,种质资源的耐低温弱光鉴定评价可为新品种选育奠定重要的材料基础。基于此,该研究利用智能人工气候室模拟低温弱光环境,对192份丝瓜种质资源开展耐低温弱光性鉴定... 详细信息

随着设施农业的不断发展,亟需选育出符合设施栽培的耐低温弱光丝瓜新品种,种质资源的耐低温弱光鉴定评价可为新品种选育奠定重要的材料基础。基于此,该研究利用智能人工气候室模拟低温弱光环境,对192份丝瓜种质资源开展耐低温弱光性鉴定,通过冷害分级、冷害指数、相对电导率等指标开展鉴定评价。结果表明,192份丝瓜种质资源的冷害指数范围为35.00%~92.86%,平均冷害指数为61.98%,变异系数为19.50%;相对电导率范围为10.39%~82.00%,平均相对电导率为49.18%,变异系数为24.80%。结合冷害指数(≤45%)和相对电导率(≤30%),筛选出耐低温弱光的丝瓜种质资源11份。将192份种质资源的冷害指数(y)与相对电导率(x)进行相关性分析,二者呈极显著正相关,并获得线性方程y=0.892x+0.1811(R^(2)=0.8101)。研究结果可为丝瓜种质资源耐低温弱光鉴定评价及耐低温弱光新品种选育奠定重要的理论和材料基础。

关键词：丝瓜种质资源低温弱光冷害指数相对电导率

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小儿金翘颗粒治疗儿童轻型流行性感冒风热证多中心随机对照临床研究

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中医杂志 2020年第14期61卷 1242-1246页

作者：马融胡思源许雅倩辛德莉冯自威赵爱利孙力代如民全惜春王永莉薛萍黄建玲张晓霞钟成梁郭圣璇天津中医药大学第一附属医院天津市300381 首都医科大学附属北京友谊医院河南省漯河市中医院陕西省咸阳市中心医院辽宁省丹东市第一医院河北省秦皇岛市第二医院河南省南阳市中医院陕西省铜川矿务局中心医院山西省太原市妇幼保健院陕西省汉中市三二0一医院辽宁省本溪市中医院

目的评价小儿金翘颗粒治疗儿童轻型流行性感冒风热证的疗效及其安全性。方法采用分层区组随机、阳性药平行对照、非劣效检验、多中心临床试验设计。计划纳入240例受试儿童,按1∶1比例随机分为治疗组和对照组。治疗组予小儿金翘颗粒,对... 详细信息

目的评价小儿金翘颗粒治疗儿童轻型流行性感冒风热证的疗效及其安全性。方法采用分层区组随机、阳性药平行对照、非劣效检验、多中心临床试验设计。计划纳入240例受试儿童,按1∶1比例随机分为治疗组和对照组。治疗组予小儿金翘颗粒,对照组予磷酸奥司他韦颗粒,疗程5天并随访2天。比较两组疾病临床痊愈时间,完全退热时间,CARIFS症状维度分与时间的曲线下面积,并发症、重症及危重症发生率,中医证候疗效(痊愈率)和安全性指标。结果共纳入临床诊断患儿240例,其中229例进入全分析数据集(FAS),200例进入符合方案数据集(PPS),233例进入安全性数据集(SS)。治疗后,主要指标疾病临床痊愈中位时间,治疗组与对照组均为3天,组间比较差异均无统计学意义(P>0.05),采用加速失效-对数正态模型,按0.75的非劣标准,治疗组非劣效于对照组,PPS与FAS分析结论一致。次要指标,治疗组和对照组的完全退热中位时间分别为42h、36h,组间比较,FAS分析差异有统计学意义(P0.05);CARIFS症状维度评分与时间曲线下面积,并发症、重症及危重症发生率,以及中医证候疗效(痊愈率)组间比较差异均无统计学意义(P>0.05)。治疗中,治疗组与对照组分别发现23例次、18例次不良事件。治疗组不良反应9例次、对照组10例次。不良事件与不良反应发生率的组间比较,差异均无统计学意义(P>0.05)。结论小儿金翘颗粒治疗儿童轻型流行性感冒具有缩短病程作用,疗效非劣于磷酸奥司他韦颗粒,临床应用的安全性较好。

关键词：小儿金翘颗粒流行性感冒风热证儿童随机对照试验

Association between soft drink consumption types and risk of lung cancer and all-cancer: A prospective study of PLCO data

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The Journal of Biomedical Research 2022年第6期36卷 390-400页

作者： Dongfang You Hongyang xu Xin Chen Jiawei Zhou yaqian Wu Yingdan Tang Zhongtian Wang Yang Zhao Fang Shao Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Critical Care Medicine Wuxi People's Hospital Affiliated to Nanjing Medical UniversityWuxiJiangsu 214023China China International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Diet/sugar-free soft drinks are considered to be healthier than regular soft ***,few studies have examined the relationship between the types of soft drinks(regular and diet/sugar-free)and lung cancer(LC)/all-cancer(AC)*** this study,we comprehensively assessed the influence of the type of soft drink consumption on LC/AC risk based on the Prostate,Lung,Colorectal,and Ovarian(PLCO)Cancer Screening *** Cox proportional hazards and competing risks Fine-Gray regression models adjusted for relevant confounders were used to estimate hazard ratios(HRs)and subdistribution HRs for different types of soft drink *** the PLCO population,female subgroup,and the ever/current smoker subgroup,consumption of both regular and diet soft drinks was associated with a significantly reduced risk of LC compared with no soft drinks at *** the non-lung cancer(NLC)risk,consumption of only diet soft drinks had a significant positive association for the total population and female *** on our findings,it was suggested that partial replacement of regular soft drinks with diet soft drinks might be beneficial to LC prevention,especially for females and ever/current ***,completely replacing regular soft drinks with diet soft drinks might be detrimental to NLC prevention,especially for females.

关键词： soft drink diet/sugar-free drink lung cancer all-cancer PLCO trial

Analysis of Risk Management for the Coal Mine Operations

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Energy and Power Engineering 2017年第4期9卷 12-18页

作者： yaqian Qi Tong xu Jun Steed Huang Hohai University Nanjing China Jiangsu University Zhenjiang China Suqian College Suqian China

More than half of the energy sources in China are provided by combustion of coal from thermal power stations. By lowering the risk of excavating coal mines, we can decrease the price of the energy. This paper stresses the danger of coal mine gas explosions and constructs a gas explosion risk prediction system based on standard Hypo-Variance by using Brain Storms Optimization implemented with MATLAB simulation software. Hypo-Variance is the new concept built on the basis of Gauss Variance and can be used to make more precise risk assessments. By analyzing the multiple connections among gas density, temperature, humidity, pressure, air velocity, we can predict the trend of the gas event and propose the most safely timed schedule: operating three shifts in a day starting from a particular hour right after the gas peaking is over.

关键词： Hypo-Variance Gauss Distribution Coal Mine Hazard

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基于远震接收函数的宜昌地区地壳结构

地震地磁观测与研究 2024年第3期45卷 16-22页

作者：况春利彭籽壹张雅茜张笑晗徐佳静王慧刘迁中国地震局地震研究所武汉430071 湖北省地震局武汉430071 中国地震台网中心北京100045 湖南省地震局长沙410004

通过湖北地震台网获得宜昌附近5个测震台站2020—2022年远震波形记录,采用时间域迭代反卷积方法,提取测震台站下方径向接收函数,并根据H-κ叠加方法进行反演,估算台站下方地壳厚度和平均波速比。结果显示,研究区地壳厚度呈EW向差异变化... 详细信息

通过湖北地震台网获得宜昌附近5个测震台站2020—2022年远震波形记录,采用时间域迭代反卷积方法,提取测震台站下方径向接收函数,并根据H-κ叠加方法进行反演,估算台站下方地壳厚度和平均波速比。结果显示,研究区地壳厚度呈EW向差异变化,数值为31.4—46.1 km,平均波速比为1.59—1.87。

关键词：接收函数 H-k叠加地壳厚度波速比

一起220kV断路器拒绝分闸故障的分析与处理

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山东电力高等专科学校学报 2024年第4期27卷 9-12页

作者：李晓磊刘雅倩张甲辉岳召许东岳崔兆亮国网山东省电力公司济南供电公司山东济南250012 国网山东省电力公司平阴县供电公司山东济南250400 国网山东省电力公司商河县供电公司山东济南251600

针对一起220 kV弹簧操动机构断路器拒绝分闸故障,分析了断路器拒绝分闸的常见原因,例如脱扣机构卡涩、分闸线圈损坏、操作板故障、二次端子接触不良等。结合现场检查和试验结果,最终确定该故障与断路器脱扣机构润滑不良、分闸线圈存在... 详细信息

针对一起220 kV弹簧操动机构断路器拒绝分闸故障,分析了断路器拒绝分闸的常见原因,例如脱扣机构卡涩、分闸线圈损坏、操作板故障、二次端子接触不良等。结合现场检查和试验结果,最终确定该故障与断路器脱扣机构润滑不良、分闸线圈存在质量问题有关,并对故障断路器进行了处理。最后提出了相应的整改措施,以减少此类故障发生的概率。

关键词：断路器拒绝分闸分闸线圈脱扣机构

Effects of interaction between single nucleotide polymorphisms and psychosocial factors on the response to antidepressant treatment in patients with major depressive disorder

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Journal of Genetics and Genomics 2022年第6期49卷 587-589页

作者： Di Luan Dongfang You yaqian Wu Fangfang Wu Zhi xu Ling Li Jiao Jiao Aini Zhang Haixia Feng Yan Kong Yang Zhao Zhijun Zhang Department of Neurology Affiliated Zhongda HospitalResearch Institution of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Environmental Health Harvard T.H.C1han School of Public HealthHarvard UniversityBoston 02115USA Department of Immunology and Medical Microbiology Nanjing University of Chinese MedicineNanjingJiangsu 210046China Department of Psychosomatics and Psychiatry Affiliated Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Nursing Affiliated Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBoston 02115USA China International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

Major depressive disorder(MDD) is the most common mental disorder. Over 95 million people in China suffer from MDD(Huang et al.,2019). Currently available antidepressants have delayed onset and a low cure rate(Malhi and Mann, 2018). Genetic and psychosocial factors, as well as their interactions, play an important role in the response to antidepressants for MDD patients(Uher, 2011;Gonda et al., 2019;Musci et al., 2019). Understanding the underlying associations and mechanisms may help to improve the first-episode cure rate in MDD patients.

关键词： patients depress

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基于成绩分析的环境卫生学教学思考与改革

卫生职业教育 2024年第16期42卷 33-36页

作者：韩雪徐学琴全善爱刘德臣王艳曲雅倩刘晓蕙河南中医药大学河南郑州450046

分析环境卫生学形成性考核和期末考试成绩,总结教学中存在的问题,从而改进教学方法,提高教学质量。结果表明,各考核项目能较好地区分学生的学习程度。学生的实践应用能力、归纳总结能力、分工合作能力及英文专业术语学习能力仍有待提高。

关键词：环境卫生学形成性考核期末考试成绩分析教学改革