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Macrophage-targeted nanomedicine for chronic diseases immunotherapy

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Chinese Chemical Letters 2022年第2期33卷 597-612页

作者： Yuejia Song yaqian huang? Fang Zhou Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Academician Workstation Changsha Medical UniversityChangsha 410219China Department of Pharmacy Southern University of Science and Technology HospitalShenzhen 518055China

Macrophage is the key innate immune effector in first-line defense against the pathogens, and can be polarized into different phenotypes to regulate a variety of immunological functions. However, the plasticity of macrophage is extraordinarily recruited, activated, and polarized under pathological conditions,playing paramount roles in occurrence, development, and prognosis of various chronic diseases, such as rheumatoid arthritis(RA), atherosclerosis(AS), and cancer. To this end, macrophage has become an important therapeutic target for etiological treatment of these diseases. Meanwhile, with the development of nanotechnology, various nano-drug delivery systems have been explored to target macrophages for disease modulation, displaying unique advantages to address both pharmaceutic and biopharmaceutic limitations of various drugs. This review aims to summarize the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy. First, the origin, polarization and biological functions of macrophages have been introduced, in which macrophages can differentiate into different phenotypes in response to physiological stimuli to play various immunological roles. Then, the macrophage disorder has been reviewed in related with various chronic diseases, and several representative diseases, including AS, RA, obesity, and cancer, have been discussed in detail to elucidate the pathological contributions of macrophages for disease progress. Next, strategies to regulate macrophages for diseases immunotherapy, such as macrophages depletion, macrophage reprograming, inhibition of macrophage recruitment,are summarized, and particular attention has been paid on bio-functional nanomaterials to engineer macrophages via different mechanisms. Further, methods for macrophage-targeting delivery nanosystems are discussed based on both passive and active targeting approaches. Finally, the perspective is speculated for potential clinical translation, and there still has

关键词： Nanoparticles Delivery Macrophages Polarization Immunotherapy

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不同破眠处理对阳光玫瑰葡萄冬芽萌发的影响

果树学报 2024年第5期41卷 897-910页

作者：饶余倩黄亚倩夏龙腾杨国顺王美军刘昆玉许延帅湖南农业大学园艺学院·湖南省葡萄工程技术研究中心长沙410128 永州市柑橘科学研究所湖南永州425045

【目的】寻找阳光玫瑰葡萄理想安全的破眠方法以及探究其破眠机制。【方法】以阳光玫瑰葡萄冬芽为试材,通过研究类休眠阶段和生理休眠阶段不同破眠处理对葡萄萌芽率、成花率和花穗质量的影响,并通过转录组测序筛选可能影响葡萄冬芽萌发... 详细信息

【目的】寻找阳光玫瑰葡萄理想安全的破眠方法以及探究其破眠机制。【方法】以阳光玫瑰葡萄冬芽为试材,通过研究类休眠阶段和生理休眠阶段不同破眠处理对葡萄萌芽率、成花率和花穗质量的影响,并通过转录组测序筛选可能影响葡萄冬芽萌发的关键基因。【结果】在萌芽前1个月对阳光玫瑰葡萄冬芽进行单氰胺处理、石硫合剂+1-氨基环丙烷羧酸(ACC)处理,均能使萌芽提前,显著提高萌芽率,不影响成花率及花穗质量。通过分析转录组数据,筛选了PYL4、PP2C24、PP2C8、PP2C37、PP2C25、SAPK2等差异表达基因,这些基因可能通过参与激素信号传导、氧化应激等途径影响葡萄芽的萌发。【结论】5°Bé石硫合剂+0.25 mg·mL-1ACC是阳光玫瑰葡萄打破休眠的一种安全、有效的处理方法。

关键词：葡萄休眠萌芽转录组

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Comments on 2018 CPCS guideline for diagnosis and treatment of syncopein children and adolescents

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Science Bulletin 2019年第5期64卷 291-292页

作者： Chunyan Tao Xueqin Liu Chunyu Zhang Yonghong Chen? yaqian huang?? Department of Pediatrics Peking University First Hospital

Syncope is one kind of transient loss of consciousness,due to transient global cerebral *** is sometimes misunderstood with other causes of transient loss of consciousness,like epilepsy,metabolic disorders,head trauma,psychological factors,and so *** in children and adolescents is common and seriously impacts the quality of their ***,its pathogenesis,etiologies,diagnosis and management are *** studies on syncope attract great interest of pediatricians and great progress has been made in this interesting *** on the improvement achieved so far,Chinese Pediatric Cardiology Society(CPCS)successfully developed a guideline for the diagnosis and treatment of syncope in children and adolescents,which would greatly improve the level of clinical management of syncope.

关键词： Comments 2018 CPCS guideline children and adolescents

ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo

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Science China(Life Sciences) 2015年第7期58卷 674-681页

作者： ZHANG Lu YU Fang WANG Li ZHENG JinGang DU YaoYao huang yaqian LIU Bo WANG Xian KONG Wei Department of Physiology and Pathophysiology School of Basic Medical Sciences Peking University Key Laboratory of Molecular Cardiovascular Science Ministry of Education Department of Cardiology China-Japan Friendship Hospital

Vascular smooth muscle cell(VSMC) proliferation and migration are pivotal for the pathogenesis of atherosclerosis and post-angioplasty restenosis. We have recently reported that a disintegrin and metalloproteinase with thrombospondin motifs-7(ADAMTS-7), a novel metalloproteinase, contributes directly to neointima formation by mediating VSMC migration. However, whether ADAMTS-7 affects VSMC proliferation remains unclear. In this study, we found that luminal adenoviral delivery of ADAMTS-7 aggravated intimal hyperplasia 7 d after injury, paralleled by an increased percentage of PCNA-positive cells in both intima and media. In contrast, perivascular administration of ADAMTS-7 si RNA, but not scrambled si RNA to injured arteries attenuated intimal thickening at day 7, paralleled with reduced intimal VSMC replication, without alteration of VSMC proliferation in the media. In accordance, [3H]-thymidine incorporation assay in primary cultured rat VSMCs revealed an enhanced replication rate(by 61%) upon ADAMTS-7 overexpression and retarded proliferation(by 23%) upon ADAMTS-7 si RNA administration. Our data demonstrates that ADAMTS-7 promotes VSMC proliferation both in vitro and in vivo. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and post-angioplasty restenosis.

关键词： vascular smooth muscle cell ADAMTS-7 proliferation

Endogenous sulfur dioxide is a new gasotransmitter with promising therapeutic potential in cardiovascular system

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Science Bulletin 2021年第16期66卷 1604-1607页

作者： yaqian huang? Heng Zhang Boyang Lv Chaoshu Tang Junbao Du Hongfang Jin Department of Pediatrics Peking University First HospitalBeijing 100034China Department of Endocrinology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Physiology and Pathophysiology Peking University Health Science CenterBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences Ministry of EducationBeijing 100191China

Sulfur dioxide(SO_(2))was previously considered only as air *** 2008,our group first detected the endogenous SO_(2)gener-ating enzymes as well as its generating pathway in cardiovascular system[1].Our recent studies have shown that endogenous SO_(2)plays important cardiovascular physiologic regulatory roles and has pathophysiological *** such,we suggested that it serves as a new gasotransmitter[1-4].

关键词：气体信号分子 generating dioxide

OsHYPK-mediated protein N-terminal acetylation coordinates plant development and abiotic stress responses in rice

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Molecular Plant 2022年第4期15卷 740-754页

作者： Xiaodi Gong yaqian huang? Yan Liang Yundong Yuan Yuhao Liu Tongwen Han Shujia Li Hengbin Gao Bo Lv Xiahe huang Eric Linster Yingchun Wang Markus Wirtz Yonghong Wang Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Crop Biology College of Life SciencesShandong Agriculture UniversityTaianShandong 271018China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Centre for Organismal Studies Heidelberg University69120 HeidelbergGermany

N-terminal acetylation is one of the most common protein modifications in eukaryotes,and approximately 40%of human and plant proteomes are acetylated by ribosome-associated N-terminal acetyltransferase A(NatA)in a co-translational ***,the in vivo regulatory mechanism of NatA and the global impact of NatA-mediated N-terminal acetylation on protein fate remain ***,we identify Huntingtin Yeast partner K(HYPK),an evolutionarily conserved chaperone-like protein,as a positive regulator of NatA activity in *** found that loss of OsHYPK function leads to developmental defects in rice plant architecture but increased resistance to abiotic stresses,attributable to perturbation of the N-terminal acetylome and accelerated global protein ***,we demonstrated that OsHYPK is also a substrate of NatA and that N-terminal acetylation of OsHYPK promotes its own degradation,probably through the Ac/N-degron pathway,which could be induced by abiotic *** together,our findings suggest that the OsHYPK-NatA complex plays a critical role in coordinating plant development and stress responses by dynamically regulating NatA-mediated N-terminal acetylation and global protein turnover,which are essential for maintaining adaptive phenotypic plasticity in rice.

关键词： rice OsHYPK N-terminal acetylation protein turnover plant architecture stress response

“一带一路”背景下的中国警务外交与海外利益保护

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公安研究 2020年第5期 75-80页

作者：黄亚茜江苏警官学院公安管理系涉外警务教研室

随着“一带一路”倡议的推进,中国海外利益的范围和深度正在迅速拓展.中国企业公民“走出去”成为常态,如何保护他们安全与合法权益已经成为中国外交不容回避的重要课题。警务外交正是应运而生的一种海外利益保护的新手段。本文尝试从... 详细信息

随着“一带一路”倡议的推进,中国海外利益的范围和深度正在迅速拓展.中国企业公民“走出去”成为常态,如何保护他们安全与合法权益已经成为中国外交不容回避的重要课题。警务外交正是应运而生的一种海外利益保护的新手段。本文尝试从警务外交的概念切入,探讨警务外交在当今时代背景下的特殊意义,并在分析当前海外利益保护现状的基础上,从深入发展职业外交、拓宽执法合作渠道、加强专业技术合作、推进国际执法话语权建设等方面提出强化警务外交的现实路径,呼唤进一步发挥警务外交的作用,以回应我国急剧增长的海外利益保护需求。

关键词： “一带一路”警务外交海外利益保护

初中教材中性别角色分析——以部编本《道德与法治》教材为例

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科教文汇 2020年第15期 136-137页

作者：黄雅倩湖南师范大学教育科学学院湖南长沙410081

本文以部编本《道德与法治》教材为对象进行文本和量化分析,得出结论:男女性别角色在教材中出现的频数存在明显差距;引用的名人名言出处大多为男性名人,女性名人事例占比例极小;男女两性在家庭和社会两个领域所扮演的角色类别与出现频... 详细信息

本文以部编本《道德与法治》教材为对象进行文本和量化分析,得出结论:男女性别角色在教材中出现的频数存在明显差距;引用的名人名言出处大多为男性名人,女性名人事例占比例极小;男女两性在家庭和社会两个领域所扮演的角色类别与出现频数存在明显差异。

关键词：部编本道德与法治教材性别角色生命教育

关于中东难民问题治理与中国建设性参与的若干思考

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中国国际财经（中英文版） 2017年第7期 6-9页

作者：黄雅倩安徽财经大学法学院安徽蚌埠233000

难民问题是长期存在的，在中东地区尤为明显。在全球治理中，国际社会通过多层次、多领域的合作，取得了明显的成效。然而一些障碍性因素的存在使得这一问题难以从根本上得到解决。在这个问题上中国与西方国家不同，西方国家一般注重问... 详细信息

难民问题是长期存在的，在中东地区尤为明显。在全球治理中，国际社会通过多层次、多领域的合作，取得了明显的成效。然而一些障碍性因素的存在使得这一问题难以从根本上得到解决。在这个问题上中国与西方国家不同，西方国家一般注重问题表面治理，而中国更加注重的是根本问题的解决。中国在中东难民问题治理中，通过单边援助与双边对话以及多边会议等多重机制在解决中东难民问题上发挥着不可替代的作用。

关键词：难民问题联合国难民署中国中东外交