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Molecular cloning,characterization and expression profile of the sucrose synthase gene family in Litchi chinensis

Horticultural Plant Journal 2021年第6期7卷 520-528页

作者： Dan Wang Jietang Zhao yaqi qin Yonghua qin Guibing Hu State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural Affairs/Guangdong Litchi Engineering Research CenterCollege of HorticultureSouth China Agricultural UniversityGuangzhou 510642China

Sucrose synthase(SUS,EC 2.***.1.13)is widely considered as a key enzyme involved in plant sucrose metabolism,and the gene family encoding different SUS isozymes has been identified and characterized in several plant ***,to date scant information about the SUS genes is available in Litchi chinensis ***,we identified five SUS genes in *** Lc SUSs shared high levels of similarity in both nucleotide and amino acid *** gene structure,phylogenetic relationships,and expression profiles were *** structure analysis indicated that the Lc SUSs have similar exon-intron *** analysis revealed that the five members could be classified into three groups(LcSUS1 and LcSUS2 in SUSⅡ,LcSUS4 and LcSUS5 in SUSⅢ,and LcSUS3 in SUSⅠ),demonstrating evolutionary conservation in the SUS family across litchi and other plant *** expression levels of Lc SUSs were investigated via real-time PCR in various tissues and different developmental stages of *** tissues and organs,Lc SUSs exhibited distinct but partially redundant expression profiles in litchi,being predominantly expressed in young leaves(sink).During aril development,the expression pattern of LcSUS1 was consistent with the trend of sugar accumulation,indicating it may play important roles in determination of sink strength in ***,transcript levels of LcSUS2,LcSUS4,and LcSUS5 varied between cultivars with different hexose/sucrose ratios,which may regulate the sugar composition in *** results provide insights into physiological functions of SUS genes in litchi,especially roles in regulating sugar accumulation in aril.

关键词： Litchi chinensis Sucrose synthase Gene expression Aril Sugar accumulation

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Network analysis of suicide ideation and depression-anxiety symptoms among Chinese adolescents

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General Psychiatry 2024年第2期37卷 216-223页

作者： Shuyin Xu Yumeng Ju Xiyu Wei Wenwen Ou Mohan Ma Guanyi Lv Xiaotian Zhao yaqi qin Yunjing Li Liang Li Mei Huang Siqi Yang Yimei Lu Yafei Chen Junwu Liu Jin Liu Bangshan Liu Yan Zhang Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina Mental Health Institute of Central South University China National Technology Institute on Mental DisordersHunan Technology Institute of PsychiatryHunan Key Laboratory of Psychiatry and Mental HealthHunan Medical Center for Mental HealthChangshaHunanChina

Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide *** The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and *** 1501 adolescents aged 12-19 years were assessed using the Patient Health Questionnaire(PHQ-9)and the Generalized Anxiety Disorder Scale,and 716 adolescents who scored≥5 on both scales were selected as *** analysis was used to identify the network structure of depressive symptoms and anxiety *** were categorised into either the suicide ideation or non-suicide ideation groups based on their scoring on the suicide-related item in PHQ-9.A comparison was made between the depression-anxiety symptom networks of the two ***‘Restlessness’,‘sad mood’and‘trouble relaxing’were the most prominent central symptoms in the depression-anxiety symptom network,and‘restlessness’,‘nervousness’and‘reduced movement’were the bridge symptoms in this network.‘Sad mood’was found to be directly related to‘suicide ideation’with the highest *** network structure was significantly different in properties between the suicide ideation group and the non-suicide ideation group,with‘restlessness’and‘sad mood’exhibiting significantly higher influence in the network of the suicide ideation group than that in the non-suicide ideation *** Restlessness and sad mood could be targeted for the intervention of depression-anxiety symptoms among adolescents with suicide ideation.

关键词： symptoms adolescent assessed

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发根农杆菌介导的荔枝LcMYB1转化烟草叶片的研究

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园艺学报 2020年第4期47卷 635-642页

作者：秦雅琪胡桂兵赵杰堂华南农业大学园艺学院亚热带农业生物资源保护与利用国家重点实验室华南地区园艺作物生物学与种质创制农业部重点实验室广东省荔枝工程技术中心广州510642

利用荔枝果皮花青苷生物合成的关键调节基因LcMYB1为标记,构建植物表达载体pBA002-LcMYB1,电转法转入发根农杆菌A4菌株,通过叶盘法转化烟草K326。结果表明,烟草叶片侵染一周后长出白色的毛状根,约3周后部分毛状根逐渐变成红色,毛状根诱... 详细信息

利用荔枝果皮花青苷生物合成的关键调节基因LcMYB1为标记,构建植物表达载体pBA002-LcMYB1,电转法转入发根农杆菌A4菌株,通过叶盘法转化烟草K326。结果表明,烟草叶片侵染一周后长出白色的毛状根,约3周后部分毛状根逐渐变成红色,毛状根诱导率为100%,红色毛状根诱导率为19.9%。当筛选培养基中添加5 mg·L^-1 Basta,毛状根诱导率降低为33.3%,但红色毛状根诱导率提高到75%。高效液相色谱分析表明,红色毛状根中积累矢车菊素-3-葡萄糖苷和矢车菊素-3-芸香糖苷,PCR检测证实红色毛状根是由LcMYB1的转入引起的。实时荧光定量PCR表明转LcMYB1可以诱导烟草毛状根中花青苷生物合成相关的结构基因和调节基因表达。

关键词：荔枝花青苷 MYB 发根农杆菌烟草转基因毛状根

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火电机组碳排放特性研究及管理建议

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中国电力 2018年第3期51卷 144-149,169页

作者：孙友源郑张秦亚琦郭振任健华电电力科学研究院有限公司浙江杭州310030

为研究燃煤机组碳排放特性,在深入分析GB/T 32151.1—2015中计算碳排放量方法学的基础上,建立了供电碳排放强度简化计算模型和详细计算模型,并通过实测单位热值含碳量和碳氧化率数据对所建模型进行了可靠性验证,证明了所建模型能相对准... 详细信息

为研究燃煤机组碳排放特性,在深入分析GB/T 32151.1—2015中计算碳排放量方法学的基础上,建立了供电碳排放强度简化计算模型和详细计算模型,并通过实测单位热值含碳量和碳氧化率数据对所建模型进行了可靠性验证,证明了所建模型能相对准确快速地获得机组碳排放强度。以某电厂超高压循环流化床机组为例,基于所建模型深入分析了供电煤耗和煤种对碳排放相关指标影响,结果表明供电煤耗和煤种标煤的碳排放系数的减小可显著降低机组碳排放强度,并给出了发电企业控制碳排放的相关建议,为发电企业碳排放管理工作提供了参考。

关键词：燃煤机组碳排放碳排放强度供电煤耗煤种标煤的碳排放系数

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智能化曝气控制A/O工艺处理低C/N生活污水有效性及其脱氮机制

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环境工程学报 2017年第10期11卷 5359-5367页

作者：徐旻旸胡湛波秦雅琪李红珍 INTHAVONGXAI Phoungern 陶村贵广西大学环境学院南宁530004 广西益江环保科技股份有限公司南宁530004

将新型智能化曝气控制系统(automatic oxygen supply device,AOSD)应用于A/O工艺中,研究AOSD系统曝气模式控制下的A/O工艺(I-A/O)与持续曝气模式的A/O工艺(C-A/O)对低C/N生活污水处理能力的有效性,并从系统活性污泥特性的角度探究I-A/O... 详细信息

将新型智能化曝气控制系统(automatic oxygen supply device,AOSD)应用于A/O工艺中,研究AOSD系统曝气模式控制下的A/O工艺(I-A/O)与持续曝气模式的A/O工艺(C-A/O)对低C/N生活污水处理能力的有效性,并从系统活性污泥特性的角度探究I-A/O系统反硝化菌在脱氮过程中对碳素的摄取、利用途径。结果表明:低进水碳源负荷下,I-A/O与C-A/O系统对COD、NH_4^+-N的平均去除率稳定且均达80%以上;I-A/O系统对TN去除率高出C-A/O系统25.97%,其对TN具有明显的去除优势;2套系统对TP均无去除效果。I-A/O系统活性污泥好氧异养菌产率系数Y_H为0.142 mg·mg^(-1),活性污泥衰减系数K_d为0.018 d^(-1),均低于C-A/O系统;在进水低C/N水平下,I-A/O系统活性污泥可通过更强的吸附贮存碳源能力、较低的好氧异养菌竞争压力、溶胞作用为反硝化菌提供更多的碳源以便脱氮反应。C/N是I-A/O系统曝气总量节省率重要影响因素之一,相比于C-A/O系统,其处理低C/N生活污水可节约曝气系统约52%的曝气量。

关键词：智能化曝气控制系统(AOSD) A/O工艺低C/N生活污水脱氮机制活性污泥特性曝气能耗

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障碍物对大型LNG储罐泄漏蒸气扩散影响的模拟研究

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石油与天然气化工 2019年第2期48卷 103-110页

作者：秦雅琦李玉星韩辉王武昌杨洁中国石油大学(华东)储运与建筑工程学院山东省油气储运安全省级重点实验室

全球液化天然气(LNG)需求日益增长,其储存与运输过程中泄漏扩散致灾是LNG安全利用的关键。通过建立大型LNG储罐泄漏的三维数值模型,基于国家规范设计挡板和3种围堰,利用Fluent软件,对不同障碍物情况气云扩散的规律进行模拟计算分析。结... 详细信息

全球液化天然气(LNG)需求日益增长,其储存与运输过程中泄漏扩散致灾是LNG安全利用的关键。通过建立大型LNG储罐泄漏的三维数值模型,基于国家规范设计挡板和3种围堰,利用Fluent软件,对不同障碍物情况气云扩散的规律进行模拟计算分析。结果表明:在扩散初期,围堰高度对于阻挡气云向外扩散起决定性作用,能够有效地推迟气云在下风方向的扩散进程,设置的围堰可推迟气云的扩散行为3～6 min;当在下风向设置挡板时,气云在下风向的扩散距离增加了5.2%,没有达到抑制气云扩散的效果;通过改变围堰的长宽比,可以加强对气云扩散行为的抑制作用。该数值计算结果为设计优化LNG罐区围堰与挡板提供了理论依据,为应急程序的制定提供了理论支持。

关键词： LNG储罐泄漏扩散 Fluent 障碍物数值模拟

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing Qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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