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Structural Changes and Rheological Properties of Dry Abalone Meat (Haliotis diversicolor) During the Process of Water Restoration

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Journal of Ocean University of China 2007年第4期6卷 403-406页

作者： GAO Xin ZHANG yaqi xu Jiachao SUN Yan ZHAO Qingxi CHANG Yaoguang College of Food Science and Engineering Ocean University of China Qingdao 266003 P.R. China

Changes in tissue structure, rheological property and water content of dry abalone meat in the process of water restora- tion were studied. The weight and volume of dry abalone meat increased with water restoration. When observed under a light micro- scope, structural change in myofibrils was obvious and a distinct network was found. When water restoration time increased from 24 h to 72 h, the instantaneous modulus E0 and viscosity η1 increased, whereas the rupture strength and relaxation time (τ1) were re- duced. There were no significant changes of rheological parameters (E0, η1, τ1, rupture strength) from 72 h to 96 h of water restoration. Therefore, the dry abalone meat was swollen enough at the time of 72 h. The rheological parameters were obviously influenced by the structural changes.

关键词： dry abalone water restoration muscle structure rheology myofibril collagen

Development of the A&GBE base editor for efficiently generating abundant genetic variation in rice

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The Crop Journal 2024年第6期12卷 1801-1805页

作者： Wenhui Zhang yaqi xu Jingxuan Cui Yingshuang xue Lijie Zhang Wenjuan Wu Chong Wang Hui Zhang Shanghai Collaborative Innovation Center of Plant Germplasm Resources Development Shanghai Key Laboratory of Plant Molecular SciencesCollege of Life SciencesShanghai Normal UniversityShanghai 200234China

We have developed a dual base editor,rA&GBE,by fusing adenine and glycosylase base *** can induce up to eight types of mutations in T0-generation rice,including single-base conversion,simultaneous multiple-base conversions,and InDels,using a single guide RNA.A-to-G and C-to-G/T conversions occur simultaneously on the same DNA *** rA&GBE system may prove useful for crop improvement and in planta direct evolution.

关键词： CRISPR A&GBE Genetic variation Rice

Early-life exposure to per-and polyfluoroalkyl substances:Analysis of levels,health risk and binding abilities to transport proteins

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Eco-Environment & Health 2024年第3期3卷 308-316页

作者： yaqi xu Xinyao Sui Jinhong Li Liyi Zhang Pengpeng Wang Yang Liu Huijing Shi Yunhui Zhang Key Lab of Health Technology Assessment National Health Commission of the People's Republic of ChinaFudan UniversityShanghai 200032China Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China

Per-and polyfluoroalkyl substances(PFAS)can pass through the placenta and adversely affect fetal ***,there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregnant women and their *** study,based on the Shanghai Maternal–Child Pairs Cohort,analyzed the concentrations of 16 PFAS in the maternal serum,cord serum,and breast milk samples from 1,076 motherchild *** placental and breastfeeding transfer efficiencies of PFAS were determined in maternal-cord and maternal-milk pairs,*** binding affinities of PFAS to five transporters were simulated using molecular *** results suggested that PFAS were frequently detected in different *** median concentration of perfluorooctane sulfonate(PFOS)was the highest at 8.85 ng/mL,followed by perfluorooctanoic acid(PFOA)at 7.13 ng/mL and 6:2 chlorinated polyfluorinated ether sulfonate at 5.59 ng/mL in maternal *** median concentrations of PFOA were highest in cord serum(4.23 ng/mL)and breast milk(1.08 ng/mL).PFAS demonstrated higher placental than breastfeeding transfer *** transfer efficiencies and the binding affinities of most PFAS to proteins exhibited alkyl chain length-dependent ***,we comprehensively assessed the estimated daily intakes(EDIs)of PFAS in breastfeeding infants of different age groups and used the hazard quotient(HQ)to characterize the potential health *** decreased with infant age,and PFOS had higher HQs than *** findings highlight the significance of considering PFAS exposure,transfer mechanism,and health risks resulting from breast milk intake in early life.

关键词： Emerging PFAS Placental transfer Breast milk Health risk Binding affinity

2018 Annual Report:China National Committee for IGCP

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Acta Geologica Sinica(English Edition) 2019年第S1期93卷 86-89页

作者： HOU Zengqian WU Zhenhan LI Wei GU Yanfei SITU Yu xu yaqi MU Langfeng Chinese Academy of Geological Sciences Beifing 100037China National Natural Science Foundation of China Beifing 100085China

Part One:Chairman,Vice Chairpersons and Secretary General of the Committee Chairman:*** Zengqian Vice President National Natural Science Foundation of China83 Shuangqing Road,Haidian District Beijing 100085,China Tel:... 详细信息

关键词： China Committee IGCP

Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years

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Eco-Environment & Health 2023年第3期2卷 152-160页

作者： Hang Wang Liyi Zhang Jie Wu Pengpeng Wang Qiang Li Xinyao Sui yaqi xu Yue Zhao Yang Liu Yunhui Zhang Key Lab of Health Technology Assessment National Health Commission of the People’s Republic of China(Fudan University)Shanghai 200032China Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China The Maternal and Child Healthcare Hospital of Songjiang District Shanghai 201600China

The connections between urinary organophosphate ester(OPE)metabolites and child growth have been identified in prior research,but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth *** study enrolled 804 maternal-child pairs,and five OPE congeners were quantified in maternal serum during *** this study,the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model(GBTM),with consideration given to sex-specific *** were frequently exposed to OPEs in utero,and tris(2-butoxyethel)phosphate(TBEP)exhibited the highest concentration levels in maternal *** male children,an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score(HCAZ),and the effect was mainly concentrated at 1 and 2 months of *** female children,an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl)ethyl)phosphate(TDCPP)concentration was associated with a 0.15-unit increase in length-for-age z-score(LAZ)and a 0.14-unit increase in weight-for-age z-score(WAZ),and the effects were mainly concentrated at 9 months of *** HCAZ trajectories,higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male *** the LAZ and WAZ trajectories,higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female *** trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth.

关键词： Organophosphate esters Child growth trajectories Sex-specific effects Birth cohort

Current Situation and Countermeasures of Household Waste Classification in Feixi County, Hefei City

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Meteorological and Environmental Research 2024年第3期15卷 77-81页

作者： yaqi xu Yalong JIANG Enqing GAO Shimao FENG Yuchen QIANG School of Urban Construction College Anhui Xinhua UniversityHefei 230088China

Feixi County has made significant progress in promoting waste classification,such as establishing a comprehensive classification system,and effectively reducing environmental pollution and waste ***,with the increase in waste generation,the county faces multiple challenges especially in the disposal of kitchen waste and improvement of residents environmental *** address these issues,Feixi County has implemented various measures,such as strengthening the construction of infrastructure for waste classification,improving regulations and clearly defining responsibilities,enhancing residents environmental awareness to encourage their participation in waste classification through education and promotion,and increasing supervision to ensure effective implementation of the *** emphasizes community governance,encourage all parties to participate in it,and strengthen publicity,education and training to enhance residents *** County has achieved positive results,but efforts are needed to further improve facilities,raise awareness,enhance supervision,and ensure the continuous effectiveness of waste classification work to promote urban green sustainable development.

关键词： Household waste classification Current situation Countermeasures Feixi County

Prenatal PM_(2.5)Exposure Associated with Neonatal Gut Bacterial Colonization and Early Children’s Cognitive Development

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Environment & Health 2024年第11期2卷 802-815页

作者： Yang Liu Liyi Zhang Jieming Wang Xinyao Sui Jiufeng Li Yuyan Gui Hang Wang Yue Zhao yaqi xu Weizhao Cao Pengpeng Wang Yunhui Zhang Key Lab of Health Technology Assessment National Health Commission of the People’s Republic of China(Fudan University)Shanghai 200032China Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China Department of Environmental and Occupational Health School of Public HealthZhengzhou UniversityHenan 450001China

Previous research indicated that fine particulate matter(PM_(2.5))exposure affected both offspring neurodevelopment and the colonization of gut microbiota(GM),while the underlying mechanism remained *** study aimed to evaluate the impacts of prenatal PM_(2.5) exposure on child cognitive development and investigate the role of neonatal GM colonization in the *** on the Shanghai Maternal−Child Pairs Cohort,361 maternal−child pairs were *** PM_(2.5) exposure concentrations were estimated using a high-spatial-resolution prediction model,and child neurodevelopment was assessed by the Ages and Stages *** linear regression models,logistic regression models,linear discriminant analysis effect size,and random forest model were applied to explore the associations among PM_(2.5) exposure,GM colonization,and children’s *** present study revealed a negative correlation between PM_(2.5) exposure throughout pregnancy and child *** PM_(2.5) exposure was associated with an increased risk of suspected developmental delay(SDD)(OR=1.683,95%CI:1.138,2.489)in infants aged 2 ***,potential operational taxonomic unit markers were identified for PM_(2.5)-related neurotoxicity,demonstrating promising classification potential for early SDD screening(AUC=71.27%).Prenatal PM_(2.5) exposure might disrupt the composition,richness,and evenness of meconium GM,thereby influencing cognitive development and the occurrence of SDD in *** PM_(2.5)-related genera,Ruminococcus gnavus group,Romboutsia,Burkholderiaceae Caballeronia Paraburkholderia,Blautia,Alistipes,Parabacteroides,and Bacteroides,were validated as correlated with prenatal PM_(2.5) exposure and the occurrence of ***,alterations of GM related to PM_(2.5) exposure and SDD might be accompanied by changes in functional pathways of amino acid,lipid,and vitamin metabolism as indicated by differentially enriched s

关键词： fine particulate matter birth cohort neurodevelopmental delay gut microbiota

Progress in adverse effects of sleep deprivation on body fertility

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中国药理学与毒理学杂志 2023年第7期37卷 486-486页

作者： ZHANG Shengxiao GUO Xingdao CHEN Wenyang xu yaqi LI Wei ZHANG Guirong College of Pharmacy Hebei North University Bioscience Today (Beijing) Biotechnology Research Institute

Sleep is essential for the maintenance of human normal functions. Nowadays, the occurrence of active sleep deprivation (ASD) or passive sleep deprivation (PSD) is becoming more and more common due to the inability of the body adapting to the rapid changes in the internal and external environment. SD is not only an action, a brief process or a result, but also a directly or indirectly sustained state, which is associated to sleep time, circadian rhythm or sleep quality. SD can lead to numerous adverse effects on the body, such as sleep-related acute and chronic diseases. Long-term SD increases the risk of neurological and cardiovascular diseases as well as immune system dysfunction. In addition, SD may affect the reproductive health of the body,giving rise to a series of potential fertility problems. In recent years, the correlation research and mechanism between SD and the related diseases have become a focus of scholars′attention. Numerous lines of evidence suggest that pathological sleep, such as insomnia and sleep apnea syndrome, is associated with impaired reproductive function. Disruptions in the circadian rhythm can also lead to impaired hypothalamic-pituitary-gonadal(HPG) axis function and thereby interfere with the reproductive process. Our research team has demonstrated that SD significantly affects the fertility of male and female rats and has adverse effects on reproduction. By new generation sequencing (NGS) and RT-PCR verification, we have identified differently expressed genes that are involved in mediating the effect of SD on ***, the mechanisms and biological macromolecules regulated by SD are worthy of being further *** paper provides a brief review of SD research and then focuses on the adverse impact of SD on fertility,conducting a literature review to sort out the ideas and provide references for research in this field.

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噬菌体在重症医学科中的应用与前景展望

中国生物工程杂志 2024年第8期44卷 148-154页

作者：任德志李函洋徐亚奇童贻刚段军中日友好医院(中日友好临床医学研究所)北京协和医学院中国医学科学院北京100029 北京化工大学生命与科学技术学院北京100029 中日友好医院重症医学科北京100029

目前重症医学科超级细菌产生逐年增加,给院内感染防控和公共卫生带来许多新挑战。噬菌体是一种能特异性感染并裂解细菌的病毒,为重症多重耐药菌感染的治疗带来新希望。总结了利用噬菌体进行院内环境消杀与监控、治疗重症感染的案例,并... 详细信息

目前重症医学科超级细菌产生逐年增加,给院内感染防控和公共卫生带来许多新挑战。噬菌体是一种能特异性感染并裂解细菌的病毒,为重症多重耐药菌感染的治疗带来新希望。总结了利用噬菌体进行院内环境消杀与监控、治疗重症感染的案例,并分析了在重症医学科中应用噬菌体的问题与可能对策,为噬菌体在重症医学科中的应用研究提供新思路。

关键词：噬菌体治疗重症医学医院感染多重耐药菌