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基于Nrf2-GPX4铁死亡轴探讨黄连-红曲对小鼠非酒精性脂肪肝的影响

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中国实验方剂学杂志 2024年第20期30卷 30-36页

作者：杨炀张小波张永卢富明罗雅琪吴晓仪四川省中医药科学院中医研究所(四川省第二中医医院) 成都610031 成都中医药大学基础医学院成都611137 自贡市中医医院四川自贡643010

目的:观察黄连-红曲对非酒精性脂肪肝小鼠的影响,并探讨其可能的作用机制。方法:60只SPF级C75BL/6J雄性小鼠随机分为空白组、模型组、黄连-红曲低、中、高剂量组(0.75、1.5、3 g·kg^(-1))、二甲双胍组(0.075 g·kg^(-1)),每组10只。利... 详细信息

目的:观察黄连-红曲对非酒精性脂肪肝小鼠的影响,并探讨其可能的作用机制。方法:60只SPF级C75BL/6J雄性小鼠随机分为空白组、模型组、黄连-红曲低、中、高剂量组(0.75、1.5、3 g·kg^(-1))、二甲双胍组(0.075 g·kg^(-1)),每组10只。利用高脂饲料喂养24周构建非酒精性脂肪性肝病(NAFLD)小鼠模型,黄连-红曲低、中、高剂量组给与相应剂量黄连-红曲灌胃,空白组和模型组给与等量生理盐水,连续处理4周。采用全自动生化仪检测血清血脂指标总胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA)和肝功能指标肝功丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)水平,采用苏木素-伊红(HE)和油红O染色检测肝脏脂质沉积情况,普鲁士蓝染色检测肝脏亚铁离子水平;采用蛋白免疫印迹法(Western blot)检测肝脏核因子E_(2)相关因子2(Nrf2)-谷胱甘肽过氧化物酶4(GPX4)轴关键蛋白的表达。结果:高脂饲养24周后,与空白组比较,模型组小鼠体质量显著增加,肝重和肝指数显著升高,血脂显著升高(P<0.01),肝脏脂质大量沉积,表现出显著的脂肪样变。与模型组比较,黄连-红曲干预后,小鼠体质量显著减轻(P<0.01),肝重和肝指数显著降低(P<0.01),血脂水平明显下降(P<0.05,P<0.01),肝功能显著降低(P<0.01),肝脏脂质沉积减轻,其中黄连-红曲低剂量组效果较好。Western blot结果显示,与空白组比较,模型组小鼠肝脏Nrf2、血红素氧合酶(HO-1)、Kelch样ECH相关蛋白(Keap1)和GPX4蛋白表达明显下降(P<0.05,P<0.01);与模型组比较,给与黄连-红曲后,各组小鼠肝脏Nrf2、HO-1、Keap1和GPX4蛋白表达升高(P<0.05,P<0.01)。结论:黄连-红曲可减轻小鼠脂肪肝,改善肝功和减轻肝脏脂质沉积,其机制可能与调控Nrf2-GPX4铁死亡轴有关。

关键词：黄连-红曲脂肪肝小鼠铁死亡核因子E_(2)相关因子2(Nrf2)-谷胱甘肽过氧化物酶4(GPX4)轴

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巨噬细胞在真菌性角膜溃疡中的作用

国际眼科杂志 2024年第10期24卷 1582-1587页

作者：罗艳婷杨珺铭罗雅琪吴瞬亮彭梓轩何宏钟兴武海南医科大学第一附属医院眼科海南省海口市570102 中山大学中山眼科中心海南眼科医院、海南省眼科医院、海南省眼科学重点实验室海南省海口市570311

真菌性角膜溃疡是严重的致盲性眼病。真菌感染的发生主要取决于真菌毒力和宿主免疫防御因素之间的相互作用。角膜被认为是免疫特权器官,驻留的巨噬细胞是主要的免疫细胞,其极化响应微环境表现出的异质性。感染早期,巨噬细胞向M1极化,促... 详细信息

真菌性角膜溃疡是严重的致盲性眼病。真菌感染的发生主要取决于真菌毒力和宿主免疫防御因素之间的相互作用。角膜被认为是免疫特权器官,驻留的巨噬细胞是主要的免疫细胞,其极化响应微环境表现出的异质性。感染早期,巨噬细胞向M1极化,促进炎症发生,利于真菌清除但产生细胞风暴加重免疫损伤;感染后期,巨噬细胞向M2极化,可抑制炎症反应、促进组织修复但可能产生免疫抑制甚至免疫逃逸,不利于病原清除。促炎反应与抗炎反应之间的平衡是保持角膜功能完整性的关键。目前抗真菌药物治疗有限,因此除了抗真菌治疗外,寻找一种针对免疫反应引发的炎症反应的治疗靶点尤为重要。文章综述了真菌性角膜溃疡中巨噬细胞亚群的表型特征和功能,需要更深入的研究来探索巨噬细胞极化的具体机制及其对真菌性角膜溃疡的影响,基于巨噬细胞的表型和功能对巨噬细胞分化进行靶向调节可能是未来治疗和管理真菌性角膜溃疡的有效方法。

关键词：巨噬细胞极化 M1/M2 真菌性角膜溃疡免疫中性粒细胞

基于网络药理学研究参桑茶治疗慢性疲劳综合征的作用机制

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中药与临床 2024年第5期15卷 37-43页

作者：黄柳雯谢宛莹杨炀罗雅琪四川省第二中医医院

目的：基于网络药理学方法结合实验验证，研究参桑茶治疗慢性疲劳综合征的作用机制。方法：利用TCMSP数据库筛选出参桑茶主要活性成分及对应靶点基因；通过DiGSeE数据库获得慢性疲劳综合征靶点基因；利用Cytoscape3.7.0软件筛选参桑茶... 详细信息

目的：基于网络药理学方法结合实验验证，研究参桑茶治疗慢性疲劳综合征的作用机制。方法：利用TCMSP数据库筛选出参桑茶主要活性成分及对应靶点基因；通过DiGSeE数据库获得慢性疲劳综合征靶点基因；利用Cytoscape3.7.0软件筛选参桑茶治疗慢性疲劳综合征的关键靶点，并利用插件进行富集分析。50只雄性BALB/c小鼠随机分为5组，每组10只，分别为对照组（N）、模型组（M）、低剂量组（D1）、中剂量组（D2）、高剂量组（D3），分别进行冷水游泳、疲劳跑步、疲劳转棒和睡眠剥夺，每天1次，持续4周，第三周开始给药。取肝脏和肌肉组织，用HE染色法观察组织切片，ELISA法检测糖原、ATP、LDH、BUN含量，免疫荧光方法检测NF-κB、TGF-β蛋白表达水平。结果：富集发现核心靶点与NF-κB与TGF-β信号转导密切相关。观察HE、免疫荧光染色结果发现，用参桑茶处理后小鼠病理情况有改善，小鼠肝脏和肌肉组织中NF-κB、TGF-β表达减少。结论：参桑茶具有抗疲劳作用，分子机制可能与NF-κB、TGF-β通路有关。

关键词：网络药理学参桑茶慢性疲劳综合征

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大疱性疥疮三例并文献复习

中国麻风皮肤病杂志 2024年第7期40卷 474-479页

作者：陈留鑫蔡艳霞刘雅芹杨艳平谢映霞邓诗音罗雅琪广东医科大学附属医院皮肤科广东湛江524000 广东医科大学广东湛江524000

大疱性疥疮(bullous scabies,BS)是疥疮的一种罕见的临床表现,极易误诊。本文报道3例既往误诊的BS患者,并通过万方及PubMed学术数据库检索“大疱性疥疮”文献,检索到44篇文献,包括60例患者,总结分析该病的人口统计学信息、发病机制、临... 详细信息

大疱性疥疮(bullous scabies,BS)是疥疮的一种罕见的临床表现,极易误诊。本文报道3例既往误诊的BS患者,并通过万方及PubMed学术数据库检索“大疱性疥疮”文献,检索到44篇文献,包括60例患者,总结分析该病的人口统计学信息、发病机制、临床表现、病理特点及治疗,发现BS好发于老年群体及男性患者,约1/3患者存在误诊史,3/4患者在接受糖皮质激素治疗后病情未见缓解或进一步进展。皮肤科医生应提高对该病的认识,并且治疗上应谨慎使用糖皮质激素。

关键词：大疱性疥疮疥螨糖皮质激素大疱性类天疱疮

Insights into the mechanisms underlying the biodegradation of phenanthrene in biochar-amended soil:from bioavailability to soil microbial communities

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Biochar 2023年第1期5卷 273-289页

作者： Meng Zhang yaqi luo Yitao Zhu Haiyun Zhang Xilong Wang Wei Li Pingping Li Jiangang Han Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China National Positioning Observation Station of Hung-tse Lake Wetland Ecosystem in Jiangsu Province Hongze 223100China Agricultural Environment and Farmland Conservation Experiment Station of Ministry Agriculture Shanghai Academy of Agricultural SciencesShanghai 201403China Laboratory for Earth Surface Processes College of Urban and Environmental SciencesPeking UniversityBeijing 100871China

The dynamic effect of biochar amendment in contaminated soil on the bioavailability of polycyclic aromatic hydrocarbons(PAHs)and microbial communities and how it comprehensively affects PAH biodegradation remain *** study investigated the effects of wheat straw-derived biochars obtained at 300 and 500℃ at different amendment levels(0.03%and 0.3%)on the mineralization kinetics of phenanthrene with different initial concentrations(2 and 20 mg kg^(−1))in soil by indigenous *** results revealed that the addition of biochar inhibited both the rates and extents of mineralization in low-concentration phenanthrene-contaminated soil(PLS)by 38.9-78.3%and 23.9-53.6%,*** was because biochar amendment in the PLS greatly reduced the bioavailable fraction of phenanthrene for degradation owing to its strong sorption and also decreased that to specific degrading bacterial genera,which hindered their growth and reduced their abundances by 1.37-36.6%.However,biochar addition into the soil contaminated with high concentrations of phenanthrene(PHS)resulted in its effective mineralization and enhanced mineralization rates and extents at high amendment levels by 32.4-86.7%and 32.0-44.7%,*** was because biochar amendment in the PHS significantly promoted the abundances of the total bacterial communities(29.9-80.4%)and potential degrading genera(1.89-25.9%)by providing nutrients and stimulated the specific PAH-degradative nidA gene abundance by 1-2 *** findings will guide the use of biochar to remediate soils with different PAH pollution levels based on the two roles that they play(i.e.,immobilizing PAHs or facilitating PAH degradation).

关键词： Biochar PAHs Microbial availability Soil microbial communities Mineralization

A Transient-Pressure-Based Numerical Approach for Interlayer Identification in Sand Reservoirs

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Fluid Dynamics & Materials Processing 2024年第3期20卷 641-659页

作者： Hao luo Haibo Deng Honglin Xiao Shaoyang Geng Fu Hou Gang luo yaqi Li Tight Oil and Gas Exploration and Development Project Department PetroChina Southwest Oil and Gas Field CompanyChengdu610051China Energy College Chengdu University of TechnologyChengdu610059China

Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas *** interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples.

关键词： Sand reservoir interlayer identification transient pressure analysis numerical well test

Bioinspired nanofluidic iontronics for brain-like computing

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Nano Research 2024年第2期17卷 503-514页

作者： Lejian Yu Xipeng Li Chunyi luo Zhenkang Lei Yilan Wang yaqi Hou Miao Wang Xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Binzhou Institute of Technology Binzhou 256600China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

The human brain performs computations via a highly interconnected network of *** inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired nanofluidic iontronics has been proposed and gradually engineered to overcome the limitations of the conventional electron-based von Neumann architecture,which shows the promising potential to enable efficient brain-like *** and tunable nanofluidic ion transport behaviors and spatial confinement show promising controllability of charge carriers,and a wide range of structural and chemical modification paves new ways for realizing brain-like ***,a comprehensive framework of mechanisms and design strategy is summarized to enable the rational design of nanofluidic systems and facilitate the further development of bioinspired nanofluidic *** review provides recent advances and prospects of the bioinspired nanofluidic iontronics,including ion-based brain computing,comprehension of intrinsic mechanisms,design of artificial nanochannels,and the latest artificial neuromorphic functions ***,the challenges and opportunities of bioinspired nanofluidic iontronics in the pioneering and interdisciplinary research fields are proposed,including brain–computer interfaces and artificial neurons.

关键词： human brain ion transport nanofluidics brain-like computing memristive effect

Optimal regulation of flexible loads in rural residential buildings considering mobile batteries:A case study in Shaanxi Province

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Building Simulation 2024年第7期17卷 1065-1083页

作者： Xi luo WenceShi School of Building Services Science and Engineering Xian University of Architecture and Technology(XAUAT)Xi'an 710055China State Key Laboratory of Green Building Xi'an 710055China

While the grid-connected capacity of rural household photovoltaics is increasing rapidly,achieving dynamic supply-demand matching despite fluctuations in solar energy is *** the rapid development of rural electrification,battery-powered technologies,such as electric vehicles and electric agricultural machinery,are becoming increasingly popular in rural *** this context,utilizing idle mobile batteries to assist in energy storage for rural residential buildings offers a new way to solve the problem of dynamic supply-demand *** this study,a field survey was conducted on several typical fruit-growing villages in the Central Shaanxi Plain in Shaanxi Province of *** rural households were selected to calculate the electricity loads of the residential buildings,with due consideration to the intervention of mobile *** the premise of installing 3 kW household photovoltaic systems in rural households,an economical efficiency-oriented model was built for the optimal regulation of flexible *** results were compared in the context of two patterns of electricity consumption,i.e.,unidirectional charging of mobile batteries from buildings and bidirectional charging and discharging between mobile batteries and *** bidirectional pattern significantly increased the photovoltaic consumption of typical rural households on various typical ***,during both scenarios of not implementing time-of-use and implementing time-of-use,the typical day of the winter slack farming season exhibited the best photovoltaic consumption effect among all types of typical ***,the bidirectional pattern also result in a significant increase in the annual electricity sales revenues for typical rural households.

关键词： demand-side response flexible load mobile battery household photovoltaics

Energy consumption simulations of rural residential buildings considering differences in energy use behavior among family members

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Building Simulation 2024年第8期17卷 1335-1358页

作者： Xi luo Lina Du School of Building Services Science and Engineering Xi'an University of Architecture and Technology(XAUAT)Xi'an 710055China State Key Laboratory of Green Building Xi'an 710055China

The“average occupant”methodology is widely used in energy consumption simulations of residential buildings;however,it fails to consider the differences in energy use behavior among family *** on a field survey on the Central Shaanxi Plain,to identify the energy use behavior patterns of typical families,a stochastic energy use behavior model considering differences in energy use behavior among family members was proposed,to improve the accuracy of energy consumption simulations of residential *** results indicated that the surveyed rural families could be classified into the following four types depending on specific energy use behavior patterns:families of one elderly couple,families of one middle-aged couple,families of one elderly couple and one child,and families of one couple and one ***,on typical summer days,the results of daily building energy consumption simulation obtained by the“average occupant”methodology were 25.39%and 28%lower than the simulation results obtained by the model proposed in this study for families of one elderly couple and families of one middle-aged couple,and 13.05%and 23.05%higher for families of one elderly couple and one child,and families of one couple and one *** typical winter days,for the four types of families,the results of daily building energy consumption simulation obtained by the“average occupant”methodology were 21.69%,10.84%,1.21%,and 8.39%lower than the simulation results obtained by the model proposed in this study,respectively.

关键词： typical energy use behavior pattern differences in occupant behavior building energy consumption simulation stochastic energy use behavior simulation