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Chinese Medical Journal 2014年第8期127卷 1590-1591页

作者： Liu Mei Wang Jianhua Ding Guichun duan yaqi Sun Pengfei Jian Wenhao Department of Ultrasound General Hospital of Beijing Military Command of People's Liberation Army Beijing 100700 China

Patent foramen ovale （PFO）, a congenital cardiac lesion that persists into adulthood, has become the subject of much clinical interest. PFO has been implicated in several serious clinical syndromes, including paradoxical systemic emboli （which contribute to ischemic stroke）, myocardial infarction, and complications of pulmonary embolism. Currently, two-dimensional transesophageal echocardiography （TEE） is the standard procedure for diagnosing PFO. The diameter and contrast score have been used to size the PFO.~ None of these techniques is optimal as they are all indirect ways of measuring PFOs. Few data exist on the relation between stroke risk, anatomical characteristics, and physiological behavior. The purpose of our study therefore was to explore the clinical feasibility of sizing or displaying the morphology and physiological behavior of PFOs using three-dimensional TEE.

关键词： three-dimensional echocardiography patent foramen ovale diagnosis

Ion channel expression and signal transduction mechanism in cardiomyocytes during murine embryonic development

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Ion channel expression and signal transduction mechanism in ...

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

湖北省生理学会2007年度年会暨学术报告会

作者： yaqi duan Ming Tang Physiology Department,Tongji Medical College,Huazhong University of Science and Technology,430030

In our group we have isolated murine embryonic atrial and ventricular cells derived from timed-preganant females at different periods and used patch-clamp procedures to investigate age

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 81-92页

作者： Zitian Huo yaqi duan Dongdong Zhan Xizhen Xu Nairen Zheng Jing Cai Ruifang Sun Jianping Wang Fang Cheng Zhan Gao Caixia Xu Wanlin Liu Yuting Dong Sailong Ma Qian Zhang Yiyun Zheng Liping Lou Dong Kuang Qian Chu Jun Qin Guoping Wang Yi Wang Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Health Commission Key Laboratory of Respiratory Diseases Tongji HosptialTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Beijing Pineal Diagnostics Co. Ltd.Beijing 102206China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Institution of Pathology The First Affiliated Hospital of Henan UniversityKaifeng 475001China Department of Tumor Biobank Shanxi Cancer HospitalTaiyuan 030013China Chongqing Key Laboratory of Big Data for Bio Intelligence School of BioinformationChongqing University of Posts and TelecommunicationsChongqing 400065China

Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction ***,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy *** proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging *** subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy *** signatures of the S-II subtype in particular suggested potential benefits from *** overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical ***,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line ***,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.

关键词： Small cell lung cancer Proteomics Prognosis Chemotherapy response Immunotherapy

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面向飞行机械臂的实时目标检测与定位算法

南京航空航天大学学报 2022年第1期54卷 27-33页

作者：张睿王尧尧段雅琦陈柏南京航空航天大学机电学院南京210016 浙江大学流体动力与机电系统国家重点实验室杭州310027 中国兵器工业集团航空弹药研究院有限公司哈尔滨150046

飞行机械臂要完成自主抓取的任务,对目标物的识别与定位尤为关键。当前飞行机械臂视觉识别算法多采用传统的特征提取等方法。为提升目标物识别及定位的精度和效率,本文设计了一种基于YOLOv5深度学习目标检测算法和RGB‑D传感器的视觉识... 详细信息

飞行机械臂要完成自主抓取的任务,对目标物的识别与定位尤为关键。当前飞行机械臂视觉识别算法多采用传统的特征提取等方法。为提升目标物识别及定位的精度和效率,本文设计了一种基于YOLOv5深度学习目标检测算法和RGB‑D传感器的视觉识别与定位算法,该算法可以实时检测目标物并对其位姿进行估计,为飞行机械臂的抓取工作服务。同时针对深度学习算法计算量庞大,在嵌入式端无法实现高性能实时检测的问题,引入了模型量化技术优化算法,大幅提升算法推理速度。本文介绍了算法的整体框架及实现过程,利用COCO数据集和动作捕捉系统分别验证了目标检测和位姿估计部分算法的有效性。

关键词：飞行机械臂 YOLOv5 RGB‑D 目标检测模型量化位姿估计

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基于不同模型的中文命名实体识别方法研究

长江信息通信 2021年第1期34卷 84-86页

作者：宫义山段亚奇沈阳工业大学信息科学与工程学院辽宁沈阳110870

目的:比较条件随机场、长短期记忆模型、BiLSTM-CRF和使用Bert预训练字符向量的BiLSTM-CRF四种命名实体识别模型。方法:分析比较四种模型在人民日报数据集和MSRA数据集上对人名、地点和机构三类实体的识别性能。结果:单一神经网络LSTM... 详细信息

目的:比较条件随机场、长短期记忆模型、BiLSTM-CRF和使用Bert预训练字符向量的BiLSTM-CRF四种命名实体识别模型。方法:分析比较四种模型在人民日报数据集和MSRA数据集上对人名、地点和机构三类实体的识别性能。结果:单一神经网络LSTM在缺乏训练数据支持的结果表现不如CRF,而使用了Bert预训练字符向量的神经网络即使使用较少的训练数据仍能获得较其他模型更好的结果,在人民日报数据集和MSRA数据集上的F值均达到0.9。结论:单一神经网络模型在缺乏训练数据时有较大局限性,使用Bert预训练字符向量的神经网络模型在中文命名实体识别任务中存在较大优势。

关键词：命名实体识别 CRF LSTM Bert 预训练字符向量

新型冠状病毒在病理石蜡样本中检测方法的探索

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中华病理学杂志 2020年第4期49卷 354-357页

作者：许三鹏况东胡愉刘聪段亚琦王国平华中科技大学同济医学院附属同济医院病理研究所武汉430030 华中科技大学同济医学院病理学系武汉430030

目的:探索使用病理石蜡样本检测新型冠状病毒的方法。方法:采用荧光定量PCR技术,使用新型冠状病毒核酸扩增试剂盒,检测临床确诊患者的肺组织病理石蜡样本1例,无病毒感染肺组织石蜡样本2例和正常人群咽拭子样本2例。建立检测体系,判读检... 详细信息

目的:探索使用病理石蜡样本检测新型冠状病毒的方法。方法:采用荧光定量PCR技术,使用新型冠状病毒核酸扩增试剂盒,检测临床确诊患者的肺组织病理石蜡样本1例,无病毒感染肺组织石蜡样本2例和正常人群咽拭子样本2例。建立检测体系,判读检测结果。结果:经过荧光定量PCR反应和信号采集,所有5例样本RNA内参HEX信号扩增曲线均有升起;临床确诊患者手术石蜡样本RNA FAM信号(N基因)扩增曲线升起(Ct值35.48),ROX信号(ORF1ab基因)曲线未升起。重复试验FAM信号扩增曲线升起(Ct值36.00),ROX信号曲线未升起。结合2次检测结果,该例患者病理石蜡样本新型冠状病毒阳性。同时作为对照的2例无感染病理石蜡组织样本和2例正常人群咽拭子样本病毒核酸检测均为阴性。结论:病理石蜡样本提取的总RNA可以满足新型冠状病毒检测的质量要求;根据新型冠状病毒检测指南建议设计和生产病毒核酸检测试剂盒可以满足病理石蜡样本检测的需要;使用所建荧光定量PCR检测体系,病理石蜡样本可以用于进行新型冠状病毒的核酸检测。

关键词：重复试验荧光定量PCR 病毒感染扩增曲线核酸检测 N基因检测体系石蜡

肺癌合并新型冠状病毒感染患者手术标本病理改变

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中华病理学杂志 2020年第5期49卷 471-473页

作者：况东许三鹏胡愉刘聪段亚琦王国平华中科技大学同济医学院附属同济医院病理研究所武汉430030 华中科技大学同济医学院病理学系武汉430030

为了探讨新型冠状病毒感染患者手术标本的病理形态特点及与临床表现的相关性,通过回顾临床病史资料及石蜡组织病毒核酸检测验证,选取1例新型冠状病毒感染并接受了手术治疗的患者术后标本,观察脏器的病理变化,并初步探讨与临床表现的联... 详细信息

为了探讨新型冠状病毒感染患者手术标本的病理形态特点及与临床表现的相关性,通过回顾临床病史资料及石蜡组织病毒核酸检测验证,选取1例新型冠状病毒感染并接受了手术治疗的患者术后标本,观察脏器的病理变化,并初步探讨与临床表现的联系。结果发现新型冠状病毒感染患者肺部可出现间质性肺炎改变,透明膜不明显,但也可能为疾病早期改变。

关键词：临床病史感染患者石蜡组织间质性肺炎术后标本病理形态特点透明膜手术标本

新型冠状病毒肺炎患者尸体解剖与病理取材流程探讨

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中华病理学杂志 2021年第3期50卷 297-299页

作者：许三鹏陈耀兵胡愉刘旭光段亚琦刘茜华中科技大学同济医学院附属同济医院病理研究所武汉430030 华中科技大学同济医学院法医学系武汉430030

对9例新型冠状病毒肺炎(COVID-19)罹难者捐献的遗体进行尸体解剖查验与病理诊断取材工作,获得大量感染罹难者体表表现、大体脏器特征和珍贵的病理检材,为获得病理形态学特征和分子病理学结果奠定基础。

关键词：分子病理学肺炎患者病理诊断尸体解剖

Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study

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Cancer Communications 2021年第12期41卷 1373-1386页

作者： Ya Wang Long Qiao Jie Yang Xiong Li yaqi duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Cancer Biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000P.R.China Department of Gynecology and Obstetrics The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014P.R.China Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Department of Obstetrics and Gynecology Wuhan Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCalifornia 90001USA Department of Thyroid and Breast Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Department of Breast Surgery Hubei Cancer HospitalWuhanHubei 430079P.R.China Department of Gynecology and Obstetrics Qilu Hospital of Shandong UniversityJinanShandong 250012P.R.China Yidu Cloud(Beijing)Technology Co. Beijing 100000P.R.China MammoCare The Breast Clinic&SurgerySingapore 329563Singapore Department of Surgery and the Massey Cancer Centre Virginia Commonwealth University School of MedicineRichmondVirginia 23298USA Department of Breast Surgery Qilu Hospital of Shandong UniversityNo.107Jinan Culture RoadJinanShandong 250012P.R.China

Background:To date,there is no approved blood-based biomarker for breast cancer ***,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic ***:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer *** cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid *** cancer patients who underwent mass excision prior to modified radical mastectomy were also *** hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast *** endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and ***-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM *** was no restriction on disease stage for ***:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy ***,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation *** AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),*** SEMA4C levels significantly decreased after surgery,and the reduction was more str

关键词： breast cancer semaphorin 4C serum biomarker diagnosis early detection ductal carcinoma in situ pan-cancer analysis enzyme-linked immunosorbent assay

Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases

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National Science Review 2020年第12期7卷 1868-1878页

作者： Qian Liu Yu Shi Jun Cai yaqi duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and Technology Institute of Pathology Southwest HospitalThird Military Medical University (Army Medical University) Key Laboratory of Tumor Immunopathology Ministry of Education of China Department of Pathology Shanghai Jiao Tong University School of Medicine Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Pathology Tongji Medical CollegeHuazhong University of Science and Technology

Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel *** this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes,immune cell signature and inflammatory factor expression in the lungs,spleen and lymph *** we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFαand IL-1β).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage *** findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients.

关键词： COVID-19 SARS-CoV-2 autopsy histopathology immune disorder