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Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： Hao Li chang Liu Ying Cui Panpan chang Wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of China Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(ELISA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A

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Generic Modeling and Control Framework for Power Systems Dominated by Power Converters Connected Through a Passive Transmission and Distribution Grid

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 292-301页

作者： Qing-chang Zhong Marcio Stefanello Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616USA Syndem LLC USA.M.Stefanello is with the Fundacao Universidade Federal do Pampa at AlegreteRS97546-550Brazil

In this paper,a compact mathematical model having an elegant structure,together with a generic control framework,are proposed for generic power systems dominated by power converters that are interconnected through a passive transmission and distribution(T&D)grid,by adopting the port-Hamiltonian(pH)systems theory and the fundamental circuit *** models of generic T&D lines are developed and then the model of a generic T&D grid is *** the proposed control framework,the controlled converters are proven to be passive and Input-to-State Stable(ISS).The compact mathematical model is scalable and can be applied to power systems with multiple power electronic converters with generic passive controllers,passive local loads,and different types of passive T&D lines connected in a meshed configuration without self-loops,so it is very ***,the resulting power system is proven to be ISS as *** analysis is carried out without assumptions on constant frequency/voltage,constant loads,and/or lossless networks,except the need of passivity for all parts involved,and without using the Clarke/Park transformations or the graph *** simplify the presentation,three-phase balanced systems are adopted but the results can be easily adapted for single-phase or unbalanced three-phase systems.

关键词： Input-to-State Stable(ISS) passivity,portHamiltonian(pH)systems Power electronic converters dominated power systems Synchronized and Democratized(SYNDEM)grid architecture

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4种方法提取蒌叶鲜叶挥发性成分的比较分析

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现代食品科技 2023年第5期39卷 225-233页

作者：昌娅琪栾新博权帆颜健黎平华南理工大学轻工科学与工程学院广东广州510640 华南农业大学资源环境学院农业农村部华南热带农业环境重点实验室广东广州510642

蒌叶鲜叶具有独特的辛香味,在我国南方地区常用作嚼槟榔青果的植物配料。为了探究蒌叶鲜叶的挥发性成分,采用气相色谱-串联质谱仪对不同方法(水蒸气蒸馏法、固相微萃取法、超声辅助正己烷法和超声辅助二氯甲烷法)提取的挥发性成分进行... 详细信息

蒌叶鲜叶具有独特的辛香味,在我国南方地区常用作嚼槟榔青果的植物配料。为了探究蒌叶鲜叶的挥发性成分,采用气相色谱-串联质谱仪对不同方法(水蒸气蒸馏法、固相微萃取法、超声辅助正己烷法和超声辅助二氯甲烷法)提取的挥发性成分进行分析。结果显示,4种方法提取和鉴定出的挥发性成分共92种,相对含量较高为酚类、烯类、酯类和醇类,主要成分为蒌叶酚、乙酸丁香酚酯、香叶烯D、4-烯丙基邻苯二酚二乙酸酯、β-石竹烯、γ-衣兰油烯等;水蒸气蒸馏法提取的挥发性成分最多,共鉴定60种;固相微萃取法、超声辅助二氯甲烷和超声辅助正己烷法提取鉴定的挥发性成分分别为53种、42种和25种;4种提取方法共有组分17种,而固相微萃取法特有成分20种,水蒸气蒸馏法获得特有成分18种。不同提取方法获得挥发性成分的种类和含量差异较大,以挥发性活性成分为目的的提取方法,水蒸气蒸馏提取法较为合适,固相微萃取法结合水蒸气蒸馏法提取蒌叶鲜叶,能够获得更加全面的挥发性成分,可为蒌叶香气物质基础的开发与利用提供参考。

关键词：蒌叶挥发性成分水蒸气蒸馏法超声波溶剂提取顶空固相微萃取气相色谱-串联质谱仪

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预算绩效管理与经济高质量发展——基于财政资源配置视角的分析

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经济问题探索 2024年第7期 15-30页

作者：肖鹏王亚琪陶畅中央财经大学财政税务学院北京100081

预算绩效管理是实现财政资源优化配置的重要手段,是推动新时代经济高质量发展的重要抓手。根据各省份预算绩效改革“逐步推开”的特点,本文利用多期双重差分模型,实证研究预算绩效管理与经济高质量发展之间的因果关系。结果表明:预算绩... 详细信息

预算绩效管理是实现财政资源优化配置的重要手段,是推动新时代经济高质量发展的重要抓手。根据各省份预算绩效改革“逐步推开”的特点,本文利用多期双重差分模型,实证研究预算绩效管理与经济高质量发展之间的因果关系。结果表明:预算绩效管理改革能够显著促进经济高质量发展,并且通过了平行趋势检验和一系列稳健性检验;机制检验表明,预算绩效管理主要通过提高财政资源配置效率、优化财政资源配置结构来促进经济高质量发展;进一步研究发现,较强的预算监督能力、较完善的制度环境、较高的信息化程度、较小的财政压力能够进一步强化预算绩效管理对经济高质量发展的促进作用,此外,“胡焕庸线”东南侧地区预算绩效改革成效更为显著。鉴于此,我国应该健全现代预算制度,继续强化绩效管理,充分发挥绩效对财政资源配置的导向作用,助力经济高质量发展。

关键词：预算绩效管理经济高质量发展财政资源配置效率财政资源配置结构

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Greedy Lattice Paths with General Weights

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2213-2222页

作者： Yin Shan chang An Qi ZHENG College of Mathematics Sichuan UniversityChengdu 610065P.R.China

Let{X_(v):v∈Z^(d)}be *** *** S(π)=Σ_(v∈π)X_(v)be the weight of a self-avoiding lattice pathπ.Let M_(n)=max{S(π):πhas length n and starts from the origin}.We are interested in the asymptotics of Mn as n→∞.This model is closely related to the first passage percolation when the weights{X_(v):v∈Z^(d)}are non-positive and it is closely related to the last passage percolation when the weights{X_(v):v∈Z^(d)}are *** general weights,this model could be viewed as an interpolation between first passage models and last passage ***,this model is also closely related to a variant of the position of right-most particles of branching random *** the two assumptions that∃α>0,E(X_(0)^(+))^(d)(log^(+)X_(0)^(+))^(d+α)0,E(X_(0)^(+))^(d)(log^(+)X_(0)^(+))^(d+α)<+∞and that E[(X_(0)^(−))^(4)]<+∞,we prove that M_(n)/n converges to the same constant M almost surely as n tends to infinity.

关键词： Last passage percolation first passage percolation greedy lattice path

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Event-triggered H_(∞) consensus control for input-constrained multi-agent systems via reinforcement learning

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Control Theory and Technology 2024年第1期22卷 25-38页

作者： Jinxuan Zhang chang-E Ren College of Information Engineering Capital Normal UniversityBeijing100089China

This article presents an event-triggered H_(∞) consensus control scheme using reinforcement learning (RL) for nonlinear second-order multi-agent systems (MASs) with control constraints. First, considering control constraints, the constrained H_(∞) consensus problem is transformed into a multi-player zero-sum game with non-quadratic performance functions. Then, an event-triggered control method is presented to conserve communication resources and a new triggering condition is developed for each agent to make the triggering threshold independent of the disturbance attenuation level. To derive the optimal controller that can minimize the cost function in the case of worst disturbance, a constrained Hamilton–Jacobi–Bellman (HJB) equation is defined. Since it is difficult to solve analytically due to its strongly non-linearity, reinforcement learning (RL) is implemented to obtain the optimal controller. In specific, the optimal performance function and the worst-case disturbance are approximated by a time-triggered critic network;meanwhile, the optimal controller is approximated by event-triggered actor network. After that, Lyapunov analysis is utilized to prove the uniformly ultimately bounded (UUB) stability of the system and that the network weight errors are UUB. Finally, a simulation example is utilized to demonstrate the effectiveness of the control strategy provided.

关键词： H_(∞)optimal control Input constrains Multi-agent systems(MASs) Reinforcement learning(RL)

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Numerical analysis of a projecting wall type oscillating water column(PW-OWC)wave energy converter in regular waves

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Journal of Hydrodynamics 2024年第3期36卷 479-491页

作者： Lei Tan Ruiyuan chang Tomoki Ikoma Department of Oceanic Architecture and Engineering College of Science and TechnologyNihon UniversityChibaJapan

Oscillating water column(OWC)based wave energy absorption devices are classic which have been widely used for harnessing ocean wave *** paper presents a numerical study on a projecting wall(PW)type OWC wave energy converter in regular *** computational fluid dynamics(CFD)modelling of a stationary floating PW-OWC model in a three-dimensional wave flume is achieved by the software *** analyses are carried out based on CFD simulations and the linear potential flow solutions with modifications to account for turbine-induced *** present numerical solutions are validated against our previous experimental *** is found that both the CFD and modified linear potential flow predictions are in reasonably good agreements with the experimental data in the first order results of OWC and air pressure *** the nonlinear responses are included in the result,the modified linear potential flow solution is found to slightly under-estimate the wave energy conversion performance at long *** the airflows above and below the chamber orifice,the CFD results suggest that they are almost unidirectional,oscillating in not only the base frequency but also subharmonic and ultraharmonic *** evolution of the OWC responses during an entire period and the phase analysis based on CFD simulations are *** phase results provide the crucial evidence to the reasonability of the physics-based modification of the potential flow model in modelling of *** present results and analysis are expected to be beneficial to the understanding on the physical mechanism of OWCs and the design of phase control strategies.

关键词： Computational fluid dynamics(CFD)simulation hydrodynamic analysis oscillating water column(OWC)damping orifice airflow phase difference

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An Experimental Study on Response and Control of a Flapping-Wing Aerial Robot Under Wind Gusts

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Journal of Bionic Engineering 2024年第1期21卷 209-223页

作者： Kazuki Shimura Hikaru Aono chang-kwon Kang Graduate School of Science and Technology Shinshu University3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical Engineering and Robotics 3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical and Aerospace Engineering University of Alabama in HuntsvilleTechnology Hall N266HuntsvilleAL35899USA

Bioinspired flapping-wing micro-air-vehicles(FWMAVs)have the potential to be useful aerial tools for gathering information in various *** recent advancements in manufacturing technologies and better understanding of aerodynamic mechanisms behind of the flapping flight,outdoor flights have become a ***,to fully realize the potential of FWMAVs,further improvements are necessary,particularly in terms of stability and robustness under gusty *** this study,the response and control of a tailless two-winged FWMAV under the wind gusts are *** experiments are conducted with a one-degree-of-freedom gimbal to focus on effects of wind gusts on the rotational motion of the ***-derivative and sliding-mode controls are adopted for the attitude *** present that the body angles changed in time and reached approximately 50°at the maximum due to the wing *** sliding-mode controller can more effectively control the rotational angle in the presence of disturbances and both the wing speed and changes in wind speed have an impact on the effectiveness of attitude *** results contribute to the development of of tailless two-winged,single-motor driven FWMAVs in terms of the design of attitude controller and testing apparatus.

关键词： Flapping-wing micro-air vehicles Sliding-mode control Pitch and roll angle-Wind gus

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Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming Luo Kun-Che chang Spencer Center for Vision Research Byers Eye InstituteStanford University School of Medicine Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine Department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness *** is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after *** stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative *** this review,we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation ***,we discuss using 3D retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and *** review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

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Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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Science China Chemistry 2024年第3期67卷 755-758页

作者： Qinglin Zhang Kang Liang chang Guo Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China

Electrosynthesis has gained widespread recognition for its extraordinary ability to precisely control the redox *** outstanding capability enables the direct conversion of non-functionalized substrates into reactive intermediates by utilizing easily accessible starting materials, eliminating the need for preliminary functionalization procedures and allowing for unconventional bond activations.

关键词： Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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