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Epidemiological, Diagnostic, Therapeutic, and Prognostic Profile of Non-Tuberculous Community-Acquired Purulent Pleurisy in Children at the Bouaké University Hospital Center, 2017-2021

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Advances in Infectious Diseases 2024年第1期14卷 220-232页

作者： yapo thomas aba Christian Yao Pacôme Monemo Richard Azagoh-Kouadio Iburaima Akandji Noelle Gonné Jean-Marie Karidioula Vincent Achi Vincent Kouadio Asse Department of Infectious and Tropical Diseases University Hospital of Bouaké Bouaké Ivory Coast University Alassane Ouattara of Bouake Bouake Ivory Coast Department of Pediatrics University Hospital of Bouaké Bouaké Ivory Coast Department of Bacteriology & Virology University Hospital of Bouake Bouaké Ivory Coast Department of Pediatrics University Hospital of Angré Abidjan Ivory Coast Department of Pneumology University Hospital of Bouake Bouaké Ivory Coast

Introduction: In Côte d’Ivoire, there is a scarcity of data on children’s purulent pleurisies. Objective: This study aims to elucidate the epidemiological, diagnostic, therapeutic, and evolutionary facets of non-tuberculous purulent pleurisies in pediatric patients. Methods: A retrospective analysis was conducted using the medical records of children aged one month to fifteen years with purulent pleurisies at Bouaké University Hospital Center from January 2017 to December 2021. Results: The study identified 124 cases of purulent pleurisies, constituting 18% of lower respiratory tract infections and 0.8% of all hospitalizations. The majority of these cases (69%) were in children between 1 and 24 months of age. Prominent symptoms included dyspnea (85.5%), O2 saturation below 95% in room air (76.6%), respiratory distress (68.5%), cutaneous-mucosal pallor (63.7%), and fever (43.5%). Radiological findings predominantly showed right-sided pleurisy (62.1%). The pleurisy was often extensive (78.2%), accompanied by pneumothorax (37.1%), alveolo-interstitial opacities (8.1% of cases), and abscess formations (1.6%). Pleural fluid cultures were positive in 46.9% of cases, with Staphylococcus aureus (75%, methi-S) identified among 32 bacteria. Initial antibiotic treatment was empirical, favoring oxacillin (53.2%) or amoxicillin-clavulanic acid (53.2%) in dual (42%) or triple therapy (33%) with gentamicin (64.1%) and/or metronidazole (21.8%). Treatments also included pleural drainage (68.5%) or repeated evacuation punctures (33.1%), and blood transfusion (39%). The mortality rate was 18.8%. Conclusion: Non-tuberculous purulent pleurisy remains a significant concern in pediatric hospitalizations at the CHU of Bouaké, marked by high mortality rates.

关键词： Community-Acquired Purulent Pleurisies Children Mortality Bouaké

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Epidemiological, Diagnostic, Therapeutic, and Prognostic Profile of Non-Tuberculous Community-Acquired Purulent Pleurisy in Children at the Bouaké University Hospital Center, 2017-2021

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Advances in Infectious Diseases（传染病进展） 2024年第1期 220页

作者： yapo thomas aba Christian Yao Pacôme Monemo Richard Azagoh-Kouadio Iburaima Akandji Noelle Gonné Jean-Marie Karidioula Vincent Achi Vincent Kouadio Asse

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Inaugural Seizures Revealing COVID-19 in an Immunocompetent Infant at the University Teaching Hospital (UTH) of Bouaké

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Open Journal of Pediatrics 2022年第4期12卷 678-687页

作者： Djakaridja Kone Iburaima Alamun Akanji Martine Tatiana yapo Kokora Junior Gawa Juliette Kadiane-Oussou Leioh Romeo Adou Jean Marie Karidioula yapo thomas aba Kouadio Vincent Asse Ouffoue Kra Department of Infectious and Tropical Diseases University Teaching Hospital of Bouaké Bouaké C&ocirc te d’Ivoire COVID-19 Care Center University Teaching Hospital of Bouaké Bouaké C&ocirc te d’Ivoire Department of Pediatrics University Teaching Hospital of Bouaké Bouaké C&ocirc te d’Ivoire Department of Bacteriology and Virology University Teaching Hospital of Bouaké Bouaké C&ocirc te d’Ivoire

Introduction: Children are likely to present with atypical and non-specific clinical manifestations of COVID-19, unlike adults. The aim of this observation is to identify the difficulties related to the diagnosis and the curative and preventive management of SARS-CoV-2 infection in children. Observation: This is a 15-month-old infant admitted for febrile seizures. The interrogation revealed signs evolving 48 hours before his admission marked by post-prandial vomiting, wet cough, hypotonia, food refusal, incessant crying, fever, and seizures. His antecedents can be summed up as an uneventful pre- and per-natal period, good eating habits, good psychomotor and staturo-ponderal development, and outdated vaccination. The physical and paraclinical examination made it possible to retain the diagnosis of severe pneumonia. The initial management consisted of oxygenation, hydroelectrolyte intake, antibiotic therapy, and neurosedation. The evolution 3 days later was marked by a worsening of the clinical features, and the hypothesis of infection with SARS-CoV-2 was raised. The nasopharyngeal swab for COVID-19 RT-PCR performed was positive. The infant was isolated in the intensive care unit, where he received oxygen therapy with a mask, enteral nutrition, antibiotic therapy, corticosteroid therapy, and adequate nursing. The evolution was favorable 48 hours later. In addition, his asymptomatic mother and 14-year-old brother were placed in isolation after a positive RT-PCR COVID-19 test. Her father who was very often away from home for professional reasons was negative for COVID-19 RT-PCR. They all four live in the same 3-room house. Conclusion: Childhood COVID-19 has many facets. Clinicians should think about it in the face of any infectious manifestation, in order to avoid delays in treatment and improve the prognosis.

关键词： COVID-19 Children Atypical Manifestations SARS-CoV-2 Bouaké

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Attitudes and Practices of Health Care Providers Regarding the Management of Uncomplicated Malaria in Abidjan, Cote d＇lvoire

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Journal of Life Sciences 2012年第7期6卷 747-753页

作者： Frederic Nogbou Ello thomas yapo aba Ismael Ouattara Didier Koumavi Ekouvi Offoue Kra Pierre Aime Assemian Amath Wade Serge-Paul Eholie Emmanuel Bissagnene Department of lnfectious and Tropical Diseases in Abidjan University Hospital of Treichville 01 BP V3 Abidjan 01 Cote d 'lvoire PAC-CI Program Abidjan University Hospital ofTreichville USAC Extension 18 BP 1954 Abidjan 18 Cote d'Ivoire Laboratoire Sanofi Aventis Sanofi-Aventis Dakar BP 3529 Senegal

Malaria is a major public health problem in the Cote d＇Ivoire where it is the leading cause of morbidity and mortality. The objective of this study was to assess the knowledge, attitudes and practices of health care providers on the diagnosis and therapeutic procedures used to ensure the management of uncomplicated malaria in the health district of Abidjan. A cross-sectional study was conducted from November 2008 to December 2008 among 169 caregivers who treated 1,691 cases of uncomplicated malaria. Results： The knowledge of the caregivers of the national guidelines regarding malaria was sufficient （89%）. A diagnosis of uncomplicated malaria was established only on clinical arguments （70%）. The percentage of patients who were prescribed artemisinin-based combination therapy （ACT） was 86%. However, 25% of the antimalarials drugs that were prescribed to patients （oral quinine, artemisinin derivatives monotherapy, and herbal medicine） did not meet the recommendations on first choice treatment as suggested by the national program against malaria. These results indicate sufficient knowledge of the national guidelines for the treatment of malaria by health care providers as evidenced by acceptable prescriptions for ACTs despite an incomplete knowledge of the guidelines.

关键词： Malaria supplier of service ACT knowledge Africa.

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Inaugural Seizures Revealing COVID-19 in an Immunocompetent Infant at the University Teaching Hospital (UTH) of Bouaké

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Open Journal of Pediatrics（儿科学期刊） 2022年第4期

作者： djakaridja kone iburaima alamun akanji martine tatiana yapo kokora junior gawa juliette kadiane-oussou leioh romeo adou jean marie karidioula yapo thomas aba kouadio vincent asse ouffoue kra

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Missed Opportunities for Diagnosing Bacilliferous Pulmonary Tuberculosis by Optical Microscopy versus GeneXpert MTB/RIF in Endemic Areas

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Advances in Infectious Diseases 2023年第4期13卷 652-659页

作者： aba yapo thomas Nassoué Dobré Olivia Yéo Liomehin Monemo Pacome yapo Matine Tatiana Achi Hoboueu Vincent Department of Infectious and Tropical Diseases University Hospital of Bouake Bouake Ivory Coast University Alassane Ouattara of Bouake Bouake Ivory Coast Department of Pneumology University Hospital of Bouake Bouake Ivory Coast Department of Bacteriology & Virology University Hospital of Bouake Bouake Ivory Coast

Objective: To assess the missed opportunities from the diagnosis of bacilliferous pulmonary tuberculosis by optical microscopy compared to GeneXpert MTB/RIF between 2015 and 2019. Methods: This is a retrospective analysis of the diagnostic results of bacilliferous pulmonary tuberculosis in patients suspected of pulmonary tuberculosis at their first episode during the period. GeneXpert MTB/RIF (GeneXpert) and optical microscopy (OM) after Ziehl-Neelsen stained smear were performed on each patient’s sputum or gastric tubing fluid sample. Results: Among 341 patients suspected of pulmonary tuberculosis, 229 patients were declared bacilliferous tuberculosis by the two tests (67%), 220 patients by GeneXpert and 95 patients by OM, i.e. 64.5% versus 28% (p i.e. 58.5% of the positive cases detected by the two tests (134/229 patients) and 39.3% of the patients suspected of tuberculosis (134/341 patients). On the other hand, among 95 patients declared positive by OM, the GeneXpert ignored 9 (9.5%), i.e. 4% of all the positive cases detected by the two diagnostic tests (9/229 patients) and 3% of the patients suspected of tuberculosis (9/341 patients). The differences observed between the results of the two tests were statistically significant at the 5% threshold (p Conclusion: This study reveals missed diagnostic opportunities for bacilliferous pulmonary mycobacteriosis, statistically significant with optical microscopy than GeneXpert. The GeneXpert/optical microscopy couple could be a good contribution to the strategies for the elimination of pulmonary tuberculosis in sub-Saharan Africa.

关键词： Bacilliferous Pulmonary Tuberculosis Missed Opportunity GeneXpert MTB/RIF Optical Microscopy

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Epidemiological, Clinical, Therapeutic, Evolutionary and Prognostic Aspects of Children with COVID-19 in Bouaké(Côte d’Ivoire)

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Advances in Infectious Diseases 2022年第2期12卷 216-229页

作者： Kone Djakaridja Kadiane-Oussou Juliette Akanji Iburaima Alamun yapo Martine Tatiana Adou Leioh Romeo Karidioula Jean Marie aba yapo thomas Asse Kouadio Vincent Kra Ouffoue Department of Infectious and Tropical Diseases University and Teaching Hospital of Bouaké Bouaké Ivory Coast Department of Pediatric University and Teaching Hospital of Bouaké Bouaké Ivory Coast

Context: Compared to adults, there are relatively few studies on pediatric COVID-19 due to the high rate of asymptomatic or paucisymptomatic forms. The aim of this study is to determine the epidemiological, clinical, therapeutic, evolutionary and prognostic aspects of COVID-19 infection in children. Patients and Methods: This was a prospective analytical study carried out from February 27, 2021 to January 27, 2022 at the COVID-19 Care Center of the Infectious and Tropical Diseases Department of the Bouaké University Teaching Hospital. The study population consisted of all children under the age of 16, seen in consultation and/or hospitalized with a positive COVID-19 RT-PCR. Data analysis was performed with Epi Info 7 software. The statistical tests used were the chi-square test and Fisher’s exact test depending on the conditions of validity with a significance threshold of p Results: Out of 955 patients received at the COVID-19 Care Center in Bouaké, there were 56 children (26 boys/30 girls), or, a prevalence of 5.86%. The mean age was 9.18 years ± 4.48 [extremes 3 months and 15 years]. Children over the age of 11 accounted for 48.21% of cases. They were contact cases in 35.71% and the contact person was the mother in 75% of cases. The main reasons for screening were cough (67.86%), fever (25%) and sneezing (21.43%). The pathological histories were asthma (83.33%), heart disease (33.33%) and sickle cell disease (16.67%). The medical examination revealed 6 cases of children in vital distress. The care consisted of home confinement for simple cases (89.29%) and hospitalization for cases presenting with vital distress (10.71%). The duration of confinement or hospitalization was between 10 and 15 days in 83.93% of cases. No cases of death were noted. The factors associated with the occurrence of symptomatic forms were age (p = 0.028), pathological history (p Conclusion: The proportion of pediatric cases of COVID-19 is low with a predominance during the season of harmatt

关键词： Epidemiology Coronavirus SARS-Cov2 Children Bouaké

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Monkeypox in an Immunocompetent Vaccined Adult: A Case Report at the University Teaching Hospital of Bouake

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Case Reports in Clinical Medicine 2022年第10期11卷 457-464页

作者： Kone Djakaridja yapo Martine Tatiana Kadiane-Oussou Juliette Akanji Iburaima Alamun Gue Irené Kouabenan Amon Stéphene Koné Famoussa Sule Mutiyu Akanbi Kouamé Kouamé Gilles Renaud Karidioula Jean Marie aba yapo thomas Kra Ouffoue Department of Infectious and Tropical Diseases University Teaching Hospital of Bouaké Bouaké Ivory Coast Department of Medicine Alassane Ouattara University (Bouaké) Bouaké Ivory Coast Dermatology Department University Teaching Hospital of Bouaké Bouaké Ivory Coast Internal Medicine Department University Teaching Hospital of Bouaké Bouaké Ivory Coast

Introduction: With the eradication of smallpox in 1980, vaccination against smallpox ceased and there was an upsurge in cases of monkeypox. The objective of this observation is to describe the characteristics of monkeypox in the vaccinated subject. Case Report: A 45-year-old, heterosexual, rural resident was referred for a rash. The history of the disease revealed signs of acute course marked by headache, asthenia, diffuse myalgia, chest pain, fever and pruritic rash. His background is marked by vaccination against smallpox in 1977, cohabitation with game hunters and domestic animals as well as a notion of contact with a person who presented similar but more generalized signs. The physical examination revealed a conscious patient with good general state, feverish, tachycardic, eupneic presenting skin lesions in the type of striated vesicles more or less umbilical, on the scalp, face, neck, trunk and the upper limbs associated with cervical lymphadenopathy. RT-PCR was performed on a dry swab by rubbing several vesicles and a throat swab proved positive for Monkeypox Virus (MPXV). Management consisted of isolation and symptomatic treatment. The evolution has been favorable. Conclusion: The symptomatology of monkeypox is similar to that of smallpox. Without widely available treatment or prophylaxis, rapid identification of cases is essential. Vaccination of people at risk is an alternative to curb the epidemic. However, the main prevention strategy is to raise awareness of the risk factors.

关键词： Monkeypox Rash Immunocompetent Bouaké

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COVID-19 in Bouake (Côte D’Ivoire): Comparative Study of the Epidemiological, Clinical, Therapeutic, Evolutionary and Prognostic Aspects in Younger and Elderly Patients

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Advances in Infectious Diseases 2022年第2期12卷 312-327页

作者： Kone Djakaridja Kadiane-Oussou Juliette Akanji Iburaima Alamun yapo Martine Tatiana Kouamé Kouamé Gilles Renaud Karidioula Jean Marie Adou Leioh Romeo Kone Famoussa Sule Mutiyu Akanbi Soumahoro Namory Junior aba yapo thomas Kra Ouffoue Department of Infectious and Tropical Diseases University and Teaching Hospital of Bouaké Bouaké Ivory Coast COVID-19 Care Center University and Teaching Hospital of Bouaké Bouaké Ivory Coast Department of Internal Medecine University and Teaching Hospital of Bouaké Bouaké Ivory Coast

Introduction: The clinical manifestations of many diseases vary with age, and older people often do not show typical symptoms of the disease. The present study aims to compare the epidemiological, clinical, therapeutic and evolutionary aspects of elderly patients with COVID-19 compared to young adult patients and to identify risk factors for mortality. Patients and Methods: This was a retrospective single-center analytical study conducted from January 27, 2021 to January 27, 2022 at the COVID-19 Care Center of the Infectious and Tropical Diseases Department of the Bouaké University Teaching Hospital. The study population consisted of all patients aged at least 18 years seen in consultation and/or hospitalized with a positive COVID-19 RT-PCR. The patients were divided into two groups: younger patients (Results: Of a total of 779 patients, 644 (82.7%) were young. The median age of all patients was 41 years (IQR 32 - 54, extreme 18 and 96). Of all the patients 38.5% had a comorbidity. Compared to younger patients, chronic heart disease (61.7% vs 21.5%;p Conclusion: Elderly people with COVID-19 have a different clinical presentation from younger, characterized by more atypical symptoms. Mortality risk factors are age, dyspnoea, impaired consciousness and fever. It is therefore necessary to act on its various factors to improve the prognosis of COVID-19 in this age group.

关键词： Epidemiology Coronavirus SARS-Cov2 Age Bouaké

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Missed Opportunities for Diagnosing Bacilliferous Pulmonary Tuberculosis by Optical Microscopy versus GeneXpert MTB/RIF in Endemic Areas

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Advances in Infectious Diseases（传染病进展） 2023年第4期

作者： aba yapo thomas Nassoué Dobré Olivia Yéo Liomehin Monemo Pacome yapo Matine Tatiana Achi Hoboueu Vincent

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