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Expert consensus on the diagnosis and therapy of endo-periodontal lesions

International Journal of Oral Science 2024年第3期16卷 381-389页

作者： Bin Chen Yanan Zhu Minkui Lin Yangheng Zhang Yanfen Li Xiangying Ouyang Song Ge Jiang Lin yaping pan Yan Xu Yi Ding Shaohua Ge Faming Chen Zhongchen Song Shaoyun Jiang Jiang Sun Lijun Luo Junqi Ling Zhi Chen Lin Yue Xuedong Zhou Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Department of Endodontics Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province&Fujian Key Laboratory of Oral Diseases&Fujian Provincial Engineering Research Center of Oral Biomaterial School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Periodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina School and Hospital of Stomatology Zunyi Medical UniversityZunyiChina Department of Stomatology Beijing TongRen HospitalCapital Medical UniversityBeijingChina Department of Periodontics School and Hospital of StomatologyChina Medical UniversityShenyangChina Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Key Laboratory of Oral DiseasesNanjing Medical UniversityNanjingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Periodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Periodontology School and Hospital of StomatologyShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral Diseases JinanJinanChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of periodontologySchool of StomatologyThe Fou

Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing *** etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical ***,EPL-affected teeth require multidisciplinary therapy,including periodontal therapy,endodontic therapy and others,but there is still much debate about the appropriate timing of periodontal therapy and root canal *** compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EPL-affected teeth,this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence.

关键词： diagnosis periodontal lesions

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论基于教学思维转型的课堂“五育”融合

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当代教育科学 2024年第8期 21-26页

作者：潘亚萍黄明杰南京师范大学课程与教学研究所南京210097 安徽商贸职业技术学院电子商务学院芜湖241000

教师作为践行课堂教学的主体,其教学思维方式对“五育”融合的课堂实践具有关键性作用。割裂式教学思维分解了“五育”融合的教学关联,概念式教学思维阻碍了“五育”融合的实践探索,学科式教学思维窄化了“五育”融合的教学空间,平面式... 详细信息

教师作为践行课堂教学的主体,其教学思维方式对“五育”融合的课堂实践具有关键性作用。割裂式教学思维分解了“五育”融合的教学关联,概念式教学思维阻碍了“五育”融合的实践探索,学科式教学思维窄化了“五育”融合的教学空间,平面式教学思维限制了“五育”融合的立体建构,这些教学思维造成了课堂“五育”融合的实践困境。因此,教师需要转向复杂式教学思维,夯实课堂“五育”融合的思维基石;立足跨学科教学思维,实现课堂“五育”融合的学科协同;形成教学现场思维,促进课堂“五育”融合的有机生成;构建立体化教学思维,促使课堂“五育”融合的协调统一。

关键词：教学思维思维转型五育融合实践智慧

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重度牙周炎患者种植体与天然牙相互影响的回顾性研究

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中华口腔医学杂志 2024年第4期59卷 336-343页

作者：杨泽邓禹苗磊李俊歌李琛潘亚萍中国医科大学口腔医学院·附属口腔医院牙周病科、辽宁省口腔疾病重点实验室沈阳110002

目的从改善天然牙牙周健康的角度,评价规律复查的重度牙周炎患者后牙区种植修复治疗对天然牙的影响,以及天然牙牙周状态对种植体的影响,为临床提供参考。方法收集2014年6月至2023年6月于中国医科大学口腔医学院·附属口腔医院牙周病科就... 详细信息

目的从改善天然牙牙周健康的角度,评价规律复查的重度牙周炎患者后牙区种植修复治疗对天然牙的影响,以及天然牙牙周状态对种植体的影响,为临床提供参考。方法收集2014年6月至2023年6月于中国医科大学口腔医学院·附属口腔医院牙周病科就诊,并完成后牙单冠种植修复治疗的重度牙周炎者53例,其中男性16例,女性37例,年龄(52.2±8.0)岁,种植体共136枚,缺牙区相邻天然牙135颗。回顾性比较种植前后口内余留天然牙的探诊深度(PD)、探诊出血(BOP)和松动度变化,并通过单因素和多因素分析探讨天然牙对种植体PD、BOP和末次复查时边缘骨丧失(MBL)的可能影响因素。结果53例患者的随访时间为(44.5±14.1)个月,最长复查间隔为(8.3±2.7)个月。缺牙区相邻天然牙PD由种植前的4.3(3.6,4.6)mm显著改善至末次复查时的3.6(3.2,4.0)mm(P0.05),松动度≥Ⅱ度的牙齿数量由1.0(0.0,1.8)颗显著降为1.0(0.0,1.0)颗(P<0.05)。结论规律复查的前提下,重度牙周炎患者后牙区种植修复治疗有助于改善余留天然牙的PD、BOP和松动度,同时初诊牙周炎分期分级可影响种植体的PD和BOP。

关键词：牙周炎牙种植牙周基础治疗支持性牙周照护口腔健康牙列缺损

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The dimension and morphology of alveolar bone at maxillaryanterior teeth in periodontitis: a retrospective analysis usingCBCT

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International Journal of Oral Science 2020年第1期12卷 50-58页

作者： Xue Zhang Yuchao Li Ziming Ge Haijiao Zhao Lei Miao yaping pan Department of Periodontics School of StomatologyChina Medical UniversityShenyangChina

The morphology of the alveolar bone at the maxillary anterior teeth in periodontitis patients was evaluated by cone-beam computed tomography(CBCT) to investigate the distribution of alveolar defects and provide guidance for clinical practice. Ninety periodontitis patients and 30 periodontally healthy individuals were selected to determine the morphology of the alveolar bone at the maxillary anterior teeth according to the degree of bone loss, tooth type, sex and age. The differences in the dimensions between periodontitis patients and healthy individuals were compared, and the distribution of alveolar bone defects was analyzed.A classification system was established regarding the sagittal positions and angulations of the teeth. The buccal residual bone was thicker and the lingual bone was thinner in the periodontitis patients than in the periodontally healthy individuals, and there were differences between the different tooth types, sexes and age subgroups. The buccal undercut was close to the alveolar ridge, while fenestration was reduced and the apical bone height was higher in periodontitis patients than in periodontally healthy *** apical bone height increased with the aggravation of bone loss and age. The proportions of different sagittal positions changed with the aggravation of bone loss. Moreover, the teeth moved more buccally regarding the positions of the maxillary anterior *** morphology of the alveolar bone at the maxillary anterior teeth differed between periodontitis patients and healthy individuals,and the differences were related to the degree of bone loss, tooth type, sex and age.

关键词： alveolar CBCT positions

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Porphyromonas gingivalis infection promotes mitochondrial dysfunction through Drp1-dependent mitochondrial fission in endothelial cells

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International Journal of Oral Science 2021年第3期13卷 300-310页

作者： Tong Xu Qin Dong Yuxiao Luo Yanqing Liu Liang Gao yaping pan Dongmei Zhang Department of Periodontics School of StomatologyChina Medical UniversityShenyangChina Department of Periodontics and Oral Biology School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseaseShenyangChina

Porphyromonas gingivalis(***),a key pathogen in periodontitis,has been shown to accelerate the progression of atherosclerosis(AS).However,the definite mechanisms remain *** evidence supports an association between mitochondrial dysfunction and *** our study,the impact of *** on mitochondrial dysfunction and the potential mechanism were *** mitochondrial morphology of ***926 cells infected with *** was assessed by transmission electron microscopy,mitochondrial staining,and quantitative analysis of the mitochondrial *** staining and flow cytometry analysis were performed to determine mitochondrial reactive oxygen species(mtROS)and mitochondrial membrane potential(MMP)*** ATP production was examined by a luminescence assay *** expression of key fusion and fission proteins was evaluated by western blot and ***-1,a specific Drp1 inhibitor,was used to elucidate the role of Drp1 in mitochondrial *** findings showed that *** infection induced mitochondrial fragmentation,increased the mtROS levels,and decreased the MMP and ATP concentration in vascular endothelial *** observed upregulation of Drp1(Ser616)phosphorylation and translocation of Drp1 to ***-1 blocked the mitochondrial fragmentation and dysfunction induced by ***,these results revealed that *** infection promoted mitochondrial fragmentation and dysfunction,which was dependent on *** dysfunction may represent the mechanism by which *** exacerbates atherosclerotic lesions.

关键词： Drp1 gingivalis dysfunction

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老年肺康复住院患者营养状况调查及其影响因素分析

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中国老年保健医学 2024年第4期22卷 92-98页

作者：陈云峰魏颖俊潘雅萍盖玉婷上海市宝山区高境镇社区卫生服务中心医务科 200435 上海市第二康复医院呼吸与重症康复科 200441 上海市宝山区高境镇社区卫生服务中心全科 200435 上海市第二康复医院老年康复科 200441

目的调查老年肺康复住院患者的营养状况,探讨营养不良风险的可能影响因素,为更好地开展肺康复患者的临床营养工作提供参考。方法研究对象选取2023年度于上海市第二康复医院住院治疗的老年肺康复患者257例,采集研究对象的基本信息和辅助... 详细信息

目的调查老年肺康复住院患者的营养状况,探讨营养不良风险的可能影响因素,为更好地开展肺康复患者的临床营养工作提供参考。方法研究对象选取2023年度于上海市第二康复医院住院治疗的老年肺康复患者257例,采集研究对象的基本信息和辅助检查结果,对其开展营养状况调查和微型营养量表评定,采用单因素和多因素回归进行分析。结果257例研究对象中,评定为营养状况正常者135例,评定为存在营养不良的风险者116例,评定为存在营养不良者6例。单因素分析结果显示性别、年龄、现存子女数量、文化程度、牙齿情况、冠心病、气管切开状态、血红蛋白、淋巴细胞百分比、总蛋白、白蛋白、前白蛋白、血肌酐、尿素氮、尿酸、氯离子等因素存在统计学意义(P<0.05)。多因素分析结果显示文化程度、牙齿情况、气管切开状态、总蛋白、白蛋白、前白蛋白、血肌酐、尿素氮、尿酸等因素存在统计学意义(P<0.05)。结论老年肺康复住院患者营养不良和营养不良风险的发生率较高,应重视其营养评估并采取针对性干预措施。

关键词：肺康复营养状况微型营养量表营养评估影响因素老年人

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补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆临床研究

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新中医 2024年第10期56卷 73-76页

作者：潘亚平沈校康魏红辉孙宁宁浙江省立同德医院老年科浙江杭州311122 浙江省立同德医院康复科浙江杭州311122

目的:观察补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆的临床疗效。方法:选取124例老年髓海不足型阿尔茨海默病痴呆进行研究,按照随机数字表法分为治疗组与对照组各62例。治疗组给予补肾生髓益智汤联合甘露特钠... 详细信息

目的:观察补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆的临床疗效。方法:选取124例老年髓海不足型阿尔茨海默病痴呆进行研究,按照随机数字表法分为治疗组与对照组各62例。治疗组给予补肾生髓益智汤联合甘露特钠胶囊治疗,对照组给予甘露特钠胶囊治疗。比较2组临床疗效,以及治疗前后简易精神状态量表(MMSE)、阿尔茨海默病评定量表-认知部分(ADAS-cog)、长谷川痴呆量表(HDS)、痴呆行为量表(BEHAVE-AD)评分。结果:治疗后,治疗组总有效率为90.32%,对照组为75.81%。2组比较,差异有统计学意义(P<0.05)。治疗后,2组MMSE评分均较治疗前上升(P<0.05),且治疗组MMSE评分高于对照组(P<0.05);2组ADAS-cog评分均较治疗前下降(P<0.05),且治疗组ADAS-cog评分低于对照组(P<0.05)。治疗后,2组HDS评分均较治疗前上升(P<0.05),且治疗组HDS评分高于对照组(P<0.05);2组BEHAVE-AD评分均较治疗前下降(P<0.05),且治疗组BEHAVE-AD评分低于对照组(P<0.05)。结论:补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆临床疗效良好,可改善患者认知功能及痴呆症状。

关键词：阿尔茨海默病痴呆髓海不足型补肾生髓益智汤甘露特钠胶囊长谷川痴呆量表痴呆行为量表

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Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

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International Journal of Oral Science 2023年第1期15卷 136-147页

作者： Shuang Lei Jian Li Jingjun Yu Fulong Li yaping pan Xu Chen Chunliang Ma Weidong Zhao Xiaolin Tang Department of Periodontics School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Pediatric Dentistry School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Preventive Dentistry School and Hospital of StomatologyLiaoning Provincial Key Laboratory of Oral DiseaseChina Medical UniversityShenyangChina Department of Developmental Cell Biology Key Laboratory of Cell BiologyChina Medical UniversityShenyangChina

Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease(AD). The blood-brain barrier(BBB) is essential for keeping toxic substances from entering brain tissues. However, the effect of P. gingivalis bacteremia on BBB permeability and its underlying mechanism remains unclear. In the present study, rats were injected by tail vein with P. gingivalis three times a week for eight weeks to induce bacteremia. An in vitro BBB model infected with P. gingivalis was also established. We found that the infiltration of Evans blue dye and Albumin protein deposition in the rat brain tissues were increased in the rat brain tissues with P. gingivalis bacteremia and P. gingivalis could pass through the in vitro BBB model. Caveolae were detected after P. gingivalis infection in BMECs both in vivo and in vitro. Caveolin-1(Cav-1) expression was enhanced after P. gingivalis *** of Cav-1 rescued P. gingivalis-enhanced BMECs permeability. We further found P. gingivalis-gingipain could be colocalized with Cav-1 and the strong hydrogen bonding between Cav-1 and arg-specific-gingipain(RgpA) were ***, P. gingivalis significantly inhibited the major facilitator superfamily domain containing 2a(Mfsd2a) expression. Mfsd2a overexpression reversed P. gingivalis-increased BMECs permeability and Cav-1 expression. These results revealed that Mfsd2a/Cav-1 mediated transcytosis is a key pathway governing BBB BMECs permeability induced by P. gingivalis, which may contribute to P. gingivalis/virulence factors entrance and the subsequent neurological impairments.

关键词： gingivalis expression inhibited

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Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics

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Molecular Plant 2016年第12期9卷 1620-1633页

作者： Shuai Huang Aruna Balgi yaping pan Meng Li Xiaoran Zhang Lilin Du Ming Zhou Michel Roberge Xin Li Michael Smith Laboratories Department of Botany University of British Columbia Vancouver BC V6T 1Z4 Canada Department of Biochemistry and Molecular Biology University of British Columbia Vancouver BC V6T 1Z3 Canada Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX 77030 USA National Institute of Biological Sciences Beijing 102206 China

Nucleotide-binding leucine-rich repeat （NLR） proteins serve as immune receptors in both plants and animals. To identify components required for NLR-mediated immunity, we designed and carried out a chemical genetics screen to search for small molecules that can alter immune responses in Arabidopsis thaliana. From 13 600 compounds, we identified Ro 8-4304 that was able to specifically suppress the severe autoimmune phenotypes of chs3-2D （chilling sensitive 3, 2D）, including the arrested growth morphology and heightened PR （Pathogenesis Related） gene expression. Further, six Ro 8-4304 insensitive mutants were uncovered from the Ro 8-4304-insensitive mutant （rim） screen using a mutagenized chs3-2D popula- tion. Positional cloning revealed thatriml encodes an allele of AtlCIn （I, currents; CI, chloride; n, nucleotide）. Genetic and biochemical analysis demonstrated that AtlCIn is in the same protein complex with the meth- ylosome components small nuclear ribonucleoprotein D3b （SmD3b） and protein arginine methyltransferase 5 （PRMT5）, which are required for the biogenesis of small nuclear ribonucleoproteins （snRNPs） involved in mRNA splicing. Double mutant analysis revealed that SmD3b is also involved in the sensitivity to Ro 8-4304, and the prmt5-1 chs3-2D double mutant is lethal. Loss of At/C/n, SmD3b, or PRMT5 function results in enhanced disease resistance against the virulent oomycete pathogen Hyaloperonospora arabidopsidis Noco2, suggesting that mRNA splicing plays a previously unknown negative role in plant immunity. The successful implementation of a high-throughput chemical genetic screen and the identification of a small-molecule compound affecting plant immunity indicate that chemical genetics is a powerful tool to study whole-organism plant defense pathways.

关键词： chemical genetics small molecule screening plant immunity TNL autoimmunity methylosome

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上海市某镇老年人营养不良风险评估与健康体检结果分析研究

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检验医学与临床 2024年第S1期21卷 29-35页

作者：陈云峰潘雅萍凌云朱泽红张丽华上海市宝山区高境镇社区卫生服务中心医务科上海200435 上海市宝山区高境镇社区卫生服务中心全科上海200435 上海市宝山区中西医结合医院急诊科上海201999

目的调查上海市高境镇参加健康体检老年人的营养情况与体检结果,并探讨营养不良和营养不良风险的可能影响因素,为社区卫生服务中心更好地开展临床营养工作提供参考。方法研究对象选取上海市高境镇参加2023年老年人免费健康体检者,采用... 详细信息

目的调查上海市高境镇参加健康体检老年人的营养情况与体检结果,并探讨营养不良和营养不良风险的可能影响因素,为社区卫生服务中心更好地开展临床营养工作提供参考。方法研究对象选取上海市高境镇参加2023年老年人免费健康体检者,采用分层随机抽样方法,纳入1326例进行营养现况调查问卷和微型营养量表评定,并追踪查询其体检结果,采用单因素和多因素回归进行分析。结果1326例研究对象中,营养状况正常者909例,存在营养不良的风险者411例,存在营养不良者6例;单因素分析结果显示,现存子女数量、高血压史、冠心病史、脑卒中史、肿瘤史、体育锻炼习惯、牙齿情况、自我评价营养情况、家庭医生签约、体检血红蛋白、肝功能、肾功能、血脂、腹部超声结果等因素存在统计学意义(P<0.05);多因素分析结果显示有高血压史、脑卒中史、肿瘤史、缺乏体育锻炼习惯、自我评价营养情况一般或不清楚、未与家庭医生签约、肾功能异常等因素是引起老年人营养不良风险的主要危险因素;而牙不全但不影响咀嚼、肝功能和腹部超声异常则是引起老年人营养不良风险的保护性因素。结论上海市高境镇老年人营养不良风险的发生率较高,应重视老年人营养评估与营养干预,有利于社区临床营养工作的开展。

关键词：营养不良风险健康体检社区卫生服务中心

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