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Recent Research Progress in Premature Ovarian Failure

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Journal of Clinical and Nursing Research 2024年第7期8卷 274-281页

作者： yaping meng Xi Xia Wenjie Jiang Minghui Hao Ziqi Fan Yihang Song Northwest Minzu University Medical College Lanzhou 730030Gansu ProvinceChina

Premature ovarian failure refers to ovarian function failure in women before the age of 40 years due to follicular depletion or follicular dysfunction resulting in abnormal hormone *** etiology and pathogenesis of premature ovarian failure may be related to genetic,immunological,medical,environmental,infectious,psychological and enzyme *** treatment involves Western medicine,Chinese medicine,and a combination of Chinese and Western medicine,and the treatment level includes hormone level,cellular level,surgery and psychological *** paper would like to review the progress of the etiology,pathogenesis and treatment of premature ovarian failure in recent years.

关键词： Premature ovarian failure Etiology Pathogenesis Treatment

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鲜湿薯类粉条品质改良关键技术研究进展

粮食加工 2024年第1期49卷 29-31页

作者：孟亚萍焦婷婷漯河食品职业学院河南漯河462300 郑州科技学院郑州450064

鲜湿薯类粉条是以马铃薯、木薯、甘薯等薯类淀粉为主要原料,经挤压熟化而成的中国传统食品。我国薯类鲜湿粉条加工企业规模大小不一,小作坊较多,加工产业长期以来存在产品质量参差不齐,产品老化变硬过快、易断条、明矾超标、加工设备自... 详细信息

鲜湿薯类粉条是以马铃薯、木薯、甘薯等薯类淀粉为主要原料,经挤压熟化而成的中国传统食品。我国薯类鲜湿粉条加工企业规模大小不一,小作坊较多,加工产业长期以来存在产品质量参差不齐,产品老化变硬过快、易断条、明矾超标、加工设备自动化程度较低等问题。分析了鲜湿薯类粉条加工过程中影响品质的关键因素及非铝品质改良剂的开发应用的进展情况,以期为行业发展提供方向和指导,并对未来前景进行了展望。

关键词：鲜湿薯类粉条品质改良剂设备自动化前景展望

专创融合背景下“食品化学”课程实践教学的完善

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粮油科学与工程 2024年第4期38卷 47-49页

作者：孟亚萍赵丹张慧敏郑州科技学院食品科学与工程学院郑州450064

“食品化学”是应用型本科高校食品类专业的必修课,该课程知识点多,是学生学习其他专业课程的基础。通过学习,学生可运用理论知识分析解决实际问题。实践教学是该课程教学的重要组成部分,是理论教学的深化和延伸,通过实践,学生可提升创... 详细信息

“食品化学”是应用型本科高校食品类专业的必修课,该课程知识点多,是学生学习其他专业课程的基础。通过学习,学生可运用理论知识分析解决实际问题。实践教学是该课程教学的重要组成部分,是理论教学的深化和延伸,通过实践,学生可提升创新应用和工程实践能力,但传统的“食品化学”实践教学存在很多问题,导致教学目标无法完全达成。为此,学院通过重组实践教学内容、改进教学模式和方法、完善考核方式、开放第二课堂等方面对实践教学进行完善,取得了较好效果。

关键词：食品化学创新工程实践能力实践教学

衡阳市科技创新与油茶产业发展的耦合机制研究

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湖南林业科技 2024年第1期51卷 88-96页

作者：朱捷孟亚萍资雅莹李维衡阳市农业科学院湖南衡阳421101 耒阳市林业局湖南耒阳421812

科技创新与油茶产业发展相互促进、相互影响,研究两者的耦合协调关系及其制约机制,对于正确处理两者的关系具有重要意义。本文研究科技创新与油茶产业发展的耦合协调关系,为优化油茶产业结构和生产要素的投入力度提供理论依据。本研究... 详细信息

科技创新与油茶产业发展相互促进、相互影响,研究两者的耦合协调关系及其制约机制,对于正确处理两者的关系具有重要意义。本文研究科技创新与油茶产业发展的耦合协调关系,为优化油茶产业结构和生产要素的投入力度提供理论依据。本研究构建了衡阳市科技创新系统与油茶产业发展系统耦合评价指标体系,以耦合度和耦合协调度为基础,引入熵权-耦合模型,定量分析科技创新与油茶产业发展的综合发展水平、耦合协调程度及同步性等级。结果表明:2012—2021年衡阳市科技创新系统与油茶产业发展系统耦合协调发展水平经历了萌芽、磨合、稳定3个阶段。耦合度从0.1410上升到0.6548,耦合协调度从0.0908上升至0.7564,由极度失调发展到中级协调;虽未达到优质协调等级,但整体呈上升趋势。同步性等级从油茶产业严重滞后型发展成基本同步型。衡阳市科技创新与油茶产业发展协调程度逐步提高,关联程度逐步加深,处于良性耦合状态,并有向协调和优质方向发展的态势。油茶产业作为衡阳市传统优势产业,发展持续向好。科技创新作为油茶产业发展的驱动因素,是油茶产业发展的前置动力和重要保障。

关键词：衡阳市油茶科技创新产业发展耦合度

基于招生-培养-就业系统耦合的中医药本科人才培养路径研究

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中医教育 2024年第2期43卷 41-45页

作者：孟亚平张艳梅赵文韬南京中医药大学南京210023

基于系统耦合理论,全面审思中医药本科人才培养全过程,分析中医药高等教育招生、培养和就业耦合背景及发展现状,探讨三者以新高考改革为突破口,构建互为支撑、互为融合、协同发展的动态关联模式。提出以健康服务需求为牵引,优化招生结构... 详细信息

基于系统耦合理论,全面审思中医药本科人才培养全过程,分析中医药高等教育招生、培养和就业耦合背景及发展现状,探讨三者以新高考改革为突破口,构建互为支撑、互为融合、协同发展的动态关联模式。提出以健康服务需求为牵引,优化招生结构;以输出高水平中医药人才为中心,改革培养过程;以高质量就业为目标,促进培养并反哺招生的系统耦合策略,为推动中医药本科教育高质量发展提供参考。

关键词：招生培养就业系统耦合中医药本科人才

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复合多糖对鲜湿薯类粉条品质的影响

粮油科学与工程 2024年第4期38卷 22-29页

作者：焦婷婷孟亚萍时文芳王娇曹现立漯河食品工程职业大学河南漯河462300 郑州科技学院郑州450064 漯河豫鼎源食品工业有限公司河南漯河462300

采用单因素实验和主成分因子分析法,研究了罗望子胶、沙蒿胶、可得然胶和海藻糖对鲜湿薯类粉条品质的影响及粉条在冷藏过程中发生的质构特性变化。结果表明:复合多糖对鲜湿薯类粉条加工原料糊化黏度影响较大,随着罗望子胶和可得然胶添... 详细信息

采用单因素实验和主成分因子分析法,研究了罗望子胶、沙蒿胶、可得然胶和海藻糖对鲜湿薯类粉条品质的影响及粉条在冷藏过程中发生的质构特性变化。结果表明:复合多糖对鲜湿薯类粉条加工原料糊化黏度影响较大,随着罗望子胶和可得然胶添加量的增加,原料糊化黏度增大;随着沙蒿胶和海藻糖添加量的增加,原料糊化黏度先增大后减小;添加复合多糖在一定程度上改善了鲜湿薯类粉条的感官品质、质构特性和冷藏稳定性;与空白样相比,添加复合多糖的鲜湿薯类粉条冷藏8 d后,硬度和黏性变化均很小。综合考虑成本等因素,罗望子胶、沙蒿胶、可得然胶和海藻糖的添加量分别为0.6%、0.2%、0.4%和0.3%时,制作的鲜湿薯类粉条品质最佳,冷藏条件下抗老化效果最好。

关键词：品质改良鲜湿薯类粉条质构特性

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Temporospatial inhibition of Erk signaling is required for lymphatic valve formation

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4850-4866页

作者： yaping meng Tong Lv Junfeng Zhang Weimin Shen Lifang Li Yaqi Li Xin Liu Xing Lei Xuguang Lin Hanfang Xu Anming meng Shunji Jia State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBejing 100084China Guangzhou Laboratory Guangzhou 510320 Guangdong ProvinceChina State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Intraluminal lymphatic valves(LVs)and lymphovenous valves(LVs)are critical to ensure the unidirectional flow of lymphatic *** abnormalities in these valves always cause lymph or blood reflux,and result in lymphedema.

关键词： lymphatic Morphological edema

Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study

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Neural Regeneration Research 2024年第8期19卷 1842-1848页

作者： Lu He Qinming Zhou Chaoyang Xiu yaping Shao Dingding Shen Huanyu meng Weidong Le Sheng Chen Department of Neurology and Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Center for Translational Research on Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalianLiaoning ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengduSichuan ProvinceChina Department of Neurology Xinrui HospitalWuxiJiangsu ProvinceChina

Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive *** is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke *** this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy *** bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral *** biomarke rs were selected based on functionality and expression *** validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent *** substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle ***,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and transl

关键词： amyotrophic lateral sclerosis cathelicidin-related antimicrobial peptide hemoglobin label-free quantitative proteomics multi-protein combined diagnostic panel serum biomarkers talin-1 translationally-controlled tumor protein zyxin

Application of Global Leadership Initiative on Malnutrition criteria in patients with liver cirrhosis

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Chinese Medical Journal 2024年第1期137卷 97-104页

作者： Minjie Jiang Juan Chen Muchen Wu Jing Wu Xiaotong Xu Juan Li Can Liu yaping Zhao Xin Hua Qinghua meng Department of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Department of Medical Oncology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Department of Nutrition Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:The Global Leadership Initiative on Malnutrition(GLIM)criteria were published to build a global consensus on nutritional *** muscle mass is a phenotypic criterion with strong evidence to support its inclusion in the GLIM consensus ***,there is no consensus regarding how to accurately measure and define reduced muscle mass in clinical *** study aimed to investigate the optimal reference values of skeletal muscle mass index for diagnosing sarcopenia and GLIM-defined malnutrition,as well as the prevalence of GLIM-defined malnutrition in hospitalized cirrhotic ***:This retrospective study was conducted on 1002 adult patients with liver cirrhosis between January 1,2018,and February 28,2022,at Beijing You-An Hospital,Capital Medical *** patients with a clinical diagnosis of liver cirrhosis and who underwent an abdominal computed tomography(CT)examination during hospitalization were included in the *** patients were randomly divided into a modeling group(cohort 1,667 patients)and a validation group(cohort 2,335 patients).In cohort 1,optimal cut-off values of skeletal muscle index at the third lumbar skeletal muscle index(L3-SMI)were determined using receiver operating characteristic analyses against in-hospital mortality in different gender ***,patients in cohort 2 were screened for nutritional risk using the Nutritional Risk Screening 2002(NRS-2002),and malnutrition was diagnosed by GLIM ***,the reference values of reduced muscle mass in GLIM criteria were derived from the L3-SMI values from cohort *** logistic regression analysis was used to analyze the association between GLIM-defined malnutrition and clinical ***:The optimal cut-off values of L3-SMI were 39.50 cm 2/m 2 for male patients and 33.06 cm 2/m 2 for female *** on the cut-off values,31.63%(68/215)of the male patients and 23.3%(28/120)of the female patients had CT-determ

关键词： Malnutrition Liver cirrhosis Sarcopenia Clinical outcomes GLIM criteria