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Endogenous Trypsin Triggers Free Fluoride Release from Antarctic Krill(Euphausia superba)Cuticle

Journal of Ocean University of China 2024年第3期23卷 766-774页

作者： PENG Yuanhuai JI Wei JI Hongwu HAN Zhiping ZHANG Shiqi wen yaping College of Food Science and Engineering Lingnan Normal UniversityZhanjiang 524048China College of Biological and Food Engineering Guangdong University of EducationGuangzhou 510303China Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety Guangdong Ocean UniversityZhanjiang 524088China College of Food Science and Technology Guangdong Ocean UniversityZhanjiang 524088China College of Continuing Education Lingnan Normal UniversityZhanjiang 524048China

During postmortem storage,fluoride in Antarctic krill can be enriched in the muscle.Trypsin,as the most important digestive enzyme in Antarctic krill with a high activity in low temperature,plays a potential role in this process.In this study,endogenous trypsin was purified and its properties were investigated.The involvement of trypsin in the generation of free fluoride from Antarctic krill cuticle was explored.Cuticle microstructure before and after hydrolysis was compared with scanning electron microscopy,and the ash samples of the hydrolyzed Antarctic krill cuticle were analyzed with X-ray diffraction,Fourier transform infrared spectroscopy,and electron dispersive spectroscopy,respectively.Mass spectrometry analysis and inhibition tests confirmed that the purified enzyme was endogenous trypsin.Results of the present study indicated that trypsin digestion caused the increases of the concentrations of both fluoride ions and free amino N simultaneously,while the protein coated on the cuticle surface was dissolved too.However,no compositional change was detected in the cuticle inorganic salts.These findings suggest that trypsin triggered free fluoride release from Antarctic krill cuticle.In addition,the kinetics of free fluoride release could be described by the equation C_(W)=(1-0.97^(-0.006t)-0.03e^(0.0558t))x337.53+10.50.The present study improved the understanding of the role of trypsin in free fluoride release from Antarctic krill cuticle,facilitating future studies aimed at reducing the fluoride content in krill protein during Antarctic krill processing.

关键词： Antarctic krill cuticle fluoride trypsin

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Current Status and Perspectives of Dual-Atom Catalysts Towards Sustainable Energy Utilization

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Nano-Micro Letters 2024年第7期16卷 402-440页

作者： Yizhe Li Yajie Li Hao Sun Liyao Gao Xiangrong Jin yaping Li Zhi LV Lijun Xu wen Liu Xiaoming Sun State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Xinjiang Coal Mine Mechanical and Electrical Engineering Technology Research Center Xinjiang Institute of EngineeringUrumqi 830023Xinjiang Uygur Autonomous RegionPeople’s Republic of China

The exploration of sustainable energy utilization requires the imple-mentation of advanced electrochemical devices for efficient energy conversion and storage,which are enabled by the usage of cost-effective,high-performance electro-catalysts.Currently,heterogeneous atomically dispersed catalysts are considered as potential candidates for a wide range of applications.Compared to conventional cata-lysts,atomically dispersed metal atoms in carbon-based catalysts have more unsatu-rated coordination sites,quantum size effect,and strong metal-support interactions,resulting in exceptional catalytic activity.Of these,dual-atomic catalysts(DACs)have attracted extensive attention due to the additional synergistic effect between two adja-cent metal atoms.DACs have the advantages of full active site exposure,high selectiv-ity,theoretical 100%atom utilization,and the ability to break the scaling relationship of adsorption free energy on active sites.In this review,we summarize recent research advancement of DACs,which includes(1)the comprehensive understanding of the synergy between atomic pairs;(2)the synthesis of DACs;(3)characterization meth-ods,especially aberration-corrected scanning transmission electron microscopy and synchrotron spectroscopy;and(4)electrochemical energy-related applications.The last part focuses on great potential for the electrochemical catalysis of energy-related small molecules,such as oxygen reduction reaction,CO_(2) reduction reaction,hydrogen evolution reaction,and N_(2) reduction reaction.The future research challenges and opportunities are also raised in prospective section.

关键词： Dual-atom catalysts Synergetic effect Electrocatalysis Oxygen reduction reaction CO_(2)reduction reaction Hydrogen evolution reaction N2 reduction reaction

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Machine learning assisted prediction of charge transfer properties in organic solar cells by using morphology-related descriptors

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Nano Research 2023年第2期16卷 3588-3596页

作者： Lulu Fu Haixia Hu Qiang Zhu Lifeng Zheng Yuming Gu yaping wen Haibo Ma Hang Yin Jing Ma Key Laboratory of Mesoscopic Chemistry of Ministry of Education School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China School of Physics Shandong UniversityJinan 250100China Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Charge transfer and transport properties are crucial in the photophysical process of exciton dissociation and recombination at the donor/acceptor(D/A)interface.Herein,machine learning(ML)is applied to predict the charge transfer state energy(ECT)and identify the relationship between ECT and intermolecular packing structures sampled from molecular dynamics(MD)simulations on fullerene-and non-fullerene-based systems with different D/A ratios(RDA),oligomer sizes,and D/A pairs.The gradient boosting regression(GBR)exhibits satisfactory performance(r=0.96)in predicting ECT withπ-packing related features,aggregation extent,backbone of donor,and energy levels of frontier molecular orbitals.The charge transport property affected byπ-packing with different RDA has also been investigated by space-charge-limited current(SCLC)measurement and MD simulations.The SCLC results indicate an improved hole transport of non-fullerene system PM6/Y6 with RDA of 1.2:1 in comparison with the 1:1 counterpart,which is mainly attributed to the bridge role of donor unit in Y6.The reduced energetic disorder is correlated with the improved miscibility of polymer with RDA increased from 1:1 to 1.2:1.The morphology-related features are also applicable to other complicated systems,such as perovskite solar cells,to bridge the gap between device performance and microscopic packing structures.

关键词： charge transfer charge transport packing modes machine learning organic solar cells

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血清FOXQ1、CEACAM19、CA72-4、CA15-3检测对宫颈癌患者的早期诊断效果分析

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首都食品与医药 2024年第7期31卷 94-96页

作者：文亚平南华大学附属长沙中心医院湖南长沙410008

目的研究宫颈癌早期诊断中应用糖类抗原72-4(CA72-4)、糖类抗原15-3(CA15-3)、叉头框蛋白Q1(FOXQ1)、癌胚抗原相关细胞黏附分子19(CEACAM19)的效果。方法以南华大学附属长沙中心医院2021年1月-2023年1月收治的90例宫颈癌患者为A组,以该... 详细信息

目的研究宫颈癌早期诊断中应用糖类抗原72-4(CA72-4)、糖类抗原15-3(CA15-3)、叉头框蛋白Q1(FOXQ1)、癌胚抗原相关细胞黏附分子19(CEACAM19)的效果。方法以南华大学附属长沙中心医院2021年1月-2023年1月收治的90例宫颈癌患者为A组,以该院同期收治的90例宫颈上皮内瘤变(CIN)患者为B组,另以同期在该院进行体检的90例健康女性为对照组,三组均采集血样检测相关血清学指标水平。结果A组CA72-4、CA15-3、FOXQ1、CEACAM19水平均高于B组与对照组,且B组高于对照组(P<0.05);低中分化宫颈癌患者CA72-4、CA15-3、FOXQ1、CEACAM19水平高于高分化患者(P<0.05);CA72-4、CA15-3、FOXQ1、CEACAM19均为宫颈癌发生的危险因素(P<0.05);CA72-4、CA15-3、FOXQ1、CEACAM19联合检测受试者工作特征曲线下面积高于单独检测(P<0.05)。结论FOXQ1、CEACAM19、CA72-4、CA15-3水平在宫颈癌患者中明显升高,其联合检测能够提高宫颈癌早期诊断效能。

关键词：宫颈癌叉头框蛋白Q1 癌胚抗原相关细胞黏附分子19 糖类抗原72-4 糖类抗原15-3

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La促进水滑石衍生镍基催化剂的原位制备及其CO_(2)甲烷化性能

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无机化学学报 2024年第3期40卷 561-570页

作者：杨文王迪迪黄子怡周亚平冯艳艳桂林理工大学化学与生物工程学院广西电磁化学功能物质重点实验室桂林541004

采用原位生长法制备水滑石衍生Ni-La/Al_(2)O_(3)催化剂,并用于CO_(2)甲烷化反应,以研究La掺杂量对所得催化剂形貌结构及催化性能的影响。利用电感耦合等离子体发射光谱、X射线衍射、氢气程序升温还原、低温氮气吸附-脱附、扫描电镜和... 详细信息

采用原位生长法制备水滑石衍生Ni-La/Al_(2)O_(3)催化剂,并用于CO_(2)甲烷化反应,以研究La掺杂量对所得催化剂形貌结构及催化性能的影响。利用电感耦合等离子体发射光谱、X射线衍射、氢气程序升温还原、低温氮气吸附-脱附、扫描电镜和透射电镜对催化剂的形貌结构进行分析。结果表明,适宜的La掺杂量能够提高活性金属Ni在载体中的分散性,减弱Ni与载体的相互作用,并且改善催化剂的孔隙结构,提高催化剂的比表面积。CO_(2)甲烷化性能表明,当Ni负载量(质量分数)为30%、La掺杂量(质量分数)为10%时,催化剂30Ni-10La/Al_(2)O_(3)具有较优的催化性能;350℃时其CO_(2)转化率及CH_(4)产率分别达到91.9%和91.5%,并且连续测试60 h后催化性能基本保持不变。

关键词： CO_(2)甲烷化水滑石衍生催化剂 La掺杂高分散性

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基于WPD-ARIMA-GARCH组合模型的酱卤肉制品安全风险区间预测

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食品科学 2024年第3期45卷 176-184页

作者：尹佳黄茜陈翔陈晨陈锂张涛徐成黄亚平郭鹏程文红湖北省食品质量安全监督检验研究院国家市场监管重点实验室(动物源性食品中重点化学危害物检测技术)湖北省食品质量安全检测工程技术研究中心湖北武汉430075 武汉理工大学计算机与人工智能学院湖北武汉430070 武汉理工大学理学院湖北武汉430070

针对传统确定性预测不能提供不确定性信息的难题,本研究提出了一种点估计和区间估计组合预测模型,并将其创新性地应用在食品安全风险预警领域。在点估计部分,使用小波包分解(wavelet packet decomposition,WPD)对周风险等级序列分解后,... 详细信息

针对传统确定性预测不能提供不确定性信息的难题,本研究提出了一种点估计和区间估计组合预测模型,并将其创新性地应用在食品安全风险预警领域。在点估计部分,使用小波包分解(wavelet packet decomposition,WPD)对周风险等级序列分解后,应用差分自回归移动平均(autoregressive integrated moving average,ARIMA)模型进行预测;在区间估计部分,使用广义自回归条件异方差(generalized autoregressive conditional heteroskedast,GARCH)模型对残差进行预测。本实验将建立的WPD-ARIMA-GARCH组合模型运用于某地区酱卤肉制品的风险预测,结果表明2019年的3月底和7月底该地区的酱卤肉制品安全风险较高,与实际情况相符;同时,该模型在10个不同地区的酱卤肉制品风险预测中,均方误差、平均绝对误差和平均绝对百分比误差分别为1.626、0.806和20.824;其90%置信区间的预测区间平均宽度和覆盖宽度标准值均为0.024,可以覆盖所有真实值。该模型具有较高的预测精度和较低的误差,能对酱卤肉制品质量安全起到风险防控作用,可为日常食品安全监管提供相应的技术支持。

关键词：酱卤肉制品小波包分解差分自回归移动平均模型广义自回归条件异方差模型区间估计

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Current approaches of nanomedicines in the market and various stage of clinical translation

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3028-3048页

作者： Xiaoting Shan Xiang Gong Jie Li Jingyuan wen yaping Li Zhiwen Zhang State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy University of AucklandAuckland 1142New Zealand

Compared with traditional drug therapy,nanomedicines exhibit intriguing biological features to increase therapeutic efficiency,reduce toxicity and achieve targeting delivery.This review provides a snapshot of nanomedicines that have been currently launched or in the clinical trials,which manifests a diversified trend in carrier types,applied indications and mechanisms of action.From the perspective of indications,this article presents an overview of the applications of nanomedicines involving the prevention,diagnosis and treatment of various diseases,which include cancer,infections,blood disorders,cardiovascular diseases,immuno-associated diseases and nervous system diseases,etc.Moreover,the review provides some considerations and perspectives in the research and development of nanomedicines to facilitate their translations in clinic.

关键词： Nanomedicines Nanoparticles Liposomes Vaccines Marketed products Clinical translations Disease-driven design Quality by design

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Space advanced technology demonstration satellite

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Science China(Technological Sciences) 2024年第1期67卷 240-258页

作者： ZHANG XiaoFeng CHEN wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao wen XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN wenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang wenG LuBin LUO Hao WANG yaping LIANG XianFeng FANG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of China Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Earth and Space Sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological University Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

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Ensemble Making Few-Shot Learning Stronger

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Data Intelligence 2022年第3期4卷 529-551页

作者： Qiang Lin Yongbin Liu wen wen Zhihua Tao Chunping Ouyang yaping Wan Computer School University of South China 421001China Hunan provincial base for scientific and technological innovation cooperation HunanChina

Few-shot learning has been proposed and rapidly emerging as a viable means for completing various tasks.Many few-shot models have been widely used for relation learning tasks.However,each of these models has a shortage of capturing a certain aspect of semantic features,for example,CNN on long-range dependencies part,Transformer on local features.It is difficult for a single model to adapt to various relation learning,which results in a high variance problem.Ensemble strategy could be competitive in improving the accuracy of few-shot relation extraction and mitigating high variance risks.This paper explores an ensemble approach to reduce the variance and introduces fine-tuning and feature attention strategies to calibrate relation-level features.Results on several few-shot relation learning tasks show that our model significantly outperforms the previous state-of-the-art models.

关键词： Few-shot learning Relation extraction Ensemble learning Attention Mechanism Fine-tuning

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基于区域细化的Siamese网络目标跟踪算法

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传感器与微系统 2024年第6期43卷 137-140页

作者：张海鹏王亚平张宝华徐利权温海英内蒙古科技大学信息工程学院内蒙古包头014010 中国移动通信集团内蒙古有限公司内蒙古包头014010

针对快速运动导致跟踪目标尺度变化大、分辨率低等问题,提出了一种基于区域细化的Siamese网络目标跟踪算法。在Siamese网络中引入多尺度特征感知模型,有效提取深层全局通道特征和局部空间特征,准确提取判别性信息;为进一步在搜索区域增... 详细信息

针对快速运动导致跟踪目标尺度变化大、分辨率低等问题,提出了一种基于区域细化的Siamese网络目标跟踪算法。在Siamese网络中引入多尺度特征感知模型,有效提取深层全局通道特征和局部空间特征,准确提取判别性信息;为进一步在搜索区域增强前景,构建区域细化模型,利用经主干网络提取的目标区域特征对搜索区域目标进行甄别,实现由粗到细的跟踪策略,有效增强目标表征能力。将所提算法在OTB100数据集上与现有的一些跟踪算法进行测试。实验结果表明,本文算法在跟踪成功率与跟踪精度方面均取得了良好的表现。同时在低分辨率、形变、光照变化等方面表现出较强的鲁棒性。

关键词：深度学习区域细化目标跟踪 Siamese网络

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