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High-level intrinsic disorder explains the universality of CLIP binding to diverse MHC class II variants

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Cellular & Molecular Immunology 2018年第1期15卷 76-78页

作者： Vladimir N Uversky yaping N tu Onyekachi Nwogu Shanitra N Butler Michael Ramsamooj George Blanck Department of Molecular Medicine Morsani College of MedicineUniversity of South Floridaand Immunology ProgramTampaFLUSA H.Lee Moffitt Cancer Center and Research Institute TampaFLUSA

MHC class I and II molecules bind peptides that are either recognized as self or as foreign to the immune system via interaction with T-cell *** T-cell receptor makes molecular contacts with the peptide and the MHC molecule in the region of the MHC peptide binding *** MHC class I and II molecules are highly polymorphic,which presumably allows for great diversity of antigen-binding sites over the population,leading to a species that is relatively fit to withstand foreign *** MHC class I molecules,this allelic variation predicts extensive variation in the sequence of peptides able to bind MHC class I molecules,and this is indeed the case.

关键词： explain class intrinsic

Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression

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Protein & Cell 2016年第6期7卷 445-449页

作者： Chuu-Yun A.Wong Haihong Jiang Peter W.Abel Margaret A.Scofield Yan Xie Taotao Wei yaping tu Department of Pharmacology Creighton University School of MedicineOmahaNE 68178USA National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

Dear Editor,P-Rex1 is a Rac-selective guanine nucleotide exchange factor （GEF） that is synergistically activated by G-protein coupled receptors and receptor tyrosine kinases （Welch et al., 2002）. We previously reported that aberrantly upreg- ulated P-Rex1 promotes prostate cancer metastasis by activating Racl signals （Qin et al., 2009）.

关键词： Breast Cancer Cell Growth Human Luminal Breast Cancer Breast Cancer Cell Cycle Suppress Breast Cancer Cell Growth Promote Prostate Cancer Metastasis

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Gαq介导的信号通路增强RGS4蛋白表达

生物物理学报 2014年第5期30卷 336-348页

作者：虞梅芳王进城卫涛涛黄有国屠亚平中国科学院生物物理研究所生物大分子国家重点实验室北京100101 中国科学院大学北京100049 Department of Pharmacology Creighton University School of MedicineOmahaNebraskaUSA北京100101 中国科学院遗传与发育研究所

RGS(regulators of G protein signaling)是G蛋白偶联信号通路中一类重要的调节蛋白,通过加速Gα结合的GTP水解,即GAP(GTPase activating protein)活性,来中止G蛋白信号通路。RGS4是RGS蛋白家族中的重要成员之一,它能有效中止Gαq介导... 详细信息

RGS(regulators of G protein signaling)是G蛋白偶联信号通路中一类重要的调节蛋白,通过加速Gα结合的GTP水解,即GAP(GTPase activating protein)活性,来中止G蛋白信号通路。RGS4是RGS蛋白家族中的重要成员之一,它能有效中止Gαq介导的信号通路。作者研究了Gαq蛋白对RGS4蛋白的表达调控。当在HEK293细胞中共转染这两个蛋白时,持续性激活的Gαq能特异性地显著增加RGS4蛋白的表达。蛋白降解实验结果证明这种增强作用与RGS4的降解被抑制无关,而与RGS4 mRNA表达增强有关。进一步克隆RGS4蛋白的启动子区域并研究其与RGS4表达相互关系的实验结果又表明,持续性激活的Gαq能够显著增强RGS4启动子区的转录活性,且具有时间和浓度效应。同时,转录因子结合区突变体实验证明,ICE(inverted CCAAT box element)转录因子结合区的突变显著影响RGS4基因的转录活性。以上结果表明Gαq可能通过RGS4的启动子区调控其基因的表达,促进RGS4蛋白表达。

关键词： Gαq RGS4蛋白表达 ICE转录因子结合区转录调控

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小叶爬崖香中苷类化合物的研究

中国药科大学学报 2024年第2期55卷 202-208页

作者：涂鹏煌姚志仁金美玲宁冠宇黄亚萍潘珂殷志琦中国药科大学中药学院中药制药系南京211198 中国药科大学中药学院天然药物化学系南京211198

为探究胡椒属植物小叶爬崖香(Piper sintenense Hatusima)中苷类化学成分,采用硅胶、ODS、MCI GEL CHP20P、Sephadex LH-20柱色谱和半制备高效液相等色谱技术,从小叶爬崖香95%乙醇提取物的正丁醇部位分离获得9个苷类化合物。根据理化性... 详细信息

为探究胡椒属植物小叶爬崖香(Piper sintenense Hatusima)中苷类化学成分,采用硅胶、ODS、MCI GEL CHP20P、Sephadex LH-20柱色谱和半制备高效液相等色谱技术,从小叶爬崖香95%乙醇提取物的正丁醇部位分离获得9个苷类化合物。根据理化性质及核磁共振数据,以上化合物被鉴定为(2S)-2-羟基-1-(4-羟基-3-甲氧基苯基)-1-丙酮-2-O-β-D-葡萄糖苷(1)、苯乙醇-β-D-葡萄糖苷(2)、苄醇-β-巢菜糖苷(3)、苄醇-β-樱草糖苷(4)、苯乙醇-β-D-呋喃芹菜糖基-(1''→2')-β-D-葡萄糖苷(5)、红景天苷(6)、苯乙醇-β-樱草糖苷(7)、(顺)-3-己烯醇-β-巢菜糖苷(8)、(顺)-3-己烯醇-β-樱草糖苷(9)。其中化合物1为新化合物,化合物3~9为首次从胡椒属中分离得到。

关键词：胡椒属小叶爬崖香化学成分糖苷分离鉴定

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Electroacupuncture improves neuropathic pain Adenosine, adenosine 5'-triphosphate disodium and their receptors perhaps change simultaneously

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Neural Regeneration Research 2012年第33期7卷 2618-2623页

作者： Wen Ren Wenzhan tu Songhe Jiang Ruidong Cheng yaping Du Institute of Social & Family Medicine Zhejiang University Hangzhou 310058 Zhejiang Province China Department of Physical Medicine and Rehabilitation The Second Affiliated Hospital of Wenzhou Medical College Wenzhou 325000Zhejiang Province China

Applying a stimulating current to acupoints through acupuncture needles–known as electroacupuncture–has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was applied in a rat model, adenosine 5-triphosphate disodium in the extracellular space was broken down into adenosine, which in turn inhibited pain transmission by means of an adenosine A1 receptor-dependent process. Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. In neuropathic pain, there is upregulation of P2X purinoceptor 3 （P2X3） receptor expression in dorsal root ganglion neurons. Conversely, the onset of mechanical hyperalgesia was diminished and established hyperalgesia was significantly reversed when P2X3 receptor expression was downregulated. The pathways upon which electroacupuncture appear to act are interwoven with pain pathways, and electroacupuncture stimuli converge with impulses originating from painful areas. Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain.

关键词： electroacupuncture analgesia adenosine adenosine 5'-triphosphate disodium A1 receptors P2Xpudnoceptor 3 receptors neuropathic pain peripheral nervous system central nervous system regeneration neural regeneration.

Evolution of surface microstructure of Cu-50Cr alloy treated by high current pulsed electron beam

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Science China(Technological Sciences) 2015年第3期58卷 462-469页

作者： CHAI LinJiang ZHOU ZhiMing XIAO ZhiPei tu Jian WANG yaping HUANG WeiJiu College of Materials Science and Engineering Chongqing University of Technology School of Science Xi'an Jiaotong University

A Cu-50Cr alloy was treated by the high current pulsed electron beam(HCPEB)at 20 and 30 ke V with pulse numbers ranging from 1 to *** morphologies and microstructures of specimens before and after the treatments were investigated by employing scanning electron microscopy and X-ray *** show that the HCPEB technique is able to induce remarkable surface modifications for the Cu-50Cr *** in Cr phases appear even after one-pulse treatment and their density always increases with the pulse *** reason for these cracks is attributed to quasi-static thermal stresses accumulated along the specimen *** with typical morphologies are formed due to the dynamic thermal field induced by the HCPEB and they are found to prefer the sites near cracks or boundaries between neighboring Cr *** microstructural characteristic produced by the HCPEB is the fine Cr spheroids,which are determined to be due to occurrence of liquid phase separation in the Cu-50Cr ***,a general microstructural evolution profile that incorporates various HCPEB-induced surface features is tentatively outlined.

关键词： Cu-Cr alloy microstructure surface modification electron beam

Effects of Recrystallization Parameters on the Formation of Hollow Silicalite-1 Zeolite

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China Petroleum Processing & Petrochemical Technology 2019年第4期21卷 1-8页

作者： Tan Cheng Dong Zhuoya Sun tu Zhang yaping Zhang Guanqun Xia Changjiu Ma Yanhang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210 University of Chinese Academy of Sciences Beijing100049 State Key Laboratory of Catalytic Materials and Reaction Engineering Research Institute of Petroleum ProcessingSINOPECBeijing 100083

Hollow silicalite-1 zeolite can be readily fabricated by hydrothermally treating the parent silicalite-1 with tetrapropylammonium hydroxide. A dissolution-recrystallization mechanism has been previously proposed to explain the formation of such hollow structures, but detailed information of this formation process still remains unclear. Herein, by tracking the evolvement of the hollow voids and morphology of the silicalite-1 under various treatments using XRD, SEM, TEM and N2 adsorption/desorption techniques, we systematically studied the formation process of the hollow structure of silicalite-1 zeolite and discovered that the organic template, water, treating temperature and time can significantly influence the morphology and size of hollow structure inside silicalite-1 zeolite crystals. Generally, a diluted synthesis medium with high template content under suitable temperature(for instance 170 °C) and extended treatment time favors the formation of single hexagonal hollow structure within silicalite-1 zeolites;while other conditions favor the formation of rounded hollow voids or even multiple-voids within silicalite-1 zeolites.

关键词： hollow silicalite-1 hydrothermal synthesis dissolution,recrystallization

450 nm半导体蓝激光“打沟去垄法”治疗大体积良性前列腺增生的疗效观察

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现代泌尿外科杂志 2024年第5期29卷 435-439页

作者：屠凡倬陈宪艳曲亚萍李松胡燕满超葛长官赵永伟泰安市中心医院迎胜院区泌尿肾病激光治疗中心山东泰安271000 泰安市中心医院消化内科中心-功能性胃肠病科山东泰安271000 河南大学淮河医院泌尿外科河南开封475000 济南市第八人民医院泌尿外科山东济南271100

目的分析450 nm半导体蓝激光“打沟去垄法”治疗大体积良性前列腺增生(BPH)的疗效及安全性,以期在临床推广应用。方法回顾性分析2023年9—12月泰安市中心医院迎胜院区泌尿肾病激光治疗中心行450 nm半导体蓝激光“打沟去垄法”治疗30例... 详细信息

目的分析450 nm半导体蓝激光“打沟去垄法”治疗大体积良性前列腺增生(BPH)的疗效及安全性,以期在临床推广应用。方法回顾性分析2023年9—12月泰安市中心医院迎胜院区泌尿肾病激光治疗中心行450 nm半导体蓝激光“打沟去垄法”治疗30例大体积BPH患者的临床资料,记录患者术中激光出光做功时间、术前及术后血红蛋白(Hb)水平、术后膀胱冲洗时间、尿管留置时间、术后住院时间、术中及术后并发症发生情况。对比患者术前及术后1个月国际前列腺症状评分(IPSS)、生活质量评定量表(QoL)评分、最大尿流率(Qmax)、膀胱残余尿量(PVR)变化情况。结果患者术前前列腺体积为(104.5±14.52)mL,术中激光出光做功时间(20.13±2.98)min,术后膀胱冲洗时间(20.27±2.56)h。所有患者术后2 d拔除导尿管,术后3 d顺利出院。术后1个月IPSS、QoL评分、Qmax、PVR均较术前明显改善,差异有统计学意义(P<0.05)。在随访期间未观察到任何并发症发生。结论采用450 nm半导体蓝激光“打沟去垄法”治疗大体积BPH是一种新型、安全、有效的手术方式。

关键词： 450 nm蓝激光前列腺汽化术打沟去垄法大体积良性前列腺增生

顾及降雨影响的动态优化时滞时序GM(1,2)模型在滑坡位移预测中的应用

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测绘学报 2022年第10期51卷 2183-2195页

作者：高雅萍陈曦涂锐长安大学地质工程与测绘学院陕西西安710054 成都理工大学地球科学学院四川成都610059 中国科学院国家授时中心陕西西安710600

滑坡体除了因自身重力产生位移外,还受到降雨的影响,但通常降雨对滑坡位移的作用具有滞后性。为了分析并预测降雨对滑坡位移的影响,本文提出一种顾及降雨影响的动态优化时滞时序GM(1,2)滑坡位移预测模型。首先,利用经验模态分解(EMD)分... 详细信息

滑坡体除了因自身重力产生位移外,还受到降雨的影响,但通常降雨对滑坡位移的作用具有滞后性。为了分析并预测降雨对滑坡位移的影响,本文提出一种顾及降雨影响的动态优化时滞时序GM(1,2)滑坡位移预测模型。首先,利用经验模态分解(EMD)分解位移序列并通过时间序列重构得到周期位移序列和趋势位移序列,对降雨数据和滑坡周期位移序列进行时滞分析和相关分析,确定时滞时间和影响程度,建立基于背景值优化的动态时滞GM(1,2)模型预测降雨量变化导致的滑坡周期位移变化;然后,建立门限自回归模型预测滑坡趋于自然变化的趋势位移;最后,通过时序叠加得到顾及降雨影响的滑坡预测位移,建立了顾及降雨因素的动态优化时滞时序GM(1,2)组合预测方法。本文以福宁高速公路八尺门滑坡和秭归县八字门滑坡监测数据为例,验证了动态优化时滞GM(1,2)模型的精度,并与其他模型的预测结果进行了对比分析。试验结果表明,动态优化时滞时序GM(1,2)组合预测模型能准确地预测降雨影响导致的滑坡位移变化,预测效果较好,该组合模型对滑坡灾害的预警与防治具有一定的参考价值。

关键词：滑坡位移预测降雨时间序列相关性分析动态优化时滞GM(1,2)模型门限自回归模型