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Incidence of persistent and high-risk human papillomavirus infection and associated factors among HIV-positive women in China, 2015-2016

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Gynecology and Obstetrics Clinical Medicine 2021年第3期1卷 130-137页

作者： yaping qiao Ailing Wang Liwen Fang Linhong Wang National Center for Women and Children's Health Chinese Center for Disease Control and PreventionBeijing10081China National Center for the Prevention and Control of Chronic Non-communicable Diseases Chinese Center for Disease Control and PreventionBeijing10025China

Background:Persistent human papillomavirus(HPV)infection is the necessary factor for cervical *** immunodeficiency virus(HIV)-positive women are a high-risk population for cervical cancer,but little is known about persistent HPV infection among HIV-positive women in *** aimed to investigate the persistence and incidence of infection with high-risk HPV(hrHPV)and associated factors among HIV-positive women in ***:Using a prospective observational study design,we collected data from 670 HIV-positive women in five counties of three provinces through interviews,medical record reviews,health examination,and laboratory tests at a baseline survey in 2015 and a follow-up survey in *** tested HIVpositive women for hrHPV infection using the Cobas 4800 HPV test,and analyzed factors associated with persistence and new incidence of hrHPV infection using logistic ***:After an average of 15 months at follow-up,the persistence and new incidence rates of hrHPV infection were 38.0%(46/121,95%CI:29.2%-46.8%)and 8.3%(35/420,95%CI:5.7%-11.1%),***-positive women in Yunnan and Guangxi were more likely to have persistent hrHPV infections than those in Xinjiang(aOR=3.18,95%CI:1.00-10.14,p=0.05;aOR=6.38,95%CI:2.29-17.77,p<0.001).Migrant women had a higher rate of new hrHPV incidence than local women(aOR=4.48,95%CI:1.65-12.15,p=0.003).HIV-positive women from Xinjiang were 6.5 times more likely to be newly infected with hrHPV than those from Yunnan(95%CI:2.40-17.60,p<0.001).HIV-positive women with HBV infection had a higher risk of being infected with hrHPV than those without HBV infection(aOR=3.48,95%CI:1.13-10.71,p=0.029).Conclusions:The persistence and new incidence rates of hrHPV infection among HIV-positive women were high and varied significantly between *** infection and being among the migrant population were associated with new hrHPV infection.

关键词： Human immunodeficiency virus(HIV) Human papillomavirus(HPV) Incidence Persistent infection

Detection and Associated Factors for Cervical Precancerous Lesions Among HIV-Positive Women from High HIV-Burden Areas — China, 2015−2016

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China CDC weekly 2020年第20期2卷 355-361页

作者： yaping qiao Ailing Wang Xiaoyan Wang Qian Wang Liwen Fang Linhong Wang National Center for Women and Children’s health Chinese Center for Disease Control and PreventionBeijingChina Center for the Prevention and Control of Chronic Non-communicable Diseases Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Cervical cancer is one of the most common cancers among HIV-positive *** World Health Organization(WHO)has recommended a program of cervical cancer screening for HIV-positive *** follow-up studies and specific recommendations on cervical cancer screening for HIV-positive women in China are not currently being performed.

关键词： Cervical cancer cervical

Screening and Treatment of Syphilis for Pregnant Women—China,2011−2018

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China CDC weekly 2020年第26期2卷 476-480页

作者： yaping qiao Xiaoyan Wang Qian Wang Zhen Li Xi Jin Ailing Wang National Center for Women and Children's Health China CDCBeijingChina

What is already known on this topic?The national program of prevention of mother-to-child transmission(PMTCT)of syphilis was initiated in 2011 and scaled to a national level since 2015.A better understanding of the implementation and outcomes of the program on PMTCT of syphilis is needed for future strategies to achieve the World Health Organization(WHO)goal of elimination of motherto-child transmission(EMTCT)of *** is added by this report Between 2011 and 2018,as the coverage of syphilis screening of pregnant women and treatment for syphilis-seropositive pregnant women and their infants have increased consistently,the incidence of congenital syphilis was significantly reduced from 91.6 cases per 100,000 live births to 18.4 cases per 100,*** rates and adequate treatment rates of syphilis-seropositive pregnant women were below the criteria of validation of EMTCT of syphilis and regional disparities were *** are the implications for public health practice?We recommend continuing to strengthen the current PMTCT intervention strategies with further commitments to achieve the targets set by the WHO’s dual EMTCT of HIV and *** to achieving high coverage of adequate treatment should be investigated and addressed at the provincial level to ensure prompt treatment for syphilis-seropositive pregnant women.

关键词： mother prevention prompt

Recommend Guideline on Prevention of Mother-to-Child Transmission of HIV in China in 2020

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Infectious Diseases & Immunity 2023年第2期3卷 52-59页

作者： Shuiling Qu Qian Wang Xiaoyan Wang yaping qiao Jun Yao Zhen Li Xi Jin Zhixin Li Ailing Wang Chinese Center for Disease Control and Prevention Beijing 102206China National Center for Women and Children's Health Chinese Center for Disease Control and PreventionBeijing 100081China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

In China, a pilot project for the prevention of mother-to-child transmission (PMTCT) of the HIV was initiated in 2001. For the PMTCT of HIV, the Chinese government has released versions of the guidelines since 2004. In 2014, the World Health Organization released guidance on global processes and criteria for the validation of elimination of mother-to-child transmission of HIV and syphilis. To promote the elimination of mother-to-child transmission of HIV, syphilis, and hepatitis B virus in China, the Chinese government updated the Guideline for PMTCT of HIV, Syphilis, and Hepatitis B in 2020 (briefly as Guideline-2020). The Guideline-2020 comprises 5 parts: goals, interventions, support measures, duties and cooperation of departments, and definition indicators for PMTCT of HIV and corresponding calculation formulas. Compared with the previous versions, the key points updated in the Guideline-2020 are that the goals are set again, and health education and promotion, the procedure of HIV testing for pregnant women, and the antiretroviral therapy regimen for HIV-positive pregnant women and antiretroviral) prophylaxis regimen for infants are all updated. The antiretroviral prophylaxis regimen as zidovudine-lamivudine-nevirapine/lopinavir/ritonavir twice per day for 6 weeks is recommended for infants at high exposure risk to HIV, whereas the third antiretroviral therapy regimen as tenofovir-lamivudine-lopinavir/ritonavir is recommended for HIV-positive pregnant women, and indicators for PMTCT of HIV and corresponding calculation formulas are defined.

关键词： HIV PMTCT Guideline Updated China

氮素及混菌发酵对苹果渣发酵饲料纯蛋白含量和氨基酸组成的影响

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饲料工业 2017年第1期38卷 58-61页

作者：任雅萍郭俏来航线薛泉宏西北农林科技大学生命科学学院陕西杨凌712100 西北农林科技大学资源环境学院陕西杨凌712100

采用固态发酵法研究原料中氮素及发酵剂组成对苹果渣发酵产物中纯蛋白质含量与氨基酸组成的影响。结果表明:1接菌及原料中添加油渣均能显著提高苹果渣发酵产物中纯蛋白质含量,在酵母菌与黑曲霉的混菌发酵中,添加油渣处理纯蛋白含量的发... 详细信息

采用固态发酵法研究原料中氮素及发酵剂组成对苹果渣发酵产物中纯蛋白质含量与氨基酸组成的影响。结果表明:1接菌及原料中添加油渣均能显著提高苹果渣发酵产物中纯蛋白质含量,在酵母菌与黑曲霉的混菌发酵中,添加油渣处理纯蛋白含量的发酵增率和接菌增率分别为428.3%和55.8%。2原料灭菌发酵相比于自然发酵能明显提高发酵产物中蛋白质含量,原料A(苹果渣+尿素)和原料B(苹果渣+尿素+油渣)的灭菌增率分别为1.2%~36.4%和4.5%~13.8%。3加入氮素及混菌发酵可增加发酵产物中各种氨基酸的含量及组成比例,且酵母菌Y+黑曲霉H混菌发酵效果优于酵母菌Y+米曲霉M。

关键词：苹果渣发酵饲料单细胞蛋白氨基酸

四川省凉山彝族自治州2008-2016年孕产妇HIV检测及感染情况分析

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中华流行病学杂志 2020年第4期41卷 552-556页

作者：乔亚萍王爱玲王潇滟王前李珍金曦中国疾病预防控制中心妇幼保健中心北京100081

目的了解2008-2016年凉山彝族自治州(凉山州)孕产妇接受HIV检测及HIV感染情况。方法利用全国预防艾滋病、梅毒和乙肝母婴传播管理信息系统中凉山州预防艾滋病母婴传播工作月报表和HIV感染孕产妇个案卡数据,分析2008-2016年凉山州孕产妇... 详细信息

目的了解2008-2016年凉山彝族自治州(凉山州)孕产妇接受HIV检测及HIV感染情况。方法利用全国预防艾滋病、梅毒和乙肝母婴传播管理信息系统中凉山州预防艾滋病母婴传播工作月报表和HIV感染孕产妇个案卡数据,分析2008-2016年凉山州孕产妇HIV检测率、检测时期和HIV阳性率及其年度和地区分布特征。结果2008-2016年凉山州孕产妇HIV检测率、孕期HIV检测率分别从40.7%(8191/20125)和8.0%(1607/20125),增加至95.7%(88000/91946)和70.1%(64421/91946)(趋势χ^2=94497.28,P<0.001,趋势χ^2=90655.03,P<0.001)。累计436519例孕产妇接受了HIV检测,报告HIV感染孕产妇3271例,HIV阳性率为0.75%(95%CI:0.72%~0.77%)。3271例HIV感染孕产妇中1527例(46.7%)在产时接受检测。孕产妇仅产时HIV阳性率逐年增加(趋势χ^2=9.21,P=0.002),2016年为1.32%(95%CI:1.18%~1.47%),高于同期孕产妇孕期HIV检测阳性率(0.67%,95%CI:0.61%~0.73%)(χ^2=88.23,P<0.001)。各县(市)孕产妇HIV检测率均呈增加趋势(趋势χ^2检验,P<0.001)。2016年布拖县、昭觉县、金阳县、美姑县和越西县孕产妇HIV阳性率≥1%。结论2008-2016年凉山州孕产妇HIV检测率增加,但产时检测率较高。孕产妇HIV感染疫情严重,妊娠期HIV检测时间偏晚,需采取措施促进孕产妇在孕期尽早接受HIV检测。

关键词：艾滋病病毒孕产妇母婴传播

316例乙型肝炎暴露婴幼儿母婴传播发生状况调查

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中国疫苗和免疫 2018年第4期24卷 397-401页

作者：宋瑶王爱玲乔亚萍苏敏金曦中国疾病预防控制中心妇幼保健中心

目的分析实施干预措施后乙型肝炎（乙肝）病毒（HBV）母婴传播发生状况及影响因素。方法采用横断面调查方法选取2016年4月1日-2017年3月31日在河北省某市住院分娩的316对乙肝表面抗原（HBsAg）阳性孕产妇及所生婴幼儿,调查HBV母婴传播... 详细信息

目的分析实施干预措施后乙型肝炎（乙肝）病毒（HBV）母婴传播发生状况及影响因素。方法采用横断面调查方法选取2016年4月1日-2017年3月31日在河北省某市住院分娩的316对乙肝表面抗原（HBsAg）阳性孕产妇及所生婴幼儿,调查HBV母婴传播干预措施,对婴幼儿进行HBV血清学检测。结果 316例HBV暴露婴幼儿在出生后采取乙肝疫苗和乙肝免疫球蛋白联合免疫的干预措施后,HBsAg阳性率为2.2%（7/316）。母亲妊娠期HBeAg阳性是婴幼儿发生HBV母婴传播的危险因素（OR=6.05,95%CI：1.01-36.08）。结论预防乙肝母婴传播的干预措施效果好,需加强对HBeAg阳性孕产妇及其所生婴幼儿的干预措施,进一步减少HBV母婴传播。

关键词：乙型肝炎母婴传播干预

2015-2017年中国HIV暴露儿童艾滋病感染早期诊断检测情况分析

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中华流行病学杂志 2019年第9期40卷 1111-1115页

作者：乔亚萍王潇滟苏敏王前李珍金曦王爱玲中国疾病预防控制中心妇幼保健中心北京100081

目的分析我国HIV暴露儿童接受儿童艾滋病感染早期诊断(early infant diagnosis,EID)检测服务情况并探讨其相关影响因素。方法利用全国预防艾滋病母婴传播管理信息系统,收集HIV感染孕产妇分娩儿童随访卡,回顾性分析我国2015-2017年随访... 详细信息

目的分析我国HIV暴露儿童接受儿童艾滋病感染早期诊断(early infant diagnosis,EID)检测服务情况并探讨其相关影响因素。方法利用全国预防艾滋病母婴传播管理信息系统,收集HIV感染孕产妇分娩儿童随访卡,回顾性分析我国2015-2017年随访满18月龄的12 096例HIV暴露儿童队列数据。描述HIV暴露儿童EID检测特征,分析EID检测相关影响因素。结果2015-2017年我国HIV暴露儿童EID检测率自65.6%增加至83.4%(趋势性χ^2检验P<0.001),出生后8周内EID检测比例自61.1%增加至76.8%(趋势性χ^2检验P<0.001),EID检测阳性率自8.7%降低至3.4%(趋势性χ^2检验P<0.001)。2015-2017年死亡儿童EID检测阳性率分别为47.7%、36.9%和36.3%,差异无统计学意义。多因素分析发现HIV暴露儿童民族、地区、满18月龄和存活情况与接受EID检测之间存在关联,差异有统计学意义(P<0.001)。结论我国EID检测工作逐步规范落实,EID检测阳性率逐年降低,但18月龄内死亡儿童,少数民族和HIV低发区儿童的EID检测比例较低。

关键词： HIV暴露儿童儿童艾滋病感染早期诊断死亡覆盖面

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2017年我国梅毒感染孕产妇梅毒治疗情况及影响因素分析

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中国艾滋病性病 2021年第1期27卷 60-63页

作者：李珍王前乔亚萍王潇滟金曦王爱玲中国疾病预防控制中心妇幼保健中心北京100081

目的探究2017年全国梅毒感染孕产妇的梅毒治疗情况及其影响因素。方法利用"中国预防艾滋病、梅毒和乙肝母婴传播管理信息系统"上报的2017年全年分娩的梅毒感染孕产妇相关信息进行单因素和多因素分析,探究孕产妇的社会人口学特征、疾病... 详细信息

目的探究2017年全国梅毒感染孕产妇的梅毒治疗情况及其影响因素。方法利用"中国预防艾滋病、梅毒和乙肝母婴传播管理信息系统"上报的2017年全年分娩的梅毒感染孕产妇相关信息进行单因素和多因素分析,探究孕产妇的社会人口学特征、疾病进程、实验室相关检测及诊断时期等相关因素对妊娠梅毒治疗的影响。结果本研究共纳入33070名梅毒感染孕产妇,有80.93%接受过梅毒治疗,其中孕早、中、晚期开始治疗的孕产妇分别占45.27%,28.40%和12.78%。多因素分析结果发现年龄越大、汉族、受教育程度较高、非务农、经产妇、产时或产后确诊梅毒、有既往梅毒感染史、隐性梅毒、梅毒滴度较低的孕产妇接受治疗的可能性越低。结论2017年全国梅毒感染孕产妇接受治疗的比例距"消除艾滋病、梅毒和乙肝母婴传播"目标要求的95%还有一定差距。多种因素对于梅毒感染孕产妇接受治疗均有影响。建议相关机构有针对性地为孕产妇提供梅毒筛查服务,做到早发现、早诊断、早治疗,进一步降低先天梅毒的发生。

关键词：先天梅毒妊娠梅毒梅毒治疗影响因素