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Identification of potential immune-related mechanisms related to the development of multiple myeloma

Chinese Medical Journal 2024年第13期137卷 1603-1613页

作者： yaomei wang Wenli Zhang Tiandong Li Mengmeng Liu Mengya Gao Xinqing Li Yufei Chen Yongping Song Wei Li Chunyan Du Fang wang Lina Liu Department of Hematology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China The Academy of Medical Science College of MedicalZhengzhou UniversityZhengzhouHenan 450052China College of Public Health Zhengzhou UniversityZhengzhouHenan 450000China Department of Research and Foreign Affairs The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China Department of Clinical Medicine Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Laboratory Animal Center School of Medical SciencesZhengzhou UniversityZhengzhouHenan 450052China

Background:Although significant advances have been made in the treatment of multiple myeloma(MM),leading to unprecedented response and survival rates among patients,the majority eventually relapse,and a cure remains *** situation is closely related to an incomplete understanding of the immune microenvironment,especially monocytes/macrophages in patients with treatment-naïve *** aim of this study was to provide insight into the immune microenvironment,especially monocytes/macrophages,in patients with treatment-naïve ***:This study used the single-cell RNA sequencing(scRNA-seq)data of both patients with MM and heathy donors to identify immune cells,including natural killer(NK)cells,T cells,dendritic cells(DCs),and monocytes/*** data and flow cytometry analysis of monocytes/macrophages were used to further examine the effect of monocytes/macrophages in treatment-naïve MM ***:A significant difference was observed between the bone marrow(BM)immune cells of the healthy controls and treatment-naïve MM patients through *** is noteworthy that,through an scRNA-seq data analysis,this study found that interferon(IFN)-induced NK/T cells,terminally differentiated effector memory(TEMRA)cells,T-helper cells characterized by expression of IFN-stimulated genes(ISG^(+)Th cells),IFN-responding exhausted T cells,mannose receptor C-type 1(MRC1)^(+)DCs,IFN-responding DCs,MHCII^(+)DCs,and immunosuppressive monocytes/macrophages were enriched in patients with treatment-naïve ***,transcriptomic data of monocytes/macrophages demonstrated that"don’t eat me"-related genes and IFN-induced genes increase in treatment-naïve MM ***,scRNA-seq,transcriptomic data,and flow cytometry also showed an increased proportion of CD16^(+)monocytes/macrophages and expression level of ***-cell communication analysis indicated that monocytes/macrophages,whose related important signaling pathways include migration i

关键词： Multiple myeloma Monocytes/macrophages Single-cell RNA sequencing Immune cell Microenvironment Bone marrow Molecular characterization

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集束化疼痛干预联合健康信念导向照顾策略对多发性骨髓瘤患者心理弹性及遵医行为的影响

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癌症进展 2024年第15期22卷 1679-1683页

作者：孙丽媛王耀美王亚丹郑州大学附属肿瘤医院/河南省肿瘤医院血液五病区郑州4500080

目的目的探讨集束化疼痛干预联合健康信念导向照顾策略对多发性骨髓瘤(MM)患者心理弹性及遵医行为的影响。方法方法根据干预方案的不同将88例MM患者分为对照组(n=46)和观察组(n=42),对照组患者接受常规干预,观察组患者给予集束化疼痛干... 详细信息

目的目的探讨集束化疼痛干预联合健康信念导向照顾策略对多发性骨髓瘤(MM)患者心理弹性及遵医行为的影响。方法方法根据干预方案的不同将88例MM患者分为对照组(n=46)和观察组(n=42),对照组患者接受常规干预,观察组患者给予集束化疼痛干预联合健康信念导向照顾策略。比较两组患者的心理弹性[Connor-Davidson心理弹性量表(CD-RISC)]、遵医行为依从性、疼痛程度[视觉模拟评分法(VAS)]和满意度。结果结果干预后,两组患者CD-RISC各维度评分均高于本组干预前,VAS评分均低于本组干预前,观察组患者CD-RISC各维度评分均高于对照组,VAS评分低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的遵医行为总依从率为97.62%,明显高于对照组患者的73.91%,差异有统计学意义(P﹤0.01)。观察组患者的干预技术、干预概念、干预质量、沟通技巧评分均明显高于对照组,差异均有统计学意义(P﹤0.01)。结论结论集束化疼痛干预联合健康信念导向照顾策略能有效改善MM患者的心理弹性,减轻疼痛程度,提高遵医行为依从性和满意度。

关键词：集束化疼痛干预健康信念导向照顾策略多发性骨髓瘤心理弹性

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Comprehensive Characterization and Global Transcriptome Analysis of Human Fetal Liver Terminal Erythropoiesis

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1117-1132页

作者： Yongshuai Han Shihui wang yaomei wang Yumin Huang Chengjie Gao Xinhua Guo Lixiang Chen Huizhi Zhao Xiuli An School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Laboratory of Membrane Biology New York Blood CenterNew YorkNY 10065USA Institute of Hematology People’s Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Hematology the Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Hematology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China

The fetal liver(FL)is the key erythropoietic organ during fetal development,but knowledge on human FL erythropoiesis is very *** this study,we sorted primary erythroblasts from FL cells and performed RNA sequencing(RNA-seq)*** found that temporal gene expression patterns reflected changes in function during primary human FL terminal ***,the expression of genes enriched in proteolysis and autophagy was up-regulated in orthochromatic erythroblasts(OrthoEs),suggesting the involvement of these pathways in *** also performed RNA-seq of in vitro cultured erythroblasts derived from FL CD34+*** of transcriptomes between the primary and cultured erythroblasts revealed significant differences,indicating impacts of the culture system on gene ***,the expression of lipid metabolism-related genes was increased in cultured *** further immortalized erythroid cell lines from FL and cord blood(CB)CD34+cells(FL-iEry and CB-iEry,respectively).FL-iEry and CB-iEry were immortalized at the proerythroblast stage and can be induced to differentiate into OrthoEs,but their enucleation ability was very *** of the transcriptomes between OrthoEs with and without enucleation capability revealed the down-regulation of pathways involved in chromatin organization and mitophagy in OrthoEs without enucleation capacity,indicating that defects in chromatin organization and mitophagy contribute to the inability of OrthoEs to ***,the expression of HBE1,HBZ,and HBG2 was up-regulated in FL-iEry compared with CB-iEry,and such up-regulation was accompanied by down-regulated expression of BCL11A and up-regulated expression of LIN28B and *** study provides new insights into human FL erythropoiesis and rich resources for future studies.

关键词： Human fetal liver Terminal erythropoiesis Transcriptome Immortalized erythroid cell line Enucleation

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Erythroblast island macrophages: recent discovery and future perspectives

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Blood Science 2019年第1期1卷 61-64页

作者： Wei Li yaomei wang Lixiang Chen Xiuli An School of Life Sciences Zhengzhou UniversityZhengzhouChina Laboratory of Membrane Biology New York Blood CenterNew YorkNYUSA Department of Hematology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhouChina

Erythroblastic island(EBI),composed of a central macrophage surrounded by developing erythroid cells,is a structure found in hematopoietic tissues such as fetal liver and bone *** is the first described hematopoietic niche that predominantly supports *** it is well accepted that EBIs and EBI macrophage play important roles during erythropoiesis,the mechanisms by which they support erythropoiesis remain largely unclear due to our inability to identify and isolate EBI *** efforts to identify surface markers for EBI macrophages have focused on the adhesion molecules which are involved in macrophage’s interaction with *** include EMP,Vcam1,CD169,CD163,and aV *** from these earlier studies suggested that combination of Vcam1,CD169,and mouse macrophage surface marker F4/80 can be used to define mouse EBI *** found that not all F4/80+Vcam1+CD169+macrophages are EBI ***,we discovered that EBI macrophages are characterized by the expression of Epor in both mouse and ***-seq analyses of the newly identified EBI macrophages revealed that EBI macrophages have involved specialized function in supporting *** findings provide foundation for future *** we will review current knowledge of EBI macrophages and discuss future perspectives.

关键词： Epor Erythroblast islands Erythroblastic island macrophages Erythropoiesis

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阮籍《咏怀诗》中的“剑”

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贵州社会科学 2006年第6期 123-124,114页

作者：王尧美山东大学山东济南250100

“剑”是阮籍《咏怀诗》中的一个重要意象,在诗中出现8次之多,它是阮籍英雄情结的象征,反映出在魏末政治高压下,阮籍仍然在苦闷中保持慷慨的底气,这是建安精神的延续。刘勰在《文心雕龙》中评价说：“阮籍使气以命诗”,这一具有气势的... 详细信息

“剑”是阮籍《咏怀诗》中的一个重要意象,在诗中出现8次之多,它是阮籍英雄情结的象征,反映出在魏末政治高压下,阮籍仍然在苦闷中保持慷慨的底气,这是建安精神的延续。刘勰在《文心雕龙》中评价说：“阮籍使气以命诗”,这一具有气势的诗歌特点通过“剑”意象得以体现出来。

关键词：《咏怀诗》剑英雄情结慷慨精神

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Study of transmission grating diffraction efficiencies for soft X-ray

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Nuclear Science and Techniques 1999年第2期10卷 78-82页

作者： YANG Jiamin DING Yaonan ZHENG Zhijian YI Rongqing SUN Kexu CUI Mingqi CUl Congwu ZHU Peiping CHEN Zhenlin LI Chaoguang wang yaomei Institute of Nuclear Physics and Chetnisfry CAEPChengdu 610003 Beijing institute of High Energy Physics the Chinese Academy of Sciences.Beijing 100039

Tansmission grating spectrometers are extensively used to measure absthlute X-ray spectra in a photon-energy range below 1000 eV. The transmission grating,as its dispersive element, must be calibrated to obtain its danaction efficiencies. Calibrations of absolute distraction efficiencies of the tlansmission grating at photon energyof 844eV have been carried out on Beliing Synchrotron mediation Facility. With theaid of grating model, all of the grating structure paraxneters have been determinedand the absolute dchaction efficiencies in a photon-energy range below 2000eV havealso been calculated and discussed.

关键词：同步加器辐射衍射效率软X射线

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图式理论与对外汉语阅读教学

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语言教学与研究 2009年第6期 68-73页

作者：王尧美张学广山东大学国际教育学院 250100

本文基于图式理论,对留学生阅读汉语篇章的心理过程与理解障碍进行了初步的分析,并提出了将图式理论应用于对外汉语阅读教学的一些具体方法和策略。

关键词：图式理论阅读教学教学策略

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基于单目视觉的空中手写数据采集系统

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信息与控制 2024年第3期53卷 339-352页

作者：屈喜文韩瑶妹胡冕军安徽工业大学计算机科学与技术学院合肥综合性国家科学中心人工智能研究院

针对基于视觉的空中手写系统使用的3维传感器体积庞大、价格昂贵的缺点，提出了一种新型的基于单目视觉的空中手写数据采集系统，该系统用体积小、价格便宜的单目摄像头代替Kinect、 Leap Motion等3维传感器，更适合于手机、空调、电视... 详细信息

针对基于视觉的空中手写系统使用的3维传感器体积庞大、价格昂贵的缺点，提出了一种新型的基于单目视觉的空中手写数据采集系统，该系统用体积小、价格便宜的单目摄像头代替Kinect、 Leap Motion等3维传感器，更适合于手机、空调、电视等家用设备集成和大规模推广使用。为了解决目前基于单目视觉的空中手写系统每次只能写入单个字符或短文本，用户书写文本长度受到限制的问题，提出了一种坐标系虚拟滑动技术。首先，该系统使用背景差分法和HSV(hue, saturation, value)颜色空间阴影消除法从2维视频帧中获取完整的手部轮廓；其次，利用手的结构特点将手掌和手指进行分割，利用构建的指尖模板从分割出的手指中进行匹配来确定指尖的位置；最后，连接连续视频帧中的指尖位置形成空中手写字符轨迹，通过提出的坐标系虚拟滑动技术使用户可以进行连续书写从而形成文本。实验结果表明，所提系统可以让用户自由地在空中连续书写，对指尖的检测准确率达到了96.8%。

关键词：空中手写单目摄像头数据采集背景差分法

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A retrospective analysis of RetroNectin-activated cytokine-induced killer cells therapy in the treatment of advanced hepatocelluar carcinoma

A retrospective analysis of RetroNectin-activated cytokine-i...

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第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： wei li huiying zhang lingdi zhao ling mai linping xu yaomei wang quanli gao Department of Immunotherapy the Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital School of Life Sciences Zhengzhou University

＜正＞Objective This retrospective study aims to explore the efficacy of RetroNectin-activated cytokine-induced killer cell（R-CIK）therapy in advanced hepatocellular carcinoma patients,which has not yet been thorough...

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干扰素α联合亚砷酸治疗JAK2^(V617F)突变阳性真性红细胞增多症和原发性血小板增多症的疗效

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现代肿瘤医学 2022年第6期30卷 1072-1075页

作者：雷林子王耀美刘玉章刘丽娜房佰俊郑州大学附属肿瘤医院、河南省肿瘤医院血液科河南郑州450008

目的:观察干扰素α(interferon-α,IFN-α)联合亚砷酸治疗JAK2^(V617F)突变阳性的真性红细胞增多症(polycythemia vera,PV)和原发性血小板增多症(essential thrombocythemia,ET)患者的有效性及安全性。方法:回顾性分析2015年12月至2021年01月在我院血液科收治的44例PV和ET患者的临床资料,比较IFN-α联合亚砷酸(观察组)以及单用IFN-α(对照组)的疗效及不良反应。结果:观察组血液学总有效率(overall response rate,ORR)为88.5%,高于对照组。至随访截止时,观察组达血液学及分子生物学缓解的ORR均高于对照组。并且观察组并未出现不良反应发生率增加的情况。结论:亚砷酸能加速并增强IFN-α抗肿瘤作用,二者联合治疗能提高JAK2^(V617F)突变阳性的PV和ET的临床缓解率和疗效持续时间,且安全性高。

关键词：真性红细胞增多症原发性血小板增多症干扰素α 亚砷酸疗效

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