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Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci

Precision Clinical Medicine 2023年第2期6卷 57-66页

作者： Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard Jacques Gardon Marc Taquet André Bouville jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire jean-baptiste Cazier University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Radiations Epidemiology"Villejuif 94805France Centre for Computational Biology University of BirminghamBirmingham B152TTUK Institute of Cancer and Genomic Sciences University of BirminghamBirmingham B152TTUK University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Exposome and Heredity"Villejuif 94805France Endocrinology Unit Territorial Hospital TaaoneF-98713PapeeteTahiti 98713French Polynesia CEA Laboratoire de Cancérologie FondamentaleInstitut de Biologie François JacobiRCMSREITLaboratoire de Cancérologie Expérimentale(LCE)UniversitéParis-SaclayFontenay aux Roses 92265France Fondation jean Dausset-Centre d’Etude du Polymorphisme Humain Paris 75010France UniversitéParis-Saclay CEACentre National de Recherche en Génomique HumaineEvry 91057France U.S.R.2003(CNRS/UPF) Faa’aTahiti 98702France University of Lorraine INSERM CIC 1433Nancy CHRUINSERM U1116Nancy 54500France Hydrosciences Montpellier Research Institute for DevelopmentCNRSUniversity of MontpellierMontpellier 62307France Research Institute for Development Center IRD on TahitiArueTahiti 98713French Polynesia National Cancer Institute(retired) BethesdaMD 20892USA Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive *** research aimed to analyze the genetic factors of DTC risk among the native FP ***:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear *** analyzed the genetic profile of our cohort to identify population *** then completed a genome-wide analysis study on the whole ***:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European *** identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and *** lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and ***:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC ***,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian ***,the functional impact of these three new loci needs to be further explored and validated.

关键词： differentiated thyroid cancer population genetics genetic susceptibility

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三轴感应电阻率测井新技术

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国外测井技术 2009年第5期24卷 57-70页

作者： Barbara Anderson Tom Barber Rob Leveridge Rabi Bastia Kamlesh Raj Saxena Anti Kumar Tyag jean-baptiste Clavaud Brian Coffin Madhumita Das Ron Hayden Theodore Klimentos Chanh Cao Mirth Stephen Williams 美国马萨诸塞州堪布里奇美国得克萨新州Sugar Land 信实工业公司印度盂买雪弗龙能源技术公司得克萨斯州休斯敦 HighMount勘探与生产公司得克萨斯州休斯敦 Utkal大学印度奥里萨邦布巴内斯瓦尔得克萨新州休斯敦印度孟买安哥拉罗安达挪威国家石油公司挪威斯塔万格

一种新型感应电阻率测井仪器能够提供远离井筒地层的三维信息，提高斜井和倾斜地层的电阻率测量精度，而且不需要接触井壁就能够直接测量地层倾角大小和方位。采用这种高精度三轴电阻率测井仪器可以减少漏掉油气层的机会，加强对储层的... 详细信息

一种新型感应电阻率测井仪器能够提供远离井筒地层的三维信息，提高斜井和倾斜地层的电阻率测量精度，而且不需要接触井壁就能够直接测量地层倾角大小和方位。采用这种高精度三轴电阻率测井仪器可以减少漏掉油气层的机会，加强对储层的认识。

关键词：电阻率测井感应电阻率三轴技术测井仪器倾斜地层三维信息测量精度

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An atypical NLR gene confers bacterial wilt susceptibility in Arabidopsis

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Plant Communications 2023年第5期4卷 277-294页

作者： Choghag Demirjian Narjes Razavi Gang Yu baptiste Mayjonade Lu Zhang Fabien Lonjon Fabien Chardon Se bastien Carrere Je rome Gouzy Ste phane Genin Alberto PMacho Fabrice Roux Richard Berthome Fabienne Vailleau LIPME Universite de ToulouseINRAECNRSCastanet-TolosanFrance Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina Universite Paris-Saclay INRAEAgroParisTechInstitut Jean-Pierre Bourgin(IJPB)78000 VersaillesFrance Present address:Department of Cell&Systems Biology University of TorontoTorontoONCanada Present address:Department of Biology NYU12 Waverly PlaceNew YorkNY 10003USA

Quantitative disease resistance(QDR)remains the most prevalent form of plant resistance in crop fields and wild ***-wide association studies(GWAS)have proved to be successful in deciphering the quantitative genetic basis of complex traits such as *** unravel the genetics of QDR to the devastating worldwide bacterial pathogen Ralstonia solanacearum,we performed a GWAS by challenging a highly polymorphic local mapping population of Arabidopsis thaliana with four *** type III effector(T3E)mutants,identified as key pathogenicity determinants after a first screen on an *** core collection of 25 *** most quantitative trait loci(QTLs)were highly specific to the identity of the T3E mutant(ripAC,ripAG,ripAQ,and ripU),we finely mapped a common QTL located on a cluster of nucleotide-binding domain and leucine-rich repeat(NLR)genes that exhibited structural *** functionally validated one of these NLRs as a susceptibility factor in response to ***,named it Bacterial Wilt Susceptibility 1(BWS1),and cloned two alleles that conferred contrasting levels of *** characterization indicated that expression of BWS1 leads to suppression of immunity triggered by different *** *** addition,we showed a direct interaction between BWS1 and RipAC T3E,and BWS1 and SUPPRESSOR OF G2 ALLELE OF skp1(SGT1b),the latter interaction being suppressed by ***,our results highlight a putative role for BWS1 as a quantitative susceptibility factor directly targeted by the T3E RipAC,mediating negative regulation of the SGT1-dependent immune response.

关键词： Ralstonia solanacearum typeⅢeffectors Arabidopsis thaliana GWAS R gene susceptibility

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灯镜之间

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现代装饰（家居） 2016年第8期 62-67页

作者： Elkeland jean-baptiste Colleuille F?LSOM Studio Alain Gilles Craft Combine Yonoh Jan Plechá & Henry Wielgus BD Barcelona Design Lefteris Tsampikakis David Derksen Bower Vera&Kyte FARG & BLANCHE Moshi-mosh 李薇范嘉苑 Auriga Studio Monica Forster Design Studio

镜子,我们生活中必不可少的物品之一,是自我修饰的专用工具,相信每个人的家中都会有一面镜子,或者好几面镜子,梳妆镜、穿衣镜、手境……每天早晨醒来,我们对着镜子洗漱、对着镜子整理妆容、对着镜子微笑,镜子见证了我们各种状态下的自己... 详细信息

镜子,我们生活中必不可少的物品之一,是自我修饰的专用工具,相信每个人的家中都会有一面镜子,或者好几面镜子,梳妆镜、穿衣镜、手境……每天早晨醒来,我们对着镜子洗漱、对着镜子整理妆容、对着镜子微笑,镜子见证了我们各种状态下的自己,它是每一位女生最真诚的＂闺蜜＂。每当我们使用镜子的时候,光线必须足够明亮,因为镜子需要依赖光的照耀和反射才能显现出它的魅力,而灯作为光源的一种,是家居空间中的另一种必须品,

关键词：专用工具必须品家居空间 Mirror 三角支架旋转装置一革线条简洁装置组成吹制

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Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma

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World Journal of Radiology 2013年第4期5卷 173-177页

作者： Aurélie Robles Antonin Levy Coralie Moncharmont Lamine Farid jean-baptiste Guy Nadia Malkoun Lysian Cartier Cyrus Chargari Isabelle Guichard jean-Noёl Talabard Guy de Laroche Nicolas Magné Department of Radiotherapy Institut de Cancérologie de la Loire Department of Radiation Oncology Institut Gustave Roussy Université Paris XI Department of Radiation Oncology Hpital d'Instruction des Armées du Val-de-Grace Department of Internal Medicine CHU Saint Etienne

AIM:To assess the feasibility of volumetric intensity-modulated arc radiotherapy (VMAT) in patients with limited polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome. METHODS:A 70-year-old male with histologically confirmed osteosclerotic myeloma was treated in our department in July 2010 with VMAT. Fourty-six Gray in 23 fractions were given on three bone lesions. Doses delivered to target volume and critical organs were compared with a tridimensional conformal radiotherapy (3D-RT) plan. Treatment was well tolerated without any side ***:VMAT improved dose homogeneity within the target volume, as compared to 3D-RT (standard deviations:2.9 Gy and 1.6 Gy for 3D and VMAT, respectively). VMAT resulted in a better sparing of critical organs. Dose delivered to 20% of organ volume (D20) was reduced from 22 Gy (3D-RT) to 15 Gy (VMAT) for small bowel, from 24 Gy (3D-RT) to 17 Gy (VMAT) for bladder and from 47 Gy (3D-RT) to 3 Gy (VMAT) for spinal cord. Volumes of critical organs that received at least 20 Gy (V20) were decreased by the use of VMAT, as compared to 3D-RT (V20 bladder:10% vs 99%; V20 small bowel:6% vs 21%). One year after treatment completion, no tumor progression has been reported. CONCLUSION:VMAT improved dose distribution as compared to 3D-RT for limited osteosclerotic myeloma, with better saving of critical organs.

关键词： Volumetric intensity-modulated arc radiotherapy Conformal radiotherapy Critical organs Osteosclerotic myeloma Polyneuropathy organomegaly endocrinopathy monoclonal gammopathy and skin change syndrome

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Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

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World Journal of Hepatology 2020年第12期12卷 1326-1340页

作者： Anais Brayette Marie Essig Paul Carrier Marilyne Debette-Gratien Anais Labrunie Sophie Alain Marianne Maynard Nathalie Ganne-Carrie Eric Nguyen-Khac Pauline Pinet Victor De Ledinghen Christophe Renou Philippe Mathurin Claire Vanlemmens Vincent Di Martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard Marc Bardou Armand Abergel Manh-Thong Dao Thierry Thevenot jean-baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard Matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti U1248 INSERM Department of Hepatology and GastroenterologyUniv.LimogesCHU LimogesLimoges F-87000France U1248 INSERM Department of Nephrology and TransplantationCHU LimogesLimoges F-87000France Department of Center of Epidemiology Biostatistics and Research MethodologyCHU LimogesLimoges F-87000France U1092 INSERM Department of VirologyCHU LimogesLimoges F-87000France Department of Hepatology Croix-Rousse University Hospital of LyonLyon 69004France Department of Hepatology Jean Verdier University Hospital of BondyBondy 93140France Department of Hepato-Gastroenterology Amiens University HospitalAmiens 80054France Department of Infectious Diseases CHU LimogesLimoges F-87000France Department of Hepatology Haut Leveque HospitalBordeaux University HospitalPessac 33604France Department of Gastroenterology Hyeres HospitalHyeres 83407France Department of Hepato-Gastroenterology Claude Huriez University HospitalLille 59037France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Infectious Diseases Bichat University HospitalParis 75018France Department of Hepatology University Hospital of AngersAngers 49933France Department of Hepato-Gastroenterology and Nutrition University Hospital of CaenCaen 14033France Department of General Medecine University Hospital of CaenCaen 14000France Department of Hepatology La Pitié-Salpêtrière University HospitalParis 75651France Department of Hepatology and Gastroenterology Dijon University HospitalDijon 21079France Department of Hepatology and Gastroenterology Estaing University HospitalClermont Ferrand 63003France Department of Hepatology Beaujon University HospitalClichy 92110France Department of Hepatology Saint-AndréUniversity HospitalBordeaux 33000France Department of Hepatology and Gastroenterology La Roche-Sur-Yon Hospital CenterLa Roche-Sur-Yon 85000France Department of Hepatology and Gastroenterology University Hospital of MontpellierMontpellier 34295France Department of Addictology Hospita

BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal *** early markers are available,but no consensus exists on their *** To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected *** A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was *** patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)*** on the early markers of SPT,the eGFR and phosphatemia,were collected *** was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(M24)were *** data were analyzed using analyses of variance or Kruskal-Wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative *** analyses were used to adjust for any potential confounding *** Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at *** M24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,P<0.42 and 50.0%vs 30.7%,P=0.32 for ETV and TDF,respectively);no patient had an eGFR lower than 50 mL/min/1.73 m²or phosphatemia less than 0.48 mmoL/*** the multivariate analysis,no explanatory variables were identified after *** cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at M24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TD

关键词： Hepatitis B virus Proximal tubulopathy Biomarkers Renal insufficiency Nucleoside analogues

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60个新观点带你另眼看世界

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新发现 2020年第9期 24-66页

作者： Marie Atteia Kheira Bettayeb Coline Buanic Thomas Cavaillé-Fol Anne Debroise Olivier Donnars Stéphane Fay Lise Gougis Coralie Hancok Román Ikonicoff Hugo Leroux Vincent Nouyrigat Alexandra Pihen Benoît Rey Yves Sciama jean baptiste Veyrieras 王隽(编译) 缪伶超(编译) 不详

它们中既有仍处于研究阶段的假设,也有尚未察觉的关联,还有已存在事实支撑但还未进行论证的主张……毕竟从灵光一现到范式形成的过程非常漫长;观点的建立与科研工作的开花结果都需要时间。植物会说话吗?雨水会引发火山喷发吗?

关键词：火山喷发科研工作另眼看开花结果观点

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基于功率谱密度的包装系统损伤估算方法

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绿色包装 2016年第6期 64-64页

作者： Victor Huartl jean-baptiste Nolot jean-Charles Candore Jér?me Pellot Nicolas Krajka Serge Odof Damien Erre

包装总是承受着一些在运输过程中的损伤,W?hler曲线通常用来确定一个包装系统的机械磨损演变。损伤估算可以用雨流法进行,但应力要求连续记录。然而,进行连续记录是不可能的,所以以全球运输振动的功率谱密度(PSD)为代表进行记录是适合... 详细信息

包装总是承受着一些在运输过程中的损伤,W?hler曲线通常用来确定一个包装系统的机械磨损演变。损伤估算可以用雨流法进行,但应力要求连续记录。然而,进行连续记录是不可能的,所以以全球运输振动的功率谱密度(PSD)为代表进行记录是适合的。本文根据W?hler曲线系统的损伤进行研究。Basquin模型被用来确定系统的机械磨损和机械行为的演化,通过从W?hler曲线中提取Basquinβ系数和常数系统C建立模型。W?hler曲线进一步体现包装系统的数据变化,及其Basquin系数B和系统常数C进行提取。损伤估算所积累的应力循环,利用Palmgren Miner规则进行排列重组,形成规律模型。在本文中,在一个信号中检测到的周期最大峰值,它的最大应力出现概率密度也由一个多元高斯模型体现。协会有相同的统计特性所对应时间的事件,因此这些统计特性可被用来提取谱矩法。此外,损伤方程提出了采用PSD,并由不同的月台幕门损伤方程确定,与振动台的实际持续时间进行比较,得出更精准的结果。

关键词：包装系统损伤方程功率谱密度

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SURVEY OF PLANTS USED IN TRADITIONAL MEDICINE AGAINST MALARIA IN BUKAVU AND UVIRA/DR CONGO

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 98-98页

作者： Henry Manya Mboni Valentin Bashige Chiribagula Salvius Bakari Amuri Dede Mbangu Munahu Joseph Kahumba Byanga Caroline Stévigny jean-baptiste Lumbu Simbi Pierre Duez Laboratoire de Pharmacognosie Faculté des Sciences Pharmaceutiques Université de Lubumbashi (UNILU) Laboratoire de Pharmacognosie Bromatologie et Nutrition humaine Université Libre de Bruxelles (ULB) Service de Chimie Organique Département de Chimie Faculté des Sciences/UNILU Institut National pour l'Etude et la Recherche Agronomique Station de Kipopo Laboratory of Therapeutic Chemistry & Pharmacognosy University of Mons (UMONS)

Malaria,for its high prevalence and morbidity,is one of the major tropical parasitic diseases,particularly in DR *** therapy not only uses modem antimalarials,for which many Resistance problems are encountered,but als... 详细信息

关键词： SURVEY OF PLANTS USED IN TRADITIONAL MEDICINE AGAINST MALARIA IN BUKAVU AND UVIRA/DR CONGO DR

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国外绘画大师经典作品欣赏——头戴珍珠的女郎

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数理天地（初中版） 2019年第2期 1-1页

作者：让·巴蒂斯特·卡米耶·柯罗不详

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